{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:19:00Z","timestamp":1789503540037,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["16ykpy14"],"award-info":[{"award-number":["16ykpy14"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Province Science and Technology Department","award":["2012A080202013"],"award-info":[{"award-number":["2012A080202013"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jep.2016.07.066","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T08:49:09Z","timestamp":1469522949000},"page":"362-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats"],"prefix":"10.1016","volume":"192","author":[{"given":"Xinmeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.07.066_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/00498250701767675","article-title":"Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases","volume":"38","author":"Bi","year":"2008","journal-title":"Xenobiotica"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2016.07.066_bib2","first-page":"S25","article-title":"Pharmacokinetics of clopidogrel","volume":"25","author":"Caplain","year":"1999","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.jep.2016.07.066_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/bdd.1918","article-title":"Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats","volume":"36","author":"Chen","year":"2015","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.jep.2016.07.066_bib4","first-page":"369","article-title":"Neuroprotective roles and mechanism of Dengzhanshengmai (DZSM) capsule for mouse model of transient ischemic attack","volume":"36","author":"Cheng","year":"2014","journal-title":"Anat. Res."},{"key":"10.1016\/j.jep.2016.07.066_bib5","unstructured":"Chinese Pharmacopoeia, 2010."},{"key":"10.1016\/j.jep.2016.07.066_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/dmd.31.1.53","article-title":"The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin","volume":"31","author":"Clarke","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2016.07.066_bib7","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2174\/138920010794328913","article-title":"Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the \u201cAdvanced Dissolution, Absorption, Metabolism (ADAM)\u201d model","volume":"11","author":"Darwich","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jep.2016.07.066_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1517\/14656566.6.5.755","article-title":"Clopidogrel for the secondary prevention of stroke","volume":"6","author":"Diener","year":"2005","journal-title":"Expert Opin. Pharm."},{"key":"10.1016\/j.jep.2016.07.066_bib31","first-page":"1517","article-title":"Determination of scutellarin in Dengzhan Shengmai capsule by HPLC","volume":"18","author":"Duan","year":"2011","journal-title":"Medical Healthcare Apparatus"},{"key":"10.1016\/j.jep.2016.07.066_bib9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jacc.2007.06.064","article-title":"Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study","volume":"51","author":"Gilard","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2016.07.066_bib10","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/rcm.2881","article-title":"Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography\/mass spectrometry: application to high-throughput inhibition screening of terpenoids","volume":"21","author":"He","year":"2007","journal-title":"Rapid Commun. Mass Spectrom.:RCM"},{"key":"10.1016\/j.jep.2016.07.066_bib11","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1124\/dmd.104.000646","article-title":"Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract","volume":"32","author":"Iwata","year":"2004","journal-title":"Drug Metab. Dispos.: Biol. Fate Chem."},{"key":"10.1016\/j.jep.2016.07.066_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/dmd.109.029132","article-title":"Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite","volume":"38","author":"Kazui","year":"2010","journal-title":"Drug Metab. Dispos.: Biol. Fate Chem."},{"key":"10.1016\/j.jep.2016.07.066_bib13","first-page":"11811","article-title":"Selective serotonin reuptake inhibitor combined with dengzhanshengmai capsule improves the fatigue symptoms: a 12-week open-label pilot study","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2016.07.066_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/aps.2013.157","article-title":"Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models","volume":"35","author":"Li","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2016.07.066_bib15","first-page":"529","article-title":"Effect of scutellarin on the expression and activity of P-gp in Caco-2 cells","volume":"18","author":"Liu","year":"2015","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2016.07.066_bib16","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/0091270011407194","article-title":"Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants","volume":"52","author":"Malati","year":"2012","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2016.07.066_bib17","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0195-668X(03)00442-1","article-title":"Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function \u2013 a flow cytometry study","volume":"24","author":"Neubauer","year":"2003","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2016.07.066_bib18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/clpt.2014.49","article-title":"Aspirin decreases systemic exposure to clopidogrel through modulation of P-glycoprotein but does not alter its antithrombotic activity","volume":"95","author":"Oh","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2016.07.066_bib19","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1124\/dmd.30.11.1288","article-title":"Structure and stereochemistry of the active metabolite of clopidogrel","volume":"30","author":"Pereillo","year":"2002","journal-title":"Drug Metab. Dispos.: Biol. Fate Chem."},{"key":"10.1016\/j.jep.2016.07.066_bib20","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2174\/138920010794328922","article-title":"Predicting drug\u2013drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein","volume":"11","author":"Tachibana","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jep.2016.07.066_bib21","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jpba.2008.08.020","article-title":"Quantitative determination of clopidogrel active metabolite in human plasma by LC-MS\/MS","volume":"48","author":"Takahashi","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2016.07.066_bib22","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1124\/dmd.105.005421","article-title":"Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity","volume":"33","author":"Taub","year":"2005","journal-title":"Drug Metab. Dispos.: Biol. Fate Chem."},{"key":"10.1016\/j.jep.2016.07.066_bib23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.clpt.2006.07.007","article-title":"Impact of P-glycoprotein on clopidogrel absorption","volume":"80","author":"Taubert","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2016.07.066_bib24","first-page":"1615","article-title":"The efficacy of Dengzhanshengmai (DZSM) capsule treated unstable angina","volume":"35","author":"Wang","year":"2014","journal-title":"Guangdong Med. J."},{"key":"10.1016\/j.jep.2016.07.066_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpba.2011.01.018","article-title":"Rapid and simultaneous measurement of midazolam, 1\u2032-hydroxymidazolam and digoxin by liquid chromatography\/tandem mass spectrometry: application to an in vivo study to simultaneously measure P-glycoprotein and cytochrome P450 3A activity","volume":"55","author":"Xue","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2016.07.066_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1476-5381.2010.00881.x","article-title":"Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro","volume":"161","author":"Zahno","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2016.07.066_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.thromres.2013.05.006","article-title":"Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients","volume":"132","author":"Zhang","year":"2013","journal-title":"Thromb. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116304937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116304937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T22:04:34Z","timestamp":1589666674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116304937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":28,"alternative-id":["S0378874116304937"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.07.066","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.07.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}