{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:47:02Z","timestamp":1778273222508,"version":"3.51.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Northwest A & F University, National Natural Science Foundation of China","award":["31170796"],"award-info":[{"award-number":["31170796"]}]},{"name":"Northwest A & F University, National Natural Science Foundation of China","award":["81373892"],"award-info":[{"award-number":["81373892"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31540008"],"award-info":[{"award-number":["31540008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jep.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T04:39:28Z","timestamp":1464928768000},"page":"272-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula"],"prefix":"10.1016","volume":"190","author":[{"given":"Tianli","family":"Pei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuetong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxue","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2016.06.001_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","article-title":"Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families","volume":"16","author":"Alkhateeb","year":"2003","journal-title":"Pigm. Cell Res."},{"issue":"5","key":"10.1016\/j.jep.2016.06.001_bib2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2230.2006.02171.x","article-title":"Vitiligo associated with other autoimmune diseases: polyglandular autoimmune syndrome types 3B+ C and 4","volume":"31","author":"Amerio","year":"2006","journal-title":"Clin. Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jep.2016.06.001_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/srep00052","article-title":"Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs","volume":"1","author":"Azuaje","year":"2011","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2016.06.001_bib5","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1089\/ars.2009.2779","article-title":"The involvement of Smac\/DIABLO, p53, NF-kB, and MAPK pathways in apoptosis of keratinocytes from perilesional vitiligo skin: protective effects of curcumin and capsaicin","volume":"13","author":"Becatti","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"19","key":"10.1016\/j.jep.2016.06.001_bib6","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1093\/bioinformatics\/btp465","article-title":"Network analyses in systems pharmacology","volume":"25","author":"Berger","year":"2009","journal-title":"Bioinformatics"},{"issue":"13","key":"10.1016\/j.jep.2016.06.001_bib7","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1073\/pnas.1337088100","article-title":"Systematic discovery of multicomponent therapeutics","volume":"100","author":"Borisy","year":"2003","journal-title":"P. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.jep.2016.06.001_bib8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/15563650903059136","article-title":"Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine","volume":"47","author":"Cheung","year":"2009","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jep.2016.06.001_bib9","unstructured":"Commission, C.P., 1999. Drug Standard of Ministry of Public Health of the People\u2019s Republic ofChina (Uygur Medicine Volumes). Xinjiang Health Science and Technology Publishing House, Urumqi, 169"},{"key":"10.1016\/j.jep.2016.06.001_bib300","series-title":"Uyghur Medicine Volume","article-title":"Pharmacopoeia of the People\u2019s Republic of China","author":"Commission","year":"2005"},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1034\/j.1600-0749.2000.130106.x","article-title":"Higher plasma catecholamine and metabolite levels in the early phase of nonsegmental vitiligo","volume":"13","author":"Cucchi","year":"2000","journal-title":"Pigm. Cell Res."},{"issue":"12","key":"10.1016\/j.jep.2016.06.001_bib11","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrd4128","article-title":"Chemical predictive modelling to improve compound quality","volume":"12","author":"Cumming","year":"2013","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"9","key":"10.1016\/j.jep.2016.06.001_bib301","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/np200274m","article-title":"Bioactive dammarane-type saponins from Operculina turpethum","volume":"74","author":"Ding","year":"2011","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.jep.2016.06.001_bib302","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejphar.2006.11.014","article-title":"The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells","volume":"557","author":"Garc\u00eda-Mediavilla","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2016.06.001_bib12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1034\/j.1600-0749.2003.00070.x","article-title":"A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy?","volume":"16","author":"Gauthier","year":"2003","journal-title":"Pigm. Cell Res."},{"issue":"7","key":"10.1016\/j.jep.2016.06.001_bib13","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1021\/tx1000865","article-title":"Developing structure \u2212 activity relationships for the prediction of hepatotoxicity","volume":"23","author":"Greene","year":"2010","journal-title":"Chem. Res. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2016.06.001_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0733-8635(18)30271-7","article-title":"Vitiligo. An overview of therapeutic approaches","volume":"11","author":"Grimes","year":"1993","journal-title":"Dermatol. Clin."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/2013.jamadermatol.386","article-title":"The efficacy of afamelanotide and narrowband UV-B phototherapy for repigmentation of vitiligo","volume":"149","author":"Grimes","year":"2013","journal-title":"JAMA Dermatol."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib16","first-page":"57","article-title":"Topical treatment and combination approaches for vitiligo: new insights, new developments","volume":"145","author":"Hossani-Madani","year":"2010","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"10.1016\/j.jep.2016.06.001_bib17","article-title":"Systems pharmacology in drug discovery and therapeutic insight for herbal medicines","author":"Huang","year":"2013","journal-title":"Brief. Bioinform."