{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T10:09:41Z","timestamp":1766830181795},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology Research Development of Guangxi Province","award":["2012GXNSFBA053094"],"award-info":[{"award-number":["2012GXNSFBA053094"]}]},{"name":"Scientific Research and Technology Development research projects of Guangxi Province","award":["0630002-2A","10124008-6"],"award-info":[{"award-number":["0630002-2A","10124008-6"]}]},{"name":"Science and Technology foundation platform construction project of Guangxi Province","award":["12-97-20"],"award-info":[{"award-number":["12-97-20"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jep.2015.06.048","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T17:22:28Z","timestamp":1436030548000},"page":"273-280","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice"],"prefix":"10.1016","volume":"172","author":[{"given":"Vanphuc","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianchun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanminh","family":"Doan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuneng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aicun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.06.048_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2165\/00002018-200225090-00003","article-title":"Mechanisms of NSAID-induced hepatotoxicity","volume":"25","author":"Boelsterli","year":"2002","journal-title":"Drug Saf."},{"key":"10.1016\/j.jep.2015.06.048_bib2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/138920006778520606","article-title":"Bioactivation and hepatotoxicity of nitroaromatic drugs","volume":"7","author":"Boelsterli","year":"2006","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jep.2015.06.048_bib3","series-title":"Chinese Modern Yao Medicine","first-page":"401","author":"Dai","year":"2009"},{"key":"10.1016\/j.jep.2015.06.048_bib4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/MEG.0b013e3282eeb4cc","article-title":"Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound","volume":"19","author":"Dastis","year":"2007","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2015.06.048_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jep.2014.01.001","article-title":"Hepatoprotective effects of Yulangsan polysaccharide against isoniazid and rifampicin-induced liver injury in mice","volume":"152","author":"Dong","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.06.048_bib6","first-page":"1592","article-title":"Protective effects of Yulangsan polysaccharide (YLS) on primary cultured rat hepatocytes injury induced by H2O2","volume":"18","author":"Duan","year":"2007","journal-title":"LiShiZhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2015.06.048_bib7","first-page":"423","article-title":"Effects of Yulangsan polysaccharide on proliferation and collagen I production of hepatic stellate cells","volume":"4","author":"Duan","year":"2008","journal-title":"China J. Mod. Med."},{"key":"10.1016\/j.jep.2015.06.048_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0009-2797(02)00052-2","article-title":"Idiosyncratic NSAID drug induced oxidative stress","volume":"142","author":"Galati","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2015.06.048_bib9","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1478-3231.2005.01140.x","article-title":"Effect of diphenyl dimethyl bicarboxylate on concanavalin A-induced liver injury in mice","volume":"25","author":"Gao","year":"2005","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2015.06.048_bib10","series-title":"Standards of Guangxi Zhuang Medicine","first-page":"72","author":"Guangxi Food and Drug Administration","year":"2008"},{"key":"10.1016\/j.jep.2015.06.048_bib11","first-page":"148","article-title":"The hepatoprotective effect of dimethyl 4, 4-dimethoxy 5, 6, 5, 6-dimethylene dioxy-biphenyl-dicarboxylate (DDB) on aflatoxin B1 induced liver injury","volume":"7","author":"Hassan","year":"2010","journal-title":"Life Sci. J."},{"key":"10.1016\/j.jep.2015.06.048_bib12","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.1208\/aapsj080106","article-title":"Mechanisms of drug-induced liver injury","volume":"8","author":"Holt","year":"2006","journal-title":"AAPS J."},{"key":"10.1016\/j.jep.2015.06.048_bib13","first-page":"321","article-title":"Effect of Yulangsan extract on the cardiac hemodynamics and the coronary flow in rats","volume":"6","author":"Huang","year":"2003","journal-title":"Chin. J. Hosp. Pharm."},{"key":"10.1016\/j.jep.2015.06.048_bib14","first-page":"1764","article-title":"Anti-inflammatory effect of Yulangsan extracts and the mechanisms","volume":"20","author":"Huang","year":"2008","journal-title":"Chin. J. Drugs"},{"key":"10.1016\/j.jep.2015.06.048_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1034\/j.1600-0773.2003.920106.x","article-title":"Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity","volume":"92","author":"Iqbal","year":"2003","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2015.06.048_bib16","first-page":"1693s","article-title":"Bcl-2 gene family and the regulation of programmed cell death","volume":"59","author":"Korsmeyer","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2015.06.048_bib17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMra021844","article-title":"Drug-induced hepatotoxicity","volume":"349","author":"Lee","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2015.06.048_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.taap.2014.01.017","article-title":"Oxidative stress\/reactive metabolite gene expression signature in