{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:30:33Z","timestamp":1789349433361,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81260674"],"award-info":[{"award-number":["81260674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81260505"],"award-info":[{"award-number":["81260505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of Guangxi Key Laboratory for the Prevention & Treatment of Regional High-Incidence Diseases","award":["KFJJ2010-71"],"award-info":[{"award-number":["KFJJ2010-71"]}]},{"name":"Foundation of Guangxi Key Laboratory for the Prevention & Treatment of Regional High-Incidence Diseases","award":["KFJJ2011-37"],"award-info":[{"award-number":["KFJJ2011-37"]}]},{"name":"Guangxi Scientific Research & Technology Development Research","award":["10124008-6"],"award-info":[{"award-number":["10124008-6"]}]},{"name":"Guangxi Scientific Research & Technology Development Research","award":["0992003A-2"],"award-info":[{"award-number":["0992003A-2"]}]},{"name":"Guangxi Science and Technology Foundation Platform","award":["12-97-20"],"award-info":[{"award-number":["12-97-20"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.jep.2013.09.009","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T02:48:12Z","timestamp":1379386092000},"page":"568-575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam"],"prefix":"10.1016","volume":"150","author":[{"given":"Quanfang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2013.09.009_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/138955707780059844","article-title":"Antivirals of ethnomedicinal origin: structure-activity relationship and scope","volume":"7","author":"Chattopadhyay","year":"2007","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.jep.2013.09.009_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.nbt.2009.03.007","article-title":"Recent advancements for the evaluation of anti-viral activities of natural products","volume":"25","author":"Chattopadhyay","year":"2009","journal-title":"New Biotechnology"},{"key":"10.1016\/j.jep.2013.09.009_bib3","series-title":"Pharmaceutical Botany","first-page":"421","author":"Gan","year":"1991"},{"key":"10.1016\/j.jep.2013.09.009_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.antiviral.2007.01.002","article-title":"Anti-hepatitis B virus activity of wogonin in vitro and in vivo","volume":"74","author":"Guo","year":"2007","journal-title":"Antiviral Research"},{"key":"10.1016\/j.jep.2013.09.009_bib5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.24505","article-title":"Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I\u2013dependent manner","volume":"54","author":"Han","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2013.09.009_bib6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2012.09.003","article-title":"Hepatoprotective and antiviral properties of isochlorogenic acid A from Laggera alata against hepatitis B virus infection","volume":"144","author":"Hao","year":"2012","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2013.09.009_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1046\/j.1365-2672.2003.02026.x","article-title":"Novel antiviral agents: a medicinal plant perspective","volume":"95","author":"Jassim","year":"2003","journal-title":"Journal of Applied Microbiology"},{"key":"10.1016\/j.jep.2013.09.009_bib8","series-title":"Flora of Taiwan","first-page":"1029","author":"Kao","year":"2000"},{"key":"10.1016\/j.jep.2013.09.009_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2893.2003.00487.x","article-title":"Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures","volume":"11","author":"Lavanchy","year":"2004","journal-title":"Journal of Viral Hepatitis"},{"key":"10.1016\/j.jep.2013.09.009_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jhep.2009.05.022","article-title":"Control of cccDNA function in hepatitis B virus infection","volume":"51","author":"Levrero","year":"2009","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.jep.2013.09.009_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3748\/wjg.v11.i3.426","article-title":"Anti-HBV effect of liposome-encapsulated matrine in vitro and in vivo","volume":"11","author":"Li","year":"2005","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2013.09.009_bib12","first-page":"26","article-title":"The treatment of 128 cases of hepatitis B virus by Hydrocotyle sibthorpioides decoction","author":"Li","year":"2000","journal-title":"Journal of Sichuan Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2013.09.009_bib13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11596-008-0410-4","article-title":"The effect of Gankang Suppository on duck hepatitis B virus, serum biochemistry and liver histology in ducklings","volume":"28","author":"Li","year":"2008","journal-title":"Journal of Huazhong University of Science and Technology"},{"key":"10.1016\/j.jep.2013.09.009_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.antiviral.2008.03.001","article-title":"In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L","volume":"79","author":"Li","year":"2008","journal-title":"Antiviral Research"},{"key":"10.1016\/j.jep.2013.09.009_bib15","first-page":"11","article-title":"The treatment of 4 cases of psoriasis by Hydrocotyle sibthorpioides extracts","author":"Li","year":"1986","journal-title":"Journal of Psoriasis"},{"key":"10.1016\/j.jep.2013.09.009_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1142\/S0192415X03001107","article-title":"Radix Sophorae flavescentis for chronic hepatitis B: a systematic review of randomized trials","volume":"31","author":"Liu","year":"2003","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2013.09.009_bib17","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/138955708785909943","article-title":"Antiviral