{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:24Z","timestamp":1791232404374,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"CONACyT"},{"name":"Mexican Institute of Social Security"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.jep.2011.12.005","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T13:24:27Z","timestamp":1323782667000},"page":"751-756","source":"Crossref","is-referenced-by-count":98,"title":["Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract"],"prefix":"10.1016","volume":"139","author":[{"given":"Javier","family":"Alarc\u00f3n-Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Alarc\u00f3n","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Herrera-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Jimenez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.12.005_bib0005","first-page":"235","article-title":"Mechanisms of the blood pressure lowering effect of the calyx extract of Hibiscus sabdariffa in rats","volume":"25","author":"Adegunloye","year":"1996","journal-title":"African Journal of Medicine and Medical Science"},{"key":"10.1016\/j.jep.2011.12.005_bib0010","first-page":"3","article-title":"Verification of the folkloric diuretic claim of Hibiscus sabdariffa L. petal extract","author":"Aguwa","year":"2004","journal-title":"Nigerian Journal of Pharmaceutical Research"},{"key":"10.1016\/j.jep.2011.12.005_bib0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-8741(91)90009-3","article-title":"Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces","volume":"31","author":"Ali","year":"1991","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0020","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jep.2006.08.005","article-title":"Mechanism of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces","volume":"109","author":"Ajay","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0025","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jep.2008.04.015","article-title":"Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats","volume":"118","author":"Arafat","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0030","first-page":"11","article-title":"Diuretic effect of ITA 529","volume":"6","author":"Arano","year":"1984","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0035","series-title":"Atlas de las Plantas de la Medicina Tradicional Mexicana","first-page":"274","article-title":"Hibiscus sabdariffa","author":"Argueta","year":"1994"},{"key":"10.1016\/j.jep.2011.12.005_bib0040","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00004872-200204000-00001","article-title":"Salt consumption, reactive oxygen species and cardiovascular ageing: a hypothetical link","volume":"20","author":"Aviv","year":"2002","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.jep.2011.12.005_bib0045","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/ndt\/13.7.1682","article-title":"The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide","volume":"13","author":"Buter","year":"1998","journal-title":"Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association \u2013 European Renal Association"},{"key":"10.1016\/j.jep.2011.12.005_bib0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0378-8741(87)90001-8","article-title":"Diuretic activity of plants used for the treatment of urinary ailments in Guatemala","volume":"19","author":"C\u00e1ceres","year":"1987","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0055","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.CIR.0000124064.00494.21","article-title":"Brain natriuretic peptide enhances renal actions of furosemide and suppresses furosemide-induced aldosterone activation in experimental heart failure","volume":"109","author":"Cataliotti","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2011.12.005_bib0060","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11906-996-0013-z","article-title":"Low sodium diet after DASH: has the situation changed? Dietary approaches to stop hypertension","volume":"4","author":"Cohen","year":"2002","journal-title":"Current Hypertension Reports"},{"key":"10.1016\/j.jep.2011.12.005_bib0065","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.CIR.101.6.594","article-title":"Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I\/angiotensin II conversion in patients with chronic heart failure","volume":"101","author":"Farquharson","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2011.12.005_bib0070","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000186753","article-title":"Sodium depletion enhances the antiproteinuric effect of ACE inhibition in established experimental nephrosis","volume":"60","author":"Gansevoort","year":"1992","journal-title":"Nephron"},{"key":"10.1016\/j.jep.2011.12.005_bib0075","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0895-7061(96)00033-7","article-title":"Effects of l-arginine infusion on renal hemodynamics and sodium excretion during hypo-, normo-, and hyperinsulinemia, as studied in dogs","volume":"9","author":"Garcia-Robles","year":"1996","journal-title":"American Journal of Hypertension"},{"key":"10.1016\/j.jep.2011.12.005_bib0080","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1001\/jama.279.17.1383","article-title":"Effects of sodium restriction on blood pressure, renin, aldosterone, catecholamines, cholesterols and triglyceride","volume":"279","author":"Graudal","year":"1998","journal-title":"JAMA: The Journal of American Medical Association"},{"key":"10.1016\/j.jep.2011.12.005_bib0085","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0378-8741(98)00157-3","article-title":"The effect of sour tea (Hibiscus sabdariffa) on essential hypertension","volume":"65","author":"Haji","year":"1999","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0090","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/01.HYP.38.3.321","article-title":"Importance of the renin system for determining blood pressure fall with acute salt restriction in hypertensive and normotensive whites","volume":"38","author":"He","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2011.12.005_bib0095","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ki.1989.190","article-title":"Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril","volume":"36","author":"Heeg","year":"1989","journal-title":"Kidney