{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:48:49Z","timestamp":1789220929806,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.jep.2014.03.037","type":"journal-article","created":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T10:53:50Z","timestamp":1395572030000},"page":"732-736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice"],"prefix":"10.1016","volume":"153","author":[{"given":"Pamela J.","family":"Weathers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Elfawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Towler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Acquaah-Mensah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2014.03.037_bib1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4269\/ajtmh.1994.50.771","article-title":"Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro","volume":"50","author":"Alin","year":"1994","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.jep.2014.03.037_bib2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4269\/ajtmh.2008.78.641","article-title":"Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model","volume":"78","author":"Batty","year":"2008","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.jep.2014.03.037_bib3","first-page":"35","article-title":"Secondary metabolites of Artemisia annua and their biological activity","volume":"80","author":"Bhakuni","year":"2001","journal-title":"Current Science"},{"key":"10.1016\/j.jep.2014.03.037_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2307\/2683591","article-title":"LOWESS: a program for smoothing scatterplots by robust locally weighted regression","volume":"35","author":"Cleveland","year":"1981","journal-title":"American Statistician"},{"key":"10.1016\/j.jep.2014.03.037_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s12272-011-0411-x","article-title":"Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin","volume":"34","author":"Choi","year":"2011","journal-title":"Archives of Pharmaceutical Research"},{"key":"10.1016\/j.jep.2014.03.037_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.foodchem.2012.02.195","article-title":"Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells","volume":"134","author":"de Magalh\u00e3es","year":"2012","journal-title":"Food Chemistry"},{"key":"10.1016\/j.jep.2014.03.037_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jms.2958","article-title":"Qualitative-(semi)quantitative data acquisition of artemisinin and its metabolites in rat plasma using an LTQ\/Orbitrap mass spectrometer","volume":"47","author":"Du","year":"2012","journal-title":"Journal of Mass Spectrometry"},{"key":"10.1016\/j.jep.2014.03.037_bib8","series-title":"Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants","author":"Duke","year":"2001"},{"key":"10.1016\/j.jep.2014.03.037_bib9","series-title":"Herbal Drugs: Ethnomedicine to Modern Medicine","first-page":"173","article-title":"Artemisinin: a versatile weapon from traditional chinese medicine","author":"Efferth","year":"2009"},{"key":"10.1016\/j.jep.2014.03.037_bib10","doi-asserted-by":"crossref","first-page":"e52746","DOI":"10.1371\/journal.pone.0052746","article-title":"Dried whole plant Artemisia annua as an antimalarial therapy","volume":"7","author":"Elfawal","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2014.03.037_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/0035-9203(87)90161-1","article-title":"Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones","volume":"81","author":"Elford","year":"1987","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.jep.2014.03.037_bib12","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00436-011-2418-0","article-title":"In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis","volume":"109","author":"Ferreira","year":"2011","journal-title":"Parasitology Research"},{"key":"10.1016\/j.jep.2014.03.037_bib13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.2001.65.690","article-title":"Artemisinin for treatment of uncomplicated falciparum malaria: is there a place for monotherapy?","volume":"65","author":"Giao","year":"2001","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.jep.2014.03.037_bib14","unstructured":"ICIPE, 2005. Whole-leaf Artemisia annua-based Antimalarial Drug: Report on Proof-of-concept Studies, Unpublished Report \u3008http:\/\/www.google.com\/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=2&ved=0CDgQFjAB&url=http%3A%2F%2Fwww.iwerliewen.org%2Findex.php%2Fcomponent%2Fedocman%2F%3Ftask%3Ddocument.download%26id%3D96%26Itemid%3D181&ei=J2miUbnFNo-80QGoi4GACw&usg=AFQjCNHoLJmPt4n0AkKyBlXPSyl5W7rc6w&sig2=ppM08\u00d71tZglQLLiaojZx1w&bvm=bv.47008514,d.dmQ\u3009 (accessed 17.01.14)."