{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:04:02Z","timestamp":1792033442812,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jep.2012.06.039","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T20:48:25Z","timestamp":1341002905000},"page":"319-324","source":"Crossref","is-referenced-by-count":18,"title":["Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga"],"prefix":"10.1016","volume":"143","author":[{"given":"Roman","family":"Pa\u0161kulin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polona","family":"Jamnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tja\u0161a","family":"Danev\u010di\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Ko\u017eelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok","family":"Kra\u0161ovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dijana","family":"Krsti\u0107-Milo\u0161evi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161ko","family":"Blagojevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borut","family":"\u0160trukelj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2012.06.039_bib1","first-page":"1","article-title":"Ibogaine: a review. The Alkaloids","volume":"56","author":"Alper","year":"2001","journal-title":"Chemistry and Biology"},{"key":"10.1016\/j.jep.2012.06.039_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2007.08.034","article-title":"The ibogaine medical subculture","volume":"115","author":"Alper","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.039_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2174\/157015911795017209","article-title":"Analysis of electrical brain waves in neurotoxicology: gamma-hydroxybutyrate","volume":"9","author":"Binienda","year":"2011","journal-title":"Current Neuropharmacology"},{"key":"10.1016\/j.jep.2012.06.039_bib4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/cr.2007.63","article-title":"Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment","volume":"17","author":"Chen","year":"2007","journal-title":"Cell Research"},{"key":"10.1016\/j.jep.2012.06.039_bib5","first-page":"128","article-title":"Direct and indirect antioxidant properties of inducers of cytoprotective proteins","volume":"52","author":"Dinkova-Kostova","year":"2008","journal-title":"Molecular Nutrition and Food Research"},{"key":"10.1016\/j.jep.2012.06.039_bib6","series-title":"Bwiti: An Ethnography of The Religious Imagination in Africa","author":"Fernandez","year":"1982"},{"key":"10.1016\/j.jep.2012.06.039_bib7","first-page":"235","article-title":"\u201cReturning to the path\u201d: the use of iboga[ine] in an equatorial African ritual context and the binding of time, space, and social relationships. The Alkaloids","volume":"56","author":"Fernandez","year":"2001","journal-title":"Chemistry and Biology"},{"key":"10.1016\/j.jep.2012.06.039_bib8","first-page":"71","article-title":"Pharmacodynamics and therapeutic applications of iboga and ibogaine","volume":"6","author":"Goutarel","year":"1993","journal-title":"Psychedelic Monographs and Essays"},{"key":"10.1016\/j.jep.2012.06.039_bib9","series-title":"Free Radicals in Biology and Medicine","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.jep.2012.06.039_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1530-0277.2008.00814.x","article-title":"Proteomic analysis demonstrates adolescent vulnerability to lasting hippocampal changes following chronic alcohol consumption","volume":"33","author":"Hargreaves","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.jep.2012.06.039_bib11","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.semcdb.2009.07.003","article-title":"Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective","volume":"20","author":"Huang","year":"2009","journal-title":"Seminars in Cell and Developmental Biology"},{"key":"10.1016\/j.jep.2012.06.039_bib12","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S1357-2725(97)00056-3","article-title":"Estimation of oxidative stress in Saccharomyces cerevisiae with fluorescent probes","volume":"11","author":"Jakubowski","year":"1997","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/j.jep.2012.06.039_bib13","first-page":"269","article-title":"The usefulness of commercial quantitation software in ibogaine LC-MS\/MS analysis","volume":"77","author":"Ko\u017eelj","year":"2010","journal-title":"Toxichem Krimtech"},{"key":"10.1016\/j.jep.2012.06.039_bib14","first-page":"117","article-title":"Applications of yeast in drug discovery","volume":"57","author":"Ma","year":"2001","journal-title":"Progress in Drug Research"},{"key":"10.1016\/j.jep.2012.06.039_bib15","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1242\/jeb.02208","article-title":"Neuron-glia metabolic coupling and plasticity","volume":"209","author":"Magistretti","year":"2006","journal-title":"The Journal of Experimental Biology"},{"key":"10.1016\/j.jep.2012.06.039_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0960327107087802","article-title":"Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review","volume":"27","author":"Maciulaitis","year":"2008","journal-title":"Human and Experimental Toxicology"},{"key":"10.1016\/j.jep.2012.06.039_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1749-6632.2000.tb05213.x","article-title":"Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures","volume":"914","author":"Mash","year":"2000","journal-title":"Annals