rat liver detects idiosyncratic hepatotoxicants","volume":"275","author":"Leone","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2015.06.048_bib19","first-page":"903","article-title":"Chemical composition of Cliffbean polysaccharide","volume":"31","author":"Lin","year":"2009","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2015.06.048_bib20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.carbpol.2013.09.037","article-title":"Protective effect of Millettia pulchra polysaccharide on cognitive impairment induced by d-galactose in mice","volume":"101","author":"Lin","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2015.06.048_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.intimp.2014.02.009","article-title":"Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide\/d-galactosamine induced fulminant hepatic failure in mice","volume":"19","author":"Lin","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2015.06.048_bib22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.tiv.2009.09.011","article-title":"Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro","volume":"24","author":"Madhulika","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.jep.2015.06.048_bib23","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1002\/hep.21062","article-title":"Apoptosis and necrosis in the liver: a tale of two deaths?","volume":"43","author":"Malhi","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2015.06.048_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s002280100312","article-title":"Fatal hepatoxicity secondary to nimesulide","volume":"57","author":"Merlani","year":"2001","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2015.06.048_bib25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/jpet.102.038620","article-title":"The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes","volume":"30","author":"Mingatto","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jep.2015.06.048_bib26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/qjmed\/hcg138","article-title":"Hepatocellular damage from non-steroidal anti-inflammatory drugs","volume":"96","author":"O\u2019connor","year":"2003","journal-title":"QJM"},{"key":"10.1016\/j.jep.2015.06.048_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.freeradbiomed.2005.08.038","article-title":"Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2+\/- mice","volume":"40","author":"Ong","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2015.06.048_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cbi.2005.04.006","article-title":"Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats","volume":"155","author":"Park","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2015.06.048_bib29","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/42867","article-title":"Double identity for proteins of the Bcl-2 family","volume":"387","author":"Reed","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jep.2015.06.048_bib30","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/sj.cdd.4401975","article-title":"Proapoptotic multidomain Bcl-2\/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities","volume":"13","author":"Reed","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2015.06.048_bib31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1478-3231.1999.tb00027.x","article-title":"Acute cholestatic hepatitis induced by nimesulide","volume":"19","author":"Romero-Gomez","year":"1999","journal-title":"Liver"},{"key":"10.1016\/j.jep.2015.06.048_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2010.05.001","article-title":"Nimesulide aggravates redox imbalance and calcium dependent mitochondrial permeability transition leading to dysfunction in vitro","volume":"275","author":"Singh","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2015.06.048_bib33","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.freeradbiomed.2005.05.013","article-title":"Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro","volume":"39","author":"Tay","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2015.06.048_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/bmj.327.7405.18","article-title":"Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs","volume":"327","author":"Traversa","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jep.2015.06.048_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jep.2011.04.014","article-title":"Abrogation of nimesulide induced oxidative stress and mitochondria mediated apoptosis by Fumaria parviflora Lam. extract","volume":"136","author":"Tripathi","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.06.048_bib36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/10408690490911701","article-title":"Dietary antioxidant compounds and liver health","volume":"44","author":"Vitaglione","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2015.06.048_bib37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/pds.2161","article-title":"Drug safety issues of nimesulide in China-nimesulide-induced liver injury","volume":"20","author":"Wang","year":"2011","journal-title":"Pharmacoepidemiol. Drug Saf."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115004456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115004456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:27:59Z","timestamp":1537489679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115004456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":37,"alternative-id":["S0378874115004456"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.06.048","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}