{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:21Z","timestamp":1788870501246,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202880"],"award-info":[{"award-number":["81202880"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Jiangsu Province, China","award":["BK2012456"],"award-info":[{"award-number":["BK2012456"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["ysxk-2010"],"award-info":[{"award-number":["ysxk-2010"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jep.2014.04.044","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T11:16:03Z","timestamp":1400066163000},"page":"696-703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparisons of pharmacokinetic and tissue distribution profile of four major bioactive components after oral administration of Xiang\u2013Fu\u2013Si\u2013Wu Decoction effective fraction in normal and dysmenorrheal symptom rats"],"prefix":"10.1016","volume":"154","author":[{"given":"Pei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er-xin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-lan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-ao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2014.04.044_bib1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.phymed.2013.05.003","article-title":"Traditional Chinese medicine for the treatment of primary dysmenorrhea: how do Yuanhu painkillers effectively treat dysmenorrhea?","volume":"20","author":"Chen","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2014.04.044_bib2","first-page":"489","article-title":"Primary dysmenorrhea","volume":"60","author":"Coco","year":"1999","journal-title":"American Family Physician"},{"key":"10.1016\/j.jep.2014.04.044_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jchromb.2007.12.028","article-title":"Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography\u2013tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis\u2013evodia herb couple","volume":"863","author":"Deng","year":"2008","journal-title":"Journal of Chromatography B"},{"key":"10.1016\/j.jep.2014.04.044_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jep.2006.09.033","article-title":"Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: a randomized clinical trial","volume":"110","author":"Doubova","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.04.044_bib5","first-page":"285","article-title":"Dysmenorrhea","volume":"71","author":"French","year":"2005","journal-title":"American Family Physician"},{"key":"10.1016\/j.jep.2014.04.044_bib6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jpag.2013.06.018","article-title":"Assessment of anxiety and depression in adolescents with primary dysmenorrhea: a case-control study","volume":"26","author":"Gagua","year":"2013","journal-title":"Journal of Pediatric and Adolescent Gynecology"},{"key":"10.1016\/j.jep.2014.04.044_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jpba.2012.10.011","article-title":"Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of Dactylicapnos scandens in rats","volume":"74","author":"Guo","year":"2013","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"10.1016\/j.jep.2014.04.044_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phymed.2004.06.016","article-title":"Effect of \u201cDang-Qui-Shao-Yao-San\u201d a Chinese medicinal prescription for dysmenorrhea on uterus contractility in vitro","volume":"13","author":"Hsu","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2014.04.044_bib9","first-page":"72","article-title":"Bioactivity evaluation of Siwu Decoction and its derived formulaes in the treatment of primary dysmenorrhea (I)","volume":"39","author":"Hua","year":"2008","journal-title":"Journal of China Pharmaceutical University"},{"key":"10.1016\/j.jep.2014.04.044_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1471-2458-6-177","article-title":"WHO systematic review of prevalence of chronic pelvic pain: a neglected reproductive health morbidity","volume":"6","author":"Latthe","year":"2006","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jep.2014.04.044_bib11","first-page":"3584","article-title":"Pharmacokinetic comparison of ferulic acid in normal and blood deficiency rats after oral administration of Angelica sinensis, Ligusticum chuanxiong and their combination","volume":"13","author":"Li","year":"2012","journal-title":"Molecular Science"},{"key":"10.1016\/j.jep.2014.04.044_bib12","first-page":"321","article-title":"Effects of oral administration of berberine on distribution and metabolism of 2-aminofluorene in Sprague\u2013Dawley rats","volume":"21","author":"Lin","year":"2007","journal-title":"in vivo"},{"key":"10.1016\/j.jep.2014.04.044_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1039\/C2MB25238D","article-title":"Biomarkers of primary dysmenorrhea and herbal formula intervention: an exploratory metabonomics study of blood plasma and urine","volume":"9","author":"Liu","year":"2013","journal-title":"Molecular BioSystems"},{"key":"10.1016\/j.jep.2014.04.044_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jep.2010.10.042","article-title":"Effects