{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:54:31Z","timestamp":1767927271833,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Shanghai Science and Technology Achievements Transformation and Industrialization Project","award":["13401900306"],"award-info":[{"award-number":["13401900306"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC, 81373519"],"award-info":[{"award-number":["NSFC, 81373519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Innovation Supporting Project for Top-grade Discipline Construction","award":["058ZY1206"],"award-info":[{"award-number":["058ZY1206"]}]},{"name":"Shanghai Interdisciplinary Cultivation Platform of Outstanding and Innovative Postgraduates"},{"name":"Shanghai \u201c085\u201d Science"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jep.2016.06.014","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T02:48:59Z","timestamp":1465267739000},"page":"20-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats"],"prefix":"10.1016","volume":"192","author":[{"given":"Junwei","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.06.014_bib1","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/ndt\/gfm393","article-title":"Treatment targets in renal fibrosis","volume":"12","author":"Boor","year":"2007","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.jep.2016.06.014_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1159\/000087853","article-title":"Hyperglycemia inhibits the uptake of dehydroascorbate in tubular epithelial cell","volume":"25","author":"Chen","year":"2005","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.jep.2016.06.014_bib3","doi-asserted-by":"crossref","first-page":"75612","DOI":"10.1039\/C5RA12710F","article-title":"A urine metabolomics study of chronic renal failure and intervention effects of total aglycone extracts of Scutellaria baicalensis in 5\/6 nephrectomy rats","volume":"92","author":"Fang","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2016.06.014_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1152\/ajpgi.00503.2001","article-title":"Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes","volume":"283","author":"Froh","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2016.06.014_bib5","first-page":"466","article-title":"Application of metabolomics\u00a0technology in renal diseases research","volume":"5","author":"Gao","year":"2011","journal-title":"Chin. J. Integr. Tradit. West. Nephrol."},{"key":"10.1016\/j.jep.2016.06.014_bib6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/nar\/gks1146","article-title":"The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013","volume":"41","author":"Hastings","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2016.06.014_bib7","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1046\/j.1523-1755.2003.00306.x","article-title":"DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition","volume":"64","author":"Higgins","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2016.06.014_bib8","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1046\/j.1523-1755.2002.00331.x","article-title":"Treatment of chronic tubulointerstitial disease: a new concept","volume":"l5","author":"Hruska","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2016.06.014_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000341485","article-title":"Effect of chenodeoxycholic acid on fibrosis, inflammation and oxidative stress in kidney in high-fructose-fed wistar rats","volume":"1","author":"Hu","year":"2012","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.jep.2016.06.014_bib10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1152\/ajprenal.00362.2001","article-title":"Obstructive nephropathy and renal fibrosis","volume":"283","author":"Klahr","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jep.2016.06.014_bib11","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/sj.ki.5001906","article-title":"Hydroxyproline ingestion and urinary oxalate and glycolate excretion","volume":"11","author":"Knight","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2016.06.014_bib12","first-page":"100","article-title":"Research progress of Scutellaria baicalensis","volume":"4","author":"Li","year":"2008","journal-title":"Chem. Eng. Equip."},{"key":"10.1016\/j.jep.2016.06.014_bib13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/path.4530","article-title":"A novel profibrotic mechanism mediated by TGF\u03b2-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells","volume":"3","author":"Luo","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2016.06.014_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.ajkd.2006.04.077","article-title":"Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease: a systematic review of the efficacy and safety data","volume":"48","author":"MacKinnon","year":"2006","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jep.2016.06.014_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2217\/fmb.13.165","article-title":"Role of altered intestinal microbiota in systemic inflammation and cardiovascular disease in chronic kidney disease","volume":"9","author":"Mafra","year":"2014","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jep.2016.06.014_bib16","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1097\/01.ASN.0000128219.65330.EA","article-title":"Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat","volume":"6","author":"Maric","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jep.2016.06.014_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.ki.5002357","article-title":"Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?","volume":"72","author":"McLennan","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2016.06.014_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12859-015-0486-3","article-title":"BiNChE: a web tool and library for chemical enrichment analysis based on the ChEBI ontology","volume":"16","author":"Moreno","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jep.2016.06.014_bib19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1517\/17425255.3.4.527","article-title":"Biochemical mechanisms of nephrotoxicity: application for metabolomics","volume":"3","author":"Niemann","year":"2007","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jep.2016.06.014_bib20","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00726-011-0869-3","article-title":"Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes","volume":"42","author":"Pal","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.jep.2016.06.014_bib21","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/bph.12348","article-title":"An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action","volume":"170","author":"Rankin","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2016.06.014_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1152\/ajpgi.2001.281.1.G200","article-title":"Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine","volume":"1","author":"Rivera","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2016.06.014_bib23","first-page":"550","article-title":"L-arginine metabolism in cardiovascular and renal tissue from hyper- and hypothyroid rats","volume":"5","author":"Rodr\u00edguez-G\u00f3mez","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jep.2016.06.014_bib24","first-page":"240","article-title":"The effect of extracted scutellaria on renal interstitial fibrosis rats and its antioxidant mechanism","volume":"3","author":"Xie","year":"2009","journal-title":"Chin. J. Integr. Tradit. West. Nephrol."},{"key":"10.1016\/j.jep.2016.06.014_bib25","first-page":"399","article-title":"Effect of cyclophosphamide on expression of MMP-9 and TGF-\u03b21 in renal tissue of rats with diabetes mellitus","volume":"2","author":"Yan","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.jep.2016.06.014_bib26","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/labinvest.2009.149","article-title":"Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-beta\/Smad activity","volume":"90","author":"Zhang","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.jep.2016.06.014_bib27","first-page":"763","article-title":"Urinary metabolomics study of renal cell carcinoma based on gas chromatography-mass spectrometry","volume":"5","author":"Zhang","year":"2015","journal-title":"J. South. Med. Univ."},{"key":"10.1016\/j.jep.2016.06.014_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/j.ajkd.2015.04.013","article-title":"Recent advances in traditional Chinese medicine for kidney disease","volume":"66","author":"Zhong","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jep.2016.06.014_bib29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/ijms14010226","article-title":"The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways","volume":"14","author":"Zhou","year":"2012","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0378874116303725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0378874116303725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:45:02Z","timestamp":1568007902000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116303725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":29,"alternative-id":["S0378874116303725"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.06.014","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.jep.2016.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}