{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:46:41Z","timestamp":1789418801866,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["01LC0022"],"award-info":[{"award-number":["01LC0022"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jep.2015.07.034","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T12:52:28Z","timestamp":1438433548000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["In vitro antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Isolona hexaloba"],"prefix":"10.1016","volume":"174","author":[{"given":"D.","family":"Musuyu Muganza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.I.","family":"Fruth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nzunzu Lami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cimanga Kanyanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.07.034_bib1","unstructured":"Adjanohoun,\u00a0E.J., Ahyi,\u00a0A.M.R., Ak\u00e9 Assi,\u00a0L., Baniakina,\u00a0J., Chibon,\u00a0P., Cusset,\u00a0G., Doulou,\u00a0V., Enzanza,\u00a0A., Eym\u00e9,\u00a0J., Goudot\u00e9,\u00a0E., Keita,\u00a0A., Mbemba,\u00a0C., Mollet,\u00a0J., Moutsambot\u00e9,\u00a0J.-M., Mpati,\u00a0J., Sita,\u00a0P., 1988. M\u00e9decine traditionnelle et pharmacop\u00e9e-Contribution aux \u00e9tudes ethnobotaniques et floristiques en R\u00e9publique Populaire du Congo ACCT, Paris, France p.606."},{"issue":"1","key":"10.1016\/j.jep.2015.07.034_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/np980144f","article-title":"Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids","volume":"62","author":"Angerhofer","year":"1999","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2015.07.034_bib3","series-title":"Etude chimique et biologique d\u2019Annonaceae gabonaises: Annona squamosa L. et Isolona hexaloba Engl. and Diels. Th\u00e8se de doctorat en Pharmacie","first-page":"11","author":"Bajin\u00a0ba Ndob","year":"2008"},{"key":"10.1016\/j.jep.2015.07.034_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0378-8741(02)00121-6","article-title":"In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid","volume":"81","author":"Banzoui","year":"2002","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2015.07.034_bib5","first-page":"47","article-title":"Medicinal plants sold in Yaound\u00e9 markets, Cameroon","volume":"23","author":"Betti","year":"2002","journal-title":"Afr. Study Monogr."},{"key":"10.1016\/j.jep.2015.07.034_bib6","series-title":"F\u00e9ticheurs et m\u00e9decines traditionnelles du Congo (Brazzaville)","first-page":"282","author":"Bouquet","year":"1969"},{"key":"10.1016\/j.jep.2015.07.034_bib7","first-page":"256","article-title":"Annonaceae","author":"Boutique","year":"1951"},{"issue":"2","key":"10.1016\/j.jep.2015.07.034_bib8","first-page":"89","article-title":"Recherches Chimiques Pr\u00e9liminaires sur les Plantes de la R\u00e9publique Populaire du Congo","volume":"51","author":"Cabalion","year":"1980","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1016\/j.jep.2015.07.034_bib9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/ptr.929","article-title":"In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei brucei","volume":"16","author":"Camacho","year":"2002","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2015.07.034_bib10","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.3390\/molecules16119714","article-title":"Trypanocidal activity of oxoaporphine and pyrimidine-\u00df-carboline alkaloids from branches of Annona foetida Mart. (Annonaceae)","volume":"16","author":"Costa","year":"2011","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.jep.2015.07.034_bib11","first-page":"692","article-title":"In vitro antileishmanial and cytotoxic activities of Annona mucosa (Annonaceae)","volume":"4","author":"De Lima","year":"2012","journal-title":"Rev. Virtual de Quimica"},{"key":"10.1016\/j.jep.2015.07.034_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-1999-13961","article-title":"Acetogenins and other compounds from Rollinia emarginata and their antiprotozoal activities","volume":"65","author":"F\u00e9vrier","year":"1999","journal-title":"Planta Med."