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2016.06.001_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.fct.2015.01.020","article-title":"Developing a QSAR model for hepatotoxicity screening of the active compounds in traditional Chinese medicines","volume":"78","author":"Huang","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2016.06.001_bib20","first-page":"016","article-title":"Effects of Qubaibabuqi Capsule containing serum on proliferation and migration of Human Melanoma A375 Cells","volume":"1","author":"Huo","year":"2012","journal-title":"Chin. J. Pharmacol. Toxicol."},{"issue":"10","key":"10.1016\/j.jep.2016.06.001_bib304","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/ptr.5161","article-title":"The effects of galangin on a mouse model of vitiligo induced by hydroquinone","volume":"28","author":"Huo","year":"2014","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.jep.2016.06.001_bib305","first-page":"452","article-title":"A comprehensive review on trivrit (operculina Turpethum Syn. Ipomoea Turpethum)","volume":"1","author":"Kohli","year":"2010","journal-title":"Int. J. Pharm. Biol. Sci."},{"key":"10.1016\/j.jep.2016.06.001_bib306","first-page":"209","article-title":"Phytochemical studies of Psoralea species-A review","volume":"13","author":"Kotiyal","year":"1992","journal-title":"Bull. Medico-Ethnobot. Res."},{"key":"10.1016\/j.jep.2016.06.001_bib21","first-page":"171","article-title":"Hepatoprotective activity of aerial parts of Plumbago zeylanica linn against carbon tetrachloride-induced hepatotoxicity in rats","volume":"1","author":"Kumar","year":"2009","journal-title":"Int. J. Pharm. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.jep.2016.06.001_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/exd.12103","article-title":"Vitiligo: interplay between oxidative stress and immune system","volume":"22","author":"Laddha","year":"2013","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.jep.2016.06.001_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.lfs.2007.05.009","article-title":"Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling","volume":"81","author":"Lee","year":"2007","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.jep.2016.06.001_bib307","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5021\/ad.2012.24.2.115","article-title":"Role of keratinocytes in the development of vitiligo","volume":"24","author":"Lee","year":"2012","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.jep.2016.06.001_bib24","first-page":"286","article-title":"Prediction of human intestinal absorption based on molecular indices","volume":"23","author":"Li","year":"2007","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2016.06.001_bib25","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.imbio.2011.05.002","article-title":"Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells","volume":"216","author":"Lin","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.jep.2016.06.001_bib26","first-page":"049","article-title":"Clinical efficacy of the Qubai Babuqi Tablets in the treatment of vitiligo","volume":"9","author":"Liu","year":"2011","journal-title":"Chin. J. Aesthetic. Med."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yrtph.2009.01.009","article-title":"Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q) SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities","volume":"54","author":"Matthews","year":"2009","journal-title":"Regul. Toxicol. Pharm."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.chemolab.2005.05.006","article-title":"Chemical information of Chinese medicines: a challenge to chemist","volume":"82","author":"Mok","year":"2006","journal-title":"Chemom. Intell. Lab. Syst."},{"issue":"5","key":"10.1016\/j.jep.2016.06.001_bib29","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/archderm.134.5.595","article-title":"Consensus workshop on the toxic effects of long-term PUVA therapy","volume":"134","author":"Morison","year":"1998","journal-title":"Arch. Dermatol."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1359-6101(97)00022-1","article-title":"Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF\/MCP-1), chemokines essentially involved in inflammatory and immune reactions","volume":"9","author":"Mukaida","year":"1998","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2016.06.001_bib31","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.5b00465","article-title":"Computational models for human and animal hepatotoxicity with a global application scope","author":"Mulliner","year":"2016","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib308","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ajpath.2010.11.033","article-title":"Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help","volume":"178","author":"Nagashima","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.jep.2016.06.001_bib32","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1600-0749.2007.00408.x","article-title":"Neurogenic dysregulation, oxidative stress, autoimmunity, and melanocytorrhagy in vitiligo: can they be interconnected?","volume":"20","author":"Namazi","year":"2007","journal-title":"Pigm. Cell Res."},{"issue":"2","key":"10.1016\/j.jep.2016.06.001_bib33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-0749.2003.00023.x","article-title":"Evidence for an autoimmune pathogenesis of vitiligo","volume":"16","author":"Ongenae","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jep.2016.06.001_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.10.001","article-title":"Physiopathology and genetics of vitiligo","volume":"25","author":"Passeron","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jep.2016.06.001_bib35","first-page":"009","article-title":"Curative effect of victoria medicine qubaibabuqi capsule on experimental vitiligo in guinea pigs","volume":"7","author":"Peng","year":"2011","journal-title":"Herald. Med."