{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:10:14Z","timestamp":1790813414531,"version":"4.1.0"},"reference-count":192,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science and Technology Major Projects for \u201cMajor New Drugs Innovation and Development\u201d","award":["2009ZX09308-003"],"award-info":[{"award-number":["2009ZX09308-003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jep.2014.11.043","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T04:32:00Z","timestamp":1417581120000},"page":"173-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":271,"special_numbering":"C","title":["A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-3474","authenticated-orcid":false,"given":"Guohong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xidan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-7812","authenticated-orcid":false,"given":"Zhuju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2014.11.043_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0301-0082(98)00037-9","article-title":"The effects of Aconitum alkaloids on the central nervous system","volume":"56","author":"Ameri","year":"1998","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.jep.2014.11.043_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jep.2013.03.017","article-title":"Myocardial lipidomics profiling delineate the toxicity of traditional Chinese medicine Aconiti Lateralis radix praeparata","volume":"147","author":"Cai","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/15563650902904407","article-title":"Aconite poisoning","volume":"47","author":"Chan","year":"2009","journal-title":"Clinical Toxicology"},{"key":"10.1016\/j.jep.2014.11.043_bib4","first-page":"12","article-title":"Observation at the cardiotonica action of Fuzi through the experiment method of serum pharmacology","volume":"3","author":"Chen","year":"1996","journal-title":"Chinese Journal of Traditional Medical Science and Technology"},{"key":"10.1016\/j.jep.2014.11.043_bib5","first-page":"792","article-title":"Studies on isolation and structural determination of salsolinol, the constituents of Fuzi, part I","volume":"17","author":"Chen","year":"1982","journal-title":"Acta Pharmacy Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib6","doi-asserted-by":"crossref","first-page":"o1432","DOI":"10.1107\/S1600536809018315","article-title":"(1\u03b2,2\u03b1,3\u03b1,7\u03b1,11\u03b1,13\u03b2)-1,3,7,11-tetraacetoxy-2,13-bis (benzyloxy)-21-methyl-19,21-secohetisan-19-al hemihydrate","volume":"E65","author":"Chen","year":"2009","journal-title":"Acta Crystallographica, Section E, Structure Reports Online"},{"issue":"324\u2013325","key":"10.1016\/j.jep.2014.11.043_bib7","first-page":"340","article-title":"The alkaloids of Fuzi cultivated in Zhongba","volume":"15","author":"Chen","year":"2003","journal-title":"Natural Product Research and Development"},{"key":"10.1016\/j.jep.2014.11.043_bib8","first-page":"33","article-title":"Study on the chemical components of Fuzi","volume":"27","author":"Chen","year":"2013","journal-title":"Research and Practice of Modern Chinese Medicines"},{"key":"10.1016\/j.jep.2014.11.043_bib9","first-page":"1126","article-title":"Research development of the toxicity of Fuzi","volume":"38","author":"Chen","year":"2013","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib10","first-page":"73","article-title":"The component-alkaloids-of Radix Aconite cultivated in Yunnan province","volume":"4","author":"Chen","year":"1982","journal-title":"Acta Botanica Yunnanica"},{"key":"10.1016\/j.jep.2014.11.043_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S2005-2901(09)60018-2","article-title":"The effects of Fu Zi on changes in the body heat of dogs","volume":"2","author":"Chen","year":"2009","journal-title":"Journal of Acupuncture and Meridian Studies"},{"key":"10.1016\/j.jep.2014.11.043_bib12","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1021\/ac500287e","article-title":"Comparative normal\/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaelii","volume":"86","author":"Chen","year":"2014","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.jep.2014.11.043_bib13","first-page":"30","article-title":"Preliminary investigation on mechanisms of immunoregulatory function of radix ginseng,radix aconiti praeparata and Shenfu decoction","volume":"16","author":"Chen","year":"1994","journal-title":"Chinese Traditional Patent Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib14","first-page":"435","article-title":"Study on Chinese Radix Aconite IV-alkaloids of Chuanwu and Fuzi","volume":"12","author":"Chen","year":"1965","journal-title":"Acta Pharmaceutica Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1055\/s-0028-1097196","article-title":"Cardioactive principle of Aconitum carmichaelii Roots","volume":"35","author":"Chohachi","year":"1979","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib16","series-title":"Flora of China","year":"2004"},{"key":"10.1016\/j.jep.2014.11.043_bib17","series-title":"Pharmacopoeia of China, Part I","year":"2010"},{"key":"10.1016\/j.jep.2014.11.043_bib18","first-page":"59","article-title":"Research on the targeting of calcineurin (CaN) to the procedure when Fuzinoside regulate heart failure","volume":"27","author":"Dang","year":"2011","journal-title":"Pharmacy and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib19","first-page":"150","article-title":"Experimental Study on dose\u2013effect relationship of chinese medicine prepared aconite root on effect of reviving yang for resuscitation","volume":"16","author":"Deng","year":"2010","journal-title":"China Journal of Experimental Traditional Medicine Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib20","first-page":"14710","article-title":"Impact of microwave processing on the ester-alkaloids of Fuzi","volume":"40","author":"Deng","year":"2012","journal-title":"Journal of Anhui Agricultural Sciences"},{"key":"10.1016\/j.jep.2014.11.043_bib21","first-page":"44","article-title":"Impact of oven roast on ester-alkaloids of Fuzi","volume":"18","author":"Deng","year":"2012","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib22","series-title":"Beijing","article-title":"Fang Jixue","author":"Deng","year":"2010"},{"key":"10.1016\/j.jep.2014.11.043_bib23","first-page":"23","article-title":"The effects of Fuzi combination with three common drugs on chronic renal failure mice induced by aristolochic acid","volume":"8","author":"Du","year":"2012","journal-title":"Asia-Pacific Traditional Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib24","first-page":"323","article-title":"The effects of the prepared aconite root on lactic acid metabolism