},{"issue":"2\u20133","key":"10.1016\/j.jep.2015.07.034_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0378-8741(88)90162-6","article-title":"Activit\u00e9 antiparasitiare d\u2019alcalo\u00efdes bisbenzylisoquinol\u00e9ines. I: Activit\u00e9 in vitro sur des promastigotes de trois souches de Leishmania","volume":"24","author":"Fournet","year":"1988","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2015.07.034_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0924-8579(97)00373-7","article-title":"The effect of bisbenzylisoquinoline alkaloids on Trypanosoma cruzi infections in mice","volume":"8","author":"Fournet","year":"1997","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"51\u201362","key":"10.1016\/j.jep.2015.07.034_bib15","article-title":"The CBD in the Democratic Republic of Congo (DRC): The project: \u201cThe Cuvette Centrale as reservoir of medicinal plants\u201d in the process of implementation","volume":"34 (1+2)","author":"Fruth","year":"2011","journal-title":"Curare"},{"key":"10.1016\/j.jep.2015.07.034_bib16","first-page":"261","article-title":"Care for health and body: an ethnobotanical approach to Nkundo plant use (Cuvette Centrale, DRC) with focus on the significance of indigenous knowledge for the human skin","volume":"34","author":"Fruth","year":"2011","journal-title":"Curare"},{"key":"10.1016\/j.jep.2015.07.034_bib17","series-title":"Phytochemical methods","author":"Harborne","year":"1998"},{"key":"10.1016\/j.jep.2015.07.034_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1055\/s-2007-969611","article-title":"Alcalo\u00efdes des Annonac\u00e9es. XLIX. Alcalo\u00efdes d\u2019Isolona hexaloba, I. zenkeri et I. pilosa","volume":"50","author":"Hocquemiller","year":"1984","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2015.07.034_bib19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1039\/b311021b","article-title":"Natural products active against African trypanosomes: a step towards new drugs","volume":"21","author":"Hoet","year":"2004","journal-title":"Nat. Products Report"},{"issue":"1","key":"10.1016\/j.jep.2015.07.034_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5134\/143430","article-title":"Lui Kotal-A new site for field research on bonobos in the Salonga National Park","volume":"10","author":"Hohmann","year":"2003","journal-title":"Pan Africa News"},{"key":"10.1016\/j.jep.2015.07.034_bib21","doi-asserted-by":"crossref","unstructured":"Laouirem, S., Mathouet, H., Sergent, J.A., Ngouala, G., Lomri, A., Lameiras, P., Hulen, C., Lomri, N., Elomri, A., 2008. Screening of plant extracts for antimicrobial and anticancer activities. Planta Medica 74-PA77 DOI: 10.1055\/s-0028-1084075","DOI":"10.1055\/s-0028-1084075"},{"issue":"6","key":"10.1016\/j.jep.2015.07.034_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1055\/s-2000-8610","article-title":"Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina","volume":"66","author":"Mambu","year":"2000","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.jep.2015.07.034_bib23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/AAC.38.1.96","article-title":"In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids","volume":"38","author":"Marshall","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2015.07.034_bib24","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1515\/znb-2004-1007","article-title":"Cazolobine, a New Sesquiterpene from Isolona hexaloba (Annonaceae)","volume":"59b","author":"Mathouet","year":"2004","journal-title":"Zeitschrift f\u00fcr Naturforschung"},{"key":"10.1016\/j.jep.2015.07.034_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jep.2007.10.028","article-title":"Antiprotozoal and cytotoxic screening of 45 plant extracts from Democratic Republic of Congo","volume":"115","author":"Mesia","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.034_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2010.05.008","article-title":"Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract","volume":"131","author":"Mesia","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2015.07.034_bib27","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.phymed.2007.10.005","article-title":"Antiplasmodial and trypanosomal activity of Triclisia sacleuxii (Pierre) Diels","volume":"15","author":"Murebwayire","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2015.07.034_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jep.2012.02.035","article-title":"In vitro antiprotozoal and cytotoxic activity of 33 ethnopharmacologically selected medicinal plants from Democratic Republic of Congo","volume":"141","author":"Musuyu Muganza","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.034_bib29","unstructured":"Musuyu Muganza,\u00a0D. 2006. Contribution \u00e0 la revue des plantes m\u00e9dicinales des Nkundo au Sud-Ouest du Parc National de la Salonga M\u00e9moire DEA Biologie\/ Universit\u00e9 de Kinshasa."