{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:24:48Z","timestamp":1790742288086,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Jiangsu Chinese Medicine Leading Talent (2006)"},{"name":"Suzhou Science and Technology program","award":["ZXY2012009"],"award-info":[{"award-number":["ZXY2012009"]}]},{"name":"College Graduate Research and Innovation Project of Jiangsu Province","award":["CXLX13_599"],"award-info":[{"award-number":["CXLX13_599"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jep.2014.12.002","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T02:18:34Z","timestamp":1418696314000},"page":"214-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Comparison on hypoglycemic and antioxidant activities of the fresh and dried Portulaca oleracea L. in insulin-resistant HepG2 cells and streptozotocin-induced C57BL\/6J diabetic mice"],"prefix":"10.1016","volume":"161","author":[{"given":"Jun-fei","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-yin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-rui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-wen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-bin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2014.12.002_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0955-2863(99)00079-0","article-title":"Antioxidant lipoate and tissue antioxidants in aged rats","volume":"11","author":"Arivazhagan","year":"2000","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.jep.2014.12.002_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0378-8741(00)00318-4","article-title":"The analgesic and antiinflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak","volume":"73","author":"Chan","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2010.02.001","article-title":"Vitamin E improves learning performance and changes the expression of nitric oxide-producing neurons in the brains of diabetic rats","volume":"210","author":"Comin","year":"2010","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.jep.2014.12.002_bib4","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1007\/s11033-012-1644-6","article-title":"Effects of aqueous extract of Portulaca oleracea L. on oxidative stress and liver, spleen leptin, PAR\u03b1 and FAS mRNA expression in high-fat diet induced mice","volume":"39","author":"Chen","year":"2012","journal-title":"Molecular Biology Reports"},{"key":"10.1016\/j.jep.2014.12.002_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejphar.2011.03.056","article-title":"Fenofibrate increases neuronal vasoconstrictor response in mesenteric arteries from diabetic rats: role of noradrenaline, neuronal nitric oxide and calcitonin gene-related peptide","volume":"666","author":"del Campo","year":"2011","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib7","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1021\/jf020805l","article-title":"Influence of drying on the flavor quality of spearmint (Mentha spicata L.)","volume":"51","author":"D\u00edaz-Maroto","year":"2003","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2014.12.002_bib8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jep.2011.06.020","article-title":"Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy","volume":"137","author":"El-Sayed","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.phymed.2005.09.010","article-title":"Antidiabetic effect of garlic (Allium sativum L.) innormal and streptozotocin-induced diabetic rats","volume":"13","author":"Eidi","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2014.12.002_bib10","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jep.2011.06.020","article-title":"Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy","volume":"137","author":"El-Sayed","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib11","first-page":"355","article-title":"Antioxidants: do they have a role in the treatment of insulin resistance","volume":"125","author":"Evans","year":"2007","journal-title":"Indian Journal of Medical Research"},{"key":"10.1016\/j.jep.2014.12.002_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.lfs.2007.12.021","article-title":"Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity","volume":"82","author":"Fang","year":"2008","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2014.12.002_bib13","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0899-9007(02)00916-4","article-title":"Free radicals, antioxidants and nutrition","volume":"18","author":"Fang","year":"2002","journal-title":"Nutrition"},{"key":"10.1016\/j.jep.2014.12.002_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/(SICI)1520-7560(200001\/02)16:1<26::AID-DMRR78>3.0.CO;2-N","article-title":"High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells","volume":"16","author":"Frittitta","year":"2000","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"10.1016\/j.jep.2014.12.002_bib15","first-page":"9","article-title":"Study on anti-oxidative activities and preliminary investigation on antibacterial, antifungal of extracted fraction rich in flavonoids from leaves of Pseuderanthemum palatiferum (Nees) Radlk","volume":"9","author":"Giang","year":"2005","journal-title":"TC khoahoc vacongnghe"},{"key":"10.1016\/j.jep.2014.12.002_bib16","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jep.2011.07.033","article-title":"Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice","volume":"137","author":"He","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/09637486.2010.530595","article-title":"Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form","volume":"62","author":"Henning","year":"2011","journal-title":"International Journal of Food Science and Nutrition"},{"key":"10.1016\/j.jep.2014.12.002_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cbf.912","article-title":"Tissue malondialdehyde and adenosine triphosphatase level after experimental liver ischaemia-reperfusion damage","volume":"19","author":"Ilhan","year":"2001","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/j.jep.2014.12.002_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1358\/mf.2009.31.4.1362513","article-title":"Experimental rodent models of type 2 diabetes: a review","volume":"31","author":"Islam","year":"2009","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib20","first-page":"2595","article-title":"Ideas and methods of fresh herb basic research based on constituent structure theory","volume":"36","author":"Jia","year":"2011","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2014.12.002_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2337\/db06-0710","article-title":"TIMP-1 transgenic mice recover from diabetes induced by multiple low-dose streptozotocin","volume":"56","author":"Jiang","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2014.12.002_bib22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jep.2010.10.046","article-title":"Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats","volume":"133","author":"Khang","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/1753-0407.12027","article-title":"FoxO6 in glucose metabolism","volume":"5","author":"Kim","year":"2013","journal-title":"Journal of Diabetes"},{"key":"10.1016\/j.jep.2014.12.002_bib24","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.lfs.2006.07.027","article-title":"Anti-diabetic effects of electrolyzed reduced water in streptozotocin -induced and genetic diabetic mice","volume":"79","author":"Kim","year":"2006","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2014.12.002_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2014.12.002_bib26","first-page":"663","article-title":"A study on hemostatic and immunological actions of fresh and dry Dihuang","volume":"24","author":"Liang","year":"1999","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2014.12.002_bib27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.phymed.2010.08.008","article-title":"Hypoglycemic