{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:01:16Z","timestamp":1787587276117,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq, Brazil)"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento Docente (CAPES, Brazil)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.jep.2015.03.032","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T05:45:47Z","timestamp":1428299147000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Modulatory effect of Senecio brasiliensis (Spreng) Less. in a murine model of inflammation induced by carrageenan into the pleural cavity"],"prefix":"10.1016","volume":"168","author":[{"given":"Renata Rodrigues","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizandra Czermainski","family":"Bretanha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Monguilhott","family":"Dalmarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir Geraldo","family":"Pizzolatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Silvia","family":"Fr\u00f6de","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.03.032_bib1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.drudis.2014.02.010","article-title":"Adenosine and inflammation: what\u05f3s new on the horizon?","volume":"19","author":"Antonioli","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2015.03.032_bib2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbagen.2008.03.019","article-title":"Carrageenan-induced NF-kappa B activation depends on distinct pathways mediated by reactive oxygen species and Hsp 27 or by Bcl10","volume":"1780","author":"Bhattacharyya","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2015.03.032_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jep.2011.03.034","article-title":"Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian \u201cArnica\u201d)","volume":"135","author":"Capelari-Oliveira","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2174\/138945011794815347","article-title":"Natural products triggering biological targets\u2014a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis","volume":"12","author":"Chen","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.jep.2015.03.032_bib5","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1021\/jf050046h","article-title":"Discriminating between the six isomers of dicaffeoylquinic acid by LC\u2013MSn","volume":"53","author":"Clifford","year":"2005","journal-title":"J. Agric. Food Chem"},{"key":"10.1016\/j.jep.2015.03.032_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09637480500131236","article-title":"Biological properties of different extracts of two Senecio species","volume":"57","author":"Conforti","year":"2006","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2015.03.032_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1258\/0004563053492847","article-title":"CG\/MS identification of toxic pyrrolizidine alkaloids in traditional remedies given to two sets of twins","volume":"42","author":"Conradie","year":"2005","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.jep.2015.03.032_bib8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1398-9995.2011.02576.x","article-title":"Th17 cells: new players in asthma pathogenesis","volume":"66","author":"Cosmi","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jep.2015.03.032_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5455\/msm.2012.24.100-105","article-title":"Asthma and chronic obstructive pulmonary disease (COPD)\u2014differences and similarities","volume":"24","author":"Cukic","year":"2012","journal-title":"Mater. Socio Med"},{"key":"10.1016\/j.jep.2015.03.032_bib10","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1055\/s-0028-1088320","article-title":"Screening for anti-inflammatory activity of 12 Arnica (Asteraceae) species assessed by inhibition of NF-kappa B and release of human neutrophil elastase","volume":"74","author":"Ekenas","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2015.03.032_bib11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cyto.2000.0816","article-title":"The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy","volume":"13","author":"Fr\u00f6de","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2015.03.032_bib12","first-page":"1312","article-title":"Rapid colorimetric method for determination of some deaminase activities","volume":"42","author":"Giusti","year":"1966","journal-title":"Boll. Soc. Ital. Biol. Sper."},{"key":"10.1016\/j.jep.2015.03.032_bib13","series-title":"Methods of Enzymatic Analysis","first-page":"315","article-title":"Adenosine Deaminase: Colorimetric Method","author":"Giusti","year":"1984"},{"key":"10.1016\/j.jep.2015.03.032_bib14","first-page":"814693","article-title":"Anti-inflammatory activity and composition of Senecio salignus Kunth","volume":"2013","author":"Gonzalez","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2015.03.032_bib15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jep.2007.07.003","article-title":"Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy","volume":"113","author":"Goulart","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib16","first-page":"285","article-title":"A new taxon of Senecio (Asteraceae) from Turkey: Senecio inops Boiss & Balansa subsp karamanicus Hamzaoglu & Budak","volume":"33","author":"Hamzaoglu","year":"2009","journal-title":"Turk. J. Bot."},{"key":"10.1016\/j.jep.2015.03.032_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jep.2012.01.002","article-title":"Gastroprotective effect of Senecio candicans DC on experimental ulcer models","volume":"140","author":"Hariprasath","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S2221-1691(13)60048-9","article-title":"Activity-guided isolation and identification of anti-staphylococcal components from Senecio tenuifolius","volume":"3","author":"Manubolu","year":"2013","journal-title":"Burm. F. leaf extracts. Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jep.2015.03.032_bib19","first-page":"1","article-title":"Inflammatory mechanisms in the lung","volume":"2","author":"Moldoveanu","year":"2009","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2015.03.032_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2015.03.032_bib21","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-kappa B signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2015.03.032_bib22","first-page":"1","article-title":"Interleukin-17 regulation: an attractive therapeutic approach for asthma","volume":"78","author":"Park","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.jep.2015.03.032_bib23","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2307\/25065905","article-title":"An ITS phylogeny of tribe Senecioneae (Asteraceae) and a new delimitation of Senecio L","volume":"56","author":"Pelser","year":"2007","journal-title":"Taxon"},{"key":"10.1016\/j.jep.2015.03.032_bib24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF00920477","article-title":"Comparative evaluation of arachidonic acid (AA)- and tetradcanoylphorbol acetate (TPA)-induced dermal","volume":"17","author":"Rao","year":"1993","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2015.03.032_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/np000114o","article-title":"Defensive Chemistry of Senecio miser","volume":"64","author":"Reina","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2015.03.032_bib26","first-page":"279","article-title":"Toll-like receptors 2 and 4 and innate immunity in neutrophilic asthma and idiopathic bronchiectasis","volume":"62","author":"Reynolds","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.jep.2015.03.032_bib27","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1476-5381.1996.tb15472.x","article-title":"Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy","volume":"118","author":"Saleh","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib28","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1016\/j.anai.2014.01.021","article-title":"Effect of Antiasthma Simplified Herbal Medicine Intervention on neutrophil predominant airway inflammation in a ragweed sensitized murine asthma model","volume":"112","author":"Srivastava","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.jep.2015.03.032_bib29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1139\/y04-023","article-title":"Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers","volume":"82","author":"Toma","year":"2004","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jep.2004.08.017","article-title":"Preventive activity of pyrrolizidine alkaloids from Senecio brasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats","volume":"95","author":"Toma","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib31","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0305-1978(03)00038-3","article-title":"Chemotaxonomic value of pyrrolizidine alkaloids in southern Brazil Senecio (Senecioneae: Asteraceae)","volume":"31","author":"Trigo","year":"2003","journal-title":"Ecol. Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2015.03.032_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2222.2003.01575.x","article-title":"Suppression of allergic reaction by lambda-carrageenan: toll-like receptor 4\/MyD88-dependent and -independent modulation of immunity","volume":"33","author":"Tsuji","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.jep.2015.03.032_bib33","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1089\/ars.2009.2538","article-title":"Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease","volume":"11","author":"van der Veen","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.jep.2015.03.032_bib34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jep.2013.05.048","article-title":"Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity","volume":"149","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.03.032_bib35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1378\/chest.11-1838","article-title":"The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma","volume":"142","author":"Wood","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jep.2015.03.032_bib36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00011-013-0633-0","article-title":"TNF-alpha signalling and inflammation: interactions between old acquaintances","volume":"62","author":"Zelova","year":"2013","journal-title":"Inflamm. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115001762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115001762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T16:55:28Z","timestamp":1537721728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115001762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":36,"alternative-id":["S0378874115001762"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.03.032","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulatory effect of Senecio brasiliensis (Spreng) Less. in a murine model of inflammation induced by carrageenan into the pleural cavity","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}