{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:51:28Z","timestamp":1791244288675,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jep.2012.11.002","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T01:45:13Z","timestamp":1353030313000},"page":"269-277","source":"Crossref","is-referenced-by-count":28,"title":["Antioxidant and anti-inflammatory effects of Urtica pilulifera extracts in type2 diabetic rats"],"prefix":"10.1016","volume":"145","author":[{"given":"Dina M.","family":"Abo-elmatty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha S.","family":"Essawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihan M.","family":"Badr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olov","family":"Sterner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2012.11.002_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3844\/ajptsp.2011.27.32","article-title":"Anti-Arthritic Activity of the Methanolic Leaf Extract of Urtica pilulifera L. on Albino Rats","volume":"6","author":"Abudoleh","year":"2011","journal-title":"American Journal of Pharmacology and Toxicology"},{"key":"10.1016\/j.jep.2012.11.002_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2012.11.002_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1530\/EJE-11-0053","article-title":"Oxidative DNA damage and obesity in type 2 diabetes mellitus","volume":"164","author":"Al-Aubaidy","year":"2011","journal-title":"European Journal of Endocrinology"},{"key":"10.1016\/j.jep.2012.11.002_bib4","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.fct.2010.06.010","article-title":"Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats","volume":"48","author":"Algandaby","year":"2010","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.jep.2012.11.002_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-8741(00)00316-0","article-title":"Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicine","volume":"2073","author":"Ali-Shtayeh","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2012.11.002_bib6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.thromres.2009.04.008","article-title":"Association of the -757TNC polymorphism in the CRP gene with circulating C-reactive protein levels and carotid atherosclerosis","volume":"124","author":"Ben Assayag","year":"2009","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.jep.2012.11.002_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0003-9861(02)00342-9","article-title":"L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine","volume":"405","author":"Chang","year":"2002","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2012.11.002_bib8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/mnfr.200900087","article-title":"Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice","volume":"54","author":"Chao","year":"2010","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.jep.2012.11.002_bib9","series-title":"Subcellular Components","author":"Chappel","year":"1969"},{"key":"10.1016\/j.jep.2012.11.002_bib10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.phymed.2007.03.014","article-title":"A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: Urticae radix","volume":"14","author":"Chrubasik","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2012.11.002_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.phrs.2004.06.002","article-title":"Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and cell damage in rat pancreas","volume":"51","author":"Coskun","year":"2005","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.jep.2012.11.002_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/cimm.1996.0062","article-title":"V beta-Specific deletion of mature thymocytes induced by the plant superantigen Urtica dioica agglutinine","volume":"168","author":"Delcourt","year":"1996","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.jep.2012.11.002_bib13","first-page":"1040","article-title":"Effects of pioglitazone on expressions of matrix metalloproteinases 2 and 9 in kidneys of diabetic rats","volume":"117","author":"Dong","year":"2004","journal-title":"Chinese Medical Journal"},{"key":"10.1016\/j.jep.2012.11.002_bib14","first-page":"96","article-title":"Effects of yixin jiangya capsules on insulin resistance and tumor necrosis factor-alpha in cases of primary hypertension with left ventricular hypertrophy","volume":"27","author":"Duan","year":"2007","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2012.11.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijdm.2011.01.004","article-title":"Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats","author":"Elberry","year":"2011","journal-title":"International Journal of Diabetes Mellitus"},{"key":"10.1016\/j.jep.2012.11.002_bib16","first-page":"237","article-title":"SH groups determination in biological fluids","volume":"46","author":"Ellman","year":"1970","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2012.11.002_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/aob\/mcl089","article-title":"Identification of oxalic acid and tartaric acid as major persistent pain-inducing toxins in the stinging hairs of the nettle, Urtica thunbergiana","volume":"98","author":"Fu","year":"2006","journal-title":"Annals of Botany"},{"key":"10.1016\/j.jep.2012.11.002_bib50","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.3923\/pjbs.2007.1200.1204","article-title":"The protective effect of Urtia Dioica leaves on blood glucose level concentration and b-cells in streptozotocin-diabetic rats","volume":"9","author":"Golalipour","year":"2007","journal-title":"Pakistan Journal of Biological Science"},{"key":"10.1016\/j.jep.2012.11.002_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0278-6915(94)90040-X","article-title":"Genotoxicity testing of different types of beverages in the drosophila wing somatic mutation and recombination test","volume":"32","author":"Graf","year":"1994","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.jep.2012.11.002_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tox.2005.09.011","article-title":"Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid)","volume":"217","author":"Gulcin","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2012.11.002_bib20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/07315724.2009.10718097","article-title":"Green tea extract decreases oxidative stress and improved insulin sensitivity in an animal model of insulin resistance, the fructose-fed rat","volume":"28","author":"Hininger-Favier","year":"2009","journal-title":"Journal of American College of Nutrition"},{"key":"10.1016\/j.jep.2012.11.002_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s10787-007-1609-x","article-title":"Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis","volume":"16","author":"Holanda","year":"2008","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2012.11.002_bib22","doi-asserted-by":"crossref","first-page":"E1125","DOI":"10.1152\/ajpendo.00430.2002","article-title":"Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats","volume":"284","author":"Iida","year":"2003","journal-title":"American Journal of Physiology, Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2012.11.002_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/mnfr.200700389","article-title":"Ursolic acid: an anti- and pro-inflammatory triterpenoid","volume":"52","author":"Ikeda","year":"2008","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.jep.2012.11.002_bib24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3844\/ajptsp.2009.22.28","article-title":"Effects