{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:59:26Z","timestamp":1778583566930,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"CONACYT","award":["226454"],"award-info":[{"award-number":["226454"]}]},{"name":"CONACYT","award":["237939"],"award-info":[{"award-number":["237939"]}]},{"name":"SEP-CONACyT"},{"name":"Proyecto de Ciencia B\u00e1sica","award":["167044"],"award-info":[{"award-number":["167044"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jep.2016.07.006","type":"journal-article","created":{"date-parts":[[2016,7,3]],"date-time":"2016-07-03T13:11:31Z","timestamp":1467551491000},"page":"90-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Anxiolytic-like effects and toxicological studies of Brickellia cavanillesii (Cass.) A. Gray in experimental mice models"],"prefix":"10.1016","volume":"192","author":[{"given":"Gabriela","family":"\u00c1vila-Villarreal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eva","family":"Gonz\u00e1lez-Trujano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azucena Ibeth","family":"Carballo-Villalobos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenice","family":"Aguilar-Guadarrama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Garc\u00eda-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Elizabeth","family":"Giles-Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Castillo-Espa\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Villalobos-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Estrada-Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.07.006_bib1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/13880200500220839","article-title":"Vasorelaxant effect of Mexican medicinal plants on isolated rat aorta","volume":"43","author":"Aguirre-Crespo","year":"2005","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2016.07.006_bib2","unstructured":"American Osteopathic Association. Benzodiazepines ineffective in treating anxiety disorders may increase dementia risk: Osteopathic psychiatrists encourage patients to review treatment options to improve outcomes, reduce risks. ScienceDaily.\u3008www.sciencedaily.com\/releases\/2015\/10\/151005132615.htm\u3009 (accessed 07.06.16)."},{"key":"10.1016\/j.jep.2016.07.006_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0944-7113(96)80041-9","article-title":"Quality assessment of herbal preparations as precondition of pharmacological and clinical studies","volume":"2","author":"Bauer","year":"1996","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2016.07.006_bib4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jep.2015.05.055","article-title":"Antidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in mice","volume":"171","author":"Cassani","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.07.006_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00404370","article-title":"Exploratory behavior in chronic disulfotan poisoning in mice","volume":"20","author":"Clark","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2016.07.006_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2007.12.010","article-title":"Assessment of luteolin (3\u2032,4\u2032,5,7-tetrahydroxyflavone) neuropharmacological activity","volume":"189","author":"Coleta","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2016.07.006_bib7","first-page":"70","article-title":"Antinociceptive effect of selected Mexican traditional medicinal species","volume":"48","author":"D\u00e9ciga-Campos","year":"2005","journal-title":"Proc. West Pharmacol. Soc."},{"key":"10.1016\/j.jep.2016.07.006_bib8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1021\/np300204p","article-title":"\u03b1-glucosidase inhibitors from Brickellia cavanillesii","volume":"75","author":"Escand\u00f3n-Rivera","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2016.07.006_bib9","doi-asserted-by":"crossref","first-page":"T1454","DOI":"10.1111\/1750-3841.12519","article-title":"Lyophilized tea extracts of Brickellia cavanillesii (Asteraceae): in vitro characterization of biological activity","volume":"79","author":"Eshiet","year":"2014","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2016.07.006_bib10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/(SICI)1099-1573(199812)12:8<600::AID-PTR363>3.0.CO;2-N","article-title":"Some pharmacological effects of the ethanol extract of leaves of Annona diversifolia on the central nervous system in mice","volume":"2","author":"Gonz\u00e1lez-Trujano","year":"1998","journal-title":"Phytother. Res"},{"key":"10.1016\/j.jep.2016.07.006_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1995-7645(14)60312-6","article-title":"Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin","volume":"8","author":"Gonz\u00e1lez-Trujano","year":"2015","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.jep.2016.07.006_bib12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1055\/s-0031-1298416","article-title":"Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana","volume":"78","author":"Gonz\u00e1lez-Trujano","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2016.07.006_bib13","series-title":"Mood and Anxiety related Phenotypes in Mice. Characterization using Behavioral Tests","first-page":"1","article-title":"The open field test","author":"Gould","year":"2009"},{"key":"10.1016\/j.jep.2016.07.006_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1099-1573(199603)10:2<145::AID-PTR793>3.0.CO;2-W","article-title":"Neuropharmacological studies on ethanol extracts of Valeriana officinalis: behavioral and anticonvulsant properties","volume":"10","author":"Hiller","year":"1996","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2016.07.006_bib15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4014\/jmb.1511.11003","article-title":"Biochemical