},{"key":"10.1016\/j.jep.2015.07.034_bib30","first-page":"135","article-title":"Bioactividad de la familia Annonaceae. Revista universidad de caldas","volume":"2006","author":"Ocampo","year":"2006","journal-title":"Enero-Diciembre"},{"key":"10.1016\/j.jep.2015.07.034_bib31","unstructured":"OCDE, 1987. Lignes Directrices de l\u2019Organisation de Coop\u00e9ration et de D\u00e9veloppement Economiques pour les Essais des Produits Chimiques. Toxicit\u00e9 Orale Aigu\u00eb. Paris, pp1\u20138."},{"issue":"1","key":"10.1016\/j.jep.2015.07.034_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jep.2005.05.021","article-title":"Biologically active bisbenyzyliquinoline alkaloids from the root bark of Epinetrum villosum","volume":"102","author":"Otshudi","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2015.07.034_bib33","series-title":"Isolation and evaluation of antiparasitic lead compounds from African medicinal plants","first-page":"216","author":"Raez","year":"1998"},{"key":"10.1016\/j.jep.2015.07.034_bib34","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.phymed.2003.10.006","article-title":"A review of natural products with antileishmanial activity","volume":"12","author":"Rocha","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2015.07.034_bib36","first-page":"5","article-title":"Etude sur les plantes m\u00e9dicinales et toxiques d\u2019Afrique \u00e9quatoriale","volume":"3","author":"Sandberg","year":"1965","journal-title":"Cahiers de la Mabok\u00e9"},{"key":"10.1016\/j.jep.2015.07.034_bib35","doi-asserted-by":"crossref","unstructured":"S\u00e9n\u00e9joux, F., Bajin ba Ndob, I., Akendengu\u00e9, B., Champy, P., 2008. New Indolic compounds from the stem bark of Isolona hexaloba (Annonaceae). In: Proceedings of the 7th joint meeting of AFERP, Poster, ASP, GA, PSE & SIF, Athens, 3\u20138 August 2008.","DOI":"10.1055\/s-0028-1084481"},{"key":"10.1016\/j.jep.2015.07.034_bib37","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/AAC.01175-08","article-title":"In vitro and in vivo properties of ellagic acid in malaria treatment","volume":"53","author":"Soh","year":"2009","journal-title":"Antimicrobial Agents Chemother."},{"key":"10.1016\/j.jep.2015.07.034_bib38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1099-1573(199903)13:2<175::AID-PTR395>3.0.CO;2-N","article-title":"Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)","volume":"13","author":"Waechter","year":"1999","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2015.07.034_bib39","series-title":"Plant drug analysis: a thin layer chromatography Atlas","first-page":"384","author":"Wagner","year":"1996"},{"key":"10.1016\/j.jep.2015.07.034_bib40","unstructured":"Wome,\u00a0B., 1985. Recherches ethnopharmacognosiques sur les plantes m\u00e9dicinales utilis\u00e9es en m\u00e9decine traditionnelle \u00e0 Kisangani (Haut-Za\u00efre) Th\u00e8se de Doctorat, ULB, Bruxelles"},{"key":"10.1016\/j.jep.2015.07.034_bib41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.2174\/1389557511313070009","article-title":"Recent developments in antimalarial natural products isolated from plants","volume":"13","author":"Xu","year":"2013","journal-title":"Mini-Rev. Med. Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115300519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115300519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T13:08:18Z","timestamp":1656680898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115300519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":41,"alternative-id":["S0378874115300519"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.07.034","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Isolona hexaloba","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}