in two kinds of chronic renal diseases mice models","volume":"35","author":"Fan","year":"2011","journal-title":"Progress in Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2014.11.043_bib25","first-page":"53","article-title":"Experimental research on the dose-effect relationship of the toxic Fuzi","volume":"29","author":"Fan","year":"2011","journal-title":"Journal of Sichuan of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jep.2011.09.005","article-title":"Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine","volume":"141","author":"Fan","year":"2012","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib27","first-page":"20","article-title":"The optimum selection of the processing technology of high pressure steam of Fuzi by orthogonal test method","volume":"18","author":"Fang","year":"2012","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib28","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.3390\/molecules17055187","article-title":"Diterpenoid alkaloids from the Chinese traditional herbal \u201cFuzi\u201d and their cytotoxic activity","volume":"17","author":"Gao","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2014.11.043_bib29","first-page":"882","article-title":"Induction of differentiation of dendritic cells derived from hepatocellular carcinoma by Fuzi polysaccharides","volume":"29","author":"Gao","year":"2012","journal-title":"Chinese Journal of Clinical Oncology"},{"key":"10.1016\/j.jep.2014.11.043_bib30","series-title":"Science of Chinese Materia Medica","author":"Gao","year":"2006"},{"key":"10.1016\/j.jep.2014.11.043_bib31","first-page":"727","article-title":"Impact of different decocting time on the alkaloids of decocted Fuzi","volume":"21","author":"Gong","year":"2011","journal-title":"Pharmacy Today"},{"key":"10.1016\/j.jep.2014.11.043_bib32","first-page":"82","article-title":"Research on toxicity of clinical application of Fuzi","volume":"33","author":"Gu","year":"2012","journal-title":"Yunnan Journal of Traditional Chinese Medicine and Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib33","first-page":"797","article-title":"Impact and metabolic of radix aconiti carmichaelii on immune liver injury model of rats","volume":"22","author":"Guo","year":"2010","journal-title":"Medical Journal of West China"},{"key":"10.1016\/j.jep.2014.11.043_bib34","first-page":"10","article-title":"New cardiotonic component of Fuzi from Jiangyou Sichuan","volume":"12","author":"Han","year":"1991","journal-title":"Academic Journal of the Second Military Medical University"},{"key":"10.1016\/j.jep.2014.11.043_bib35","first-page":"30","article-title":"Studies on the alkaloids and a new cardiac principle isolated from Jiangyou Fuzi","volume":"9","author":"Han","year":"1997","journal-title":"Natural Product Research and Development"},{"key":"10.1016\/j.jep.2014.11.043_bib36","doi-asserted-by":"crossref","first-page":"e86539","DOI":"10.1371\/journal.pone.0086539","article-title":"Fuzi attenuates diabetic neuropathy in rats and protects schwann cells from apoptosis induced by high glucose","volume":"9","author":"Han","year":"2014","journal-title":"Plos One"},{"key":"10.1016\/j.jep.2014.11.043_bib37","first-page":"218","article-title":"Reflection on safety of clinical application of Fuzi","volume":"30","author":"Hou","year":"2011","journal-title":"Beijing Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0378-8741(89)90035-4","article-title":"Mechanisms of hypoglycemic activity of aconitan A, a glycan from Aconitum carmichaelii roots","volume":"25","author":"Hikino","year":"1989","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1021\/np50026a006","article-title":"Structure of hokbusine A and B, diterpenic alkoloids of Aconitum carmichaelii roots from Japan","volume":"46","author":"Hikino","year":"1983","journal-title":"Journal of Nature Products"},{"key":"10.1016\/j.jep.2014.11.043_bib42","first-page":"931","article-title":"Synthesis of Higenaming","volume":"16","author":"Huang","year":"1981","journal-title":"Acta Pharmacy Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-511X-9-9","article-title":"Polysaccharide from fuzi (FPS) prevents hypercholesterolemia in rats","volume":"9","author":"Huang","year":"2010","journal-title":"Lipids Health Disease"},{"key":"10.1016\/j.jep.2014.11.043_bib44","first-page":"181","article-title":"Research on the stability of Fuzi\u05f3s extract","volume":"27","author":"Huang","year":"2012","journal-title":"West China Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2014.11.043_bib45","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1248\/yakushi1947.86.7_585","article-title":"Alkaloids from Aconitum carmichaelii","volume":"86","author":"Iwasa","year":"1966","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.jep.2014.11.043_bib46","first-page":"1314","article-title":"Research on mechanism of Smac\/Diablo of FPS\u05f3s anti-cardiomyocytes-apoptosis effect","volume":"35","author":"Ji","year":"2012","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"10.1016\/j.jep.2014.11.043_bib47","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/1934578X1200700606","article-title":"Structure-cardiac activity relationship of C19diterpenoid alkaloids","volume":"7","author":"Jian","year":"2012","journal-title":"Natural Product Communications"},{"key":"10.1016\/j.jep.2014.11.043_bib48","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/np300225t","article-title":"Diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii","volume":"75","author":"Jiang","year":"2012","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2014.11.043_bib49","first-page":"37","article-title":"Pharmacological effects and poisonousness of monkshood","volume":"13","author":"Jiang","year":"1991","journal-title":"Liaoning Journal of Traditional ChineseMedicine"},{"key":"10.1016\/j.jep.2014.11.043_bib50","first-page":"1658","article-title":"Chemical components and pharmacological effect of Fuzi","volume":"31","author":"Kao","year":"2010","journal-title":"Shanxi Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11418-010-0466-x","article-title":"The relationship between growth of the aerial part and alkaloid content variation in cultivated Aconitum carmichaelii Debeaux","volume":"65","author":"Kawasaki","year":"2011","journal-title":"Journal of Natural Medicines"},{"key":"10.1016\/j.jep.2014.11.043_bib52","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1254\/jjp.48.290","article-title":"Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-Sino medicine \u201cbushi\u201d (aconite root)","volume":"48","author":"Kimura","year":"1988","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib53","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1248\/yakushi1947.104.8_848","article-title":"Chemical