characterization of recombinant UDP-glucose: sterol 3-O-Glycosyltransferase from Micromonospora rhodorangea ATCC 31603 and enzymatic biosynthesis of Sterol-3-O-\u03b2-Glucosides","volume":"26","author":"Hoang","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jep.2016.07.006_bib16","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1248\/bpb.34.1481","article-title":"Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress","volume":"34","author":"Ishisaka","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2016.07.006_bib17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jep.2016.07.006_bib18","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/jf9045182","article-title":"Isolation and characterization of nicotiflorin obtained by enzymatic hydrolysis of two precursors in tea seed extract","volume":"58","author":"Lee","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2016.07.006_bib19","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jep.2010.11.039","article-title":"Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis'edulis\u2019 and Passiflora edulis'flavicarpa\u2019","volume":"133","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.07.006_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2016.07.006_bib21","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jep.2012.03.028","article-title":"Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: sedative effect and chemical analysis of an aqueous extract","volume":"141","author":"Mart\u00ednez-V\u00e1zquez","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.07.006_bib22","unstructured":"Monroy-Ortiz, C., Castillo-Espa\u00f1a, P., 2007. Plantas Medicinales Utilizadas en el Estado de Morelos, ed., Centro de Investigaciones Biol\u00f3gicas, Universidad Aut\u00f3noma del Estado de Morelos. 2nd Edition. In Spanish."},{"key":"10.1016\/j.jep.2016.07.006_bib23","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/ajcn\/74.4.418","article-title":"Flavonoids: a review of probable mechanisms of action and potential applications","volume":"74","author":"Nijveldt","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2016.07.006_bib24","series-title":"Guideline for Testing Of Chemical,\u00a0Guideline 420, Acute Oral Toxicity-fixed Dose Procedure","author":"OECD","year":"2001"},{"key":"10.1016\/j.jep.2016.07.006_bib25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jep.2008.05.012","article-title":"Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia","volume":"118","author":"Palacios-Espinosa","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.07.006_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.drudis.2015.01.009","article-title":"An analysis of FDA-approved drugs: natural products and their derivatives","volume":"21","author":"Patridge","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2016.07.006_bib27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jep.2016.01.040","article-title":"Tagetes lucida Cav.: ethnobotany, phytochemistry and pharmacology of its tranquilizing properties","volume":"181","author":"P\u00e9rez-Ortega","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.07.006_bib28","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1089\/acm.2014.0177","article-title":"An alternative treatment for anxiety: a systematic review of human trial results reported for the ayurvedic herb ashwagandha (Withania somnifera)","volume":"20","author":"Pratte","year":"2014","journal-title":"J. Altern. Complement Med."},{"key":"10.1016\/j.jep.2016.07.006_bib29","first-page":"33","article-title":"Investigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley rat","volume":"77","author":"Raines","year":"2009","journal-title":"AANA J."},{"key":"10.1016\/j.jep.2016.07.006_bib30","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1038\/ncomms7803","article-title":"Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype","volume":"6","author":"Ralvenius","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2016.07.006_bib31","first-page":"1018","article-title":"Anti-tyrosinase and anti-cancer activities of flavonoids from Blumea balsamifera DC","volume":"5","author":"Saewan","year":"2011","journal-title":"J. Med. Plant Res."},{"key":"10.1016\/j.jep.2016.07.006_bib32","first-page":"614","article-title":"Administration of substances to laboratory animals: routes of administration and factors to consider","volume":"50","author":"Turner","year":"2011","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.jep.2016.07.006_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1211\/0022357056000","article-title":"Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs and Valeriana edulis hydroalcoholic extract in mice","volume":"57","author":"Ugalde","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2016.07.006_bib34","unstructured":"WHO. General guidelines for methodologies on research and evaluation of traditional medicine. WHO\/EDM\/TRM\/2000.1 2000. downloaded on March 27, 2016 \u3008http:\/\/whqlibdoc.who.int\/hq\/2000\/WHO_EDM_TRM_2000.1.pdf\u3009."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116304305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116304305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:40:41Z","timestamp":1589676041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116304305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":34,"alternative-id":["S0378874116304305"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.07.006","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anxiolytic-like effects and toxicological studies of Brickellia cavanillesii (Cass.) A. Gray in experimental mice models","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}