{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:03:04Z","timestamp":1781305384978,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jep.2015.09.008","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T14:54:05Z","timestamp":1442069645000},"page":"181-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Aqueous root extract of Lecaniodiscus cupanioides restores nitric oxide\/cyclic guanosine monophosphate pathway in sexually impaired male rats"],"prefix":"10.1016","volume":"175","author":[{"given":"Quadri O.","family":"Nurudeen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taofeek O.","family":"Ajiboye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa T.","family":"Yakubu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oghenetega T.","family":"Oweh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omoregie","family":"Nosarieme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2015.09.008_bib1","first-page":"10","article-title":"Analgesic activity of the aqueous root extract Lecaniodiscus cupanioides","volume":"20","author":"Adeyemi","year":"2005","journal-title":"West Afr. J. Pharmacol. Drug Res."},{"key":"10.1016\/j.jep.2015.09.008_bib2","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1743-6109.2008.01064.x","article-title":"Erectile dysfunction management options in Nigeria","volume":"6","author":"Afolayan","year":"2009","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.jep.2015.09.008_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1515\/jbcpp-2013-0061","article-title":"Aphrodisiac effect of aqueous root extract of Lecaniodiscus cupanioides in sexually impaired rats","volume":"25","author":"Ajiboye","year":"2014","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2015.09.008_bib4","first-page":"53","article-title":"Sexual function improving effect of Mucuna pruriens in sexually normal male rats","volume":"67","author":"Amin","year":"1996","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2015.09.008_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/1534734603002001006","article-title":"Plant medicines of Indian origin for wound healing activity: a review","volume":"2","author":"Biswas","year":"2003","journal-title":"Int. J. Low. Extrem. Wounds"},{"key":"10.1016\/j.jep.2015.09.008_bib6","doi-asserted-by":"crossref","first-page":"29M","DOI":"10.1016\/j.amjcard.2005.07.008","article-title":"Phosphodiesterase 5 mechanisms and therapeutic applications","volume":"96","author":"Burnett","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jep.2015.09.008_bib500","doi-asserted-by":"crossref","unstructured":"Chan, J.S., Waldingger, M.D., Oliver, B., Oosting, R.S., 2010. Drug-induced sexual dysfunction in rats. Curr Protocol Neurosci; Chapter 9: Unit 9.34","DOI":"10.1002\/0471142301.ns0934s53"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2015.09.008_bib7","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/sj.ijir.3901205","article-title":"Mechanisms of action of PDE5 inhibition in erectile dysfunction","volume":"16","author":"Corbin","year":"2004","journal-title":"Int. J. Impot. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2015.09.008_bib8","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1038\/sj.ijir.3901215","article-title":"Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat","volume":"16","author":"De Tejada","year":"2004","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.jep.2015.09.008_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00499972","article-title":"A rapid and simple procedure for the determination of guanosine 3?,5?-monophosphate by use of the protein-binding method","volume":"284","author":"Dinnendahl","year":"1974","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.jep.2015.09.008_bib501","series-title":"Ethnomedical uses of plants in Nigeria","first-page":"276","author":"Gill","year":"1992"},{"key":"10.1016\/j.jep.2015.09.008_bib10","first-page":"1489","article-title":"Phosphodiesterase inhibitors for the treatment of erectile dysfunction","volume":"3","author":"K\u00fcthe","year":"2002","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.jep.2015.09.008_bib11","first-page":"218","article-title":"Effect of garlic bulb on paroxetine-induced sexual dysfunction in male rats","volume":"1","author":"Malviya","year":"2011","journal-title":"Asian J. Pharm. Biol. Res."},{"key":"10.1016\/j.jep.2015.09.008_bib502","unstructured":"National Research Council, 2011. Guide for the Care and Use of Laboratory Animals: Eighth Edition, in: Guide for the Care and Use of Laboratory Animals. p. 118"},{"key":"10.1016\/j.jep.2015.09.008_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S2305-0500(13)60062-7","article-title":"Aqueous root extract of Lecaniodiscus cupanioides restores the alterations in testicular parameters of sexually impaired male rats","volume":"1","author":"Nurudeen","year":"2012","journal-title":"Asian Pac. J. Reprod."},{"key":"10.1016\/j.jep.2015.09.008_bib504","unstructured":"Odugbemi, T., 2008. A Textbook of Medicinal Plants from Nigeria"},{"key":"10.1016\/j.jep.2015.09.008_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cca.2013.06.008","article-title":"A novel spectrophotometric method for indirect determination of nitric oxide (NO) in serum","volume":"424","author":"Wo","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jep.2015.09.008_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1745-7262.2005.00052.x","article-title":"Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats","volume":"7","author":"Yakubu","year":"2005","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jep.2015.09.008_bib505","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.fitote.2005.02.010","article-title":"CNS depressant activity of Lecaniodiscus cupanioides","volume":"76","author":"Yemitan","year":"2005","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2015.09.008_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S2305-0500(13)60060-3","article-title":"Effects of aqueous extract of Cnestis ferruginea (Vahl ex De Cantolle) root on paroxetine-induced sexual dysfunction in male rats","volume":"1","author":"Yakubu","year":"2012","journal-title":"Asian Pac. J. Reprod."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115301331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874115301331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T08:56:00Z","timestamp":1537347360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874115301331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":20,"alternative-id":["S0378874115301331"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2015.09.008","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aqueous root extract of Lecaniodiscus cupanioides restores nitric oxide\/cyclic guanosine monophosphate pathway in sexually impaired male rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2015.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}