{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:43:18Z","timestamp":1775612598699,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Guangdong Province Administration of Traditional Chinese Medicine","award":["21031055"],"award-info":[{"award-number":["21031055"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jep.2015.06.032","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T01:56:09Z","timestamp":1435110969000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Acupuncture reduced apoptosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia\u2013ischemia in neonatal rats"],"prefix":"10.1016","volume":"172","author":[{"given":"Yong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng-Na","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Zhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.06.032_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/exnr.2000.7492","article-title":"BDNF protects against spatial memory deficits following neonatal hypoxia\u2013ischemia","volume":"166","author":"Almli","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-8993(03)02436-3","article-title":"Neonatal cerebral hypoxia\u2013ischemia causes lateralized memory impairments in the adult rat","volume":"973","author":"Arteni","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2015.06.032_bib3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.STR.17.3.472","article-title":"Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination","volume":"17","author":"Bederson","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2015.06.032_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ana.22670","article-title":"Cell therapy for neonatal hypoxia\u2013ischemia and cerebral palsy","volume":"71","author":"Bennet","year":"2012","journal-title":"Annal. Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2008.11.048","article-title":"Neuroprotective effects of hydrogen saline in neonatal hypoxia\u2013ischemia rat model","volume":"1256","author":"Cai","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2015.06.032_bib6","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s11064-004-6869-x","article-title":"Mitochondria and neuronal death\/survival signaling pathways in cerebral ischemia","volume":"29","author":"Chan","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2015.06.032_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00004647-200101000-00005","article-title":"The protective effect of ceramide in immature rat brain hypoxia\u2013ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells","volume":"21","author":"Chen","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jep.2015.06.032_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jnen\/62.4.329","article-title":"Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra","volume":"62","author":"Ferrer","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/nbdi.1999.0275","article-title":"BDNF blocks caspase-3 activation in neonatal hypoxia\u2013ischemia","volume":"7","author":"Han","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jep.2015.06.032_bib10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s11726-010-0425-9","article-title":"Exploration of the clinical regularity of acupuncture and moxibustion treatment for cerebral palsy syndrome","volume":"8","author":"Hong","year":"2010","journal-title":"J. Acupunct. Tuina Sci."},{"key":"10.1016\/j.jep.2015.06.032_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0736-5748(02)00082-5","article-title":"Bimodal upregulation of glial cell line-derived neurotrophic factor (GDNF) in the neonatal rat brain following ischemic\/hypoxic injury","volume":"20","author":"Ikeda","year":"2002","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.jep.2015.06.032_bib12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/sj.jcbfm.9600025","article-title":"Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia\u2013ischemia","volume":"25","author":"Jantzie","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jep.2015.06.032_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2003.11.002","article-title":"Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia\u2013ischemia in rats","volume":"153","author":"Kumral","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2015.06.032_bib14","first-page":"905","article-title":"The role of TNF-alpha, IL-6, IL-10, and GDNF in neuronal apoptosis in neonatal rat with hypoxic-ischemic encephalopathy","volume":"18","author":"Li","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2015.06.032_bib15","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.3727\/096368913X672208","article-title":"Intracranial transplant of olfactory ensheathing cells can protect both upper and lower motor neurons in amyotrophic lateral sclerosis","volume":"22","author":"Li","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jep.2015.06.032_bib16","first-page":"826","article-title":"Clinical observation on infantile cerebral palsy treated with quick meridian needling therapy plus scalp acupuncture","volume":"30","author":"Liu","year":"2010","journal-title":"Zhongguo Zhen Jiu"},{"key":"10.1016\/j.jep.2015.06.032_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2015.06.032_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2014.01.007","article-title":"Beneficial effects of early environmental enrichment on motor development and spinal cord plasticity in a rat model of cerebral palsy","volume":"263","author":"Marques","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2015.06.032_bib19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.22419","article-title":"Neuronal cell death in neonatal hypoxia\u2013ischemia","volume":"69","author":"Northington","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/nbdi.2000.0371","article-title":"Early neurodegeneration after hypoxia\u2013ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis","volume":"8","author":"Northington","year":"2001","journal-title":"Neurobiol.