{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:43:45Z","timestamp":1790696625643,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.jep.2015.07.019","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T20:38:03Z","timestamp":1437165483000},"page":"128-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Anti-influenza virus effects of crude phenylethanoid glycosides isolated from ligustrum purpurascens via inducing endogenous interferon-\u03b3"],"prefix":"10.1016","volume":"179","author":[{"given":"Xiao-peng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-ming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-hui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-qiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-he","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-dan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.07.019_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.11.002","article-title":"Interferons: signaling, antiviral and viral evasion","volume":"122","author":"Bonjardim","year":"2009","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2015.07.019_bib2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.bcp.2013.06.009","article-title":"Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-alpha production in human leukemia cells with expressed Bcr\/Abl","volume":"86","author":"Chen","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.019_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fsi.2014.03.017","article-title":"Differential regulation of Tetraodon nigroviridis Mx gene promoter activity by constitutively-active forms of STAT1, STAT2, and IRF9","volume":"38","author":"Cheng","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jep.2015.07.019_bib4","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.jep.2014.07.051","article-title":"The roots of Ilex asprella extract lessens acute respiratory distress syndrome in mice induced by influenza virus","volume":"155","author":"Dai","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.019_bib5","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.8456300","article-title":"Multiple defects of immune cell function in mice with disrupted interferon-gamma genes","volume":"259","author":"Dalton","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jep.2015.07.019_bib6","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.4049\/jimmunol.1302600","article-title":"The natural product phyllanthusmin C enhances IFN-\u03b3 production by human NK cells through upregulation of TLR-mediated NF-kB signaling","volume":"193","author":"Deng","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2015.07.019_bib7","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1182\/blood-2006-02-001578","article-title":"Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27","volume":"109","author":"Fakruddin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jep.2015.07.019_bib8","first-page":"821","article-title":"Effect of fenbendazole on three behavioral tests in male C57BL\/6N Mice","volume":"49","author":"Gadad","year":"2010","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.jep.2015.07.019_bib9","first-page":"111","volume":"vol. 1","author":"Gao","year":"2006"},{"key":"10.1016\/j.jep.2015.07.019_bib10","doi-asserted-by":"crossref","first-page":"e94392","DOI":"10.1371\/journal.pone.0094392","article-title":"The mechanism of poly-galloyl-glucoses preventing Influenza A virus entry into host cells","volume":"9","author":"Ge","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2015.07.019_bib11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/np020568g","article-title":"Antioxidative glycosides from the leaves of ligustrum robustum","volume":"66","author":"He","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2015.07.019_bib12","first-page":"328","article-title":"Glycosides from Ligustrum purpurascens","volume":"14","author":"He","year":"1992","journal-title":"Acta Bot. Yunnanica"},{"key":"10.1016\/j.jep.2015.07.019_bib13","first-page":"1","article-title":"The textual research of Kudingcha","volume":"vol. 1","author":"He","year":"2010"},{"key":"10.1016\/j.jep.2015.07.019_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1478-811X-12-29","article-title":"Beta-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I\/NF-kappaB signaling","volume":"12","author":"Hillesheim","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2015.07.019_bib15","doi-asserted-by":"crossref","first-page":"16785","DOI":"10.3390\/ijms131216785","article-title":"Antiviral activity of baicalein and quercetin against the Japanese Encephalitis virus","volume":"13","author":"Johari","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2015.07.019_bib16","first-page":"278","article-title":"6-Acetonyl-5,6-dihydrosanguinarine (ADS) from Chelidonium majus L. triggers proinflammatory cytokine production via ROS-JNK\/ERK-NF-\u03baB signaling pathway","volume":"58","author":"Kim","year":"2013","journal-title":"Food\u00a0Chem. Toxicol."},{"key":"10.1016\/j.jep.2015.07.019_bib17","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature11868","article-title":"Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells","volume":"496","author":"Kleinewietfeld","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jep.2015.07.019_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-8741(02)00192-7","article-title":"Anti-oxidative, anti-inflammatory and hepato-protective effects of Ligustrum robustum","volume":"83","author":"Lau","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.019_bib19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.phytochem.2014.04.010","article-title":"Quinoid glycosides from Forsythia suspensa","volume":"104","author":"Li","year":"2014","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2015.07.019_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11418-013-0758-z","article-title":"The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha Ilex