{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:55:27Z","timestamp":1772045727397,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jep.2012.06.003","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T01:00:13Z","timestamp":1339549213000},"page":"795-803","source":"Crossref","is-referenced-by-count":40,"title":["Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities"],"prefix":"10.1016","volume":"142","author":[{"given":"Jeng-Shyan","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chih","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Luan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Chun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Amagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyh-Shyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Jhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2012.06.003_bib1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1665-2681(19)31908-8","article-title":"New role of antinutritional factors, phytic acid and catechin in the treatment of CCl4 intoxication","volume":"6","author":"Abdel\u2013Hamid","year":"2007","journal-title":"Annals of Hepatology"},{"key":"10.1016\/j.jep.2012.06.003_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2012.06.003_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/phrs.1997.0236","article-title":"3, 4, 5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity","volume":"36","author":"Anand","year":"1997","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.jep.2012.06.003_bib4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.nut.2005.01.006","article-title":"Preventive action of green tea from changes in the liver antioxidant abilities of different aged rats intoxicated with ethanol","volume":"21","author":"Augustyniak","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.jep.2012.06.003_bib5","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1177\/0960327110390065","article-title":"Neuroprotective effects of resveratrol derivatives from the roots of Vitis thunbergii var. sinuate against glutamate-induced neurotoxicity in primary cultured rat cortical cells","volume":"30","author":"Chung","year":"2011","journal-title":"Human and Experimental Toxicology"},{"key":"10.1016\/j.jep.2012.06.003_bib6","first-page":"57","article-title":"Polyphenols from Vitis thunbergii Sieb. et Zucc","volume":"12","author":"Dou","year":"2003","journal-title":"Journal of Chinese Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2012.06.003_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulphydryl group","volume":"82","author":"Ellman","year":"1959","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2012.06.003_bib8","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.clnu.2008.08.004","article-title":"Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver","volume":"27","author":"Fang","year":"2008","journal-title":"Clinical Nutrition"},{"key":"10.1016\/j.jep.2012.06.003_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(84)05013-8","article-title":"Superoxide dismutase assays","volume":"105","author":"Flohe","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2012.06.003_bib10","doi-asserted-by":"crossref","first-page":"18411","DOI":"10.1074\/jbc.272.29.18411","article-title":"Thiol compounds interact with nitric oxide in regulating heme oxygenase- 1 induction in endothelial cells: involvement of superoxide and peroxynitrite anions","volume":"29","author":"Foresti","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2012.06.003_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbrc.2008.10.155","article-title":"TNF-alpha is required for cholestasis-induced liver fibrosis in the mouse","volume":"378","author":"Gabele","year":"2009","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2012.06.003_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408449509089886","article-title":"Oxygen and xenobiotic reductase activities of cytochrome P450","volume":"25","author":"Goeptar","year":"1995","journal-title":"Critical Reviews in Toxicology"},{"key":"10.1016\/j.jep.2012.06.003_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2012.06.003_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1177\/000456329703400610","article-title":"Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage","volume":"34","author":"Halim","year":"1997","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.jep.2012.06.003_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/10715769900300841","article-title":"Antioxidant defense mechanisms: from the beginning to the end","volume":"31","author":"Halliwell","year":"1999","journal-title":"Free Radical Research"},{"key":"10.1016\/j.jep.2012.06.003_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1021\/np049686p","article-title":"Resveratrol derivatives from the roots of Vitis thunbergii","volume":"68","author":"Huang","year":"2005","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2012.06.003_bib17","first-page":"133","article-title":"Recombinant Sporamin and its synthesized peptides with antioxidant activities in vitro","volume":"48","author":"Huang","year":"2007","journal-title":"Botanical studies"},{"key":"10.1016\/j.jep.2012.06.003_bib18","first-page":"317","article-title":"Antihypertensive activities of extracts from tissue cultures of Vitis thunbergii var. taiwaniana","volume":"51","author":"Huang","year":"2010","journal-title":"Botanical Studies"},{"key":"10.1016\/j.jep.2012.06.003_bib19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jep.2010.11.005","article-title":"Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo","volume":"133","author":"Huang","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib20","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.fct.2006.03.009","article-title":"Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats","volume":"44","author":"Hung","year":"2006","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.jep.2012.06.003_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1142\/S0192415X11008877","article-title":"Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities","volume":"39","author":"Hsieh","year":"2011","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2012.06.003_bib22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1248\/bpb.33.983","article-title":"Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury","volume":"33","author":"Itoh","year":"2010","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2012.06.003_bib23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.phymed.2003.05.002","article-title":"Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents","volume":"11","author":"Janbaz","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2012.06.003_bib24","series-title":"The Catalogue of Medicinal Plant Resources in Taiwan, Committee on Chinese Medicine and Pharmacy, Department of Health","author":"Lin","year":"2003"},{"key":"10.1016\/j.jep.2012.06.003_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jnutbio.2005.05.013","article-title":"Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes","volume":"16","author":"Masella","year":"2005","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.jep.2012.06.003_bib26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(98)00220-2","article-title":"Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride","volume":"56","author":"Muriel","year":"1998","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2131\/jts.32.453","article-title":"Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis","volume":"32","author":"Nagata","year":"2007","journal-title":"The Journal of Toxicological Sciences"},{"key":"10.1016\/j.jep.2012.06.003_bib28","first-page":"158","article-title":"Studies on the quantitive and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.jep.2012.06.003_bib29","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/oxfordjournals.bmb.a072634","article-title":"Liver damage due to free radicals","volume":"49","author":"Poli","year":"1993","journal-title":"British Medical Bulletin"},{"key":"10.1016\/j.jep.2012.06.003_bib30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jep.2004.08.013","article-title":"Toxicological studies of the aqueous extract from Achyrocline satureioides (Lam.) DC (Marcela)","volume":"95","author":"Rivera","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jep.2009.01.027","article-title":"The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities","volume":"122","author":"Shen","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jep.2009.11.014","article-title":"Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes","volume":"127","author":"Somasundaram","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jss.2006.07.051","article-title":"Effect of 6-gingerol on pro-inflammatorycytokine production and costimulatory molecule expression in murine peritoneal macrophages","volume":"138","author":"Tripathi","year":"2007","journal-title":"The Journal of Surgical Research"},{"key":"10.1016\/j.jep.2012.06.003_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2012.06.003_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1089\/jmf.2009.1162","article-title":"Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo","volume":"13","author":"Wang","year":"2010","journal-title":"Journal of Medicinal Food"},{"key":"10.1016\/j.jep.2012.06.003_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2009.08.030","article-title":"Effect of Laggera alata on hepatocyte damage induced by carbon tetrachloride in vitro and in vivo","volume":"126","author":"Wu","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jep.2009.05.010","article-title":"Hepatoprotective and antioxidant activity of Amaranthus spinosus against CCl4 induced toxicity","volume":"125","author":"Zeashan","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.003_bib38","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0891-5849(00)00396-8","article-title":"The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl(4)-induced acute liver injury of mice","volume":"29","author":"Zhu","year":"2000","journal-title":"Free Radical Biology and Medicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411200390X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411200390X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T19:00:31Z","timestamp":1561834831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411200390X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S037887411200390X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2012.06.003","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}