studies on crude drug processing. II. Aconiti tuber (1). On the constituents of \u201cchuan-wu\u201d, the dried tuber of Aconitum carmichaelii Debx","volume":"104","author":"Kitagawa","year":"1984","journal-title":"Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan"},{"key":"10.1016\/j.jep.2014.11.043_bib54","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1248\/cpb.30.758","article-title":"Four new lipo-alkaloids from Aconiti tuber","volume":"30","author":"Kitagawa","year":"1982","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2014.11.043_bib55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-2007-969436","article-title":"Isolation and hypoglycemic activity of aconitans A\u2013D, glycans of Aconitum carmichaelii roots","author":"Konno","year":"1985","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib56","first-page":"150","volume":"35","author":"Konno","year":"1979","journal-title":"Cardioactive principle of Aconitum carmichaelii roots, Planta medica"},{"key":"10.1016\/j.jep.2014.11.043_bib57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/np50020a003","article-title":"Structure of senbusine A\u2013C, diterpenic alkoloids of Aconitum carmichaelii roots from China","volume":"45","author":"Konno","year":"1982","journal-title":"Journal of Nature Products"},{"key":"10.1016\/j.jep.2014.11.043_bib58","first-page":"335","article-title":"Study on cardiac principle of Aconite root","volume":"16","author":"Kosuge","year":"1972","journal-title":"Symposium on the Chemistry of Natural Products"},{"key":"10.1016\/j.jep.2014.11.043_bib59","series-title":"Chemistry of Chinese Materia Medica","author":"Kuang","year":"2002"},{"key":"10.1016\/j.jep.2014.11.043_bib60","first-page":"1404","article-title":"The effects of Cortex Phellodendri, FuZi and their monomers on the rat CYP3A activity","volume":"23","author":"Lai","year":"2012","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2014.11.043_bib61","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/1934578X1300800637","article-title":"Aconitamide, a novel alkaloid from the roots of Aconitum carmichaelii","volume":"8","author":"Lee","year":"2013","journal-title":"Natural Product Communications"},{"key":"10.1016\/j.jep.2014.11.043_bib62","first-page":"655","article-title":"Research on chemical component of Fuzi","volume":"44","author":"Lei","year":"2013","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.jep.2014.11.043_bib63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1254\/jphs.13057SC","article-title":"Anticonvulsant effects of fuzi total alkaloid on pentylenetetrazole-induced seizure in mice","volume":"123","author":"Li","year":"2013","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.jep.2014.11.043_bib64","first-page":"84","article-title":"Preliminary study on the anti-tumor effect of Fuzi medicinal liquor","volume":"32","author":"Li","year":"2013","journal-title":"Journal of Henan University (Medical Science)"},{"key":"10.1016\/j.jep.2014.11.043_bib65","first-page":"5","article-title":"Experimental research on the impact of the compatibility, Fuzi-Rhizoma Pinelliae, on rats","volume":"3","author":"Li","year":"2009","journal-title":"Chinese Journal of Modern Drug Application"},{"key":"10.1016\/j.jep.2014.11.043_bib66","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jep.2008.01.014","article-title":"Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae)","volume":"116","author":"Li","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib67","first-page":"31","article-title":"Research on the comparison of the action of cause restoration from collapse between crude Fuzi and Heishunpian","volume":"21","author":"Li","year":"2005","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib68","first-page":"5","article-title":"Impact of Fuzi on TNF-\u03b1 of adriamycin-induced nephropathy in rats","volume":"14","author":"Li","year":"2012","journal-title":"Chinese Community Doctors"},{"key":"10.1016\/j.jep.2014.11.043_bib69","article-title":"(1\u03b1,2\u03b2,3\u03b1,7\u03b1,11\u03b1,13\u03b2)-1,3,11-triacetoxy-2,13-bis (benzoyloxy)-7-hydroxy-21-methyl-N,19-secohetisan-19-al","volume":"E64","author":"Li","year":"2008","journal-title":"Acta Crystallographica, Section E: Structure Reports Online"},{"key":"10.1016\/j.jep.2014.11.043_bib70","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1934578X1300800204","article-title":"carmichaeline A: a new C20-diterpenoid alkaloid from Aconitum carmichaelii","volume":"8","author":"Li","year":"2013","journal-title":"Natural Product Communications"},{"key":"10.1016\/j.jep.2014.11.043_bib71","first-page":"431","article-title":"Impact of Fuzi preparations processed in different time to the functon of the hearts of rats anaesthitizing by chloral hydrate","volume":"33","author":"Li","year":"2009","journal-title":"Journal of Shandong University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib72","first-page":"2986","article-title":"Study on acute toxicity of total alkaloids of processed Radix Aconiti Lateralis and its effects on blood histamine contents and pathomorphological changes in nasal mucosa in allergic rhinitis guinea pigs","volume":"26","author":"Liang","year":"2011","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"10.1016\/j.jep.2014.11.043_bib73","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.3390\/molecules17089939","article-title":"Alkaloids isolated from the lateral roots of Aconitum carmichaelii","volume":"17","author":"Liang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2014.11.043_bib74","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1142\/S0192415X13500262","article-title":"Polysaccharide from Fuzi likely protects against starvation-induced cytotoxicity in H9c2 cells by increasing autophagy through activation of the AMPK\/mTOR pathway","volume":"41","author":"Liao","year":"2013","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib75","first-page":"42","article-title":"The effect of monkshood-cake moxibustion on the red-cell immune function of the aged","volume":"16","author":"Liao","year":"1996","journal-title":"Journal of Hunan College of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib76","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1631\/jzus.B1100006","article-title":"Microcalorimetry studies on the antibacterial effect of crude monkshood polysaccharide","volume":"12","author":"Lin","year":"2011","journal-title":"Journal Zhejiang University \u2013 Science B"},{"key":"10.1016\/j.jep.2014.11.043_bib77","first-page":"557","article-title":"Zhi-fuzi, a