{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:00:10Z","timestamp":1781787610058,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":470,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jep.2012.10.040","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T14:45:34Z","timestamp":1351781134000},"page":"127-138","source":"Crossref","is-referenced-by-count":72,"title":["From popular use to pharmacological validation: A study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract"],"prefix":"10.1016","volume":"145","author":[{"given":"Liliane","family":"TrivellatoGrassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Malheiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Meyre-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliani","family":"da Silva Buss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Dalmarco","family":"Monguilhott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia S.","family":"Fr\u00f6de","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn Ana Bortolini Sim\u00e3o","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2012.10.040_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2463","article-title":"Nitric oxide in inflammation and pain associated with osteoarthritis","volume":"10","author":"Abramson","year":"2008","journal-title":"Arthritis Research Therapy"},{"key":"10.1016\/j.jep.2012.10.040_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00000542-200401000-00010","article-title":"Nefopam, a non-sedative benzoxazocineanalgesic, selectively reduces the shivering threshold in unanesthetizedsubjects","volume":"100","author":"Alfonsi","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jep.2012.10.040_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1476-5381.2010.00696.x","article-title":"Shikonin reduces oedema induced by phorbol ester by interfering with IkBa degradation thus inhibiting translocation of NF-kB to the nucleus","volume":"160","author":"And\u00fajar","year":"2010","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib4","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1124\/jpet.106.101998","article-title":"Antinociceptive and hypothermic effects of salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice","volume":"318","author":"Ansonoff","year":"2006","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2012.10.040_bib5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/ibd.20316","article-title":"Pharmacological modulation of adenosine system: novel options for treatment of inflammatory bowel diseases","volume":"14","author":"Antonioli","year":"2008","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.jep.2012.10.040_bib6","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/ars.2009.2927","article-title":"Hydrogen sulfide and substance P in inflammation","volume":"12","author":"Bhatia","year":"2010","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.jep.2012.10.040_bib7","unstructured":"Brasil, 2008. Minist\u00e9rio Da Sa\u00fade, Secretaria de Ci\u00eancias, Tecnologia e Insumos Estrat\u00e9gicos. Portaria Interministerial n\u00b0 2960 em 9 de dezembro de 2008. Publica Programa de Nacional de Plantas Medicinais e Fitoter\u00e1picos. Di\u00e1rio Oficial da Uni\u00e3o, 10 de dez."},{"key":"10.1016\/j.jep.2012.10.040_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jep.2009.12.017","article-title":"Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice","volume":"128","author":"Busnardo","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1164\/rccm.200504-538OC","article-title":"Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation","volume":"173","author":"Cailhier","year":"2006","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.jep.2012.10.040_bib10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/sj.bjp.0706012","article-title":"Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes","volume":"143","author":"Calixto","year":"2004","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/pca.761","article-title":"Combined analysis of the essential oil of Chenopodium ambrosioides by GC, GC\u2013MS and 13C NMR spectroscopy: quantitative determination of ascaridole, a heatsensitive compound","volume":"15","author":"Cavalli","year":"2004","journal-title":"Phytochemical Analysis"},{"key":"10.1016\/j.jep.2012.10.040_bib12","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1128\/AAC.40.7.1703","article-title":"Distribution of systemically administered ampicillin, benzylpenicillin, and flucloxacillin in excisional wounds in diabetic and normal rats and effects of local topical vasodilator treatment","volume":"40","author":"Cross","year":"1996","journal-title":"Antimicrobial Agents Chemotherapy"},{"key":"10.1016\/j.jep.2012.10.040_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/09629350210000015700","article-title":"Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy","volume":"11","author":"Dalmarco","year":"2002","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.jep.2012.10.040_bib14","doi-asserted-by":"crossref","unstructured":"Dembitsky, V., Shkrob, I., Hanus, L.O., 2008. Ascaridole and related peroxides from the genus Chenopodium. Biomedical Papers of the Medical Faculty of the University Palack\u00fd, Olomouc, Czechoslovakia 152, 209\u2013215.","DOI":"10.5507\/bp.2008.032"},{"key":"10.1016\/j.jep.2012.10.040_bib15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/10412905.2000.9699510","article-title":"The antifungal activity of oils as determinated by different screening methods","volume":"12","author":"Delespaul","year":"2000","journal-title":"Journal of Essential Oil Research"},{"key":"10.1016\/j.jep.2012.10.040_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jep.2007.07.021","article-title":"Antinociceptive and anti-infammatory effects of compounds isolated from Scaphyglottislivida and Maxillariadensa","volume":"114","author":"D\u00e9ciga-Campos","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological deficit in rats and mice","volume":"46","author":"Dunham","year":"1957","journal-title":"Journal of the American Pharmaceutical Association"},{"key":"10.1016\/j.jep.2012.10.040_bib18","first-page":"4221","article-title":"Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells","volume":"22","author":"Efferth","year":"2002","journal-title":"Anticancer Research"},{"key":"10.1016\/j.jep.2012.10.040_bib19","first-page":"56","article-title":"O extrato das folhas de babosa, Aloe vera na cicatriza\u00e7\u00e3o de feridas experimentais em pele de ratos, num ensaio controlado por placebo","volume":"7","author":"Faleiro","year":"2009","journal-title":"Natureza on Line"},{"key":"10.1016\/j.jep.2012.10.040_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-0115(00)00094-X","article-title":"The role of sensorial neuropeptides in the edematogenic responses mediated by B(1) agonist des-Arg (9) BK in rats pre-treated with LPS","volume":"89","author":"Ferreira","year":"2000","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.jep.2012.10.040_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test in mice: dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"Hunskaar","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.jep.2012.10.040_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3923\/ijp.2007.111.115","article-title":"Studies