{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:15:18Z","timestamp":1791296118677,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["CEBA: ANR-10-LABX-0025"],"award-info":[{"award-number":["CEBA: ANR-10-LABX-0025"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.jep.2015.03.015","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T12:05:25Z","timestamp":1426680325000},"page":"279-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: Takamalaim\u00eb (Psidium acutangulum Mart. ex DC., Myrtaceae)"],"prefix":"10.1016","volume":"166","author":[{"given":"Emeline","family":"Hou\u00ebl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Fleury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-309X","authenticated-orcid":false,"given":"Guillaume","family":"Odonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-1633","authenticated-orcid":false,"given":"Flore","family":"Nardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Bourdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vonthron-S\u00e9n\u00e9cheau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Obrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Eparvier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Deharo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Stien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.03.015_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-1759(94)90396-4","article-title":"A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]-thymidine incorporation assay","volume":"170","author":"Ahmed","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2015.03.015_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1475-2875-12-279","article-title":"Is a Plasmodium lactate dehydrogenase (pLDH) enzyme-linked immunosorbent (ELISA)-based assay a valid tool for detecting risky malaria blood donations in Africa?","volume":"12","author":"Atchade","year":"2013","journal-title":"Malar. J,"},{"key":"10.1016\/j.jep.2015.03.015_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4269\/ajtmh.1996.54.67","article-title":"In vitro antimalarial activity of vegetal extracts used in West African traditional medicine","volume":"54","author":"Benoit","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jep.2015.03.015_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2004.12.020","article-title":"Evaluation of French Guiana traditional antimalarial remedies","volume":"98","author":"Bertani","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2015.03.015_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0163-7258(03)00060-3","article-title":"The pathophysiology of falciparum malaria","volume":"99","author":"Clark","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2015.03.015_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1475-2875-5-85","article-title":"Human malarial disease: a consequence of inflammatory cytokine release","volume":"5","author":"Clark","year":"2006","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2015.03.015_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tmaid.2007.07.002","article-title":"Understanding the role of inflammatory cytokines in malaria and related diseases","volume":"6","author":"Clark","year":"2008","journal-title":"Travel Med. Infect. Dis."},{"key":"10.1016\/j.jep.2015.03.015_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.crvi.2009.01.006","article-title":"Ants as biological indicators of Wayana Amerindian land use in French Guiana","volume":"332","author":"Delabie","year":"2009","journal-title":"Comptes Rendus Biol."},{"key":"10.1016\/j.jep.2015.03.015_bib10","unstructured":"Fleury, M., \"Busi-nenge\" ; les Hommes-for\u00eat. Essai d'ethnobotanique chez les Aluku (Boni) en Guyane fran\u00e7aise, Universit\u00e9 Paris 6 (Ed), 1991, Paris."},{"key":"10.1016\/j.jep.2015.03.015_bib11","unstructured":"Fleury, M., 2003. Se soigner en for\u00eat guyanaise: enqu\u00eates sur l\u2019autom\u00e9dication par les plantes m\u00e9dicinales chez les Am\u00e9rindiens Wayana. In: Proceedings of the 5\u00e8me Colloque International d\u2019Ethnopharmacologie, 8\u201310 Mai 2003. Valence, Espagne."},{"key":"10.1016\/j.jep.2015.03.015_bib12","series-title":"Rem\u00e8des wayana-Wajana epit","author":"Fleury","year":"2007"},{"key":"10.1016\/j.jep.2015.03.015_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1475-2875-9-80","article-title":"Annual variations in the number of malaria cases related to two different patterns of Anopheles darlingi transmission potential in the Maroni area of French Guiana","volume":"9","author":"Fouque","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2015.03.015_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0378-8741(86)90094-2","article-title":"A preliminary classification of the healing potential of medicinal plants, based on a rational analysis of an ethnopharmacological field survey among Bedouins in the Negev Desert, Israel","volume":"16","author":"Friedman","year":"1986","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cll.2009.10.001","article-title":"Malaria","volume":"30","author":"Garcia","year":"2010","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.jep.2015.03.015_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1179\/136485911X12899838683322","article-title":"Unravelling the relationships between Anopheles darlingi (Diptera: Culicidae) densities, environmental factors and malaria incidence: understanding the variable patterns of malarial transmission in French Guiana (South America)","volume":"105","author":"Girod","year":"2011","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.jep.2015.03.015_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological samples","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2015.03.015_bib18","series-title":"Pharmacop\u00e9es traditionnelles en","first-page":"508","author":"Grenand","year":"2004"},{"key":"10.1016\/j.jep.2015.03.015_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jep.2009.07.037","article-title":"Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity","volume":"126","author":"Hou\u00ebl","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib20","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jep.2007.01.032","article-title":"Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant","volume":"110","author":"Houghton","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jep.2010.06.013","article-title":"Antiplasmodial, anti-inflammatory and cytotoxic activities of various plant extracts from the Mascarene Archipelago","volume":"136","author":"Jonville","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2008.03.007","article-title":"In