{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:50:57Z","timestamp":1769604657423,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"am","delay-in-days":303,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004605","name":"Youth Innovation Fund of the First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Sciences Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81173530"],"award-info":[{"award-number":["81173530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Sciences Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81102447"],"award-info":[{"award-number":["81102447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Research Program of Applied Basic and Cutting-edge Technologies","award":["12JCZDJC25900"],"award-info":[{"award-number":["12JCZDJC25900"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jep.2016.06.044","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T19:47:10Z","timestamp":1466452030000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Antidepressant-like effect of the saponins part of ethanol extract from SHF"],"prefix":"10.1016","volume":"191","author":[{"given":"Yan","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongquan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meina","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengjie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuedong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.06.044_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.niox.2011.02.002","article-title":"Nitric oxide and major depression","volume":"24","author":"Ashish","year":"2011","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.jep.2016.06.044_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.17305\/bjbms.2013.2390","article-title":"Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders","volume":"13","author":"Birg\u00fcl","year":"2013","journal-title":"Bosn. J. Basic Med Sci."},{"issue":"8","key":"10.1016\/j.jep.2016.06.044_bib3","first-page":"1082","article-title":"Behavioral profile of Hypericum perforatum (St. John\u2019s Wort) extract. A comparison with standard antidepressants in animal models of depression","volume":"17","author":"Bukhari","year":"2013","journal-title":"Eur. Rev. Med Pharmacol. Sci."},{"key":"10.1016\/j.jep.2016.06.044_bib4","first-page":"11","article-title":"Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice","author":"Castagn\u00e9","year":"2011","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.jep.2016.06.044_bib5","series-title":"Methods in Enzymology, XVIIB","first-page":"692","article-title":"MAO activity in rabbit serum","author":"Charles","year":"1977"},{"key":"10.1016\/j.jep.2016.06.044_bib6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1472-8206.2012.01040.x","article-title":"Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress","volume":"27","author":"Chhillar","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2016.06.044_bib7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model to assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jep.2016.06.044_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1476-5381.1963.tb01302.x","article-title":"A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine","volume":"20","author":"Corne","year":"1963","journal-title":"Br. J. Pharm. Chemother."},{"key":"10.1016\/j.jep.2016.06.044_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pnpbp.2009.12.010","article-title":"Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system","volume":"34","author":"Freitas","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2016.06.044_bib10","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jep.2011.11.059","article-title":"Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrine","volume":"139","author":"Gu","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2016.06.044_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pnpbp.2009.11.015","article-title":"Antidepressant-like effect of the methanolic extract from Bupleurumfalcatum in the tail suspension test","volume":"34","author":"Kwon","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2016.06.044_bib12","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S1734-1140(13)71504-4","article-title":"New trends in the neurobiology and pharmacology of affective disorders","volume":"65","author":"Laso\u0144","year":"2013","journal-title":"Pharm. Rep."},{"key":"10.1016\/j.jep.2016.06.044_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jep.2012.02.026","article-title":"Antidepressant-like effect of the ethanolic extract from Suanzaorenhehuan Formula in mice models of depression","volume":"141","author":"Liu","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2016.06.044_bib14","doi-asserted-by":"crossref","first-page":"e0138904","DOI":"10.1371\/journal.pone.0138904","article-title":"A meta-analysis of oxidative stress markers in depression","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2016.06.044_bib15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.foodchem.2012.09.028","article-title":"Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L","volume":"136","author":"Machado","year":"2013","journal-title":"Food Chem."},{"issue":"6","key":"10.1016\/j.jep.2016.06.044_bib16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1017\/S1461145707008401","article-title":"Oxidative stress in psychiatric disorders: evidence base and therapeutic implications","volume":"11","author":"Ng","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jep.2016.06.044_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1742-2094-9-75","article-title":"Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress","volume":"9","author":"Peng","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.jep.2016.06.044_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","article-title":"Behavioural despair in rats and mice: strain differences and the effects of imipramine","volume":"51","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2016.06.044_bib19","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1997","journal-title":"Arch. Int. Pharm. Ther."