{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:46:21Z","timestamp":1789620381608,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["600-RMI\/TRGS 5\/3 (1\/2014)-4"],"award-info":[{"award-number":["600-RMI\/TRGS 5\/3 (1\/2014)-4"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.jep.2015.03.016","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T03:17:22Z","timestamp":1426475842000},"page":"109-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC\/MS Q-TOF"],"prefix":"10.1016","volume":"166","author":[{"given":"M.S.","family":"Rofiee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.I.M.","family":"Yusof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.E.","family":"Abdul Hisam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Bannur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.A.","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.N.","family":"Somchit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.K.","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Z.","family":"Salleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.03.016_bib1","first-page":"1318","article-title":"A review of natural products with hepatoprotective activity","volume":"13","author":"Adewusi","year":"2010","journal-title":"J. Med. Plants Res."},{"issue":"2","key":"10.1016\/j.jep.2015.03.016_bib2","first-page":"117","article-title":"Hepatoprotective and some haematological parameters effect of Allium ampeloprasum against carbon tetrachloride induced liver toxicity in albino rats","volume":"3","author":"Afyaa","year":"2012","journal-title":"Kufa J. Vet. Med. Sci."},{"key":"10.1016\/j.jep.2015.03.016_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0271-5317(99)00159-1","article-title":"Effect of fresh leek (Allium Porrum) on lipid metabolism in male rats","volume":"20","author":"Aouadi","year":"2011","journal-title":"Nutr. Res."},{"key":"10.1016\/j.jep.2015.03.016_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/MEG.0b013e3282f4710a","article-title":"Bile acid levels are increased in the liver of patients with steatohepatitis","volume":"20","author":"Aranha","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2015.03.016_bib5","first-page":"122","article-title":"Effect of aqueous extract of bitter leaf (Vernonia Amygdalina Del) on carbon tetrachloride (CCl4) induced liver damage in albino wistar rats","volume":"26","author":"Arhoghro","year":"2009","journal-title":"Eur. J. Sci. Res."},{"key":"10.1016\/j.jep.2015.03.016_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1172\/JCI115013","article-title":"Enhanced activity of the free radical producing enzyme xanthine oxidase in hypoxic rat liver. Regulation and pathophysiologic significance","volume":"87","author":"Brass","year":"1991","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2015.03.016_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0272-0590(86)90260-5","article-title":"Oral toxicity of carbon tetrachloride: acute, sub acute and subchronic studies in rats","volume":"6","author":"Bruckner","year":"1986","journal-title":"Fundam. Appl. Toxicol."},{"issue":"10","key":"10.1016\/j.jep.2015.03.016_bib8","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1055\/s-2005-871223","article-title":"Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura","volume":"71","author":"Chen","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2015.03.016_bib9","unstructured":"Fleming, L.E., & Hodgson, M., 1992. Carbon tetrachloride toxicity. U.S. Dept. of Health & Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, (Atlanta, Georgia), pp. 21."},{"issue":"1","key":"10.1016\/j.jep.2015.03.016_bib200","first-page":"17","article-title":"The effect of the aqueous extract of Kohauta grandiflora on paracetamol incuded liver damage in albino rats","volume":"24","author":"Gabra","year":"2009","journal-title":"Niger. J. Physiol. Sci"},{"issue":"2","key":"10.1016\/j.jep.2015.03.016_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1631\/jzus.B1000117","article-title":"Evaluation of the hepatoprotecitve and antioxidant activities of Rubus parvifolius L","volume":"12","author":"Goa","year":"2011","journal-title":"J. Zhejiang Univ. Sci. B (Biomed. Biotechnol.)"},{"key":"10.1016\/j.jep.2015.03.016_bib11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0891-5849(91)90169-4","article-title":"Effects of hypoxia and reoxygenation on the conversion of xanthine dehydrogenase to oxidase in Chinese hamster V79 cells","volume":"11","author":"Hasan","year":"1991","journal-title":"Free Radic. Biol. Med."},{"issue":"16","key":"10.1016\/j.jep.2015.03.016_bib12","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3748\/wjg.14.2566","article-title":"Hepatoprotective activity of Sapindus mukorossi and Rheum emodiextracts: invitro and in vivo studies","volume":"14","author":"Ibrahim","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2015.03.016_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/13880209209054009","article-title":"Chemical screening of medicinal plants used in the traditional pharmacopoeia of Niger","volume":"30","author":"Ikhiri","year":"1992","journal-title":"Int. J. Pharmacogn."},{"issue":"6","key":"10.1016\/j.jep.2015.03.016_bib14","first-page":"37","article-title":"Malay traditional medicine: an overview of scientific and technological progress","volume":"23","author":"Jamal","year":"2006","journal-title":"Asia Pacific Tech Monitor"},{"key":"10.1016\/j.jep.2015.03.016_bib15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/np50073a019","article-title":"Plant anticancer agents, XLVII. New cytotoxic flavanoids from Muntingia calabura roots","volume":"54","author":"Kaneda","year":"1991","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2015.03.016_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1751-7133.2010.00209.x","article-title":"Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease","volume":"17","author":"Li","year":"2011","journal-title":"Congest. Heart Fail."