cardiotonic Chinese herb, a new medical treatment choice for portal hypertension","volume":"232","author":"Lin","year":"2007","journal-title":"Experimental Biology and Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib78","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1142\/S0192415X09006874","article-title":"Study on pretreatment of FPS-1 in rats with hepatic ischemia-reperfusion injury","volume":"37","author":"Lin","year":"2009","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib79","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jep.2005.02.014","article-title":"Comparison of the antinociceptive action of crude Fuzi, the root of Aconitum, and its processed products","volume":"99","author":"Liou","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib80","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jep.2006.01.001","article-title":"The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaelii), in streptozotocin-induced diabetic rats","volume":"106","author":"Liou","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib81","first-page":"960","article-title":"Research on the alteration of the content of the main alkaloids of Fuzi when precessing","volume":"23","author":"Liu","year":"2012","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2014.11.043_bib82","first-page":"417","article-title":"Influence of aconite normal butanol and water extract on ATPase activity and energy charge in rat model of deficiency-cold syndrome","volume":"41","author":"Liu","year":"2012","journal-title":"Chongqing Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib83","first-page":"60","article-title":"Influence of aconite normal butanol and water extract on lactic acid content and pyruvic acid content in rat model of deficiency-cold syndrome","volume":"36","author":"Liu","year":"2012","journal-title":"Journal of Shandong University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib84","first-page":"184","article-title":"Experimental treatment of rheumatoid arthritis by aconiti lateralis radix praeparata","volume":"17","author":"Liu","year":"2011","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib85","first-page":"28","article-title":"The effects and mechanism of fuzi on chronic renal failure in mice","volume":"6","author":"Liu","year":"2010","journal-title":"Asia-Pacific Traditional Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib86","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1254\/jphs.12163FP","article-title":"Antidepressant-like effect of Fuzi total alkaloid on ovariectomized mice","volume":"120","author":"Liu","year":"2012","journal-title":"Journal of Pharmacology Science"},{"key":"10.1016\/j.jep.2014.11.043_bib87","first-page":"1801","article-title":"Experimental research of the toxicity of the compatibility, Fuzi-Bulbus Fritillariae, to the rats\u2019 heart, liver and kidney","volume":"21","author":"Liu","year":"2010","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2014.11.043_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tca.2013.07.031","article-title":"Action of crude Radix Aconiti Lateralis (Fuzi) and its processed products on splenic lymphocytes growth investigated by microcalorimetry","volume":"571","author":"Liu","year":"2013","journal-title":"Thermochimica Acta"},{"key":"10.1016\/j.jep.2014.11.043_bib89","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1248\/cpb.60.144","article-title":"Cardioactive C19 diterpenoid alkaloids from the lateral roots of Aconitum carmichaeli, Fuzi","volume":"60","author":"Liu","year":"2012","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2014.11.043_bib90","first-page":"53","article-title":"Effects of fuzi polymccharide postconditioning on expression of manganese superoxide dismutase in neonatal rat cardiomyocytes with hypoxia-reoxygenation","volume":"27","author":"Liu","year":"2011","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib91","first-page":"504","article-title":"Protection of Fuzi polysaccharide against hypoxia-reoxygenation injury in neonatal rat cardiomycytes and its mechanism","volume":"23","author":"Liu","year":"2012","journal-title":"Traditional Chinese Drug Research and Clinical Pharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib92","first-page":"169","article-title":"Effect of STAT3 in mechanism of fuzi polysaccharides postconditioning protecting cardiomyocytes with hypoxia-reoxygenation in neonate rats","volume":"35","author":"Liu","year":"2012","journal-title":"Journal of Beijing University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib93","first-page":"459","article-title":"Fuzi polysaccharide protects neonatal rat cardiomyocytes with hypoxia-reoxygenation by inhibiting endoplasmic reticulum stress","volume":"28","author":"Liu","year":"2012","journal-title":"Chinese Journal of Pathophysiology"},{"key":"10.1016\/j.jep.2014.11.043_bib94","first-page":"281","article-title":"Protective mechanism of fuzi polymccharide against hypoxia-reoxygenation injury in neonatal rat cardiomyocytes","volume":"29","author":"Liu","year":"2012","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"key":"10.1016\/j.jep.2014.11.043_bib95","first-page":"172","article-title":"Metallothionein mediates protection by Fuzi polymccharide on neonatal rat cardiomyocytes with hypoxia-reoxygenation","volume":"18","author":"Liu","year":"2012","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib96","first-page":"1523","article-title":"Effects of acetoacetate extract of Radix Aconite on hepatic contents of LA, LDH, PA, Gn, and ATPase activities in deficient cold model rats","volume":"31","author":"Liu","year":"2011","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib97","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1055\/s-0029-1240688","article-title":"Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaelii (Fuzi) based on the chemical analysis of their diester diterpenoid alkaloids","volume":"76","author":"Lu","year":"2010","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib98","first-page":"1250","article-title":"Research on the alteration of the content of aconitine after Fuzi combined with Radix glycyrrhizae and Zingiber officinale","volume":"19","author":"Lu","year":"2010","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib99","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3839\/jabc.2008.029","article-title":"Isolation of flavonoids from processed aconiti tuber","volume":"51","author":"Lyu","year":"2008","journal-title":"Journal of Applied Biological Chemistry"},{"key":"10.1016\/j.jep.2014.11.043_bib100","first-page":"342","article-title":"The effect of aconitine on Ia expression of