{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:19:43Z","timestamp":1784866783568,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Gazi University Scientific Research Foundation","award":["02-2010\/2011"],"award-info":[{"award-number":["02-2010\/2011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jep.2016.02.045","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T01:24:09Z","timestamp":1457141049000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Bioassay-guided isolation of wound healing active compounds from Echium species growing in Turkey"],"prefix":"10.1016","volume":"185","author":[{"given":"Nuraniye","family":"Eruygur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclderen","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Kutsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6zde","family":"Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"\u00dcst\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.02.045_bib1","doi-asserted-by":"crossref","first-page":"141548","DOI":"10.5402\/2012\/141548","article-title":"Effect of Echium amoenum Fisch. et Mey a traditional Iranian herbal remedy in an experimental model of acute pancreatitis","volume":"2012","author":"Abed","year":"2012","journal-title":"ISRN Gastroenterol."},{"key":"10.1016\/j.jep.2016.02.045_bib2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1590\/S1413-86702004000500008","article-title":"Antibacterial effect of borage (Echium amoenum) on Staphylococcus aureus","volume":"8","author":"Abolhassani","year":"2004","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.jep.2016.02.045_bib3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.5114\/aoms.2010.14256","article-title":"Antiviral activity of borage (Echium amoenum)","volume":"6","author":"Abolhassani","year":"2010","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib4","first-page":"185","article-title":"Introduction of medicinal plants species with the most traditional usage in Alamut region","volume":"11","author":"Ahvazi","year":"2012","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.jep.2016.02.045_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jep.2009.03.019","article-title":"Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models","volume":"124","author":"Akkol","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib6","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1016\/j.chroma.2009.01.098","article-title":"Identification of Shikonin and its ester derivatives from the roots of Echium italicum L","volume":"1216","author":"Albreht","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2016.02.045_bib7","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.sbspro.2011.05.195","article-title":"Ethnomedicinal studies on the plant resources of east Anatolia, Turkey","volume":"19","author":"Altundag","year":"2011","journal-title":"Procedia \u2013 Soc. Behav. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib8","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1021\/acs.jafc.5b00857","article-title":"Lipid-encapsulated Echium oil (Echium plantagineum) increases the content of Stearidonic acid in plasma lipid fractions and milk fat of dairy cows","volume":"63","author":"Bainbridge","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2016.02.045_bib10","first-page":"37","article-title":"Anxiolytic effect of Echium amoenum L. in mice","volume":"1","author":"Bijan Shafaghi","year":"2002","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.jep.2016.02.045_bib11","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.jep.2016.02.045_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2010.08.017","article-title":"An ethnobotanical survey of medicinal plants in Sivrice (Elaz\u0131\u011f-Turkey)","volume":"132","author":"\u00c7akilcio\u011flu","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib13","first-page":"22","article-title":"Harput (Elaz\u0131\u011f) Ve \u00e7evresinin Etnobotanik \u00f6zellikleri","author":"\u00c7ak\u0131lc\u0131o\u011flu","year":"2007","journal-title":"Do\u011fu Anadolu B\u00f6lgesi Ara\u015ft\u0131rmalar\u0131"},{"key":"10.1016\/j.jep.2016.02.045_bib14","series-title":"The Encyclopedia of Medicinal Plants","author":"Chevallier","year":"1996"},{"key":"10.1016\/j.jep.2016.02.045_bib15","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1016\/j.fct.2008.08.004","article-title":"Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants","volume":"46","author":"Conforti","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2016.02.045_bib16","first-page":"46","article-title":"Antiviral effect assay of aqueous extract of Echium amoenum L against HSV-1","volume":"15","author":"Farahani","year":"2013","journal-title":"Zahedan J. Res. Med. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib17","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.foodchem.2008.11.028","article-title":"Antioxidant activity of Portuguese honey samples: different contributions of the entire honey and phenolic extract","volume":"114","author":"Ferreira","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2016.02.045_bib50","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/BF02863092","article-title":"Traditional medicine in Turkey VII . Folk medicine in Middle and West Black Sea Regions","volume":"49","author":"Fujita","year":"2013","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2016.02.045_bib18","first-page":"91","article-title":"Evaluation of the anxiolytic effect of Echium amoenum petals extract, during chronic treatment in rat","volume":"11","author":"Gholamzadeh","year":"2007","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib19","first-page":"176","article-title":"Anxiolytic effect of Echium amoenum during different treatment courses","volume":"3","author":"Gholamzadeh","year":"2008","journal-title":"Res. J. Biol. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib20","volume":"2","author":"Grieve","year":"1982"},{"key":"10.1016\/j.jep.2016.02.045_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jep.2005.08.027","article-title":"Evaluation of the analgesic effect of Echium amoenum Fisch & C.A. Mey. Extract in mice: possible mechanism involved","volume":"103","author":"Heidari","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.17795\/jjnpp-4589","article-title":"Anxiolytic and hypnotic effects of aqueous and ethanolic extracts of aerial parts of Echium italicum L. in mice","volume":"7","author":"Hosseinzadeh","year":"2012","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.jep.2016.02.045_bib24","first-page":"371","article-title":"Beta-adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle","volume":"44","author":"Kumar","year":"2006","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jep.2016.02.045_bib25","first-page":"327","article-title":"Ethnopharmacological survey of medicinal plants in Maraveh Tappeh region, north of Iran","volume":"2","author":"Mirdeilami","year":"2011","journal-title":"Iran. J. Plant Physiol."},{"key":"10.1016\/j.jep.2016.02.045_bib26","first-page":"189","article-title":"Evaluation of antidepressant effects of aerial parts of Echium vulgare on mice","volume":"10","author":"Moallem","year":"2007","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib27","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.fct.2010.08.007","article-title":"Antioxidant activity of selected plant species; potential new sources of natural antioxidants","volume":"48","author":"Niciforovic","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2016.02.045_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1248\/bpb.19.233","article-title":"Accelerative effect of Nanshikon and its constituents on the proliferation of granulation tissue in rats","volume":"19","author":"Ozaki","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2016.02.045_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1248\/bpb.16.683","article-title":"Comparative study on the accelerative effect of Koushikon and Nanshikon and their constituents on proliferation of granuloma tissue in rats","volume":"16","author":"Ozaki","year":"1993","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2016.02.045_bib30","first-page":"451","article-title":"Naphthoquinones from the Roots of Onosma argentatum Hub.-Mor. (Boraginaceae)","volume":"28","author":"Ozgen","year":"2004","journal-title":"Turk. J. Chem."},{"key":"10.1016\/j.jep.2016.02.045_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1521-3773(19990201)38:3<270::AID-ANIE270>3.0.CO;2-0","article-title":"The chemistry and biology of Alkannin, Shikonin, and related Naphthazarin natural products","volume":"38","author":"Papageorgiou","year":"1999","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jep.2016.02.045_bib32","first-page":"71","article-title":"Antibiotic effect of Echium extracts","volume":"22","author":"Peter","year":"1970","journal-title":"Studii si Cercetari de Biologie, Seria Botanica"},{"key":"10.1016\/j.jep.2016.02.045_bib33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jep.2012.09.017","article-title":"In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma","volume":"144","author":"Rajasekar","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ecam\/nel031","article-title":"Antioxidant activity of Iranian Echium amoenum Fisch & C.A. Mey flower decoction in humans: a cross-sectional before\/after clinical trial","volume":"3","author":"Ranjbar","year":"2006","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2016.02.045_bib35","first-page":"507","article-title":"Medicinal plants with anticonvulsant. Studies in natural products","volume":"22","author":"Raza","year":"2000","journal-title":"Chemistry"},{"key":"10.1016\/j.jep.2016.02.045_bib36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jep.2010.01.051","article-title":"Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside","volume":"129","author":"S\u00fcntar","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib37","first-page":"157","article-title":"Cytoprotective and antioxidant effects of Echium amoenum anthocyanin-rich extract in human endothelial cells (HUVECs)","volume":"5","author":"Safaeian","year":"2015","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.jep.2016.02.045_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pnpbp.2005.10.005","article-title":"A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression","volume":"30","author":"Sayyah","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2016.02.045_bib39","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.pnpbp.2009.08.021","article-title":"Efficacy