{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:39:54Z","timestamp":1790692794021,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Traditional Chinese Medicine Department of Zhejiang Province","award":["2010ZA101"],"award-info":[{"award-number":["2010ZA101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jep.2012.06.028","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T10:02:43Z","timestamp":1340877763000},"page":"228-235","source":"Crossref","is-referenced-by-count":41,"title":["The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain"],"prefix":"10.1016","volume":"143","author":[{"given":"Man","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2012.06.028_bib1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/35021228","article-title":"Toll-like receptors in the induction of the innate immune response","volume":"6797","author":"Aderem","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jep.2012.06.028_bib2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nature Immunology"},{"key":"10.1016\/j.jep.2012.06.028_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0952-7915(99)00045-X","article-title":"Toll signaling pathways in the innate immune response","volume":"12","author":"Anderson","year":"2000","journal-title":"Current Opinion in Immunology"},{"key":"10.1016\/j.jep.2012.06.028_bib4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1179\/016164105X25225","article-title":"New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies","volume":"27","author":"Aronowski","year":"2005","journal-title":"Neurological research"},{"key":"10.1016\/j.jep.2012.06.028_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pbb.2010.07.007","article-title":"Baicalein is neuroprotective in rat MCAO model: role of 12\/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2","volume":"96","author":"Cui","year":"2010","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.jep.2012.06.028_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2010.02.036","article-title":"Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12\/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability","volume":"1325","author":"Cui","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2012.06.028_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1179\/016164110X12759951866876","article-title":"Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats","volume":"33","author":"Cui","year":"2011","journal-title":"Neurological Research"},{"key":"10.1016\/j.jep.2012.06.028_bib8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1161\/STROKEAHA.107.500876","article-title":"Fas system activation in perihematomal areas after spontaneous intracerebral hemorrhage","volume":"39","author":"Delgado","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib9","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1097\/00003246-199310000-00032","article-title":"Intracerebral hemorrhage: pathophysiology and management","volume":"21","author":"Diringer","year":"1993","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.jep.2012.06.028_bib10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00011-010-0300-7","article-title":"Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4\/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury","volume":"60","author":"Dong","year":"2011","journal-title":"Inflammation Research"},{"key":"10.1016\/j.jep.2012.06.028_bib11","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1046\/j.1440-1746.2002.02885.x","article-title":"Effects of oxymatrine on the serum levels of T helper cell 1 and 2 cytokines and the expression of the S gene in hepatitis B virus S gene transgenic mice: a study on the anti-hepatitis B virus mechanism of oxymatrine","volume":"17","author":"Dong","year":"2002","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.jep.2012.06.028_bib12","doi-asserted-by":"crossref","unstructured":"Fan, H., Li, L., Zhang, X., Liu, Y., Yang, G., Yang, Y., Yin, J., 2009. Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators of Inflammation doi:10.1155\/2009\/704706.","DOI":"10.1155\/2009\/704706"},{"key":"10.1016\/j.jep.2012.06.028_bib13","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1194\/jlr.M800200-JLR200","article-title":"Formation of eicosanoids, E2\/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain","volume":"49","author":"Farias","year":"2008","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.jep.2012.06.028_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/1073858405285923","article-title":"Brain cytosolic phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly","volume":"12","author":"Farooqui","year":"2006","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jep.2012.06.028_bib15","doi-asserted-by":"crossref","first-page":"492","DOI":"10.33588\/rn.4008.2004236","article-title":"Inflammatory response in spontaneous intracerebral hemorrhage","volume":"40","author":"Godoy-Torres","year":"2005","journal-title":"Revista de Neurologia"},{"key":"10.1016\/j.jep.2012.06.028_bib16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1080\/00207450802325496","article-title":"Changes of blood flow perfusion by MR and NF-\u03ba\u03b2 expression in the region of perihematoma after experimental intracerebral hemorrhage: a correlation study","volume":"119","author":"He","year":"2009","journal-title":"International Journal of Neuroscience"},{"key":"10.1016\/j.jep.2012.06.028_bib17","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1161\/01.STR.30.11.2472","article-title":"Nuclear factor-\u03baB and cell death after experimental intracerebral hemorrhage in rats","volume":"30","author":"Hickenbottom","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.2452","article-title":"Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats","volume":"22","author":"Hong-Li","year":"2008","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2012.06.028_bib19","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/intimm\/dxf089","article-title":"Differential involvement of IFN-\u03b2 in Toll-like receptor-stimulated dendritic cell activation","volume":"14","author":"Hoshino","year":"2002","journal-title":"International Immunology"},{"key":"10.1016\/j.jep.2012.06.028_bib20","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1161\/01.STR.0000083698.20199.1F","article-title":"Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage","volume":"34","author":"Jeong","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib21","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1161\/STROKEAHA.108.514927","article-title":"Protecting against cerebrovascular injury: contributions of 12\/15-lipoxygenase to edema formation after transient focal ischemia","volume":"39","author":"Jin","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib22","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1161\/01.STR.0000131270.45822.85","article-title":"HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage","volume":"35","author":"Jung","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib23","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1111\/j.1471-4159.2006.03697.x","article-title":"Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage","volume":"96","author":"Lee","year":"2006","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jep.2012.06.028_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0896-6273(00)80953-8","article-title":"A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion","volume":"19","author":"Li","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.jep.2012.06.028_bib25","first-page":"728","article-title":"Effect