vitro immunomodulatory properties of selected Sudanese medicinal plants","volume":"118","author":"Koko","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jep.2009.03.039","article-title":"Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages","volume":"123","author":"Kumar-Roin\u00e9","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib24","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1021\/jm300514y","article-title":"Design, synthesis and pharmacological evaluation of N-acylhydrazones (NAH) and novel conformationally constrained compounds as selective and potent orally active PDE4 inhibitors","volume":"55","author":"K\u00fcmmerle","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2015.03.015_bib25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4269\/ajtmh.1983.32.447","article-title":"In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test","volume":"32","author":"Le Bras","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jep.2015.03.015_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/13880200701214748","article-title":"Antimalarial flavonol glycosides from Euphorbia hirta","volume":"45","author":"Liu","year":"2007","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2015.03.015_bib27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ajpa.20522","article-title":"Genetic studies in French Guiana populations: synthesis","volume":"132","author":"Mazieres","year":"2007","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.jep.2015.03.015_bib28","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0031-9422(00)95188-4","article-title":"3\u2032-formyl-2\u2032,4\u2032,6\u2032-trihydroxydihydrochalcone from Psidium acutangulum","volume":"30","author":"Miles","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2015.03.015_bib29","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/S0960-894X(01)00467-X","article-title":"New anti-malarial flavonol glycoside from Hydrangeae dulcis folium","volume":"11","author":"Murakami","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jep.2015.03.015_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1590\/0074-0276140031","article-title":"Malaria on the Guiana shield: a review of the situation in French Guiana","volume":"109","author":"Musset","year":"2014","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.jep.2015.03.015_bib31","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jep.2011.07.044","article-title":"Treatment of leishmaniasis in the Oyapock basin (French Guiana): A K.A.P. survey and analysis of the evolution of phytotherapy knowledge amongst Way\u00e3pi Indians","volume":"137","author":"Odonne","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jep.2012.12.014","article-title":"Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon)","volume":"146","author":"Odonne","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0367-326X(98)00010-0","article-title":"Pharmacological studies on the leaf of Psidium guajava","volume":"70","author":"Olajide","year":"1999","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2015.03.015_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1523-1739.1994.08010225.x","article-title":"Quantitative ethnobotany and Amazonian conservation","volume":"8","author":"Phillips","year":"1994","journal-title":"Conserv. Biol."},{"key":"10.1016\/j.jep.2015.03.015_bib35","first-page":"217","article-title":"Flavonoids extracted from Psidium species (Myrtaceae) in Venezuela","volume":"30","author":"Rivero-Maldonado","year":"2013","journal-title":"Rev. Fac. Agron."},{"key":"10.1016\/j.jep.2015.03.015_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jep.2012.07.015","article-title":"Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark","volume":"143","author":"Rojas-Duran","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.agee.2009.08.012","article-title":"Decreasing fallow duration in tropical slash-and-burn agriculture alters soil macroinvertebrate diversity: a case study in southern French Guiana","volume":"135","author":"Rossi","year":"2010","journal-title":"Agric. Ecosyst. Environ."},{"key":"10.1016\/j.jep.2015.03.015_bib38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.2042-7158.1998.tb06180.x","article-title":"A study of the anti-pyretic effect of quinine, an alkaloid effective against cerebral malaria, on fever induced by bacterial endotoxin and yeast in rats","volume":"50","author":"Santos","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib1000","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.ejmech.2014.08.033","article-title":"Recent developments in biological activities of chalcones: a mini review","volume":"85","author":"Singh","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2015.03.015_bib39","series-title":"Pharmacop\u00e9e v\u00e9g\u00e9tale carib\u00e9enne","author":"TRAMIL","year":"1999"},{"key":"10.1016\/j.jep.2015.03.015_bib40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2005.01.049","article-title":"Antimalarial remedies in French Guiana: a knowledge attitudes and practices study","volume":"98","author":"Vigneron","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.015_bib41","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1128\/JCM.02250-09","article-title":"Reliability of antimalarial sensitivity tests depends on drug mechanisms of action","volume":"48","author":"Wein","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jep.2015.03.015_bib42","first-page":"199","article-title":"Antifungal activity of four plants used in Peruvian traditional medicine: isolation of the active principle of Psidium acutangulum","volume":"77","author":"Wen","year":"2011","journal-title":"Rev. Soc. Quim. del Peru"},{"key":"10.1016\/j.jep.2015.03.015_bib43","unstructured":"World Health Organization (WHO). 2013. World malaria report, French Guiana. \u3008www.who.int\/entity\/malaria\/publications\/country-profiles\/profile_guf_en.pdf\u3009. (accessed 15.09.14.)."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115001592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115001592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T23:32:55Z","timestamp":1566430375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115001592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":43,"alternative-id":["S0378874115001592"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.03.015","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: Takamalaim\u00eb (Psidium acutangulum Mart. ex DC., Myrtaceae)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}