peritoneal macrophage of mice","volume":"13","author":"Ma","year":"1997","journal-title":"Chinese Pharmacological Bulletin"},{"key":"10.1016\/j.jep.2014.11.043_bib101","first-page":"379","article-title":"Effects of mankshood, dry ginger, Chinese goldthread and rhubarb on energy metabolism of rats","volume":"34","author":"Ma","year":"2010","journal-title":"Journal of Shandong University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib102","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.forsciint.2012.10.021","article-title":"Distribution of Aconitum alkaloids in autopsy cases of aconite poisoning","volume":"227","author":"Niitsu","year":"2013","journal-title":"Forensic Science International"},{"key":"10.1016\/j.jep.2014.11.043_bib103","first-page":"23","article-title":"Vasodilation effect of water decoction of the common monkshood prepared daughter root on rabbit aorta in vitro","volume":"20","author":"Niu","year":"2004","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib104","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jep.2013.04.056","article-title":"The effects of Rhizoma zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis-Rhizoma zingiberis","volume":"148","author":"Peng","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib105","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jep.2013.07.022","article-title":"A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula (\u201cSini Tang\u201d)","volume":"149","author":"Peter","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib106","first-page":"618","article-title":"Impact of different steaming, decocting time on the cardiotonic action and heart toxicity of Fuzi","volume":"15","author":"Qin","year":"2002","journal-title":"Medical Information"},{"key":"10.1016\/j.jep.2014.11.043_bib107","first-page":"2888","article-title":"Comparative study on the natures of water extracts of Aconitum carmichaelii, Scutellaria baicalensis and Andrographis paniculata on SH-SY5Y cells apoptosis induced by MPP+","volume":"23","author":"Qiu","year":"2012","journal-title":"China Pharmacy"},{"key":"10.1016\/j.jep.2014.11.043_bib108","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1479-5876-10-S2-A56","article-title":"Elementary analysis on safety and countermeasures of clinical excessive application of Fuzi in Urumqi City Hospital of traditional Chinese medicine","volume":"30","author":"Qiu","year":"2012","journal-title":"Xinjiang Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib109","first-page":"34","article-title":"Effect of Radix Aconiti Praeparata extract on cell apoptosis in transplanted liver cancer H22","volume":"28","author":"Ren","year":"2008","journal-title":"Henan Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib110","first-page":"176","article-title":"Anti-cold diarrhea effect of Aconiti Lateralis Radix Praeparata on mice with spleen Yang deficiency syndrome","volume":"17","author":"Shao","year":"2011","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib111","first-page":"2329","article-title":"Analgesic and anti-inflammatory effects of different processed products of Aconiti lateralis radix praeparata","volume":"22","author":"Shao","year":"2011","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2014.11.043_bib112","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hlca.201000152","article-title":"Two new C20diterpenoids alkaloids from Aconitum carmichaelii","volume":"94","author":"Shen","year":"2011","journal-title":"Helvetica Chimica Acta"},{"key":"10.1016\/j.jep.2014.11.043_bib113","first-page":"43","article-title":"Effects of monotherapy with Radix Aconiti Lateralis Preparata, Spironolactone, and their combination on NOS inhibition induced hypertensive mice","volume":"8","author":"Shi","year":"2012","journal-title":"Asia-Pacific Traditional Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib114","first-page":"208","article-title":"Positive inotropic effect of Higenamine and 6-gingerol on cardiac myocytes","volume":"19","author":"Shi","year":"2013","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib115","first-page":"1731","article-title":"Experience in treatment for one case of crude Fuzi acute poisoning","volume":"33","author":"Shi","year":"2011","journal-title":"Hebei Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib116","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1248\/cpb.51.999","article-title":"Norditerpenoid alkaloids from the processed tubers of Aconitum carmichaelii","volume":"51","author":"Shim","year":"2003","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2014.11.043_bib117","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/BF02978206","article-title":"Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaelii","volume":"28","author":"Shim","year":"2005","journal-title":"Archives of Pharmacal Research"},{"key":"10.1016\/j.jep.2014.11.043_bib118","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jep.2006.01.004","article-title":"Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors","volume":"106","author":"Shu","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib119","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2009.07.031","article-title":"Aconitum in traditional Chinese medicine - a valuable drug or an unpredictable risk","volume":"126","author":"Singhuber","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib120","first-page":"895","article-title":"Research on clinical application and safety evaluation of Fuzi","volume":"28","author":"Song","year":"2013","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"10.1016\/j.jep.2014.11.043_bib121","first-page":"97","article-title":"Impact of microbial fermentation on the content of alkaloids of Chuanwu and Fuzi","volume":"37","author":"Su","year":"2010","journal-title":"Journal of Beijing University of Chemical Technology"},{"key":"10.1016\/j.jep.2014.11.043_bib122","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ab.2009.08.014","article-title":"Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography\/time-of-flight mass spectrometry","volume":"395","author":"Sun","year":"2009","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2014.11.043_bib123","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/rcm.3992","article-title":"A metabolomic analysis of the toxicity of Aconitum sp. alkaloids in rats using gas chromatography\/mass spectrometry","volume":"23","author":"Sun","year":"2009","journal-title":"Rapid Communication in Mass Spectrometry"},{"key":"10.1016\/j.jep.2014.11.043_bib124","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1039\/C1AN15833C","article-title":"Metabolomics study on Fuzi and