\u00a0Dis."},{"key":"10.1016\/j.jep.2015.06.032_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2008.10.017","article-title":"Long-term effects of environmental stimulation following hypoxia\u2013ischemia on the oxidative state and BDNF levels in rat hippocampus and frontal cortex","volume":"1247","author":"Pereira","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2015.06.032_bib22","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/01.STR.29.12.2622","article-title":"Apoptosis in a neonatal rat model of cerebral hypoxia\u2013ischemia","volume":"29","author":"Pulera","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2015.06.032_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic\u2013ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib24","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1212\/WNL.49.4.1035","article-title":"Higher neonatal cerebral blood flow correlates with worse childhood neurologic outcome","volume":"49","author":"Rosenbaum","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.jep.2015.06.032_bib25","first-page":"123","article-title":"Increased Bax\/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis","volume":"21","author":"Salakou","year":"2007","journal-title":"In Vivo"},{"key":"10.1016\/j.jep.2015.06.032_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroscience.2013.01.066","article-title":"Early hypoxia\u2013ischemia causes hemisphere and sex-dependent cognitive impairment and histological damage","volume":"237","author":"Sanches","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2015.06.032_bib27","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1136\/jnnp.2003.021485","article-title":"Randomised control trial of tongue acupuncture versus sham acupuncture in improving functional outcome in cerebral palsy","volume":"75","author":"Sun","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jep.2015.06.032_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1203\/00006450-199004000-00001","article-title":"Experimental biology of cerebral hypoxia\u2013ischemia: relation to perinatal brain damage","volume":"27","author":"Vannucci","year":"1990","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jep.2015.06.032_bib100","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1542\/peds.95.6.868","article-title":"Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat","volume":"95","author":"Vannucci","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.jep.2015.06.032_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.brainresbull.2012.05.001","article-title":"Ultrasound-induced release of GDNF from lipid coated microbubbles injected into striatum reduces hypoxic-ischemic injury in neonatal rats","volume":"88","author":"Wang","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2015.06.032_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/aim.2009.000703","article-title":"Modulation of involuntary movements in cerebral palsy with acupuncture","volume":"27","author":"Watson","year":"2009","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.jep.2015.06.032_bib31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/08830738060210061001","article-title":"Pilot study of positron emission tomography (PET) brain glucose metabolism to assess the efficacy of tongue and body acupuncture in cerebral palsy","volume":"21","author":"Wong","year":"2006","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.cr.7290054","article-title":"Executionary pathway for apoptosis: lessons from mutant mice","volume":"10","author":"Woo","year":"2000","journal-title":"Cell Res."},{"key":"10.1016\/j.jep.2015.06.032_bib33","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1177\/0883073808318049","article-title":"Effect of acupuncture on the brain in children with spastic cerebral palsy using functional neuroimaging (FMRI)","volume":"23","author":"Wu","year":"2008","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.jep.2015.06.032_bib34","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11726-010-0457-1","article-title":"Clinical applications of acupoints baihui (GV 20) and sishencong (Ex-HN 1)","volume":"8","author":"Wu","year":"2010","journal-title":"J. Acupunct. Tuina Sci."},{"key":"10.1016\/j.jep.2015.06.032_bib35","doi-asserted-by":"crossref","first-page":"e107192","DOI":"10.1371\/journal.pone.0107192","article-title":"Therapeutic benefits of delayed lithium administration in the neonatal rat after cerebral hypoxia\u2013ischemia","volume":"9","author":"Xie","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2015.06.032_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2013.10.025","article-title":"Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice","volume":"258","author":"Zhou","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2015.06.032_bib37","first-page":"924","article-title":"Effect of acupuncture combined language training on cerebral palsy children with language retardation","volume":"33","author":"Zou","year":"2013","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115004419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115004419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T01:25:55Z","timestamp":1652577955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115004419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":38,"alternative-id":["S0378874115004419"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.06.032","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acupuncture reduced apoptosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia\u2013ischemia in neonatal rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}