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib318","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.femsle.2004.09.018","article-title":"Galangin expresses bactericidal activity against multiple-resistant bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa","volume":"240","author":"Pepeljnjak","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"issue":"9","key":"10.1016\/j.jep.2016.06.001_bib36","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nchembio.216","article-title":"Target profiling of small molecules by chemical proteomics","volume":"5","author":"Rix","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jep.2016.06.001_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.abb.2014.07.003","article-title":"Cyclic AMP (cAMP) signaling in melanocytes and melanoma","volume":"563","author":"Rodr\u00edguez","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"10.1016\/j.jep.2016.06.001_bib309","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0367-326X(02)00187-9","article-title":"Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin","volume":"73","author":"Russo","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2016.06.001_bib310","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.phytol.2014.12.014","article-title":"Butein: From ancient traditional remedy to modern nutraceutical","volume":"11","author":"Semwal","year":"2015","journal-title":"Phytochem. Lett."},{"issue":"8","key":"10.1016\/j.jep.2016.06.001_bib39","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1600-0625.2009.00850.x","article-title":"Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells","volume":"18","author":"Schallreuter","year":"2009","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.jep.2016.06.001_bib40","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1208\/s12248-013-9490-6","article-title":"Protective effects of kaempferol on isoniazid-and rifampicin-induced hepatotoxicity","volume":"15","author":"Shih","year":"2013","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.jep.2016.06.001_bib41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization","volume":"27","author":"Smoot","year":"2011","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.jep.2016.06.001_bib42","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1600-0625.2006.00497.x","article-title":"The genetics of generalized vitiligo","volume":"15","author":"Spritz","year":"2006","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.jep.2016.06.001_bib43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0749.2007.00384.x","article-title":"The genetics of generalized vitiligo and associated autoimmune diseases","volume":"20","author":"Spritz","year":"2007","journal-title":"Pigm. Cell Res."},{"issue":"10","key":"10.1016\/j.jep.2016.06.001_bib44","doi-asserted-by":"crossref","first-page":"20443","DOI":"10.3390\/ijms141020443","article-title":"Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K\/Akt, MEK\/ERK and Wnt\/\u03b2-catenin signaling pathways in B16F10 cells","volume":"14","author":"Su","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2016.06.001_bib45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5455\/jice.20160301094913","article-title":"Imbalance of the antioxidative System by plumbagin and Plumbago indica L. Extract Induces Hepatotoxicity in Mice","volume":"5","author":"Sukkasem","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-5945-8-2","article-title":"A systematic review of natural health product treatment for vitiligo","volume":"8","author":"Szczurko","year":"2008","journal-title":"BMC Dermatol."},{"issue":"11","key":"10.1016\/j.jep.2016.06.001_bib47","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.trac.2009.09.004","article-title":"Sample preparation for analyzing traditional Chinese medicines","volume":"28","author":"Tang","year":"2009","journal-title":"TrAC Trends Anal. Chem."},{"issue":"4","key":"10.1016\/j.jep.2016.06.001_bib48","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.0736-8046.2004.21418.x","article-title":"Calcipotriene and corticosteroid combination therapy for vitiligo","volume":"21","author":"Travis","year":"2004","journal-title":"Pediatr. Dermatol."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib49","first-page":"63","article-title":"Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system","volume":"52","author":"Vizi","year":"2000","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.jep.2016.06.001_bib50","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1039\/C2IB20204B","article-title":"Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication","volume":"5","author":"Wang","year":"2013","journal-title":"Integr. Biol."},{"key":"10.1016\/j.jep.2016.06.001_bib51","first-page":"8","article-title":"Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2016.06.001_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/srep11970","article-title":"Large-scale direct targeting for drug repositioning and discovery","volume":"5","author":"Zheng","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jep.2016.06.001_bib53","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11030-014-9521-y","article-title":"System-level multi-target drug discovery from natural products with applications to cardiovascular diseases","volume":"18","author":"Zheng","year":"2014","journal-title":"Mol. Divers."},{"key":"10.1016\/j.jep.2016.06.001_bib311","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/481405","article-title":"Protective effects of kaempferol against myocardial ischemia\/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3","volume":"2015","author":"Zhou","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jep.2016.06.001_bib54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cyto.2015.01.034","article-title":"Calcitonin gene-related peptide cooperates with substance P to inhibit melanogenesis and induces apoptosis of B16F10 cells","volume":"74","author":"Zhou","year":"2015","journal-title":"Cytokine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116303531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116303531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:35:01Z","timestamp":1568010901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116303531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":66,"alternative-id":["S0378874116303531"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.06.001","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}