of the New York Academy for Sciences"},{"key":"10.1016\/j.jep.2012.06.039_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/15563656908990930","article-title":"Psychotherapeutic possibilities of new fantasy-enhancing drugs","volume":"2","author":"Naranjo","year":"1969","journal-title":"Clinical Toxicology"},{"key":"10.1016\/j.jep.2012.06.039_bib19","series-title":"The Healing Journey\u2014New Approaches to Consciousness","author":"Naranjo","year":"1973"},{"key":"10.1016\/j.jep.2012.06.039_bib20","series-title":"The Music of Life: Biology Beyond Genes","author":"Noble","year":"2006"},{"key":"10.1016\/j.jep.2012.06.039_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00248-006-9143-8","article-title":"Environmental stress determines quality of bacterial lysate and its utilization efficiency in a simple microbial loop","volume":"53","author":"Odi\u0107","year":"2007","journal-title":"Microbial Ecology"},{"key":"10.1016\/j.jep.2012.06.039_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejphar.2006.09.008","article-title":"Ibogaine affects brain energy metabolism","volume":"552","author":"Pa\u0161kulin","year":"2006","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2012.06.039_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejphar.2006.09.008","article-title":"Induction of energy related enzymes in yeast Saccharomyces cerevisiae exposed to ibogaine is adaptation to acute decrease in ATP energy pool","volume":"552","author":"Pa\u0161kulin","year":"2010","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2012.06.039_bib24","series-title":"The Encyclopedia of Psychoactive Plants: Ethnopharmacology and its Implications","author":"Ratsch","year":"1998"},{"key":"10.1016\/j.jep.2012.06.039_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/167770a0","article-title":"Reversion of the effect of vitamin B1 on yeast fermentation as a result of growth in the presence of cocaine","volume":"167","author":"Ryman","year":"1951","journal-title":"Nature"},{"key":"10.1016\/j.jep.2012.06.039_bib26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1042\/bj0500570","article-title":"Some effects of cocaine on the metabolism of Saccharomyces cerevisiae","volume":"50","author":"Ryman","year":"1952","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.jep.2012.06.039_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0306-3623(96)00165-6","article-title":"Effect of methadone addiction on glucose metabolism in rats","volume":"28","author":"Sadava","year":"1997","journal-title":"General Pharmacology"},{"key":"10.1016\/j.jep.2012.06.039_bib28","first-page":"25","article-title":"The plant kingdom and hallucinogens","volume":"22","author":"Schultes","year":"1970","journal-title":"Bulletin on Narcotics"},{"key":"10.1016\/j.jep.2012.06.039_bib29","series-title":"Plants of the Gods: Their Sacred, Healing and Hallucinogenic Powers","author":"Schultes","year":"2001"},{"key":"10.1016\/j.jep.2012.06.039_bib30","series-title":"Bioactive Compounds in Phytomedicine","first-page":"143","article-title":"Polyphenols as adaptogens\u2014the real mechanism of the antioxidant effect?","author":"Stevenson","year":"2012"},{"key":"10.1016\/j.jep.2012.06.039_bib31","first-page":"30","article-title":"The near-death experience: a cerebellar method to protect body and soul\u2014lessons from the Iboga healing ceremony in Gabon","volume":"14","author":"Strubelt","year":"2008","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"10.1016\/j.jep.2012.06.039_bib32","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2174\/1381612043384655","article-title":"The antioxidants and pro-antioxidants network: an overview","volume":"10","author":"Vertuani","year":"2004","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.jep.2012.06.039_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0378-8741(83)90066-1","article-title":"Screening of antimicrobial activity of some plants belonging to the Apocynaceae and Loganiaceae","volume":"8","author":"Verpoorte","year":"1983","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.06.039_bib34","series-title":"The Strategy of Genes","author":"Waddington","year":"1957"},{"key":"10.1016\/j.jep.2012.06.039_bib35","series-title":"Yeast Physiology and Biotechnology","author":"Walker","year":"1998"},{"key":"10.1016\/j.jep.2012.06.039_bib36","unstructured":"\u3008www.ibogaine.co.uk\/experience.htm\u3009 (accessed December 18, 2011)"},{"key":"10.1016\/j.jep.2012.06.039_bib37","unstructured":"\u3008www.sacrament.kibla.si\u3009 (accessed December 18, 2011)"},{"key":"10.1016\/j.jep.2012.06.039_bib38","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1271\/bbb.62.1201","article-title":"HPLC method for evaluation of the free radical-scavenging activity of foods by using 1,1-diphenyl-2-picrylhydrazyl","volume":"62","author":"Yamaguchi","year":"1998","journal-title":"Bioscience, Biotechnology and Biochemistry"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112004394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112004394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T08:10:37Z","timestamp":1561882237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874112004394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0378874112004394"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2012.06.039","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}