its processed products using ultra-performance liquid-chromatography\/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis","volume":"137","author":"Sun","year":"2012","journal-title":"Analyst"},{"key":"10.1016\/j.jep.2014.11.043_bib125","first-page":"16","article-title":"Investigation on detoxification and synergism of Fuzi, based on biotransformation","volume":"18","author":"Sun","year":"2012","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib126","first-page":"104","article-title":"Experimental research on the acute toxicity of the compatibility, Fuzi-Rhizoma Pinelliae","volume":"28","author":"Sun","year":"2011","journal-title":"Chinese Journal of Information on Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib127","first-page":"3097","article-title":"Effect of Aconiti Lateralis Radix Praeparata and Taraxaci herba on Chinese medicine signs and symptoms of urethane-induced lung cancer in mice","volume":"37","author":"Sun","year":"2012","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib128","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1055\/s-2003-43217","article-title":"8-O-cinnamoylneoline, a new alkaloid from the flower buds of Aconitum carmichaelii and its toxic and analgesic activities","volume":"69","author":"Taki","year":"2003","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib129","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jep.2014.02.011","article-title":"Metabolic profiling reveals therapeutic biomarkers of processed Aconitum carmichaelii Debx in treating hydrocortisone induced Kidney-Yang deficiency syndrome rats","volume":"152","author":"Tan","year":"2014","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib130","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jep.2013.11.048","article-title":"Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaelii Debx. against severe-stage osteoarthritis model induced by mono-iodoacetate","volume":"151","author":"Tong","year":"2014","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib131","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jep.2013.01.025","article-title":"Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaelii) and its application in rheumatoid arthritis therapy","volume":"146","author":"Tong","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib132","first-page":"90","article-title":"Effect of Fuzi on cAMP-PKA signal transduction pathways in rat of chronic arrhythmia","volume":"29","author":"Tong","year":"2013","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib133","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1016\/j.bmcl.2012.04.132","article-title":"A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaelii Debx. with potential analgesic activity and less toxicity","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"key":"10.1016\/j.jep.2014.11.043_bib134","series-title":"Reserch on the identification and pharmacologica effect of the effective components of Fuzi","author":"Wang","year":"2005"},{"key":"10.1016\/j.jep.2014.11.043_bib135","first-page":"84","article-title":"Observation at safety of clinical application of Fuzi","volume":"18","author":"Wang","year":"2011","journal-title":"China Modern Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib136","first-page":"596","article-title":"Experimental research on cardiotonic effect of the effective parts of crude Fuzi and processed Fuzi","volume":"34","author":"Wang","year":"2009","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib137","first-page":"102","article-title":"Analysis and research on relative factors of individual difference of the dosage of Fuzi","volume":"18","author":"Wang","year":"2011","journal-title":"China Modern Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib138","first-page":"961","article-title":"The influence of aconite root on the expressions of genes related to the metabolism of oxygen free radicals and sex hormones","volume":"32","author":"Wang","year":"2012","journal-title":"Chinese Journal of Gerontology"},{"key":"10.1016\/j.jep.2014.11.043_bib139","first-page":"1083","article-title":"Effect of Radix Aconiti Lateralis Preparta in rat models of neuropathic pain","volume":"28","author":"Wang","year":"2010","journal-title":"Chinese Archives of Traditoinal Chinese Medciine"},{"key":"10.1016\/j.jep.2014.11.043_bib140","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1021\/pr200963e","volume":"11","author":"Wang","year":"2012","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/j.jep.2014.11.043_bib141","first-page":"716","article-title":"Study on alkaloids of Fuzi cultivated in Zhongba","volume":"30","author":"Wang","year":"1995","journal-title":"Chinese Pharmaceutical Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib142","first-page":"74","article-title":"Study on alkaloids of Fuzi cultivated in Zhongba","volume":"31","author":"Wang","year":"1996","journal-title":"Chinese Pharmaceutical Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib143","first-page":"286","article-title":"Research on the rationality of processing methods of toxic herbal, Fuzi, based on chemical analysis","volume":"48","author":"Wen","year":"2013","journal-title":"Acta Phamaceutica Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib144","first-page":"911","article-title":"Effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats","volume":"27","author":"Wu","year":"2011","journal-title":"Chinese Journal of Pathophysiology"},{"key":"10.1016\/j.jep.2014.11.043_bib145","first-page":"91","article-title":"Study on chemical components of Fuzi","author":"Wu","year":"2013","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"10.1016\/j.jep.2014.11.043_bib146","first-page":"1942","article-title":"Experience in treatment of 20 cases of acute aconite poisoning","volume":"33","author":"Wu","year":"2012","journal-title":"Jilin Medical Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib147","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1479-5876-10-S2-A41","article-title":"Impact of Fuzi and Caulis Aristolochiae manshuriensis on the rhabdomyolysis model induced by simvastatin andgemfibrozil combination, and their comparison","volume":"8","author":"Wu","year":"2012","journal-title":"Asia-Pacific Traditional Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib148","doi-asserted-by":"crossref","first-page":"o2238","DOI":"10.1107\/S1600536812026463","article-title":"8-O-Ethylyunaconitine from the roots of Aconitum carmichaelii Debx","volume":"68","author":"Wu","year":"2012","journal-title":"Acta Crystallographica, Section E: Structure Reports Online"},{"key":"10.1016\/j.jep.2014.11.043_bib149","first-page":"1005","article-title":"Effect