of oxymatrine on inflammation and its mechanism","volume":"31","author":"Liu","year":"2005","journal-title":"Journal of Jilin University, Medicine Edition"},{"key":"10.1016\/j.jep.2012.06.028_bib26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainres.2009.02.069","article-title":"Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-kappaB expression","volume":"1268","author":"Liu","year":"2009","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2012.06.028_bib27","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1161\/STROKEAHA.106.472746","article-title":"Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial","volume":"38","author":"Lyden","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2005.01.036","article-title":"Oxidative DNA injury after experimental intracerebral hemorrhage","volume":"1039","author":"Nakamura","year":"2005","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2012.06.028_bib29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-3-211-98811-4_57","article-title":"Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat","volume":"106","author":"Nakamura","year":"2010","journal-title":"Acta Neurochirurgica"},{"key":"10.1016\/j.jep.2012.06.028_bib30","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/jcbfm.2008.60","article-title":"Role of the p38 mitogen-activated protein kinase\/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion","volume":"28","author":"Nito","year":"2008","journal-title":"Journal of Cerebral Blood Flow Metabolism"},{"key":"10.1016\/j.jep.2012.06.028_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0028-3908(00)00170-2","article-title":"Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke","volume":"40","author":"Peeling","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2012.06.028_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(02)03142-6","article-title":"Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemiareperfusion injury","volume":"951","author":"Pilitsis","year":"2002","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2012.06.028_bib33","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/S0140-6736(09)60371-8","article-title":"Intracerebral haemorrhage","volume":"373","author":"Qureshi","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2012.06.028_bib34","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","article-title":"Spontaneous intracerebral hemorrhage","volume":"344","author":"Qureshi","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jep.2012.06.028_bib35","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1227\/01.NEU.0000057694.96978.BC","article-title":"Apoptosis as a form of cell death in intracerebral hemorrhage","volume":"52","author":"Qureshi","year":"2003","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jep.2012.06.028_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11910-996-0004-0","article-title":"Latest advances in intracerebral hemorrhage","volume":"6","author":"Ribo","year":"2006","journal-title":"Current Neurology and Neuroscience Reports"},{"key":"10.1016\/j.jep.2012.06.028_bib37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/(SICI)1098-1136(199908)27:2<110::AID-GLIA2>3.0.CO;2-C","article-title":"Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration","volume":"27","author":"Stephenson","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.jep.2012.06.028_bib38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jocn.2004.12.012","article-title":"Primary intracerebral hemorrhage","volume":"13","author":"Sutherland","year":"2006","journal-title":"Journal of Clinical Neuroscience"},{"key":"10.1016\/j.jep.2012.06.028_bib39","first-page":"473276","article-title":"Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats","author":"Teng","year":"2009","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.jep.2012.06.028_bib40","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ni774","article-title":"TLR4, but not TLR2, mediates IFN-\u03b2-induced STATI \u03b1\/\u03b2-dependent gene expression in macrophages","volume":"3","author":"Toshchakov","year":"2002","journal-title":"Nature Immunology"},{"key":"10.1016\/j.jep.2012.06.028_bib41","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1161\/01.STR.0000249004.25444.a5","article-title":"Baicalein and 12\/15-lipoxygenase in the ischemic brain","volume":"37","author":"Van Leyen","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib42","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/01.STR.0000255033.02904.db","article-title":"Modeling intracerebral hemorrhage: glutamate, nuclear factor-\u03baB signaling and cytokines","volume":"38","author":"Wagner","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2012.06.028_bib43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neures.2008.10.013","article-title":"Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: the role of iron","volume":"63","author":"Wan","year":"2009","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.jep.2012.06.028_bib44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.pneurobio.2010.08.001","article-title":"Preclinical and clinical research on inflammation after intracerebral hemorrhage","volume":"92","author":"Wang","year":"2010","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.jep.2012.06.028_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0006-8993(02)03268-7","article-title":"Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage","volume":"953","author":"Wu","year":"2002","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2012.06.028_bib46","first-page":"593","article-title":"Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis","volume":"115","author":"Xiang","year":"2002","journal-title":"Chinese Medical Journal"},{"key":"10.1016\/j.jep.2012.06.028_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jep.2005.01.026","article-title":"Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen activated protein kinase","volume":"98","author":"Xu","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.028_bib48","first-page":"S295","article-title":"Basic and clinical study of oxymatrine on HBV infection","volume":"14","author":"Zeng","year":"1999","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.jep.2012.06.028_bib49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4103\/0028-3886.28115","article-title":"Brain edema after intracerebral hemorrhage in rats: the role of inflammation","volume":"54","author":"Zhang","year":"2006","journal-title":"Neurology India"},{"key":"10.1016\/j.jep.2012.06.028_bib50","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00595-008-3785-8","article-title":"Oxymatrine attenuates intestinal ischemia\/reperfusion injury in rats","volume":"38","author":"Zhao","year":"2008","journal-title":"Surgery Today"},{"key":"10.1016\/j.jep.2012.06.028_bib51","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1471-4159.2006.04414.x","article-title":"Distinct patterns of intracerebral hemorrhage-induced alterations in NF-\u03baB subunit, iNOS, and COX-2 expression","volume":"101","author":"Zhao","year":"2007","journal-title":"Journal of Neurochemistry"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411200428X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411200428X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T10:34:46Z","timestamp":1561890886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411200428X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S037887411200428X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2012.06.028","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}