{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:36:43Z","timestamp":1779903403320,"version":"3.53.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jep.2016.08.045","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T02:22:51Z","timestamp":1472178171000},"page":"368-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Anti-tumor effects of osthole on ovarian cancer cells in vitro"],"prefix":"10.1016","volume":"193","author":[{"given":"Guoqiang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.jep.2016.08.045_bib1","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.7314\/APJCP.2015.16.16.7179","article-title":"Phytochemical analysis and anti-cancer investigation of Boswellia serrata bioactive constituents in vitro","volume":"16","author":"Ahmed","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"4","key":"10.1016\/j.jep.2016.08.045_bib2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1556\/AMicr.57.2010.4.8","article-title":"Cell type specific expression of the apoptosis stimulating protein (ASPP-2) in human tissues","volume":"57","author":"Alenzi","year":"2010","journal-title":"Acta Microbiol. Immunol. Hung."},{"issue":"5","key":"10.1016\/j.jep.2016.08.045_bib3","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.3892\/or.2016.4679","article-title":"Sedum sarmentosum bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway","volume":"35","author":"Bai","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2016.08.045_bib4","doi-asserted-by":"crossref","first-page":"27847","DOI":"10.1074\/jbc.271.44.27847","article-title":"Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase\/metaphase transition","volume":"271","author":"Borgne","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jep.2016.08.045_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1757-2215-6-41","article-title":"Sulforaphane induced cell cycle arrest in the G2\/M phase via the blockade of cyclin B1\/CDC2 in human ovarian cancer cells","volume":"6","author":"Chang","year":"2013","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2016.08.045_bib6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3109\/13880209.2013.850517","article-title":"Osthole induces G2\/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells","volume":"52","author":"Chao","year":"2014","journal-title":"Pharm. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2016.08.045_bib7","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.3233\/THC-151063","article-title":"G2\/M arrest and apoptosis of human colorectal cancer cells induced by water extract from residues of jelly fig achene","volume":"24","author":"Chou","year":"2015","journal-title":"Technol. Health Care : Off. J. Eur. Soc. Eng. Med."},{"key":"10.1016\/j.jep.2016.08.045_bib8","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot087130","article-title":"Triggering apoptosis in hematopoietic cells with cytotoxic drugs","author":"Crowley","year":"2016","journal-title":"Cold Spring Harb. Protoc."},{"issue":"1","key":"10.1016\/j.jep.2016.08.045_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3892\/ijmm.2015.2402","article-title":"Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK","volume":"37","author":"Duan","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.jep.2016.08.045_bib10","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1039\/C5FO01479D","article-title":"Chemical characterization and bioactive properties of Geranium molle L.: from the plant to the most active extract and its phytochemicals","volume":"7","author":"Graca","year":"2016","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.jep.2016.08.045_bib11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/14786419.2014.951854","article-title":"Ethanolic extract of Ferula gummosa is cytotoxic against cancer cells by inducing apoptosis and cell cycle arrest","volume":"29","author":"Gudarzi","year":"2015","journal-title":"Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.jep.2016.08.045_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-2999(95)00812-8","article-title":"Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens","volume":"298","author":"Guh","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2016.08.045_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1248\/bpb.b15-00358","article-title":"Osthole alleviates Bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2\/angiotensin-(1-7) axis and decreasing inflammation responses in rats","volume":"39","author":"Hao","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2016.08.045_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2016.05.161","article-title":"Exploration of Bcl-2 family and caspases-dependent apoptotic signaling pathway in Zearalenone-treated mouse endometrial stromal cells","author":"Hu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2016.08.045_bib15","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.9317","article-title":"Altered glutamine metabolism in platinum resistant ovarian cancer","author":"Hudson","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2016.08.045_bib16","doi-asserted-by":"crossref","DOI":"10.1039\/C6MB00066E","article-title":"Identification of novel selective MMP-9 inhibitors as potential anti-metastatic lead using structure-based hierarchical virtual screening and molecular dynamics simulation","author":"Kalva","year":"2016","journal-title":"Mol. Biosyst."},{"issue":"Suppl 1","key":"10.1016\/j.jep.2016.08.045_bib17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.4103\/0974-8490.178650","article-title":"Anti-leishmania activity of osthole","volume":"8","author":"Kermani","year":"2016","journal-title":"Pharmacogn. Res."},{"issue":"4","key":"10.1016\/j.jep.2016.08.045_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.cr.7290056","article-title":"Temperature dependent expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis","volume":"10","author":"Kong","year":"2000","journal-title":"Cell Res."