{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:15:20Z","timestamp":1777616120046,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.jep.2013.11.029","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T09:46:05Z","timestamp":1385113565000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds"],"prefix":"10.1016","volume":"151","author":[{"given":"Edwin Ogechukwu","family":"Omeje","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Parvez","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patience Ogoamaka","family":"Osadebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepshikha","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Faheem","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Dev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naibedya","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2013.11.029_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ajmg.a.30927","article-title":"Cleidocranial dysplasia: molecular genetic analysis and phenotypic-based description of a Middle European patient group","volume":"139A","author":"Baumert","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.jep.2013.11.029_bib2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/jcb.22264","article-title":"Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling","volume":"108","author":"Bhargavan","year":"2009","journal-title":"J. Cell Biochem."},{"issue":"1","key":"10.1016\/j.jep.2013.11.029_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jnutbio.2010.11.002","article-title":"Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor \u03b2-mediated osteogenic action of medicarpin","volume":"23","author":"Bhargavan","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.jep.2013.11.029_bib4","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.ajog.2005.08.049","article-title":"Strategies for the prevention and treatment of osteoporosis during early postmenopause","volume":"194","author":"Delaney","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4 Suppl 1","key":"10.1016\/j.jep.2013.11.029_bib5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2005.12.017","article-title":"Preventing osteoporosis-related fractures: an overview","volume":"119","author":"Gass","year":"2006","journal-title":"Am. J. Med."},{"issue":"4","key":"10.1016\/j.jep.2013.11.029_bib6","first-page":"297","article-title":"Developmental aspects of fracture healing and the use of pharmacological agents to alter healing","volume":"3","author":"Gerstenfeld","year":"2003","journal-title":"J. Musculoskel. Neuron Interact."},{"issue":"1","key":"10.1016\/j.jep.2013.11.029_bib7","first-page":"30","article-title":"The role of cytokines in the pathogenesis of endocrine disease","volume":"28","author":"Gianoukakis","year":"2004","journal-title":"Can. J. Diabet."},{"key":"10.1016\/j.jep.2013.11.029_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3923\/ajps.2010.163.167","article-title":"Isolation of lupeol, stigmasterol and campesterol from petroleum ether extract of woody stem of Wrightia tinctoria","volume":"9","author":"Jain","year":"2010","journal-title":"Asian J. Plant Sci."},{"issue":"1","key":"10.1016\/j.jep.2013.11.029_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1210\/edrv.23.1.0456","article-title":"Changes in proinflammatory cytokine activity after menopause","volume":"23","author":"Johannes","year":"2002","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.jep.2013.11.029_bib10","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1210\/endo.143.3.8698","article-title":"Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues","volume":"143","author":"John","year":"2002","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.jep.2013.11.029_bib100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01128975","article-title":"Methyl- 3, 4, 5- trihydroxybenzoate is a potent and highly specific inhibitor of herpes simplex virus in vitro. Purification and characterization of methyl gallates from Sapium sebiferum","volume":"8","author":"Kane","year":"1988","journal-title":"Biosci. Rep."},{"issue":"S1-S6","key":"10.1016\/j.jep.2013.11.029_bib11","first-page":"11","article-title":"Post menopausal osteoporosis: fracture risk and prevention","volume":"58","author":"Kaunitz","year":"2009","journal-title":"J. Fam. Pract."},{"issue":"4","key":"10.1016\/j.jep.2013.11.029_bib12","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00198-012-2121-8","article-title":"Positive skeletal effects of cladrin, a naturally occurring dimethoxydaidzein, in osteopenic rats that were maintained after treatment discontinuation","volume":"24","author":"Khan","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jep.2013.11.029_bib13","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1152\/ajpregu.00327.2006","article-title":"An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations","volume":"292","author":"Kregel","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jep.2013.11.029_bib14","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/pmic.200900666","article-title":"Identification of kaempferol-regulated proteins in rat calvarial osteoblasts during mineralization by proteomics","volume":"10","author":"Kumar","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.jep.2013.11.029_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/toxsci\/54.1.154","article-title":"Estrogenic activity of octylphenol, nonylphenol, biphenyl A and methoxychlor in rats","volume":"54","author":"Laws","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jep.2013.11.029_bib16","first-page":"637","article-title":"BMP Signaling Is Required for RUNX2-Dependent Induction of the Osteoblast Phenotype","volume":"21","author":"Mattabhor","year":"2006","journal-title":"J. Bone Miner. Res. 2006"},{"key":"10.1016\/j.jep.2013.11.029_bib17","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0031-9422(00)89569-2","article-title":"13C NMR Spectra of pentacyclic triterpenoids \u2013 a compilation and some salient features","volume":"37","author":"Mahato","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2013.11.029_bib18","article-title":"The anti-inflammatory, phytoestrogenic, and antioxidative role of Labisia pumila in prevention of postmenopausal osteoporosis","volume":"2012","author":"Nadia","year":"2012","journal-title":"Adv. Pharm. Sci."