International"},{"key":"10.1016\/j.jep.2011.12.005_bib0100","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.phymed.2004.04.001","article-title":"Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial","volume":"11","author":"Herrera-Arellano","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2011.12.005_bib0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2006-957065","article-title":"Clinical effects produced by a standarized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial","volume":"73","author":"Herrera-Arellano","year":"2007","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2011.12.005_bib0110","first-page":"120","article-title":"In vitro enzyme inhibitory and in vivo cardioprotective activities of hibiscus (Hibiscus sabdariffa L)","volume":"45","author":"Jonadet","year":"1990","journal-title":"Journal de Pharmacie de Belgique"},{"key":"10.1016\/j.jep.2011.12.005_bib0115","first-page":"314","article-title":"Changes in urinary chemical composition in healthy volunteers after consuming roselle (Hibiscus sabdariffa Linn.) juice","volume":"77","author":"Kirdpon","year":"1994","journal-title":"Journal of the Medical Association of Thailand"},{"key":"10.1016\/j.jep.2011.12.005_bib0120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.atherosclerosis.2008.08.007","article-title":"Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta","volume":"204","author":"Lodi","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jep.2011.12.005_bib0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3945\/jn.109.115097","article-title":"Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults","volume":"140","author":"McKay","year":"2010","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.jep.2011.12.005_bib0130","first-page":"593","article-title":"Effect of quercetin on kinetic properties of renal Na,K-ATPasa in normotensive and hypertensive rats","volume":"61","author":"Mezesova","year":"2010","journal-title":"Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0135","first-page":"77","article-title":"An investigation of the diuretic effect of an aqueous extract of the petals of Hibiscus sabdariffa","volume":"2","author":"Mojiminiyi","year":"2000","journal-title":"Journal of Medicine and Medical Sciences"},{"key":"10.1016\/j.jep.2011.12.005_bib0140","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000186743","article-title":"Effects of acute arginine loading on renal and systemic hemodynamics in dogs","volume":"60","author":"Napathorn","year":"1992","journal-title":"Nephron"},{"key":"10.1016\/j.jep.2011.12.005_bib0145","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00005344-198706000-00016","article-title":"Diuretic effects of angiotensin-converting enzyme inhibition: comparison of low and liberal sodium diet in hypertensive patients","volume":"9","author":"Navis","year":"1987","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0150","first-page":"1","article-title":"Diuretic effect of Pluchea indica","volume":"11","author":"Nilveses","year":"1989","journal-title":"Thai Journal of Pharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0155","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-8741(03)00078-3","article-title":"Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats","volume":"86","author":"Odigie","year":"2003","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0160","first-page":"7L 10","article-title":"Inhibition of angiotensin converting enzyme (ACE) activity by anthocyanins dephinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa","volume":"128","author":"Ojeda","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/(SICI)1099-0844(199909)17:3<199::AID-CBF829>3.0.CO;2-2","article-title":"Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats","volume":"17","author":"Onyenekwe","year":"1999","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/j.jep.2011.12.005_bib0170","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2125.1989.tb05397.x","article-title":"A comparison of the effects of ibuprofen and indomethacin upon renal haemodynamics and electrolyte excretion in the presence and absence of frusemide","volume":"27","author":"Passmore","year":"1989","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0175","doi-asserted-by":"crossref","first-page":"R1050","DOI":"10.1152\/ajpregu.00181.2009","article-title":"Nitric oxide produced by endothelial nitric oxide synthase promotes diuresis","volume":"298","author":"Perez-Rojas","year":"2010","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.jep.2011.12.005_bib0180","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jep.2008.02.036","article-title":"Uricosuric effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former subjects","volume":"117","author":"Prasongwatana","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0185","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jep.2004.01.006","article-title":"Diuretic activity of Spilanthes acmella flowers in rats","volume":"91","author":"Ratnasooriya","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.005_bib0190","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"The Journal of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.jep.2011.12.005_bib0195","doi-asserted-by":"crossref","first-page":"R1744","DOI":"10.1152\/ajpregu.00871.2007","article-title":"l-Arginine-induced glomerular hyperfiltration response: the roles o insulin and ANG II","volume":"294","author":"Ruiz","year":"2008","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.jep.2011.12.005_bib0200","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1074\/jbc.271.11.6518","article-title":"Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae","volume":"271","author":"Shaul","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2011.12.005_bib0205","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejphar.2005.10.019","article-title":"Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril","volume":"527","author":"Westendorp","year":"2005","journal-title":"European Journal of Pharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111008725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111008725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T15:55:51Z","timestamp":1543334151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111008725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0378874111008725"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.12.005","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}