C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities","volume":"67","author":"Li","year":"2013","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2015.07.019_bib21","doi-asserted-by":"crossref","first-page":"e1440","DOI":"10.1038\/cddis.2014.323","article-title":"Severe influenza A(H1N1)pdm09 infection induces thymic atrophy through activating innate CD8(+)CD44(hi) T cells by upregulating IFN-gamma","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2015.07.019_bib22","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1128\/JVI.80.7.3515-3522.2006","article-title":"Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression","volume":"80","author":"Matikainen","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jep.2015.07.019_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.virusres.2004.02.033","article-title":"Surveillance of influenza isolates for susceptibility to neuraminidase inhibitors during the 2000\u20132002 influenza seasons","volume":"103","author":"Mungall","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.jep.2015.07.019_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-4889(02)00328-2","article-title":"The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells","volume":"1593","author":"Nair","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2015.07.019_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/vim.2009.0099","article-title":"Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins","volume":"23","author":"Nayak","year":"2010","journal-title":"Viral Immunol."},{"key":"10.1016\/j.jep.2015.07.019_bib26","doi-asserted-by":"crossref","first-page":"e31006","DOI":"10.1371\/journal.pone.0031006","article-title":"Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses","volume":"7","author":"Nguyen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2015.07.019_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2015.07.019_bib28","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s10875-010-9431-4","article-title":"Inflammasomes and anti-viral immunity","volume":"30","author":"Rathinam","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jep.2015.07.019_bib29","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12118","article-title":"The TLR4 antagonist Eritoran protects mice from lethal influenza infection","volume":"497","author":"Shirey","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jep.2015.07.019_bib30","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jep.2012.09.047","article-title":"Immunomodulatory effects of crude phenylethanoid glycosides from Ligustrum purpurascens","volume":"144","author":"Song","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.019_bib31","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1248\/cpb.52.1242","article-title":"A new lignan glycoside and phenylethanoid glycosides from Strobilanthes cusia BREMEK","volume":"52","author":"Tanaka","year":"2004","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2015.07.019_bib32","doi-asserted-by":"crossref","first-page":"570894","DOI":"10.1155\/2014\/570894","article-title":"Reduction of IL-17A might suppress the Th1 response and promote the Th2 response by boosting the function of Treg cells during silica-induced inflammatory response in vitro","volume":"2014","author":"Tang","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2015.07.019_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/irv.12182","article-title":"Clinical diagnosis of pandemic A(H1N1) 2009 influenza in children with negative rapid influenza diagnostic test by lymphopenia and lower C-reactive protein levels","volume":"8","author":"Wang","year":"2014","journal-title":"Influenza Other Resp. Viruses"},{"key":"10.1016\/j.jep.2015.07.019_bib34","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.1128\/JVI.02082-14","article-title":"Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses","volume":"88","author":"Wolferst\u00e4tter","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jep.2015.07.019_bib35","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/jf0100604","article-title":"Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens","volume":"49","author":"Wong","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2015.07.019_bib36","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1158\/1078-0432.CCR-07-4405","article-title":"lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells","volume":"14","author":"Wu","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jep.2015.07.019_bib37","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00284-013-0381-y","article-title":"Immunologic mechanism of Patchouli alcohol anti-H1N1 influenza virus may through regulation of the RLH signal pathway in vitro","volume":"67","author":"Wu","year":"2013","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.jep.2015.07.019_bib38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/1743-422X-10-291","article-title":"Cross-protective immunity against influenza A\/H1N1 virus challenge in mice immunized with recombinant vaccine expressing HA gene of influenza A\/H5N1 virus","volume":"10","author":"Yang","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.jep.2015.07.019_bib39","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.phymed.2014.06.016","article-title":"Effect of chito-oligosaccharide on the intestinal absorptions ofphenylethanoid glycosides in Fructus Forsythiae extract","volume":"21","author":"Zhou","year":"2014","journal-title":"Phytomedicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115300349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115300349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T17:50:02Z","timestamp":1537465802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115300349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":39,"alternative-id":["S0378874115300349"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.07.019","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-influenza virus effects of crude phenylethanoid glycosides isolated from ligustrum purpurascens via inducing endogenous interferon-\u03b3","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}