{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:54:46Z","timestamp":1762113286688},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Program of Kyung Hee University","award":["KHU-20081268"],"award-info":[{"award-number":["KHU-20081268"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.jep.2011.12.015","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T18:26:42Z","timestamp":1323800802000},"page":"883-888","source":"Crossref","is-referenced-by-count":25,"title":["Dangguijakyak-san protects dopamine neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity under postmenopausal conditions"],"prefix":"10.1016","volume":"139","author":[{"given":"Jin-Moo","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok-Sang","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Geun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Sook","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.12.015_bib0005","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11357-010-9148-6","article-title":"Acute effects of 17 beta-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats","volume":"32","author":"Alonso","year":"2010","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.jep.2011.12.015_bib0010","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1212\/WNL.55.9.1358","article-title":"Parkinson's disease and parkinsonism in a longitudinal study: two-fold higher incidence in men","volume":"55","author":"Baldereschi","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jep.2011.12.015_bib0015","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/mds.1170","article-title":"Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case control study","volume":"16","author":"Benedetti","year":"2001","journal-title":"Movement Disorders"},{"key":"10.1016\/j.jep.2011.12.015_bib0020","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.jep.2011.12.015_bib0025","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1248\/bpb.31.1145","article-title":"Estrogenic effects of a Kampo formula, Tokishakuyakusan, in parous ovariectomized rats","volume":"31","author":"Chung","year":"2008","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2011.12.015_bib0030","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ptr.1928","article-title":"Estrogenic activity of standardized extract of Angelica sinensis","volume":"20","author":"Circosta","year":"2006","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2011.12.015_bib0035","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.neuropharm.2004.08.020","article-title":"Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER [alpha] agonist","volume":"47","author":"D\u2019Astous","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2011.12.015_bib0040","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0892-0362(96)00086-4","article-title":"Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57\/B1 mice","volume":"18","author":"Dluzen","year":"1996","journal-title":"Neurotoxicology and Teratology"},{"key":"10.1016\/j.jep.2011.12.015_bib0045","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/ptr.1671","article-title":"Protective effect of Toki-shakuyaku-san on amyloid beta 25\u201335-induced neuronal damage in cultured rat cortical neurons","volume":"19","author":"Egashira","year":"2005","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2011.12.015_bib0050","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00006254-200205000-00023","article-title":"Phytoestrogens in the management of the menopause: up-to-date","volume":"57","author":"Ewies","year":"2002","journal-title":"Obstetrical & Gynecological Survey"},{"key":"10.1016\/j.jep.2011.12.015_bib0055","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S1474-4422(08)70214-X","article-title":"Non-dopaminergic treatments in development for Parkinson's disease","volume":"7","author":"Fox","year":"2008","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.jep.2011.12.015_bib0060","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ptr.2650070602","article-title":"An overview of kampo medicine: Toki-Shakuyaku-San (TJ-23)","volume":"7","author":"Hagino","year":"1993","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2011.12.015_bib0065","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jep.2010.11.017","article-title":"Dangguijakyak-san; a medicinal herbal formula; protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity","volume":"133","author":"Hwang","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.015_bib0070","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jep.2004.11.020","article-title":"Neuroprotective effects of the aqueous extract of the Chinese medicine Danggui-Shaoyao-san on aged mice","volume":"97","author":"Kou","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.12.015_bib0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2006.04.110","article-title":"Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice","volume":"1102","author":"Kuang","year":"2006","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2011.12.015_bib0080","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1115035","article-title":"Caspases 3 and 7: key mediators of mitochondrial events of apoptosis","volume":"311","author":"Lakhani","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jep.2011.12.015_bib0085","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1523\/JNEUROSCI.20-23-08604.2000","article-title":"Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory","volume":"20","author":"Leranth","year":"2000","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.jep.2011.12.015_bib0090","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/sj.bjp.0706732","article-title":"Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor","volume":"148","author":"Liu","year":"2006","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2011.12.015_bib0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neures.2007.10.005","article-title":"Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease","volume":"60","author":"Liu","year":"2008","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.jep.2011.12.015_bib0100","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4522(02)00578-X","article-title":"Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females","volume":"116","author":"Murray","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2011.12.015_bib0105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000116351","article-title":"MPTP-induced