},{"key":"10.1016\/j.jep.2015.03.016_bib17","series-title":"Edible Medicinal And Non-Medicinal Plants: Volume 3, Fruits","first-page":"486","author":"Lim","year":"2012"},{"key":"10.1016\/j.jep.2015.03.016_bib18","series-title":"Melmon and Morrelli\u05f3s Clinical Pharmacology: Basic Principles of Therapeutics","author":"Melmon","year":"1992"},{"issue":"8","key":"10.1016\/j.jep.2015.03.016_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrd1157","article-title":"Opinion: understanding \u2018global\u05f3 systems biology: metabonomics and the continuum of metabolism","volume":"2","author":"Nicholson","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2015.03.016_bib20","series-title":"Metabolome Analysis: An Introduction","first-page":"320","article-title":"Metabolomics in Functional Genomics and Systems Biology","author":"Nielsen","year":"2007"},{"issue":"1\u20132","key":"10.1016\/j.jep.2015.03.016_bib21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.phymed.2003.09.009","article-title":"Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats","volume":"12","author":"Porchezhian","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2015.03.016_bib22","first-page":"526","article-title":"Effect of pre-treatment of Cassia fistula Linn. Leaf extract against subacute CCl4 induced hepatotoxicity in rats","volume":"43","author":"Pradeep","year":"2005","journal-title":"Indian J. of Exp. Biol."},{"key":"10.1016\/j.jep.2015.03.016_bib23","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/ajplegacy.1962.203.6.1033","article-title":"Epinephrine release and liver glycogen levels after carbon tetrachloride administration","volume":"203","author":"Rubinstein","year":"1962","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.jep.2015.03.016_bib24","doi-asserted-by":"crossref","first-page":"S737","DOI":"10.1016\/S2221-1691(12)60306-2","article-title":"In-Vivo antioxidant activity of ethanolic extract of Mentha pulegium leaf against CCl4 induced toxicity in rats","volume":"2","author":"Sachin","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jep.2015.03.016_bib25","doi-asserted-by":"crossref","unstructured":"Thomson, S.J., Askari A., Bishop-Bailey D., 2012. Anti-inflammatory effects of epoxyeicosatrienoic acids. Int. J. Vasc. Med. Article ID 605101, 7 pp. \u300810.1155\/2012\/605101\u3009","DOI":"10.1155\/2012\/605101"},{"key":"10.1016\/j.jep.2015.03.016_bib26","doi-asserted-by":"crossref","unstructured":"Tiangang, L., John Y.L.C., 2012. Bile acid signaling in liver metabolism and diseases. J. Lipids. Article ID 754067, 9pp. \u300810.1155\/2012\/754067\u3009","DOI":"10.1155\/2012\/754067"},{"issue":"11","key":"10.1016\/j.jep.2015.03.016_bib27","first-page":"1122","article-title":"Healing plants","volume":"75","author":"Valiathan","year":"1998","journal-title":"Curr. Sci."},{"issue":"3","key":"10.1016\/j.jep.2015.03.016_bib28","first-page":"290","article-title":"The in vitro antibacterial activity of Muntingia calabura extracts.","volume":"2","author":"Zakaria","year":"2006","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.jep.2015.03.016_bib29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3923\/ijp.2007.428.431","article-title":"In vitro antistaphylococcal activity of the extracts of several neglected plants in Malaysia","volume":"3","author":"Zakaria","year":"2007","journal-title":"Int. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2015.03.016_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1142\/S0192415X11008749","article-title":"In vitro antiproliferative and antioxidant activities of the extracts of Muntingia calabura leaves","volume":"39","author":"Zakaria","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2015.03.016_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000098366","article-title":"The antinociceptive action of aqueous extract from Muntingia calabura leaves: the role of opioid receptors","volume":"16","author":"Zakaria","year":"2007","journal-title":"Med. Princ. Pract."},{"issue":"4","key":"10.1016\/j.jep.2015.03.016_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s11418-007-0167-2","article-title":"Antinociceptive, anti-inflammatory and antipyretic effects of Muntingia calabura aqueous extract in animal models","volume":"61","author":"Zakaria","year":"2007","journal-title":"J. Nat. Med."},{"issue":"3","key":"10.1016\/j.jep.2015.03.016_bib33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0009-2797(00)00149-6","article-title":"Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes","volume":"125","author":"Zangar","year":"2000","journal-title":"Chemico-Biol. Interact."},{"issue":"27","key":"10.1016\/j.jep.2015.03.016_bib34","doi-asserted-by":"crossref","first-page":"23631","DOI":"10.1074\/jbc.R110.171405","article-title":"Metabolomics pathway regulation, and pathway discovery","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jep.2015.03.016_bib35","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jep.2013.05.027","article-title":"In vitro and in vivo hepatoprotective and antioxidant activity of ethanolic extract from Meconopsis integrifolia (Maxim.) Franch","volume":"148","author":"Zhou","year":"2013","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115001609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115001609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:17:54Z","timestamp":1759940274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115001609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":36,"alternative-id":["S0378874115001609"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.03.016","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC\/MS Q-TOF","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}