},{"key":"10.1016\/j.jep.2014.03.037_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/pst.449","article-title":"Estimation of pharmacokinetic parameters with the R package PK","volume":"10","author":"Jaki","year":"2011","journal-title":"Pharmaceutical Statistics"},{"key":"10.1016\/j.jep.2014.03.037_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0163-7258(90)90053-5","article-title":"Metabolism of antimalarial sesquiterpene lactones","volume":"48","author":"Lee","year":"1990","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2014.03.037_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1756-0500-1-26","article-title":"Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite","volume":"1","author":"Lehane","year":"2008","journal-title":"BMC Research Notes"},{"key":"10.1016\/j.jep.2014.03.037_bib18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/BF00236389","article-title":"Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures","volume":"11","author":"Liu","year":"1992","journal-title":"Plant Cell Reports"},{"key":"10.1016\/j.jep.2014.03.037_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1128\/MMBR.60.2.301-315.1996","article-title":"Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy","volume":"60","author":"Meshnick","year":"1996","journal-title":"Microbiology Reviews"},{"key":"10.1016\/j.jep.2014.03.037_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF03189697","article-title":"Metabolic fate of qinghaosu in rats; a new TLC densitometric method for its determination in biological material","volume":"10","author":"Niu","year":"1985","journal-title":"European Journal of Drug Metabolism and Pharmacokinetics"},{"key":"10.1016\/j.jep.2014.03.037_bib21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/1475-2875-10-326","article-title":"Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries","volume":"10","author":"O'Connell","year":"2011","journal-title":"Malaria Journal"},{"key":"10.1016\/j.jep.2014.03.037_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4172\/2167-0412.1000125","article-title":"The surprising efficiency of Artemisia annua powder capsules","volume":"2","author":"Onimus","year":"2013","journal-title":"Medicinal and Aromatic Plants"},{"key":"10.1016\/j.jep.2014.03.037_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature12051","article-title":"High-level semi-synthetic production of the potent antimalarial artemisinin","volume":"496","author":"Paddon","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jep.2014.03.037_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.toxlet.2009.09.002","article-title":"CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells","volume":"191","author":"Sergent","year":"2009","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.jep.2014.03.037_bib25","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1046\/j.1365-2125.1999.00044.x","article-title":"Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin","volume":"48","author":"Svensson","year":"1999","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.1016\/j.jep.2014.03.037_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10412905.2006.12067134","article-title":"The biological activities of 20 nature identical essential oil constituents","volume":"18","author":"van Zyl","year":"2006","journal-title":"Journal of Essential Oil Research"},{"key":"10.1016\/j.jep.2014.03.037_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11101-010-9166-0","article-title":"Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases","volume":"10","author":"Weathers","year":"2011","journal-title":"Phytochemistry Reviews"},{"key":"10.1016\/j.jep.2014.03.037_bib28","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jep.2013.11.043","article-title":"Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria","volume":"151","author":"Weathers","year":"2014","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.03.037_bib29","series-title":"Artemisia annua \u2013 Pharmacology and Biotechnology","first-page":"51","article-title":"Whole plant approaches to therapeutic use of Artemisia annua, L. (Asteraceae)","author":"Weathers","year":"2014"},{"key":"10.1016\/j.jep.2014.03.037_bib30","unstructured":"WHO, 2012. 10 Facts on Malaria. \u3008http:\/\/www.who.int\/features\/factfiles\/malaria\/en\/index.html\u3009 (accessed 17.01.14)."},{"key":"10.1016\/j.jep.2014.03.037_bib31","doi-asserted-by":"crossref","first-page":"13577","DOI":"10.1021\/ja3061479","article-title":"A concise synthesis of (+)-artemisinin","volume":"134","author":"Zhu","year":"2012","journal-title":"Journal of the American Chemical Society"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411400227X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411400227X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T18:06:32Z","timestamp":1597601192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411400227X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S037887411400227X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2014.03.037","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2014.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}