},{"issue":"5","key":"10.1016\/j.jep.2016.08.045_bib19","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.3892\/or.2016.4649","article-title":"Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt\/mTOR\/MMP-9 signaling pathway","volume":"35","author":"Kou","year":"2016","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.jep.2016.08.045_bib20","doi-asserted-by":"crossref","first-page":"e0150235","DOI":"10.1371\/journal.pone.0150235","article-title":"Cudrania tricuspidata stem extract induces apoptosis via the extrinsic pathway in SiHa cervical cancer cells","volume":"11","author":"Kwon","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2016.08.045_bib21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpba.2012.10.018","article-title":"Investigation of the biotransformation of osthole by liquid chromatography\/tandem mass spectrometry","volume":"74","author":"Li","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2016.08.045_bib22","article-title":"Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway","author":"Liu","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2016.08.045_bib23","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1142\/S0192415X15500500","article-title":"Cnidium monnieri: a review of traditional uses, phytochemical and ethnopharmacological properties","volume":"43","author":"Li","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2016.08.045_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.taap.2014.11.003","article-title":"Jaridonin-induced G2\/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1\/2-Cdc25C pathway","volume":"282","author":"Ma","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2016.08.045_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007414.pub3","article-title":"Maintenance chemotherapy for ovarian cancer","author":"Mei","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2016.08.045_bib26","doi-asserted-by":"crossref","DOI":"10.3233\/CBM-160614","article-title":"Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are predictive of chemotherapeutic response and prognosis in epithelial ovarian cancer patients treated with platinum-based chemotherapy","author":"Miao","year":"2016","journal-title":"Cancer Biomark. : Sect. A Dis. Markers"},{"issue":"6","key":"10.1016\/j.jep.2016.08.045_bib27","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.3892\/ol.2016.4513","article-title":"Neutrophil to lymphocyte ratio in the pre-treatment phase of final-line chemotherapy predicts the outcome of patients with recurrent ovarian cancer","volume":"11","author":"Nakamura","year":"2016","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.jep.2016.08.045_bib28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0006-2952(02)01606-4","article-title":"Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway","volume":"65","author":"Okamoto","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2016.08.045_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/157340607779317607","article-title":"Synthetic derivatives of osthole for the prevention of hepatitis","volume":"3","author":"Okamoto","year":"2007","journal-title":"Med. Chem."},{"issue":"4","key":"10.1016\/j.jep.2016.08.045_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.15252\/embj.201593384","article-title":"Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores","volume":"35","author":"Salvador Gallego","year":"2016","journal-title":"Embo J."},{"issue":"8","key":"10.1016\/j.jep.2016.08.045_bib31","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2174\/1568009614666141028100640","article-title":"Bioactive albumin-based carriers for tumour chemotherapy","volume":"14","author":"Shahzad","year":"2014","journal-title":"Curr. Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.jep.2016.08.045_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.7555\/JBR.27.20120115","article-title":"Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis","volume":"29","author":"Wang","year":"2015","journal-title":"J. Biomed. Res."},{"issue":"6","key":"10.1016\/j.jep.2016.08.045_bib33","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1159\/000445573","article-title":"Osthole induces cell cycle arrest and inhibits migration and invasion via PTEN\/Akt pathways in osteosarcoma. cellular physiology and biochemistry","volume":"38","author":"Wang","year":"2016","journal-title":"Int. J. Exp. Cell. Physiol., Biochem., Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2016.08.045_bib34","first-page":"10816","article-title":"Protective role of Osthole on myocardial cell apoptosis induced by doxorubicin in rats","volume":"8","author":"Xu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2016.08.045_bib35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2147\/OTT.S45865","article-title":"Apoptosis and G2\/M Arrest Induced by allium ursinum (ramson) watery extract in an ags gastric cancer cell line","volume":"6","author":"Xu","year":"2013","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.jep.2016.08.045_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1756-9966-30-33","article-title":"Osthole induces G2\/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K\/Akt pathway","volume":"30","author":"Xu","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.jep.2016.08.045_bib37","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1271\/bbb.100110","article-title":"Effects of osthole on migration and invasion in breast cancer cells","volume":"74","author":"Yang","year":"2010","journal-title":"Biosci., Biotechnol., Biochem."},{"issue":"6","key":"10.1016\/j.jep.2016.08.045_bib38","first-page":"1592","article-title":"Anticancer effects of bishydroxycoumarin are mediated through apoptosis induction, cell migration inhibition and cell cycle arrest in human glioma cells","volume":"20","author":"Zhang","year":"2015","journal-title":"J. B.U.ON.: Off. J. Balk. Union Oncol."},{"key":"10.1016\/j.jep.2016.08.045_bib39","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/mrd.20703","article-title":"Polo-like kinase 1 may regulate G2\/M transition of mouse fertilized eggs by means of inhibiting the phosphorylation of Tyr 15 of Cdc2","volume":"74","author":"Zhang","year":"2007","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jep.2016.08.045_bib40","article-title":"Cardio protective effect of novel sulphonamides-1,3,5-triazine conjugates against Ischemic-reperfusion injury via selective inhibition of MMP-9","author":"Zheng","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"issue":"5","key":"10.1016\/j.jep.2016.08.045_bib41","first-page":"7425","article-title":"Biological effects of ray cartilage extract on human breast cancer cell line MCF-7 and its mechanism","volume":"8","author":"Zhu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116305803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116305803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T21:15:13Z","timestamp":1692479713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116305803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":41,"alternative-id":["S0378874116305803"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.08.045","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-tumor effects of osthole on ovarian cancer cells in vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.08.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}