of leaf extract of Urtica pilulifera L. on male reproductive system of streptozotocin-diabetic rats","volume":"4","author":"Irshaid","year":"2009","journal-title":"American Journal of Pharmacology and Toxicology"},{"key":"10.1016\/j.jep.2012.11.002_bib25","first-page":"675","article-title":"The effects of methanol extract derived from Urtica pilulifera Leaves on some hematological and biochemical parameters of diabetic rats","volume":"4","author":"Irshaid","year":"2009","journal-title":"Research Journal of Biological Science"},{"key":"10.1016\/j.jep.2012.11.002_bib26","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2012.11.002_bib27","series-title":"Study Design and Statistical Analysis: A Practical Guide for Clinicians","author":"Katz","year":"2006"},{"key":"10.1016\/j.jep.2012.11.002_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0378-8741(02)00315-X","article-title":"Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats","volume":"84","author":"Kavalali","year":"2003","journal-title":"Journal of Ethnopharmacolgy"},{"key":"10.1016\/j.jep.2012.11.002_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.33549\/physiolres.930522","article-title":"Regeneration of coenzyme Q9 redox state and inhibition of oxidative stress by rooibos tea (Aspalathus linearis) administration in carbon tetrachloride liver damage","volume":"53","author":"Kucharsk\u00e1","year":"2004","journal-title":"Physiological Research"},{"key":"10.1016\/j.jep.2012.11.002_bib30","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/mnfr.200900012","article-title":"Beta-sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells","volume":"54","author":"Loizou","year":"2010","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.jep.2012.11.002_bib31","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s11255-006-9173-7","article-title":"Efficacy and safety of a combination of Sabal and Urtica extract in lower urinary tract symptoms-long-term follow-up of a placebo-controlled, double-blind, multicenter trial","volume":"39","author":"Lopatkin","year":"2007","journal-title":"International Urology and Nephrology"},{"key":"10.1016\/j.jep.2012.11.002_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3923\/tmr.2006.1.8","article-title":"Study of some antioxidant parameters in mice livers affected with Urtica pilulifera extracts","volume":"1","author":"Mahmoud","year":"2006","journal-title":"Trends in Medical Research"},{"key":"10.1016\/j.jep.2012.11.002_bib33","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1016\/S0021-9258(19)50482-3","article-title":"Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isoenzymes in fibroblasts","volume":"267","author":"Marklund","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2012.11.002_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/carcin\/21.3.361","article-title":"Oxyradicals and DNA damage","volume":"21","author":"Marnett","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jep.2012.11.002_bib35","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/1071576031000107344","article-title":"Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice","volume":"37","author":"Matsumoto","year":"2003","journal-title":"Free Radical Research"},{"key":"10.1016\/j.jep.2012.11.002_bib36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2012.11.002_bib37","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1182\/blood-2002-08-2406","article-title":"Antithrombin reduces ischemia\/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production","volume":"101","author":"Mizutani","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jep.2012.11.002_bib38","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1089\/ars.2005.7.1543","article-title":"Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications","volume":"7","author":"Obrosova","year":"2005","journal-title":"Antioxidant and Redox Signaling"},{"key":"10.1016\/j.jep.2012.11.002_bib39","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1089\/jmf.2009.1303","article-title":"Antioxidant properties of Urtica pilulifera root, seed, flower, and leaf extract","volume":"13","author":"Ozen","year":"2010","journal-title":"Journal of Medicinal Food"},{"key":"10.1016\/j.jep.2012.11.002_bib40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/07315724.1998.10718736","article-title":"Comparative effects of chromium, vanadium and Gymnema sylvestre on sugar-induced blood pressure elevations in SHR","volume":"17","author":"Preuss","year":"1998","journal-title":"Journal of The American College of Nutrition"},{"key":"10.1016\/j.jep.2012.11.002_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cbi.2008.08.010","article-title":"Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes","volume":"176","author":"Ramachandran","year":"2008","journal-title":"Chemico\u2013Biological Interactions"},{"key":"10.1016\/j.jep.2012.11.002_bib42","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/meta.2000.17721","article-title":"A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat","volume":"49","author":"Reed","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.jep.2012.11.002_bib43","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2337\/diabetes.52.3.581","article-title":"Glucose toxicity in \u03b2-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection","volume":"52","author":"Robertson","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2012.11.002_bib44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/0973-3930.53125","article-title":"Lipoprotein (a) in type 2 diabetes mellitus: relation to LDL: HDL ratio and glycemic control","volume":"29","author":"Singla","year":"2009","journal-title":"International Journal of Diabetes in Developing Countries"},{"key":"10.1016\/j.jep.2012.11.002_bib45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1358\/mf.2004.26.5.831322","article-title":"Reversal of glucose intolerance by PIO in high-fat diet fed rats","volume":"26","author":"Srinivasan","year":"2004","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"10.1016\/j.jep.2012.11.002_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinvansan","year":"2005","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.jep.2012.11.002_bib47","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.metabol.2007.07.017","article-title":"High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle","volume":"56","author":"Tanaka","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.jep.2012.11.002_bib48","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1210\/er.2006-0033","article-title":"Adipose tissue-derived factors: impact on health and disease","volume":"27","author":"Trujillo","year":"2006","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.jep.2012.11.002_bib49","series-title":"The Laboratory Rat","first-page":"627","article-title":"Anesthesia and analgesia","author":"Vogler","year":"2006"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112007611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874112007611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T11:59:20Z","timestamp":1714564760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874112007611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0378874112007611"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2012.11.002","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}