activities of A-and B-type procyanidin oligomer-rich extracts from different Cinnamon barks","volume":"18","author":"Lu","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2014.12.002_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MCA.0b013e328335790e","article-title":"Increased expression of plasminogen activator inhibitor type-1 (PAI-1) in HEPG2 cells induced by insulin mediated by the 3\u2032-untranslated region of the PAI-1 gene and its pharmacologic implications","volume":"21","author":"Miyagawa","year":"2010","journal-title":"Coronary Artery Disease"},{"key":"10.1016\/j.jep.2014.12.002_bib29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jemt.20039","article-title":"Effect of streptozotocin on the ultrastructure of rat pancreatic islets","volume":"63","author":"Mythili","year":"2004","journal-title":"Microscopy Research and Technique"},{"key":"10.1016\/j.jep.2014.12.002_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0009-8981(03)00200-6","article-title":"Analysis of glutathione: implications in redox and detoxification","volume":"333","author":"Pastore","year":"2003","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jep.2014.12.002_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1196\/annals.1372.038","article-title":"Mechanism of exocrine pancreatic insufficiency in streptozotocin-induced type 1 diabetes mellitus","volume":"1084","author":"Patel","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jep.2014.12.002_bib34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejphar.2007.02.064","article-title":"Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice","volume":"565","author":"Priel","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-8741(03)00194-6","article-title":"Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1","volume":"88","author":"Rashed","year":"2003","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib36","doi-asserted-by":"crossref","first-page":"455","DOI":"10.18433\/J3H59R","article-title":"Comparison of rosmarinic acid content in commercial tinctures produced from fresh and dried lemon balm (Melissa officinalis)","volume":"10","author":"Sanchez-Medina","year":"2007","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences."},{"key":"10.1016\/j.jep.2014.12.002_bib37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1177\/147323001204000235","article-title":"Increase in total antioxidant capacity of plasma despite high levels of oxidative stress in uncomplicated type 2 diabetes mellitus","volume":"40","author":"Savu","year":"2012","journal-title":"Journal of International Medical Research"},{"key":"10.1016\/j.jep.2014.12.002_bib38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1196\/annals.1331.020","article-title":"Oxidative stress and antioxidant treatment in diabetes","volume":"1031","author":"Scott","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jep.2014.12.002_bib39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jep.2005.10.033","article-title":"Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus","volume":"104","author":"Sharma","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib40","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1053\/meta.2002.34715","article-title":"Effects of berberine on glucose metabolism in vitro","volume":"51","author":"Yin","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.jep.2014.12.002_bib41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0031-9422(02)00564-2","article-title":"Recent advances in betalain research","volume":"62","author":"Strack","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2014.12.002_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1753-0407.2012.00210.x","article-title":"Dietary supplements of Ipomoea aquatica (whole leaf powder) attenuates maternal and fetal oxidative stress in streptozotocin-diabetic rats","volume":"5","author":"Shivananjappa","year":"2012","journal-title":"Journal of Diabetes"},{"key":"10.1016\/j.jep.2014.12.002_bib43","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.fitote.2011.10.020","article-title":"Comparative characteristic of the inflammatory diterpenes in the roots of Euphorbia fischeriana with different preparation method using HPLC-ELSD","volume":"83","author":"Tang","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2014.12.002_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-1759(91)90205-T","article-title":"Cell mediated cytotoxicity against U 937 cells by human monocytes andmacrophages in a modified colorimetric MTT assay: a methodological study","volume":"141","author":"Vande-Loosdrecht","year":"1991","journal-title":"Journal of Immunological Methods"},{"issue":"47","key":"10.1016\/j.jep.2014.12.002_bib45","first-page":"14","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"40","author":"Wu","year":"2008","journal-title":"Current Protocols in Pharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib46","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.phytochem.2005.08.011","article-title":"Alkaloids from Portulaca oleracea L","volume":"66","author":"Xiang","year":"2005","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2014.12.002_bib47","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.2337\/db05-1275","article-title":"Recovery of islet beta-cell function in streptozotocin-induced diabetic mice: an indirect role for the spleen","volume":"55","author":"Yin","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2014.12.002_bib48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00394-010-0161-4","article-title":"Impairment of cardiac insulin signaling in fructose-fed ovariectomized female Wistar rats","volume":"50","author":"Zakula","year":"2011","journal-title":"European Journal Nutrition"},{"key":"10.1016\/j.jep.2014.12.002_bib49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jep.2003.09.018","article-title":"Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic and its mechanism","volume":"90","author":"Zhang","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jep.2010.10.028","article-title":"Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring","volume":"133","author":"Zheng","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib51","first-page":"277","article-title":"Experimental studies on antibiotic functions of Portulaca oleracea L. in vitro","volume":"14","author":"Zhang","year":"2002","journal-title":"Chinese Journal of Microecology"},{"key":"10.1016\/j.jep.2014.12.002_bib52","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jep.2011.06.018","article-title":"Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ","volume":"137","author":"Zheng","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2014.12.002_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-011-0243-6","article-title":"Epinephrine and the metabolic syndrome","volume":"14","author":"Ziegler","year":"2012","journal-title":"Current Hypertension Reports"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874114008678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874114008678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T09:33:04Z","timestamp":1566120784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874114008678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":50,"alternative-id":["S0378874114008678"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2014.12.002","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison on hypoglycemic and antioxidant activities of the fresh and dried Portulaca oleracea L. in insulin-resistant HepG2 cells and streptozotocin-induced C57BL\/6J diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2014.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}