},{"key":"10.1016\/j.jep.2013.11.029_bib19","article-title":"Three hydroxylated Lupeol-based triterpenoid esters isolated from Eastern Nigeria Mistletoe parasitic on Kola acuminata","volume":"2011","author":"Omeje","year":"2011","journal-title":"Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.jep.2013.11.029_bib20","first-page":"412","article-title":"Immunomodulatory activity of a lupane triterpenoid ester isolated from the Eastern Nigeria mistletoe, Loranthus micranthus (Linn)","volume":"4","author":"Omeje","year":"2011","journal-title":"Asian Pacific J. Trop. Med., 2011"},{"key":"10.1016\/j.jep.2013.11.029_bib21","article-title":"Steroids and triterpenoids and steroids from the leaves of the Eastern Nigeria mistletoe with immunomodulatory potentials","author":"Omeje","year":"2011","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2013.11.029_bib22","doi-asserted-by":"crossref","DOI":"10.3109\/13880209.2011.621129","article-title":"A novel sesquiterpene acid and an alkaloid from leaves of the Eastern Nigeria mistletoe with potent immunostimulatory activity on C57BL6 splenocytes","author":"Omeje","year":"2011","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2013.11.029_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jep.2009.08.024","article-title":"Comparative toxicities and immunomodulatory potentials of five Eastern Nigeria mistletoes","volume":"126","author":"Osadebe","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"845\u2013869","key":"10.1016\/j.jep.2013.11.029_bib25","first-page":"2003","article-title":"Phytoestrogens: a review of the present state of research","volume":"17","author":"Ososki","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2013.11.029_bib26","article-title":"Emerging roles of mistletoes in malignancy management","author":"Patel","year":"2013","journal-title":"3 Biotech."},{"issue":"\u00be","key":"10.1016\/j.jep.2013.11.029_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02829964","article-title":"Tools to evaluate estrogenic potency of dietary phytoestrogens: A consensus paper from The EU thematic network \u201cPhytohealth\u201d (QLKI-2002-2453)","volume":"1","author":"Saarinen","year":"2006","journal-title":"Genes Nutr."},{"issue":"4","key":"10.1016\/j.jep.2013.11.029_bib28","doi-asserted-by":"crossref","first-page":"R154","DOI":"10.1186\/ar3107","article-title":"Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis","volume":"12","author":"Seo","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2013.11.029_bib29","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3945\/ajcn.2009.27981","article-title":"The pharmacokinetic behavior of the soy isoflavone metabolite S-(\u2212)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers","volume":"90","author":"Setchell","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2013.11.029_bib30","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1359\/JBMR.051023","article-title":"Teriparatide [human PTH (1-34)]: 2.5 years of experience on the use and safety of the drug for the treatment of osteoporosis","volume":"21","author":"Tashjian","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2013.11.029_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mce.2009.01.011","article-title":"Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol","volume":"302","author":"Trivedi","year":"2009","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jep.2013.11.029_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mce.2008.02.027","article-title":"Kaempferol has osteogenic effect in ovariectomized adult Sprague\u2013Dawley rats","volume":"289","author":"Trivedi","year":"2008","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jep.2013.11.029_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/156652410791065372","article-title":"Anabolics in osteoporosis: the emerging therapeutic tool","volume":"10","author":"Trivedi","year":"2010","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jep.2013.11.029_bib34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1248\/bpb.25.509","article-title":"Progressive development of the osteoblast phenotype during differentiation of osteoprogenitor cells derived from fetal rat calvaria: model for in vitro bone formation","volume":"25","author":"Yamamoto","year":"2002","journal-title":"Biol. Pharm. Bull."},{"issue":"12","key":"10.1016\/j.jep.2013.11.029_bib35","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.5012\/bkcs.2005.26.12.2057","article-title":"Synthesis and antioxidant activity of 3-methoxyflavones","volume":"26","author":"Yoo","year":"2005","journal-title":"Bull. Korean Chem. Soc."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874113008234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874113008234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:52:03Z","timestamp":1539031923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874113008234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0378874113008234"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2013.11.029","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2013.11.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}