{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:00:29Z","timestamp":1781064029145,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jep.2012.05.039","type":"journal-article","created":{"date-parts":[[2012,6,9]],"date-time":"2012-06-09T05:41:08Z","timestamp":1339220468000},"page":"684-693","source":"Crossref","is-referenced-by-count":27,"title":["Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells"],"prefix":"10.1016","volume":"142","author":[{"given":"Hyo","family":"Won Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ki","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheong","family":"Weon Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Seong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ki","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2012.05.039_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.pharmthera.2007.01.012","article-title":"Allergic rhinitis and its pharmacology","volume":"114","author":"Al Suleimani","year":"2007","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.jep.2012.05.039_bib2","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.intimp.2008.06.010","article-title":"Validation of guinea pig model of allergic rhinitis by oral and topical drugs","volume":"8","author":"Bahekar","year":"2008","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.jep.2012.05.039_bib3","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.4049\/jimmunol.151.7.3853","article-title":"Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation","volume":"151","author":"Bradding","year":"1993","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jep.2012.05.039_bib4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2222.1995.tb01071.x","article-title":"TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis","volume":"25","author":"Bradding","year":"1995","journal-title":"Clinical & Experimental Allergy"},{"key":"10.1016\/j.jep.2012.05.039_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5115\/acb.2010.43.1.36","article-title":"Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48\/80-induced mast cell activation","volume":"43","author":"Choi","year":"2010","journal-title":"Anatomy & Cell Biology"},{"key":"10.1016\/j.jep.2012.05.039_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0091-6749(97)70089-7","article-title":"The Human Mast Cell","volume":"99","author":"Church","year":"1997","journal-title":"The Journal of Allergy Clinical Immunology"},{"key":"10.1016\/j.jep.2012.05.039_bib7","first-page":"173","article-title":"Role of tumor necrosis factor-alpha in allergic inflammation and airway hyperresponsiveness","volume":"16","author":"Grzelewska-Rzymowska","year":"2004","journal-title":"Pol Merkur Lekarski"},{"key":"10.1016\/j.jep.2012.05.039_bib8","series-title":"Dongui Bogam","author":"Heo","year":"1985"},{"key":"10.1016\/j.jep.2012.05.039_bib9","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jep.2012.05.039_bib10","doi-asserted-by":"crossref","first-page":"27339","DOI":"10.1074\/jbc.274.39.27339","article-title":"The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation","volume":"274","author":"Karin","year":"1999","journal-title":"The Journal of Biological chemistry"},{"key":"10.1016\/j.jep.2012.05.039_bib11","first-page":"181","article-title":"A study on a morphological identification of Ostericum root","volume":"21","author":"Kil","year":"2006","journal-title":"The Korea Journal of Herbology"},{"key":"10.1016\/j.jep.2012.05.039_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02857821","article-title":"Pharmacological activities of water extracts of Umbelliferae plants","volume":"14","author":"Kim","year":"1991","journal-title":"Archives of Pharmacal Research"},{"key":"10.1016\/j.jep.2012.05.039_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1142\/S0192415X0000009X","article-title":"Inhibition of mast cell-mediated anaphylaxis by sochungryong-tang","volume":"28","author":"Kim","year":"2000","journal-title":"The American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2012.05.039_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-2000-11107","article-title":"Effects of luteolin and other flavonoids on IgE-mediated allergic reactions","volume":"66","author":"Kimata","year":"2000","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2012.05.039_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1254\/fpj.66.237","article-title":"Pharmacological actions of baicalin and baicalein. 2. On passive anaphylaxis","volume":"66","author":"Koda","year":"1970","journal-title":"Nihon Yakurigaku Zasshi Folia pharmacologica Japonica"},{"key":"10.1016\/j.jep.2012.05.039_bib16","first-page":"31","article-title":"How to treat allergic rhinitis","volume":"171","author":"Lee","year":"1999","journal-title":"Best Practice"},{"key":"10.1016\/j.jep.2012.05.039_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/187221308786241965","article-title":"Seasonal allergic rhinitis","volume":"2","author":"Leung","year":"2008","journal-title":"Recent Patents on Inflammation & Allergy Drug Discovery"},{"key":"10.1016\/j.jep.2012.05.039_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.cr.7290350","article-title":"The presence of ANP in rat peritoneal mast cells","volume":"15","author":"Martynova","year":"2005","journal-title":"Cell Research"},{"key":"10.1016\/j.jep.2012.05.039_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1081\/IPH-200026912","article-title":"Effect of Boo Yong-Tang on mast cell-mediated allergic reaction","volume":"26","author":"Na","year":"2004","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"10.1016\/j.jep.2012.05.039_bib20","first-page":"1","article-title":"Recent progress in allergen immunotherapy","volume":"5","author":"Nouri-Aria","year":"2008","journal-title":"Iranian Journal of Immunology"},{"key":"10.1016\/j.jep.2012.05.039_bib21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11882-008-0021-y","article-title":"Complementary therapy in allergic rhinitis","volume":"8","author":"Resnick","year":"2008","journal-title":"Current Allergy and Asthma Reports"},{"key":"10.1016\/j.jep.2012.05.039_bib22","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1016\/j.addr.2007.08.016","article-title":"Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma","volume":"59","author":"Smolensky","year":"2007","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.jep.2012.05.039_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/107999004323065057","article-title":"The role of human mast cell-derived cytokines in eosinophil biology","volume":"24","author":"Shakoory","year":"2004","journal-title":"Journal of Interferon & Cytokine Research"},{"key":"10.1016\/j.jep.2012.05.039_bib24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/BF02977340","article-title":"In vitro effects of essential oils from Ostericum koreanum against antibiotic-resistant Salmonella sp.","volume":"28","author":"Shin","year":"2005","journal-title":"Archives of Pharmacol Research"},{"key":"10.1016\/j.jep.2012.05.039_bib25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3109\/08923970903078443","article-title":"Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice","volume":"31","author":"Shinmei","year":"2009","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"10.1016\/j.jep.2012.05.039_bib26","first-page":"1440","article-title":"Treatment of allergic rhinitis","volume":"81","author":"Sur","year":"2010","journal-title":"South African Family Practice"},{"key":"10.1016\/j.jep.2012.05.039_bib27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1055\/s-2000-8626","article-title":"Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction","volume":"66","author":"Taniguchi","year":"2000","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2012.05.039_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1365-2222.1998.00235.x","article-title":"Inflammatory mediators in naturally occurring rhinitis","volume":"28","author":"Wilson","year":"1998","journal-title":"Clinical & Experimental Allergy"},{"key":"10.1016\/j.jep.2012.05.039_bib29","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.intimp.2010.06.020","article-title":"Therapeutic effects of Baicalein on atopic dermatitis-like skin lesions of NC\/Nga mice induced by dermatophagoides pteronyssinus","volume":"10","author":"Yun","year":"2010","journal-title":"International Immunopharmacology"}],"updated-by":[{"DOI":"10.1016\/j.jep.2014.11.046","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000}},{"DOI":"10.1016\/j.jep.2014.12.037","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112003492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112003492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T07:30:32Z","timestamp":1687505432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874112003492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0378874112003492"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2012.05.039","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}