of Xiang\u2013Fu\u2013Si\u2013Wu Decoction and its main components for dysmenorrhea on uterus contraction","volume":"133","author":"Liu","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.04.044_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jchromb.2013.04.022","article-title":"Simultaneous determination of bioactive components in essential oil of Xiang\u2013Fu\u2013Si\u2013Wu formula in Beagle dog plasma by UPLC\u2013MS\/MS and its application to pharmacokinetics","volume":"929","author":"Liu","year":"2013","journal-title":"Journal of Chromatography B"},{"key":"10.1016\/j.jep.2014.04.044_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jep.2013.10.031","article-title":"Pharmacokinetic comparisons of berberine and palmatine in normal and metabolic syndrome rats","volume":"151","author":"Liu","year":"2014","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.04.044_bib17","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1124\/dmd.110.033936","article-title":"Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats","volume":"38","author":"Liu","year":"2010","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/j.jep.2014.04.044_bib18","series-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.jep.2014.04.044_bib19","first-page":"8","article-title":"Tissue distribution of berberine and its metabolites after oral administration in rats","author":"Tan","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.jep.2014.04.044_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jpba.2012.09.001","article-title":"Development and validation of liquid chromatography\u2013tandem mass spectrometry method for simultaneous determination of four tertiary alkaloids in rat plasma and its application to a pharmacokinetic study","volume":"72","author":"Wang","year":"2013","journal-title":"Journal of Pharmaceutical and Biomedical"},{"key":"10.1016\/j.jep.2014.04.044_bib21","first-page":"18","article-title":"Pharmacokinetic of ferulic acid in microcirculation dysfunction (blood stasis) rabbits","volume":"1995","author":"Wen","year":"1995","journal-title":"Chinese Journal of Clinical Pharmacology"},{"key":"10.1016\/j.jep.2014.04.044_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jep.2013.05.043","article-title":"Comparative pharmacokinetics and bioavailability of four alkaloids in different formulations from Corydalis decumbens","volume":"149","author":"Wu","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"issue":"1069\u20131070","key":"10.1016\/j.jep.2014.04.044_bib23","first-page":"1072","article-title":"The effect of Tongjingshu oral liquid on hemorheology of dysmenorrhea rates and PGF2\u03b1 of uterine tissues","volume":"10","author":"Wu","year":"2008","journal-title":"Chinese Journal of Medicinal Guide"},{"key":"10.1016\/j.jep.2014.04.044_bib24","first-page":"1273","article-title":"Phamacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC\u2013MS\u2013MS","volume":"34","author":"Xiaoxia","year":"2009","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.04.044_bib25","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.fitote.2011.07.012","article-title":"Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription","volume":"82","author":"Yan","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2014.04.044_bib26","first-page":"238","article-title":"Xiangfu Siwu Decoction\u05f3s effects on rat ovary granulosa cells proliferation and its active component analysis","volume":"27","author":"Yu","year":"2011","journal-title":"Journal of Nanjing University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.04.044_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.contraception.2009.09.014","article-title":"Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review","volume":"81","author":"Zahradnik","year":"2010","journal-title":"Contraception"},{"key":"10.1016\/j.jep.2014.04.044_bib28","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1124\/dmd.106.011361","article-title":"Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography\/ion trap mass spectrometry","volume":"34","author":"Zuo","year":"2006","journal-title":"Drug Metabolism and Disposition"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874114003328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874114003328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T19:19:57Z","timestamp":1589224797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874114003328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0378874114003328"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2014.04.044","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparisons of pharmacokinetic and tissue distribution profile of four major bioactive components after oral administration of Xiang\u2013Fu\u2013Si\u2013Wu Decoction effective fraction in normal and dysmenorrheal symptom rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2014.04.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}