},{"key":"10.1016\/j.jep.2016.06.044_bib20","first-page":"602","article-title":"Studies on antidepressant effective fraction of Suanzaoren Hehuan Formula","volume":"22","author":"Ren","year":"2011","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2016.06.044_bib21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.euroneuro.2011.04.002","article-title":"Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence","volume":"21","author":"Sarris","year":"2011","journal-title":"Eur. Neurpsychopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2016.06.044_bib22","first-page":"78","article-title":"Clinical applications of Platycladi Seed","volume":"03","author":"Shi","year":"2011","journal-title":"J. China Tradit. Chin. Med. Inf."},{"issue":"3","key":"10.1016\/j.jep.2016.06.044_bib23","first-page":"302","article-title":"Antipsychotics as antidepressants: what is the mechanism?","volume":"23","author":"Sagud","year":"2011","journal-title":"Psychiatr. Danub."},{"issue":"4","key":"10.1016\/j.jep.2016.06.044_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00228-013-1636-z","article-title":"Changes in the prescribing pattern of antidepressant drugs in elderly patients: an Italian, nationwide, population-based study","volume":"70","author":"Sultana","year":"2014","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2016.06.044_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.jep.2016.06.044_bib26","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.foodchem.2010.08.026","volume":"124","author":"Sun","year":"2011","journal-title":"Food Chem."},{"issue":"05","key":"10.1016\/j.jep.2016.06.044_bib27","first-page":"394","article-title":"Effect of Semen Platycladi saponins and semen platycladi oil on improvement of sleep","volume":"05","author":"Sun","year":"2010","journal-title":"World J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2016.06.044_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.peptides.2014.04.009","article-title":"Alarin-induced antidepressant-like effects and their relationship with hypothalamus\u2013pituitary\u2013adrenal axis activity and brain derived neurotrophic factor levels in mice","volume":"56","author":"Wang","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2016.06.044_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0149-7634(05)80194-0","article-title":"Chronic mild stress-induced anhedonia: a realistic animal model of depression","volume":"16","author":"Willner","year":"1992","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.jep.2016.06.044_bib30","first-page":"8","article-title":"Clinical study of Jiawei Sini Decoction in the treatment of 38 dysthymic patients","volume":"12","author":"Xie","year":"2005","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2016.06.044_bib31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jep.2012.10.013","article-title":"Antidepressant-like effects of the extract from Cimicifuga foetida L","volume":"144","author":"Ye","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2016.06.044_bib32","doi-asserted-by":"crossref","first-page":"e0133775","DOI":"10.1371\/journal.pone.0133775","article-title":"Changes of functional brain networks in major depressive disorder: a graph theoretical analysis of resting-state fMRI","volume":"10","author":"Ye","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2016.06.044_bib33","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/ptr.3456","article-title":"Antidepressant-like effects of l-theanine in the forced swim and tail suspension tests in mice","volume":"25","author":"Yin","year":"2011","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2016.06.044_bib34","first-page":"34","article-title":"Clinical study of XiaoYao-San in the treatment of depressive neurosis","author":"Zhang","year":"1998","journal-title":"J. Shangdong Univ. Tradit. Chin. Med. 22"},{"key":"10.1016\/j.jep.2016.06.044_bib35","first-page":"19","article-title":"A mental-tranquilizer-Albizzia julibrssin","volume":"3","author":"Zhang","year":"2003","journal-title":"Spec. Househ."},{"issue":"7","key":"10.1016\/j.jep.2016.06.044_bib36","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/chromsci\/bmt100","article-title":"Degradation kinetics of jujuboside B by rat intestinal flora in vitro with an RRLC-MS-MS method","volume":"52","author":"Zhang","year":"2013","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jep.2016.06.044_bib37","series-title":"Chinese Materia Medica Chemistry, Pharmacology and Applications","first-page":"519","author":"Zhu","year":"1998"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116304044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116304044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T22:59:48Z","timestamp":1712444388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116304044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":37,"alternative-id":["S0378874116304044"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.06.044","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidepressant-like effect of the saponins part of ethanol extract from SHF","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.06.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}