{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:42:54Z","timestamp":1779356574546,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The Kaduna State University","award":["Kaduna, Nigeria, KASU\/489\/13-1"],"award-info":[{"award-number":["Kaduna, Nigeria, KASU\/489\/13-1"]}]},{"name":"National Institute for Pharmaceutical Research and Development","award":["Abuja, Nigeria, NIPRD\/P.375"],"award-info":[{"award-number":["Abuja, Nigeria, NIPRD\/P.375"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Bonn, Germany, BE 1466\/15-1"],"award-info":[{"award-number":["Bonn, Germany, BE 1466\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jep.2016.03.003","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T09:20:46Z","timestamp":1456996846000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action"],"prefix":"10.1016","volume":"184","author":[{"given":"Ben A.","family":"Chindo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Koeberle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Werz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.03.003_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1300\/J044v09n01_06","article-title":"Anti-inflammatory and antinociceptive effects of Ficus platyphylla extract in mice and rats","volume":"9","author":"Amos","year":"2002","journal-title":"J. Herbs Spices Med. Plants"},{"key":"10.1016\/j.jep.2016.03.003_bib2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1517\/14728222.2014.945425","article-title":"Targeting 5-Lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease","volume":"18","author":"Antoniu","year":"2014","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/j.jep.2016.03.003_bib3","first-page":"157","article-title":"Medicinal plants and their use in Bauchi state","volume":"54","author":"Audu","year":"1989","journal-title":"Nigerian Field"},{"key":"10.1016\/j.jep.2016.03.003_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1078\/0944-7113-00103","article-title":"Anticonvulsant activity of aqueous extract of Leonotis leonurus","volume":"9","author":"Bienvenu","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2016.03.003_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12325-011-0100-7","article-title":"5-Lipoxygenase metabolic contributions to NSAID-induced organ Toxicity","volume":"29","author":"Burnett","year":"2012","journal-title":"Adv. Ther."},{"key":"10.1016\/j.jep.2016.03.003_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1006\/phrs.2000.0784","article-title":"Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept","volume":"43","author":"Celotti","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2016.03.003_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3959(85)90145-9","article-title":"Pain measurement: an overview","volume":"22","author":"Chapman","year":"1985","journal-title":"Pain"},{"key":"10.1016\/j.jep.2016.03.003_bib8","first-page":"306","article-title":"Etude pharmacologique d\u2019un antitussif le fumarate acid, de Phenethyl-1[Propyne-2yl)-4-Propionoxy-4-piperidine","volume":"134","author":"Charlier","year":"1961","journal-title":"Arch. Int. Pharmacodyn. Ther"},{"key":"10.1016\/j.jep.2016.03.003_bib9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1365-2044.2012.07246.x","article-title":"The pre-emptive analgesic effect of a cyclooxygenase-2 inhibitor in a rat model of acute Postoperative pain","volume":"67","author":"Chen","year":"2012","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jep.2016.03.003_bib10","series-title":"Studies on the neuropharmacological properties of the methanolic extract of Ficus platyphylla stem bark","author":"Chindo","year":"1999"},{"key":"10.1016\/j.jep.2016.03.003_bib11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.brainresbull.2008.12.005","article-title":"Anticonvulsant properties of saponins from Ficus platyphylla stem bark","volume":"78","author":"Chindo","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2016.03.003_bib12","first-page":"415","article-title":"Saponins are involved in the analgesic and anti-inflammatory properties of Ficus platyphylla stem bark","volume":"4","author":"Chindo","year":"2010","journal-title":"Int. J. Biol. Chem. Sci."},{"key":"10.1016\/j.jep.2016.03.003_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2014.03.061","article-title":"Behavioral and anticonvulsant effects of the standardized extract of Ficus platyphylla stem bark","volume":"154","author":"Chindo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.03.003_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.phymed.2014.10.005","article-title":"Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice","volume":"22","author":"Chindo","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2016.03.003_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pharep.2013.12.011","article-title":"Pharmacological characterization of carrageenan induced heat muscle Hyperalgesia in rats using non-selective, preferential and selective COX-2 inhibitors","volume":"66","author":"Chopade","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jep.2016.03.003_bib16","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.lfs.2010.04.012","article-title":"Peripheral mu-, kappa- and delta-opioid receptors mediate the hypoalgesic effect of celecoxib in a rat model of thermal hyperalgesia","volume":"86","author":"Correa","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2016.03.003_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1568010043483971","article-title":"Novel non-steroidal anti-inflammatory drugs: what we have learned from animal studies","volume":"3","author":"Coruzzi","year":"2004","journal-title":"Curr. Drug. Targets Inflamm. Allergy"},{"key":"10.1016\/j.jep.2016.03.003_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-2999(02)02920-5","article-title":"Enhancement of Antinociception by co-administration of an opioid drug (morphine) and a preferential Cyclooxygenase-2 inhibitor (Rofecoxib) in rats","volume":"460","author":"Deciga-Campos","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2016.03.003_bib19","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1096\/fj.02-0815fje","article-title":"Phosphorylation- and stimulus-dependent inhibition of cellular 5-Lipoxygenase activity by nonredox-type inhibitors","volume":"17","author":"Fischer","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2016.03.003_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuropharm.2006.02.012","article-title":"Endogenous opioids mediate the Hypoalgesia induced by selective inhibitors of cyclooxygenase 2 in rat paws treated with carrageenan","volume":"51","author":"Franca","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2016.03.003_bib21","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1213\/01.ANE.0000061461.55712.C5","article-title":"Cyclooxygenase-2 inhibitors","volume":"96","author":"Gajraj","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.jep.2016.03.003_bib22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-0773.1998.tb01478.x","article-title":"Aspects on tail-flick, hot-plate and electrical stimulation tests for morphine Antinociception","volume":"83","author":"Gardmark","year":"1998","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2016.03.003_bib23","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/jnc.12957","article-title":"High-affinity glutamate transporters