on the anti-inflammatory and analgesic properties of Chenopodium ambrosioides leaf extract in rats","volume":"3","author":"Ibironke","year":"2007","journal-title":"International Journal of Pharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1590\/S0365-05962003000400010","article-title":"Neuropept\u00eddeos na pele","volume":"78","author":"Kalil-Gaspar","year":"2003","journal-title":"Anais Brasileiros de Dermatologia"},{"key":"10.1016\/j.jep.2012.10.040_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jep.2003.10.009","article-title":"Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoria","volume":"90","author":"Kaur","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib26","first-page":"456","article-title":"Modern natural products drug discovery and its relevance to biodiversity conservation","volume":"74","author":"Kinsgton","year":"2011","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2012.10.040_bib27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0277-9536(85)90144-3","article-title":"Studies on the traditional herbal anthelmintic Chenopodium ambrosioides L.: ethonopharmacological evalution and clinical fields trials","volume":"21","author":"Kliks","year":"1985","journal-title":"Social Science and Medicine"},{"key":"10.1016\/j.jep.2012.10.040_bib28","first-page":"280","article-title":"The genus Chenopodium: phytochemistry, ethnopharmacology and pharmacology","volume":"3","author":"Kokanova-Nedialkova","year":"2009","journal-title":"Pharmacognosy Review"},{"key":"10.1016\/j.jep.2012.10.040_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijfoodmicro.2006.10.017","article-title":"Evaluation of Chenopodium ambrosioides oil as a potential source of antifungal, antiaflatoxigenic and antioxidant activity","volume":"115","author":"Kumar","year":"2007","journal-title":"International Journal of Food Microbiology"},{"key":"10.1016\/j.jep.2012.10.040_bib30","series-title":"Plantas medicinais no Brasil: nativas e ex\u00f3ticas cultivadas","author":"Lorenzi","year":"2002"},{"key":"10.1016\/j.jep.2012.10.040_bib31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1590\/S0102-86502006000900010","article-title":"An\u00e1lise comparativa da cicatriza\u00e7\u00e3o da pele com o uso intraperitoneal de extrato aquoso de Orbignya phalerata (baba\u00e7u). Estudo controlado em ratos","volume":"21","author":"Martins","year":"2006","journal-title":"Acta Cir\u00fargica Brasileira"},{"key":"10.1016\/j.jep.2012.10.040_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.npep.2005.12.001","article-title":"Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina","volume":"40","author":"Mattos","year":"2006","journal-title":"Neuropeptides"},{"key":"10.1016\/j.jep.2012.10.040_bib33","first-page":"433","article-title":"Fatal poisoning caused by oil of epazote, Chenopodium graveolens","volume":"132","author":"Montoya-Cabrera","year":"1996","journal-title":"Gaceta M\u00e9dicado Mexico"},{"key":"10.1016\/j.jep.2012.10.040_bib34","first-page":"123","article-title":"Pleural models of inflammation: immune and nonimmune","volume":"225","author":"Moore","year":"2003","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.jep.2012.10.040_bib36","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jep.2010.05.065","article-title":"Antinociceptive and anti-inflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1 inhibition","volume":"136","author":"Nonato","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib37","first-page":"529","article-title":"Pharmacological screening of the methanolic extract of Chenopodium ambrosioides","volume":"68","author":"Olajide","year":"1997","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2012.10.040_bib38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jep.2003.12.025","article-title":"Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre","volume":"91","author":"Panthong","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jep.2009.12.018","article-title":"Evaluation of the subchronic toxicity of oral treatment with Chenopodium ambrosioides in mice","volume":"127","author":"Pereira","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-3565(24)29656-7","article-title":"Antianalgesic action of nociceptin originating in the brain is mediated by spinal prostaglandin E2 in mice","volume":"296","author":"Rady","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2012.10.040_bib41","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1476-5381.1996.tb15472.x","article-title":"Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy","volume":"118","author":"Saleh","year":"1996","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib42","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2012.10.040_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(97)00722-2","article-title":"Ruthenium red and capsazepineantinociceptive effect in formalin and capsaicina models of pain in mice","volume":"235","author":"Santos","year":"1997","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.jep.2012.10.040_bib44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jep.2010.07.002","article-title":"Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear oedema induced by different irritant agents","volume":"136","author":"Saraiva","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.10.040_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/937642","article-title":"Antinociceptive activity of Melicope ptelefolia ethanolic extract in experimental animals","volume":"2010","author":"Sulaiman","year":"2010","journal-title":"Journal of Biomedicine and Biotechnology"},{"key":"10.1016\/j.jep.2012.10.040_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-8069-6-29","article-title":"Absence of histamine-induced itch in the African naked mole-rat and \u201crescue\u201d by substance P","volume":"6","author":"Smith","year":"2010","journal-title":"Molecular Pain"},{"key":"10.1016\/j.jep.2012.10.040_bib48","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.2174\/092986706777585095","article-title":"Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclooxygenase, NF-kappaB and other unidentified targets","volume":"13","author":"Terraciano","year":"2006","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.jep.2012.10.040_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ptr.2650060102","article-title":"Actions of compounds from Mandevilla velutina on croton oil-induced ear oedema in mice. A comparative study with steroidal and nonsteroidal anti-inflammatory drugs","volume":"6","author":"Zanini","year":"1992","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2012.10.040_bib51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112007374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112007374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T02:24:10Z","timestamp":1745115850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874112007374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0378874112007374"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2012.10.040","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}