{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:40:19Z","timestamp":1787510419793,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T00:00:00Z","timestamp":1470441600000},"content-version":"vor","delay-in-days":340,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","award":["01137-09\/05238-12"],"award-info":[{"award-number":["01137-09\/05238-12"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jep.2015.07.032","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T08:48:44Z","timestamp":1438073324000},"page":"330-337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis"],"prefix":"10.1016","volume":"173","author":[{"given":"N\u00edcolas de Castro Campos","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Cunha","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane Mello","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Leiras Mota","family":"Conegundes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina Moura","family":"Gualberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacy","family":"Gameiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Moreira Chedier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Christina Marques Nogueira","family":"Casta\u00f1on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elita","family":"Scio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.07.032_bib1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0031-9422(96)00343-3","article-title":"Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects","volume":"43","author":"Akihisa","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2015.07.032_bib2","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1096\/fasebj.4.11.2199284","article-title":"Biological of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF-\u03b1)","volume":"4","author":"Akira","year":"1990","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2015.07.032_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pharmthera.2009.10.005","article-title":"The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation","volume":"125","author":"Alawi","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2015.07.032_bib4","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2011.01.006","article-title":"Immune functions of the skin","volume":"29","author":"Bangert","year":"2011","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.jep.2015.07.032_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/PL00000305","article-title":"Tea tree oil reduces histamine-induced oedema in murine ears","volume":"51","author":"Brand","year":"2002","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2015.07.032_bib6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0022-4731(82)90035-8","article-title":"Influence of 16 \u03b1, 17 \u03b1-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids","volume":"16","author":"Brattsand","year":"1982","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jep.2015.07.032_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01966592","article-title":"Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents","volume":"17","author":"Carlson","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2015.07.032_bib8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bjp.2014.11.008","article-title":"Wound healing properties and mucilage content of Pereskia aculeata from different substrates","volume":"24","author":"Carvalho","year":"2014","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2015.07.032_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01965627","article-title":"Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compounds","volume":"20","author":"Crummey","year":"1987","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2015.07.032_bib10","series-title":"Medicinal Natural Products: A Biosynthetic Approach","author":"Dewick","year":"2009"},{"key":"10.1016\/j.jep.2015.07.032_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1590\/S0102-695X2005000200006","article-title":"Estudo anat\u00f4mico de folha e caule de Pereskia aculeata Mill. (Cactaceae)","volume":"15","author":"Duarte","year":"2005","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2015.07.032_bib12","first-page":"129","article-title":"Models of Acute Inflammation in the Ear","author":"G\u00e1bor","year":"2003"},{"key":"10.1016\/j.jep.2015.07.032_bib13","series-title":"Mouse Ear Inflammation Models and Their Pharmacological Applications","author":"G\u00e1bor","year":"2000"},{"key":"10.1016\/j.jep.2015.07.032_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01991233","article-title":"Development and inhibition of mouse ear edema induced with capsaicin","volume":"36","author":"G\u00e1bor","year":"1992","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2015.07.032_bib15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/carcin\/bgn114","article-title":"Curcumin decreases 12-O-tetradecanoylphorbol-13-acetate induced protein kinase C translocation to modulate downstream targets in mouse skin","volume":"29","author":"Garg","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jep.2015.07.032_bib16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0014-2999(99)00846-8","article-title":"Anti-inflammatory glycoterpenoids from Scrophularia auriculata","volume":"389","author":"Giner","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1515\/znc-1999-1113","article-title":"Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models","volume":"54","author":"G\u00f3mez","year":"1999","journal-title":"Z. Naturforschung"},{"key":"10.1016\/j.jep.2015.07.032_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2125.1987.tb03184.x","article-title":"Lack of effect of topical indomethacin on psoriasis","volume":"24","author":"Green","year":"1987","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jep.2012.10.064","article-title":"Combretum leprosum Mart. (Combretaceae): potential as an antiproliferative and anti-inflammatory agent","volume":"145","author":"Horinouchi","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF01837912","article-title":"Involvement of substance-P as a mediator in capsaicin-induced mouse ear edema","volume":"44","author":"Inoue","year":"1995","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2015.07.032_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1254\/jjp.69.61","article-title":"Participation of serotonin in capsaicin-induced mouse ear edema","volume":"69","author":"Inoue","year":"1995","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib22","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1476-5381.1993.tb14009.x","article-title":"Profile of capsaicin-induced mouse ear edema as neurogenic inflammatory model-comparison with arachidonic acid-induced ear edema","volume":"110","author":"Inoue","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-2006-957469","article-title":"Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens","volume":"64","author":"Just","year":"1998","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2015.07.032_bib24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.dsi.2012.08.004","article-title":"Pathophysiology of chemokines and chemokine receptors in dermatological science: a focus on psoriasis and cutaneous T-cell lymphoma","volume":"30","author":"Lee","year":"2012","journal-title":"Dermatol. Sin."},{"key":"10.1016\/j.jep.2015.07.032_bib25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF02980087","article-title":"Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin","volume":"27","author":"Lim","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jep.2015.07.032_bib26","first-page":"227","article-title":"Mechanisms underlying the inhibitory actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate.Eur","volume":"559","author":"Medeiros","year":"2007","journal-title":"J. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib27","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bcp.2006.01.005","article-title":"Involvement of tumor necrosis factor (TNF)-\u03b1 in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice","volume":"71","author":"Murakawa","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib28","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1021\/tx700201z","article-title":"Phenol-induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion","volume":"20","author":"Murray","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jep.2015.07.032_bib29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1248\/bpb.24.470","article-title":"Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens Clem","volume":"24","author":"Navarro","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2015.07.032_bib30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and diseases","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2015.07.032_bib31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as source of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2015.07.032_bib32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jaci.2011.06.051","article-title":"Regulation of the immune response and inflammation by histamine and histamine receptors","volume":"128","author":"O\u00b4Mahoni","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2015.07.032_bib33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1753-4887.2011.00399.x","article-title":"Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory properties","volume":"69","author":"Othman","year":"2011","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jep.2015.07.032_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.tem.2006.08.005","article-title":"Nuclear receptor versus inflammation: mechanisms of transrepression","volume":"17","author":"Pascual","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jep.2015.07.032_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biocontrol.2008.09.012","article-title":"Using molecular methods to determine the origin of weed populations of Pereskia aculeata in South Africa and its relevance to biological control","volume":"48","author":"Paterson","year":"2009","journal-title":"Biol. Control."},{"key":"10.1016\/j.jep.2015.07.032_bib36","first-page":"1","article-title":"Pereskia aculeata: a plant food with antinociceptive activity","volume":"18","author":"Pinto","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2015.07.032_bib37","first-page":"63","article-title":"Cytotoxic and antioxidant activity of Pereskia aculeata Miller","volume":"3","author":"Pinto","year":"2012","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.jep.2015.07.032_bib38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11130-014-0423-z","article-title":"The biological activities and chemical composition of Pereskia species (Cactaceae)\u2014a review","volume":"69","author":"Pinto","year":"2014","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.jep.2015.07.032_bib39","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.otc.2010.04.003","article-title":"A comprehensive review of the adverse effects of systemic corticosteroids","volume":"43","author":"Poetker","year":"2010","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"10.1016\/j.jep.2015.07.032_bib40","first-page":"217","article-title":"In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols","volume":"59","author":"Puglia","year":"2008","journal-title":"J. Cosmet. Sci."},{"key":"10.1016\/j.jep.2015.07.032_bib41","series-title":"Pharmacology","author":"Rang","year":"2012"},{"key":"10.1016\/j.jep.2015.07.032_bib42","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1\u03b1 and IL-1\u03b2 recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2015.07.032_bib43","first-page":"415","article-title":"Morphology and anatomy of the fruit (hypanthium, pericarp and seed) development of Pereskia aculeata Miller (Cactaceae)","volume":"25","author":"Rosa","year":"2003","journal-title":"Acta Sci. Biol. Sci."},{"key":"10.1016\/j.jep.2015.07.032_bib44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jep.2010.07.002","article-title":"Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents","volume":"136","author":"Saraiva","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib45","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.clinthera.2011.09.009","article-title":"Incidence and US costs of corticosteroid-associated adverse events: a systematic literature review","volume":"33","author":"Sarnes","year":"2011","journal-title":"Clin. Ther."},{"key":"10.1016\/j.jep.2015.07.032_bib46","first-page":"149","article-title":"Estudo da a\u00e7\u00e3o cicatrizante de folhas de Pereskia aculeata","volume":"3","author":"Sartor","year":"2010","journal-title":"Sa\u00fade e Pesqui."},{"key":"10.1016\/j.jep.2015.07.032_bib47","first-page":"230","article-title":"Antiiflamatory activity and bioavailability of percutaneous piroxican","volume":"32","author":"Schiantarelli","year":"1982","journal-title":"Drug. Res."},{"key":"10.1016\/j.jep.2015.07.032_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/fcp.12049","article-title":"Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress","volume":"28","author":"Silva","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib49","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000210960","article-title":"Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol- 13-acetate","volume":"4","author":"Stanley","year":"1991","journal-title":"Skin Pharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib50","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.npep.2004.07.005","article-title":"Forty years in capsaicin research for sensory pharmacology and physiology","volume":"38","author":"Szolcs\u00e1nyi","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.jep.2015.07.032_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/09637480802534509","article-title":"Nutritive evaluation of a non-conventional leafy vegetable (Pereskia aculeata Miller)","volume":"60","author":"Takeiti","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2015.07.032_bib52","doi-asserted-by":"crossref","unstructured":"The Organisation for Economic Co-operation and Development (OECD)., 2002. Test No 404: Acute Dermal Irritation Corrosion, In: OECD Guideline for the Testing of Chemicals. OECD Publishing, http:\/\/dx.doi.org\/10.1787\/20745788.","DOI":"10.1787\/20745788"},{"key":"10.1016\/j.jep.2015.07.032_bib53","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/1523-1747.ep12383512","article-title":"Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical induced inflammation in mouse skin","volume":"102","author":"Wilmer","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jep.2015.07.032_bib54","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.intimp.2012.12.032","article-title":"Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation","volume":"15","author":"Yao","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2015.07.032_bib55","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/1523-1747.ep12260709","article-title":"The mouse ear inflammatory response to topical arachidonic acid","volume":"82","author":"Young","year":"1984","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jep.2015.07.032_bib56","first-page":"13","article-title":"Clinical and experimental aspects of cutaneous neurogenic inflammation","volume":"58","author":"Zegarska","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jep.2015.07.032_bib57","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jep.2012.02.020","article-title":"Effects of taraxasterol of inflammatory response in lipopolysccharide-induced RAW 264.7 macrophages","volume":"141","author":"Zhang","year":"2012","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115300490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115300490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T07:54:41Z","timestamp":1556351681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115300490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":57,"alternative-id":["S0378874115300490"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.07.032","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.07.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}