{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:32:04Z","timestamp":1773887524365,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Fundaci\u00f3n Carolina, Ministerio de Ciencia y tecnolog\u00eda","award":["AGL2008-02475"],"award-info":[{"award-number":["AGL2008-02475"]}]},{"name":"Consejer\u00eda de Innovaci\u00f3n Ciencia y Empresa","award":["AGR-6609"],"award-info":[{"award-number":["AGR-6609"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jep.2013.06.013","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T21:46:31Z","timestamp":1371678391000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Abarema cochliacarpos reduces LPS-induced inflammatory response in murine peritoneal macrophages regulating ROS-MAPK signal pathway"],"prefix":"10.1016","volume":"149","author":[{"given":"S.","family":"S\u00e1nchez-Fidalgo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"C\u00e1rdeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aparicio-Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.H.","family":"Frankland Sawaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.M.","family":"Souza-Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Alarc\u00f3n","family":"de la Lastra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2013.06.013_bib1","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1038\/sj.onc.1203128","article-title":"Role of redox potential and reactive oxygen species in stress signaling","volume":"18","author":"Adler","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2013.06.013_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jep.2007.08.017","article-title":"Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach","volume":"114","author":"Albuquerque","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2013.06.013_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1189\/jlb.71.4.677","article-title":"Regulation of murine macrophage proinflammatory and anti-inflammatory cytokines by ligands for peroxisome proliferator-activated receptor-gamma: counter-regulatory activity by IFN-gamma","volume":"71","author":"Alleva","year":"2002","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.jep.2013.06.013_bib4","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1476-5381.2009.00322.x","article-title":"Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages","volume":"157","author":"Altavilla","year":"2009","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2013.06.013_bib5","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jep.2013.06.013_bib6","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.4049\/jimmunol.157.4.1630","article-title":"In vivo antioxidant treatment suppresses nuclear factor-\u03baB activation and neutrophilic lung inflammation","volume":"157","author":"Blackwell","year":"1996","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jep.2013.06.013_bib7","doi-asserted-by":"crossref","first-page":"25941","DOI":"10.1074\/jbc.272.41.25941","article-title":"Lipid peroxidation is involved in the activation of NF-\u03baB by tumor necrosis factor but interleukin-1 in the human endothelial cell line ECV304","volume":"272","author":"Bowie","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib9","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.foodchem.2011.01.114","article-title":"Antiinflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo","volume":"127","author":"Chang","year":"2011","journal-title":"Food Chemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1208\/s12248-009-9162-8","article-title":"Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention","volume":"12","author":"Cheung","year":"2010","journal-title":"AAPS Journals"},{"key":"10.1016\/j.jep.2013.06.013_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.33549\/physiolres.931088","article-title":"The influence of wine polyphenols on reactive oxygen and nitrogen species production by murine macrophages RAW 264.7","volume":"57","author":"Ciz","year":"2008","journal-title":"Physiological Research"},{"key":"10.1016\/j.jep.2013.06.013_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cca.2010.12.020","article-title":"MAP kinases in inflammatory bowel disease","volume":"412","author":"Coskun","year":"2011","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jep.2013.06.013_bib13","article-title":"Redox properties of A. cochliacarpos (Gomes) Barneby and Sime (Fabaceae) stem bark ethanol extract and fractions","author":"Dias","year":"2012","journal-title":"Natural Product Research"},{"key":"10.1016\/j.jep.2013.06.013_bib14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.freeradbiomed.2011.06.002","article-title":"Dietary flavonoids: Role of (\u2212)-epicatechin and related procyanidins in cell signaling","volume":"51","author":"Fraga","year":"2011","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.jep.2013.06.013_bib15","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","article-title":"NF-kappaB activation by reactive oxygen species, fifteen years