of aqueous extract of Echium amoenum in treatment of obsessive-compulsive disorder","volume":"33","author":"Sayyah","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2016.02.045_bib41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02862090","article-title":"Traditional Medicine in Turkey VIII. Folk Medicine in East Anatolia; Erzurum, Erzincan, A\u011f\u0131r, Kars, I\u011fd\u0131r Province","volume":"51","author":"Sezik","year":"1997","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2016.02.045_bib42","first-page":"112","article-title":"Plant naphthoquinones as inhibitors of yeasts as well as lactic acid and acetic acid bacteria","volume":"8","author":"Shcherbanovskii","year":"1972","journal-title":"Rastitel'nye Resursy"},{"key":"10.1016\/j.jep.2016.02.045_bib43","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.1523-1747.1999.00761.x","article-title":"Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing","volume":"113","author":"Sidhu","year":"1999","journal-title":"J. Investig. Derm."},{"key":"10.1016\/j.jep.2016.02.045_bib44","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1663\/0013-0001(2004)058[0705:AESOTB]2.0.CO;2","article-title":"An ethnobotanical survey of the Beypazar\u0131, Aya\u015f and G\u00fcd\u00fclL district towns of Ankara province ( TURKEY )","volume":"58","author":"Sim\u015fek","year":"2004","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2016.02.045_bib45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent","volume":"299","author":"Singleton","year":"1999","journal-title":"Oxid. Antioxid."},{"key":"10.1016\/j.jep.2016.02.045_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1055\/s-2007-971456","article-title":"Antimicrobial activity of quinone derivatives from Echium lycopsis callus cultures","volume":"44","author":"Tabata","year":"1982","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2016.02.045_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/13880209409082966","article-title":"Traditional medicine in Turkey III. Folk medicine in east Anatolia, Van and Bitlis provinces","volume":"32","author":"Tabata","year":"1994","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2016.02.045_bib48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ijbiomac.2014.06.008","article-title":"Extraction, antioxidant and antilisterial activities of polysaccharides from the flower of Viper\u2019s bugloss","volume":"69","author":"Tahmouzi","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2016.02.045_bib49","first-page":"30","article-title":"Identification of Shikonin from the roots of Echium pycnanthum Pomel","volume":"5","author":"Tar\u0131k","year":"2012","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.jep.2016.02.045_bib51","first-page":"139","article-title":"Traditional medicine in Bilecik Province (Turkey) and antimicrobial activities of selected species","volume":"7","author":"\u00dcnsal","year":"2010","journal-title":"Turk. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2016.02.045_bib52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/0748233712468019","article-title":"The use of endemic Iranian plant, Echium amoenum, against the ethyl methanesulfonate and the recovery of mutagenic effects","volume":"31","author":"Uysal","year":"2012","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.jep.2016.02.045_bib53","first-page":"709","article-title":"Screening of selected plants for pyrrolizidine alkaloids and antitumor activity","volume":"42","author":"Wassel","year":"1987","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2016.02.045_bib54","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","article-title":"The determination of hydroxyproline in tissue and protein samples containing small proportions of this Imino acid","volume":"93","author":"Woessner","year":"1961","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2016.02.045_bib55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-8741(93)90048-A","article-title":"Traditional medicine in Turkey. IV. Folk medicine in the Mediterranean subdivision","volume":"39","author":"Yesilada","year":"1993","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0378-8741(95)01241-5","article-title":"Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains","volume":"46","author":"Yesilada","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.02.045_bib57","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jnutbio.2007.08.005","article-title":"Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice","volume":"19","author":"Zhang","year":"2008","journal-title":"J. Nutr. Biochem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116300873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116300873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T11:54:38Z","timestamp":1536926078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116300873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":54,"alternative-id":["S0378874116300873"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.02.045","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioassay-guided isolation of wound healing active compounds from Echium species growing in Turkey","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}