of prepared aconite root on pain threshold of spinal nerve ligaed model rats","volume":"20","author":"Wu","year":"2009","journal-title":"Medical Journal of the Chinese People\u05f3s Armed Police Forces"},{"key":"10.1016\/j.jep.2014.11.043_bib150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1360\/aps050046","article-title":"A pharmacophylogenteic study of Aconitum L (Ranunculaceae) from China","volume":"44","author":"Xiao","year":"2006","journal-title":"Acta Phytotaxonomica Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib151","first-page":"964","article-title":"Research on the cardiotonic components of crude Fuzi from Jiangyou, Sichuan","volume":"35","author":"Xu","year":"2004","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.jep.2014.11.043_bib152","first-page":"381","article-title":"Analgesic effect of processed Aconiti tuber in rats with neuropathic pain","volume":"25","author":"Xu","year":"2005","journal-title":"Chinese Journal of Anesthesiology"},{"key":"10.1016\/j.jep.2014.11.043_bib153","first-page":"9","article-title":"Effects of Fuzi and Wu Zhuyu on coagulation system and formation of experimental thrombus","volume":"5","author":"Xu","year":"1990","journal-title":"Northwest Pharmaceutical Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib154","series-title":"Research on the material basis and action link of the detoxification of Fuzi-Radix glycyrrhizae and Fuzi-Zingiber officinale","author":"Xu","year":"2006"},{"key":"10.1016\/j.jep.2014.11.043_bib155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2004.09.028","article-title":"Aconiti tuber increases plasma nitrite and nitrate levels in humans","volume":"96","author":"Yamada","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib156","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1017\/S1461145709990733","article-title":"Fuzi polysaccharide-1 produces antidepressant-like effects in mice","volume":"13","author":"Yan","year":"2010","journal-title":"International Journal Neuropsychopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib157","first-page":"834","article-title":"Effects of Aconite extract of petroleum ether and chloroform on deficiency model of rat serum thyroid-stimulating hormone, triiodothyronine and thyroxine contents","volume":"21","author":"Yang","year":"2011","journal-title":"Zhejiang Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib158","first-page":"527","article-title":"Effects of aconite petroleum ether extract and aconite chloroform extract on LDH and SDH activities in liver of deficiency-cold rats","volume":"35","author":"Yang","year":"2011","journal-title":"Journal of Shandong University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib159","first-page":"1068","article-title":"Study on the chemical components of aerial part of Fuzi","volume":"15","author":"Yang","year":"2011","journal-title":"Anhui Medical and Pharmaceutical Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib160","first-page":"39","article-title":"Experimental study of prepared commonot on adriamycin-induced nephropathy in rats","volume":"26","author":"Yang","year":"2010","journal-title":"Shanxi Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib161","first-page":"54","article-title":"Experimental study on the Fuzi\u05f3s anti fatigue and anti hypoxia effect on mice with Yang deficiency","volume":"33","author":"Yang","year":"2010","journal-title":"Guangxi Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib162","first-page":"1035","article-title":"Research on the ingredients of Fuzi without Zingiber officinale","volume":"35","author":"Ye","year":"2013","journal-title":"Chinese Traditional Patent Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib163","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jccs.201200077","article-title":"A new alkaloid from the roots of Aconitum carmichaelii Debx","volume":"59","author":"Yu","year":"2012","journal-title":"Journal of Chinese Chemical Society"},{"key":"10.1016\/j.jep.2014.11.043_bib164","first-page":"2535","article-title":"Effects of aconite root on energy metabolism and expression of related genes in rats","volume":"36","author":"Yu","year":"2011","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib165","first-page":"23","volume":"18","author":"Yu","year":"2012","journal-title":"Effects of Radix Aconiti Lateralis Preparata and Rhizoma Zingiberis on energy metabolism and expression of the genes related to metabolism in rats, Chinese Journal of Integrative Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib166","first-page":"11","article-title":"The effect of Fuzi polysaccharides on the glucose intake of insulin-resistance adipocytes and the possible mechanism","volume":"5","author":"Yu","year":"2009","journal-title":"Asia-Pacific Traditional Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib167","first-page":"86","article-title":"Alteration of the component content of Fuzi after compatibility with Radix glycyrrhizae","volume":"22","author":"Yu","year":"2010","journal-title":"Strait Pharmaceutical Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib168","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.talanta.2008.10.022","article-title":"Studies on the aconitine-type alkaloids in the roots of Aconitum carmichaelii Debx. by HPLC\/ESIMS\/MSn","volume":"77","author":"Yue","year":"2009","journal-title":"Talanta"},{"key":"10.1016\/j.jep.2014.11.043_bib169","first-page":"481","article-title":"Study on the components of Fuzi II \u2013 the component of Baifupian","volume":"13","author":"Zhang","year":"1982","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.jep.2014.11.043_bib170","first-page":"2206","article-title":"Research on the impact of Fuzi-Radix glycyrrhizae on the in vivo activity of CYP3A4","volume":"37","author":"Zhang","year":"2012","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib171","first-page":"165","article-title":"Research on the comparison between chemical components of the precipitate in the decoction of Fuzi-Radix glycyrrhizae and those in the decoction of Fuzi","volume":"44","author":"Zhang","year":"2013","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.jep.2014.11.043_bib172","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jep.2013.02.019","article-title":"Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from Fuzi-Gancao herb-pair decoction for its potential interaction mechanism investigation","volume":"147","author":"Zhang","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib173","first-page":"193","article-title":"The Effective Component of Aconitum carmichaelii Debx. for Antiventricular