later","volume":"72","author":"Gloire","year":"2006","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2013.06.013_bib16","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.jep.2013.06.013_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cell Signaling"},{"key":"10.1016\/j.jep.2013.06.013_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0952-7915(99)00050-3","article-title":"NF-kappaB and the innate immune response","volume":"12","author":"Hatada","year":"2000","journal-title":"Current Opinion in Immunology"},{"key":"10.1016\/j.jep.2013.06.013_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of the flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2013.06.013_bib20","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/mnfr.200600075","article-title":"Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs","volume":"50","author":"Huang","year":"2006","journal-title":"Molecular Nutrition and Food Research"},{"key":"10.1016\/j.jep.2013.06.013_bib21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.gtc.2006.07.002","article-title":"Molecular biology of dysplasia and cancer in inflammatory bowel disease","volume":"35","author":"Itzkowitz","year":"2006","journal-title":"Gastroenterology Clinics of North America"},{"key":"10.1016\/j.jep.2013.06.013_bib22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5009\/gnl.2012.6.2.188","article-title":"Epigallocatechin-3-gallate inhibits LPS-induced NF-\u03baB and MAPK signaling pathways in bone marrow-derived macrophages","volume":"6","author":"Joo","year":"2012","journal-title":"Gut and Liver"},{"key":"10.1016\/j.jep.2013.06.013_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbapap.2005.08.017","article-title":"MAPK signalling pathways as molecular targets for anti-inflammatory therapy\u2014from molecular mechanisms to therapeutic benefits","volume":"1754","author":"Kaminska","year":"2005","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.jep.2013.06.013_bib24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.intimp.2012.08.006","article-title":"Malabaricone C suppresses lipopolysaccharide-induced inflammatory responses via inhibiting ROS-mediated Akt\/IKK\/NF-\u03baB signaling in murine macrophages","volume":"14","author":"Kang","year":"2012","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.jep.2013.06.013_bib25","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.fitote.2012.09.014","article-title":"Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells","volume":"83","author":"Kim","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2013.06.013_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000337581","article-title":"The suppressive effects of Bursopentine (BP5) on oxidative stress and NF-\u0138B activation in lipopolysaccharide-activated murine peritoneal macrophages","volume":"29","author":"Li","year":"2012","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib27","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/01.RES.0000188210.72062.10","article-title":"Redox-dependent transcriptional regulation","volume":"97","author":"Liu","year":"2005","journal-title":"Circulation Research"},{"key":"10.1016\/j.jep.2013.06.013_bib28","doi-asserted-by":"crossref","first-page":"22201","DOI":"10.1074\/jbc.273.35.22201","article-title":"Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites","volume":"273","author":"Marks-Konczalik","year":"1998","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1054\/bjoc.2001.1943","article-title":"Chronic immune activation and inflammation as the cause of malignancy","volume":"85","author":"O\u2019Byrne","year":"2001","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.jep.2013.06.013_bib30","unstructured":"Pires, A.M.L., 2011. Estudo fitoqu\u00edmico de A. cochliacarpos (Gomes) Barneby e J.W. Grimes e Calliandra depauperata Benth. Tese (doutorado) Universidade Federal do Cear\u00e1. Programa de P\u00f3s-gradua\u00e7\u00e3o em Qu\u00edmica. Fortaleza."},{"key":"10.1016\/j.jep.2013.06.013_bib31","doi-asserted-by":"crossref","first-page":"38969","DOI":"10.1074\/jbc.M509352200","article-title":"Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages","volume":"280","author":"Qi","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib32","unstructured":"Santos A.L.S., 2008. Intera\u00e7\u00e3o de comunidades rurais com recursos vegetais: o caso dos remanescentes de floresta estacional do munic\u00edpio de Junqueiro (AL-Brasil). 133 f. Tese de doutorado. Universidade Federal de Pernambuco."