parkinsonian model in mice: biochemistry, pharmacology and behavior","volume":"26","author":"Ogawa","year":"1987","journal-title":"European Neurology"},{"key":"10.1016\/j.jep.2011.12.015_bib0110","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2008.07.019","article-title":"Effects of estrogens on striatal damage after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in male and female mice","volume":"296","author":"Ookubo","year":"2008","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.jep.2011.12.015_bib0115","first-page":"213","article-title":"A clinical trial to verify the quality of life improvement efficacy of Dangguijakyak-san and Gyejibongnyeong-hwan granulation in postmenopausal women","volume":"20","author":"Park","year":"2007","journal-title":"Journal of Oriental Obstetrics & Gynecology"},{"key":"10.1016\/j.jep.2011.12.015_bib0120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1212\/01.wnl.0000171344.87802.94","article-title":"Effect of reproductive factors and postmenopausal hormone use on the risk of Parkinson disease","volume":"65","author":"Popat","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jep.2011.12.015_bib0125","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cellbi.2007.10.004","article-title":"Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade","volume":"32","author":"Qian","year":"2008","journal-title":"Cell Biology International"},{"key":"10.1016\/j.jep.2011.12.015_bib0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jnr.10833","article-title":"Estrogen interacts with the IGF 1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6 hydroxdopamine lesions","volume":"75","author":"Quesada","year":"2004","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.jep.2011.12.015_bib0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000070277","article-title":"Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male mice","volume":"77","author":"Ramirez","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jep.2011.12.015_bib0140","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/sj.cdd.4401975","article-title":"Proapoptotic multidomain Bcl-2\/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities","volume":"13","author":"Reed","year":"2006","journal-title":"Cell Death & Differentiation"},{"key":"10.1016\/j.jep.2011.12.015_bib0145","first-page":"277","article-title":"Preventive effect of ferulic acid on bone loss in ovariectomized rats","volume":"17","author":"Sassa","year":"2003","journal-title":"In Vivo"},{"key":"10.1016\/j.jep.2011.12.015_bib0150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000109348","article-title":"Effects of phytoestrogen in brain and neurodegenerative diseases","volume":"4","author":"Shi","year":"2007","journal-title":"Neuroembryology and Aging"},{"key":"10.1016\/j.jep.2011.12.015_bib0155","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cbf.1423","article-title":"Possible role of mitochondrial dysfunction in central neurodegeneration of ovariectomized rats","volume":"26","author":"Shi","year":"2008","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/j.jep.2011.12.015_bib0160","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/19768354.2010.528615","article-title":"Inhibitory effect of Ssanghwa-tang on bone loss in ovariectomized rats","volume":"14","author":"Shim","year":"2010","journal-title":"Animal Cells and Systems"},{"key":"10.1016\/j.jep.2011.12.015_bib0165","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3109\/00016348609157034","article-title":"Inhibition by plant herb extracts of steroid bindings in uterus, liver and serum of the rabbit","volume":"65","author":"Tamaya","year":"1986","journal-title":"Acta obstetricia et gynecologica Scandinavica"},{"key":"10.1016\/j.jep.2011.12.015_bib0170","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neulet.2008.02.038","article-title":"Estrogen enhances the number of nigral dopaminergic neurons of adult male mice without affecting nigral neuroglial number and morphology","volume":"435","author":"Tripanichkul","year":"2008","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.jep.2011.12.015_bib0175","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1212\/WNL.54.12.2292","article-title":"Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations","volume":"54","author":"Tsang","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jep.2011.12.015_bib0180","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1142\/S0192415X02000247","article-title":"The improvement of luteal insufficiency in fecund women by Tokishakuyakusan treatment","volume":"2","author":"Usuki","year":"2002","journal-title":"The American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2011.12.015_bib0185","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aje\/kwg068","article-title":"Incidence of Parkinson's disease: variation by age, gender, and race\/ethnicity","volume":"157","author":"Van Den Eeden","year":"2003","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.jep.2011.12.015_bib0190","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/gme.0b013e3181847619","article-title":"Effects of anthocyanins on learning and memory of ovariectomized rats","volume":"16","author":"Varadinova","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.jep.2011.12.015_bib0195","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","article-title":"Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease","volume":"98","author":"Vila","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jep.2011.12.015_bib0200","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/gme.0b013e318196a0c9","article-title":"Memory complaints and memory performance in the menopausal transition","volume":"16","author":"Weber","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.jep.2011.12.015_bib0205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0278-5846(03)00168-4","article-title":"Protection against [beta]-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice","volume":"28","author":"Yan","year":"2004","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111008828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111008828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T20:27:47Z","timestamp":1713212867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111008828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0378874111008828"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.12.015","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}