Arrhythmias","volume":"11","author":"Zhang","year":"2000","journal-title":"Li Shizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2014.11.043_bib174","first-page":"262","article-title":"Study on chemical components of Fuzi","volume":"18","author":"Zhang","year":"2010","journal-title":"Pharmaceutical and Clinical Research"},{"key":"10.1016\/j.jep.2014.11.043_bib175","first-page":"135","article-title":"Experimental study on Fuzi effect on anti-oxidation system of the elderly rats","volume":"21","author":"Zhang","year":"2001","journal-title":"Chinese Journal of Gerontology"},{"key":"10.1016\/j.jep.2014.11.043_bib176","first-page":"670","article-title":"Study on alkaloids of Fuzi from Jiangyou, Sichuan","volume":"27","author":"Zhang","year":"1992","journal-title":"Acta Pharmaceutica Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib177","first-page":"665","article-title":"Study on apoptosis induction by aconite root in SGC-7901 gastric cancer cell","volume":"35","author":"Zhang","year":"2011","journal-title":"Journal of Zhejiang Chinese Medical University"},{"key":"10.1016\/j.jep.2014.11.043_bib178","first-page":"272","article-title":"Reflection on one case of Fuzi poisoning","volume":"15","author":"Zhang","year":"2013","journal-title":"Journal of Chinese Community Doctors"},{"key":"10.1016\/j.jep.2014.11.043_bib179","first-page":"1986","article-title":"Antitumor effect of total alkaloids from Aconiti Lateralis Radix Praeparata on breast cancer in mice","volume":"43","author":"Zhang","year":"2012","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"10.1016\/j.jep.2014.11.043_bib180","first-page":"884","article-title":"Impact of processsing to the cardiotonic action of Fuzi","volume":"24","author":"Zhang","year":"2011","journal-title":"Heilongjiang Medicine Journal"},{"key":"10.1016\/j.jep.2014.11.043_bib181","first-page":"69","article-title":"Research development of the detoxification and synergism of Fuzi combined with different herbals with different properties","volume":"30","author":"Zhang","year":"2011","journal-title":"Nei Mongol Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib182","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.carres.2005.11.032","article-title":"Isolation and structural characterization of an immunostimulating polysaccharide from fuzi, Aconitum carmichaelii","volume":"341","author":"Zhao","year":"2006","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.jep.2014.11.043_bib183","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0254-6272(13)60030-8","article-title":"Pharmacological effects of Chinese herb aconite (fuzi) on cardiovascular system","volume":"32","author":"Zhao","year":"2012","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib184","first-page":"1455","article-title":"Impact of Fuzi on the glycogen, LD content, LDH activity and liver SDH, ATP enzyme activity in liver tissue of rats with deficency","volume":"38","author":"Zhao","year":"2011","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib185","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00253-013-5385-9","article-title":"Microcalorimetry coupled with chemometric techniques for toxicity evaluation of Radix Aconiti Lateralis Preparata (Fuzi) and its processed products on Escherichia coli","volume":"98","author":"Zhao","year":"2014","journal-title":"Applied Microbiology and Biotechnology"},{"key":"10.1016\/j.jep.2014.11.043_bib186","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jep.2014.03.011","article-title":"Spectrum-effect relationships between UPLC fingerprints and bioactivities of crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi) and its three processed products on mitochondrial growth coupled with canonical correlation analysis","volume":"153","author":"Zheng","year":"2014","journal-title":"Journal Of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.11.043_bib187","first-page":"991","article-title":"Effects of Aconiti tuber polysaccharides on hypercholesterolemia and hepatic cholesterol 7\u03b1-hydroxylase expression in rats","volume":"27","author":"Zhou","year":"2011","journal-title":"Chinese Journal of Pathophysiology"},{"key":"10.1016\/j.jep.2014.11.043_bib188","first-page":"492","article-title":"Research into hypocholesterolemic effects and the mechanisms of FPS in dietary hypercholestrolemic rats","volume":"27","author":"Zhou","year":"2011","journal-title":"Chinese Pharmacological Bulletin"},{"key":"10.1016\/j.jep.2014.11.043_bib189","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3736\/jcim20120810","article-title":"Analysis on the alteration of the chemical components of Fuzi when decocting, based on UPLC\/Q\u2013TOF\u2013MS","volume":"10","author":"Zhou","year":"2012","journal-title":"Journal of Chinese Integrative Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib190","doi-asserted-by":"crossref","first-page":"284","DOI":"10.6023\/A1109143","article-title":"Analysis on the material basis of the incompatibility, Fuzi-Rhizoma Pinelliae, based on UPLC\/Q\u2013TOF\u2013MS","volume":"3","author":"Zhou","year":"2012","journal-title":"Acta Chimica Sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib191","first-page":"394","article-title":"Pharmacology effects and toxicity of Fuzi and its principal component","volume":"18","author":"Zhou","year":"1983","journal-title":"Acta Pharmaceutica sinica"},{"key":"10.1016\/j.jep.2014.11.043_bib192","first-page":"198","article-title":"Review and reappraise on researches of Fuzi\u05f3s effect on cardiovarscular system, part one","volume":"29","author":"Zhou","year":"2013","journal-title":"Pharmacology and clinics of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2014.11.043_bib193","first-page":"29","article-title":"Impact of aqueous extract of Fuzi to cardiovascular system","volume":"14","author":"Zhou","year":"1983","journal-title":"Chinese Herbal Medicine"},{"key":"10.1016\/j.jep.2014.11.043_bib194","first-page":"43","article-title":"Therapeutic effect of aqueous extract of Fuzi to endotoxin shock","volume":"13","author":"Zhou","year":"1988","journal-title":"Bulletin of Chinese Materia Medica"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874114008605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874114008605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T23:15:04Z","timestamp":1566083704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874114008605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":192,"alternative-id":["S0378874114008605"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2014.11.043","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2014.11.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}