},{"key":"10.1016\/j.jep.2013.06.013_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0367-326X(02)00081-3","article-title":"Tannin composition of barbatimao species","volume":"73","author":"Santos","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2013.06.013_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1590\/S0102-695X2007000200014","article-title":"Atividade antimicrobiana in vitro do extrato de Abarema cochliacarpos (Gomes) Barneby and Grimes","volume":"17","author":"Santos","year":"2007","journal-title":"Brazilian Journal of Pharmacognosy"},{"key":"10.1016\/j.jep.2013.06.013_bib35","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.jep.2013.06.013_bib36","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1590\/S0102-33062006000400007","article-title":"Plantas medicinais usadas nos dist\u00farbios do trato gastrintestinal no povoado Col\u00f4nia Treze, Lagarto, SE Brasil","volume":"20","author":"Silva","year":"2006","journal-title":"Acta Botanica Brasilica"},{"key":"10.1016\/j.jep.2013.06.013_bib37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jep.2010.08.001","article-title":"Abarema cochliacarpos: Gastroprotective and ulcer-healing activities","volume":"132","author":"da Silva","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2013.06.013_bib38","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jep.2010.01.024","article-title":"Anti-inflammatory intestinal activity of Abarema cochliacarpos (Gomes) Barneby and Grimes in TNBS colitis model","volume":"128","author":"da Silva","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2013.06.013_bib39","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1590\/S0102-695X2011005000122","article-title":"Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats","volume":"21","author":"da Silva","year":"2011","journal-title":"Brazilian Journal of Pharmacognosy"},{"key":"10.1016\/j.jep.2013.06.013_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1590\/S0102-695X2009000100011","article-title":"Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby and J. W. Grimes (Mimosaceae)","volume":"19","author":"da Silva","year":"2009","journal-title":"Brazilian Journal of Pharmacognosy"},{"key":"10.1016\/j.jep.2013.06.013_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.jep.2013.06.013_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jnutbio.2005.10.005","article-title":"Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration","volume":"17","author":"Sutherland","year":"2006","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.jep.2013.06.013_bib43","unstructured":"The Nature Conservancy, 2010. Protecting the Caatinga in Brazil. \u3008http:\/\/www.nature.org\/ourinitiatives\/regions\/southamerica\/brazil\/placesweprotect\/caatinga.xml\u3009, (accessed 13.01.13)."},{"key":"10.1016\/j.jep.2013.06.013_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/biof.5520170128","article-title":"Redox signaling and the MAP kinase pathways","volume":"17","author":"Torres","year":"2003","journal-title":"Biofactors"},{"key":"10.1016\/j.jep.2013.06.013_bib45","doi-asserted-by":"crossref","unstructured":"Vane, J.R., Mitchell, J.A., Appleton, I., Tomlinson, A., Bishop-Bailey, D., Croxtall, J., Willoughby, D.A., 1994. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. In: Proceedings of the National Academy of Sciences USA 91, pp. 2046\u20132050.","DOI":"10.1073\/pnas.91.6.2046"},{"key":"10.1016\/j.jep.2013.06.013_bib46","unstructured":"Watkinson G., 2012. Abarema cochliocarpos. In: Proceedings of the IUCN 2012. IUCN Red List of Threatened Species. Version 2012.2. \u3008www.iucnredlist.org\u3009, (accessed 13.01.13)."},{"key":"10.1016\/j.jep.2013.06.013_bib47","unstructured":"World Conservation Monitoring Center, 1998. Abarema cochliacarpos. Red list of threatened species. \u3008http:\/\/www.iucnredlist.org\u3009, (accessed 11.09)."},{"key":"10.1016\/j.jep.2013.06.013_bib48","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbalip.2006.02.017","article-title":"Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 5 alpha, 6 beta-triol in ECV-304 cells","volume":"1761","author":"Wu","year":"2006","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.jep.2013.06.013_bib49","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1084\/jem.177.6.1779","article-title":"Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide","volume":"177","author":"Xie","year":"1993","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.jep.2013.06.013_bib50","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1084\/jem.20061849","article-title":"Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock","volume":"204","author":"Yang","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.jep.2013.06.013_bib51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1179\/096805100101532414","article-title":"Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors","volume":"6","author":"Zhang","year":"2000","journal-title":"Journal of Endotoxin Research"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874113004315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874113004315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T13:19:38Z","timestamp":1688303978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874113004315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0378874113004315"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2013.06.013","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abarema cochliacarpos reduces LPS-induced inflammatory response in murine peritoneal macrophages regulating ROS-MAPK signal pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2013.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}