{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:50:57Z","timestamp":1781304657025,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jep.2016.05.058","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T19:39:55Z","timestamp":1464723595000},"page":"159-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali"],"prefix":"10.1016","volume":"190","author":[{"given":"Ingvild","family":"Austarheim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Thu","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Feng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drissa","family":"Diallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Egil","family":"Malterud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Wangensteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.05.058_bib1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1055\/s-2002-36339","article-title":"Differentiation between the complement modulating effects of an arabinogalactan-protein from Echinacea purpurea and heparin","volume":"68","author":"Alban","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2016.05.058_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.carbpol.2012.03.005","article-title":"Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia","volume":"89","author":"Austarheim","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2016.05.058_bib3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1475-2875-12-298","article-title":"Azadirachta indica ethanolic extract protects neurons from apoptosis and mitigates brain swelling in experimental cerebral malaria","volume":"12","author":"Bedri","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2016.05.058_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4269\/ajtmh.1996.54.67","article-title":"In vitro antimalarial activity of vegetal extracts used in West African traditional medicine","volume":"54","author":"Benoit","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jep.2016.05.058_bib5","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/infdis\/jiv283","article-title":"Complement activation correlates with disease severity and contributes to cytokine responses in Plasmodium falciparum malaria","volume":"212","author":"Berg","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jep.2016.05.058_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.molmed.2014.01.001","article-title":"Complement activation in malaria: friend or foe?","volume":"20","author":"Biryukov","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jep.2016.05.058_bib7","series-title":"The Useful Plants of West Tropical Africa","first-page":"147","volume":"Vol. 5","author":"Burkill","year":"2000"},{"key":"10.1016\/j.jep.2016.05.058_bib8","first-page":"11","article-title":"Does the complement system work for or against the host during parasite infections","volume":"1","author":"Goto","year":"2013","journal-title":"Int. Trends Immun."},{"key":"10.1016\/j.jep.2016.05.058_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2217\/fmb.11.155","article-title":"Cerebral malaria pathogenesis: revisiting parasite and host contributions","volume":"7","author":"Grau","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jep.2016.05.058_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1746-4269-4-26","article-title":"Ethnopharmacological survey of six medicinal plants from Mali, West-Africa","volume":"4","author":"Gronhaug","year":"2008","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2016.05.058_bib11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/eri.11.96","article-title":"Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria","volume":"9","author":"Higgins","year":"2011","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"10.1016\/j.jep.2016.05.058_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1203\/PDR.0b013e3181eee738","article-title":"Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome","volume":"68","author":"Idro","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jep.2016.05.058_bib13","first-page":"61","article-title":"Prevalence and case-control study of cerebral malaria in Limbe of the South-West Cameroon","volume":"9","author":"Ikome","year":"2002","journal-title":"Afr. J. Health Sci."},{"key":"10.1016\/j.jep.2016.05.058_bib14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/bm050330h","article-title":"A complement fixing polysaccharide from Biophytum petersianum Klotzsch, a medicinal plant from Mali, West Africa","volume":"7","author":"Inngjerdingen","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jep.2016.05.058_bib15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bjid.2013.03.004","article-title":"Modulation of cerebral malaria by curcumin as an adjunctive therapy","volume":"17","author":"Jain","year":"2013","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.jep.2016.05.058_bib16","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1586\/eri.10.90","article-title":"Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria","volume":"8","author":"John","year":"2010","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"10.1016\/j.jep.2016.05.058_bib17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.niox.2008.04.008","article-title":"Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells","volume":"19","author":"Konkimalla","year":"2008","journal-title":"Nitric Oxide: Biol. Chem.\/Off. J. Nitric Oxide Soc."},{"key":"10.1016\/j.jep.2016.05.058_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1196\/annals.1352.020","article-title":"Herbal complement inhibitors in the treatment of neuroinflammation - future strategy for neuroprotection","volume":"1056","author":"Kulkarni","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jep.2016.05.058_bib19","series-title":"Plant-medicinal Dictionary for East Africa","first-page":"60","volume":"Vol. 2","author":"Lye","year":"2008"},{"key":"10.1016\/j.jep.2016.05.058_bib20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1365-3083.2000.00801.x","article-title":"Interaction between human complement and a pectin type polysaccharide fraction, PMII, from the leaves of Plantago major L","volume":"52","author":"Michaelsen","year":"2000","journal-title":"Scand. J. Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2016.05.058_bib21","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1475-2875-10-S1-S10","article-title":"The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria","volume":"10","author":"Mimche","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2016.05.058_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrneurol.2009.23","article-title":"Diagnosis and management of the neurological complications of falciparum malaria","volume":"5","author":"Mishra","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jep.2016.05.058_bib23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jep.2005.08.028","article-title":"Lack of toxicity of hydroethanolic extract from Mitragyna inermis (Willd.) O. Kuntze by gavage in the rat","volume":"103","author":"Monjanel-Mouterde","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.05.058_bib24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0035-3787(07)90464-6","article-title":"Persistent neurological sequelae due to cerebral malaria in a cohort of children from Mali","volume":"163","author":"Ngoungou","year":"2007","journal-title":"Rev. Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2016.05.058_bib25","first-page":"39","article-title":"The effects of chloroquine and hydroxychloroquine on nitric oxide production in RAW 264.7 and bone marrow-derived macrophages","volume":"60","author":"Perecko","year":"2014","journal-title":"Folia Biol."},{"key":"10.1016\/j.jep.2016.05.058_bib26","doi-asserted-by":"crossref","first-page":"10312","DOI":"10.3390\/molecules180910312","article-title":"Bioactive flavone-C-glycosides of the African medicinal plant Biophytum umbraculum","volume":"18","author":"Pham","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2016.05.058_bib27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0378-8741(91)90113-R","article-title":"Can ethnopharmacology contribute to the development of antimalarial agents?","volume":"32","author":"Phillipson","year":"1991","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.05.058_bib28","series-title":"Immunomodulatory Agents from Plants","first-page":"137","article-title":"Low-molecular weight compounds with complement activity","author":"Pieters","year":"1999"},{"key":"10.1016\/j.jep.2016.05.058_bib29","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0006-2952(99)00044-1","article-title":"Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b","volume":"57","author":"Sahu","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2016.05.058_bib30","first-page":"217","article-title":"Traditional medicinal plants and Malaria in Africa","volume":"1021","author":"Sayed","year":"2009","journal-title":"Am. Chem. Soc. Symp. Ser."},{"key":"10.1016\/j.jep.2016.05.058_bib31","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1462-5822.2010.01492.x","article-title":"Complement driven innate immune response to malaria: fuelling severe malarial diseases","volume":"12","author":"Silver","year":"2010","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jep.2016.05.058_bib32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.exppara.2006.09.016","article-title":"In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models","volume":"115","author":"Snyder","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jep.2016.05.058_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1746-4269-4-6","article-title":"Ethnopharmacological uses of Erythrina senegalensis: a comparison of three areas in Mali, and a link between traditional knowledge and modern biological science","volume":"4","author":"Togola","year":"2008","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2016.05.058_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-8741(03)00144-2","article-title":"In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected Ivorian plants","volume":"87","author":"Vonthron-Senecheau","year":"2003","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116303397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116303397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T14:54:43Z","timestamp":1536677683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116303397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":34,"alternative-id":["S0378874116303397"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.05.058","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.05.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}