in chronic pain: an emerging therapeutic target","volume":"131","author":"Gegelashvili","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jep.2016.03.003_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1358\/mf.2007.29.6.1119170","article-title":"An effective dose of Valdecoxib in experimental mouse models of pain","volume":"29","author":"Guo","year":"2007","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2016.03.003_bib25","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1097\/j.pain.0000000000000176","article-title":"Cerebral analgesic response to non-steroidal anti-inflammatory drug ibuprofen","volume":"156","author":"Hodkinson","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.jep.2016.03.003_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fncel.2015.00135","article-title":"Cross-talk and regulation between glutamate and GABAB receptors","volume":"9","author":"Kantamneni","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.jep.2016.03.003_bib27","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bcp.2009.02.005","article-title":"Identification of 5-Lipoxygenase and microsomal prostaglandin E2 Synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol","volume":"77","author":"Koeberle","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2016.03.003_bib28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Animal models of nociception","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2016.03.003_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12017-015-8351-0","article-title":"A dual inhibitor of Cyclooxygenase and 5-Lipoxygenase protects against Kainic acid-induced brain injury","volume":"17","author":"Minutoli","year":"2015","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.jep.2016.03.003_bib30","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1248\/bpb.34.1163","article-title":"Leukotrienes in nociceptive pathway and neuropathic\/inflammatory pain","volume":"34","author":"Noguchi","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2016.03.003_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejpain.2007.05.008","article-title":"Examination of the interaction between peripheral lumiracoxib and opioids on the 1% formalin test in rats","volume":"12","author":"Ortiz","year":"2008","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.jep.2016.03.003_bib32","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/ejn.12398","article-title":"Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond","volume":"39","author":"Palazzo","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jep.2016.03.003_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1517\/13543771003602012","article-title":"5-Lipoxygenase inhibitors: a review of recent developments and patents","volume":"20","author":"Pergola","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.jep.2016.03.003_bib34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pbb.2005.07.017","article-title":"Analgesic synergism between intrathecal morphine and cyclooxygenase-2 inhibitors in mice","volume":"82","author":"Pinardi","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2016.03.003_bib35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2014.08.012","article-title":"5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease","volume":"1851","author":"Radmark","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2016.03.003_bib36","doi-asserted-by":"crossref","first-page":"81s","DOI":"10.18433\/J3T886","article-title":"Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond","volume":"11","author":"Rao","year":"2008","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jep.2016.03.003_bib37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pain.2008.12.005","article-title":"The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids","volume":"142","author":"Rezende","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.jep.2016.03.003_bib38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000336346","article-title":"Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system","volume":"89","author":"Rezende","year":"2012","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2016.03.003_bib39","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jep.2016.03.003_bib40","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1471-4159.1993.tb03248.x","article-title":"Glutamate binding to brain membranes is increased in pentylenetetrazole-kindled rats","volume":"60","author":"Schr\u00f6der","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jep.2016.03.003_bib41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4522(94)90247-X","article-title":"Specific [3H]L-glutamate binding and [3H]d-aspartate release in the hippocampus of rat after pentylenetetrazol kindling and long-term Potentiation","volume":"60","author":"Schr\u00f6der","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2016.03.003_bib42","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.neuropharm.2008.12.010","article-title":"Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor","volume":"56","author":"Schr\u00f6der","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2016.03.003_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuint.2010.10.018","article-title":"Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue","volume":"58","author":"Schr\u00f6der","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2016.03.003_bib44","series-title":"Natural Products Isolation","first-page":"356","article-title":"Special problems with extraction of plants","author":"Silva","year":"1998"},{"key":"10.1016\/j.jep.2016.03.003_bib45","series-title":"Medical Plants and Traditional Medicine in Africa","author":"Sofowora","year":"2008"},{"key":"10.1016\/j.jep.2016.03.003_bib46","doi-asserted-by":"crossref","first-page":"e76603","DOI":"10.1371\/journal.pone.0076603","article-title":"Synergistic analgesia of duloxetine and celecoxib in the mouse formalin test: a combination analysis","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2016.03.003_bib47","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.pharmthera.2006.05.009","article-title":"Therapeutic options for 5-lipoxygenase inhibitors","volume":"112","author":"Werz","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2016.03.003_bib48","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/00000539-200204000-00035","article-title":"The role of cyclooxygenase-1 and -2 in the rat formalin test","volume":"94","author":"Yamamoto","year":"2002","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.jep.2016.03.003_bib49","doi-asserted-by":"crossref","first-page":"654257","DOI":"10.1155\/2013\/654257","article-title":"Ionotropic glutamate receptors and voltage-gated Ca2+ channels in long-term potentiation of spinal dorsal horn synapses and pain hypersensitivity","volume":"2013","author":"Youn","year":"2013","journal-title":"Neural Plast."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116301088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116301088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T16:19:42Z","timestamp":1748794782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116301088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":49,"alternative-id":["S0378874116301088"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.03.003","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}