activity of phytochemicals: a comprehensive review","volume":"8","author":"Naithani","year":"2008","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.jep.2013.09.009_bib18","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/ptr.3155","article-title":"In vitro antiviral activity of lutein against hepatitis B virus","volume":"24","author":"Pang","year":"2010","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2013.09.009_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11596-010-0118-0","article-title":"In vitro anti-hepatitis B virus effect of Hypericum perforatum L","volume":"30","author":"Pang","year":"2010","journal-title":"Journal of Huazhong University of Science and Technology"},{"key":"10.1016\/j.jep.2013.09.009_bib20","first-page":"35","article-title":"Ethanol extract from ampelopsis sinica root exerts anti-hepatitis B virus activity via inhibition of p53 pathway in vitro","volume":"2011","author":"Pang","year":"2010","journal-title":"Evidence Based Complementary and AlternativeMedicine"},{"key":"10.1016\/j.jep.2013.09.009_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P","article-title":"Estimates of the worldwide incidence of 25 major cancers in 1990","volume":"80","author":"Parkin","year":"1999","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.jep.2013.09.009_bib22","first-page":"20","volume":"c1981-","author":"Perrillo","year":"2005"},{"key":"10.1016\/j.jep.2013.09.009_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-4419-0981-7_14","article-title":"Strategies for global prevention of hepatitis B virus infection","volume":"VI","author":"Van Damme","year":"2010","journal-title":"Hot Topics in Infection and Immunity in Children"},{"key":"10.1016\/j.jep.2013.09.009_bib24","doi-asserted-by":"crossref","first-page":"E67","DOI":"10.1046\/j.1440-1746.2000.02100.x","article-title":"Treatment of chronic liver diseases with traditional Chinese medicine","volume":"15","author":"Wang","year":"2000","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.jep.2013.09.009_bib25","first-page":"432","article-title":"The treatment of 40 cases of herpes zoster by Hydrocotyle sibthorpioides infusion","author":"Wang","year":"2000","journal-title":"Journal of Zhejiang Chinese Traditional Medicine"},{"key":"10.1016\/j.jep.2013.09.009_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1248\/bpb.32.132","article-title":"Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali","volume":"32","author":"Wang","year":"2009","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2013.09.009_bib27","first-page":"241","article-title":"Update on viral hepatitis: 2005","volume":"22","author":"Wong","year":"2006","journal-title":"Current Opinion in Gastroenterology"},{"key":"10.1016\/j.jep.2013.09.009_bib28","first-page":"2012","article-title":"Anti-hepatitis B virus effect and possible mechanism of action of 3, 4-O-dicaffeoylquinic acid in vitro and in vivo","author":"Wu","year":"2012","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"10.1016\/j.jep.2013.09.009_bib29","first-page":"1512","article-title":"Clinical observation of Tian Hu Shui Yu Gan Tablet(THSYG)in the treatment of jaundice hepatitis B","volume":"7","author":"Xiong","year":"2009","journal-title":"Chinese Journal of Medicinal Guide"},{"key":"10.1016\/j.jep.2013.09.009_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.antiviral.2012.10.003","article-title":"Anti-hepatitis B virus activities of \u03b1-DDB-FNC, a novel nucleoside-biphenyldicarboxylate compound in cells and ducks, and its anti-immunological liver injury effect in mice","volume":"96","author":"Yang","year":"2012","journal-title":"Antiviral Research"},{"key":"10.1016\/j.jep.2013.09.009_bib31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.phymed.2006.03.010","article-title":"Effects of Hydrocotyle sibthorpioides extract on transplanted tumors and immune function in mice","volume":"14","author":"Yu","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2013.09.009_bib32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.phymed.2010.01.008","article-title":"Protective effects of asiaticoside on acute liver injury induced by lipopolysaccharide\/d-galactosamine in mice","volume":"17","author":"Zhang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2013.09.009_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jep.2009.06.030","article-title":"Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L. var. grandiflorum","volume":"125","author":"Zhao","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2013.09.009_bib34","first-page":"6","article-title":"Quantitative detection of hepatitis B virus cccDNA in infected hepatocytes","volume":"23","author":"Zhao","year":"2005","journal-title":"Chinese Journal of Infectious Disease"},{"key":"10.1016\/j.jep.2013.09.009_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.antiviral.2006.12.005","article-title":"Protocatechuic aldehyde inhibits hepatitis B virus replication both in vitro and in vivo","volume":"74","author":"Zhou","year":"2007","journal-title":"Antiviral Research"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874113006429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874113006429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T01:58:47Z","timestamp":1539395927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874113006429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0378874113006429"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2013.09.009","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2013.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}