{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:31:20Z","timestamp":1792312280318,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005672","name":"FUNDECT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jep.2016.08.053","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:42:19Z","timestamp":1473453739000},"page":"510-515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"special_numbering":"C","title":["Anti-inflammatory, antioxidant and anti- Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk."],"prefix":"10.1016","volume":"192","author":[{"given":"Lucas Noboru Fatori","family":"Trevizan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla Felipe do","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Alencar","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Andrea Lima","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Carmo","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Martinez Figueira","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Croda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelise Samara Nazari","family":"Formagio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.08.053_bib1","first-page":"1902","article-title":"Identification of essential oil components by gas chromatography\/quadrupole mass spectroscopy","volume":"16","author":"Adams","year":"2001","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jep.2016.08.053_bib2","first-page":"153","article-title":"Plantas medicinales y etnofarmacolog\u00eda en la provincia de Misiones (Argentina)","volume":"10","author":"Amat","year":"1991","journal-title":"Acta Farm Bonaer."},{"key":"10.1016\/j.jep.2016.08.053_bib3","first-page":"78","article-title":"Chemical and pharmaceutical studies on medicinal plants in Paraguay: constituents of angiotensin converting enzyme inhibitory fraction from \u201cCocu,\u201d Allophylus edulis RADLK","volume":"43","author":"Arisawa","year":"1989","journal-title":"Shoyakugaku Zasshi"},{"key":"10.1016\/j.jep.2016.08.053_bib4","first-page":"69","article-title":"Survey of Argentine medicinal plants. I. Folklore and phytochemical screening","volume":"35","author":"Bandoni","year":"1972","journal-title":"Lloydia"},{"key":"10.1016\/j.jep.2016.08.053_bib5","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.jep.2016.08.053_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0003-2670(01)01307-1","article-title":"Spectrometric identifications of sesquiterpene alcohols from niaouli (Melaleuca quinquenervia) essential oil","volume":"447","author":"Bombarda","year":"2001","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jep.2016.08.053_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phytochem.2015.05.005","article-title":"Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L.: studies on the conformation of viridiflorol","volume":"117","author":"D\u2019Ambrosio","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2016.08.053_bib8","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1124\/jpet.300.3.946","article-title":"The role of ATP-sensitive potassium channels in neutrophil migration and plasma exudation","volume":"300","author":"Da Silva-Santos","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jep.2016.08.053_bib9","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.phymed.2014.07.004","article-title":"Chemical composition and free radical-scavenging, anticancer and anti-inflammatory activities of the essential oil from Ocimum kilimandscharicum","volume":"21","author":"de Lima","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2016.08.053_bib10","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.carres.2008.07.014","article-title":"First record of L-quebrachitol in Allophylus edulis (Sapindaceae)","volume":"343","author":"D\u00edaz","year":"2008","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jep.2016.08.053_bib11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2005.04.028","article-title":"Antioxidant activity of some algerian medicinal plants extracts containing phenolic compounds","volume":"97","author":"Djeridane","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2016.08.053_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/cyto.2001.0980","article-title":"The effects of IL-6 and IL-10 and their specific antibodies in the acute inflammatory responses induced by carrageenan in the mouse model of pleurisy","volume":"17","author":"Frode","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2016.08.053_bib13","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/S0040-4020(01)88765-2","article-title":"The synthesis of mono- and dihydroxy aromadendrane sesquiterpenes, starting from natural (+)-aromadendrene-III","volume":"48","author":"Gijsen","year":"1992","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2016.08.053_bib14","first-page":"243","article-title":"Mouse paw edema. a new model for inflammation?","volume":"20","author":"Henriques","year":"1987","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jep.2016.08.053_bib15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1476-5381.1990.tb14671.x","article-title":"Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse","volume":"99","author":"Henriques","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2016.08.053_bib16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1055\/s-2006-961546","article-title":"Antihepatotoxic C-glycosylflavones from the leaves of Allophyllus edulis var. edulis and gracilis","volume":"58","author":"Hoffmann-Bohm","year":"1992","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2016.08.053_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0305-1978(01)00112-0","article-title":"Chemical variation in the leaf essential oil of Melaleuca quinquenervia (Cav.) S.T. Blake","volume":"30","author":"Ireland","year":"2002","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2016.08.053_bib18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.sajb.2007.04.061","article-title":"Compounds from Mentha aquatica with affinity to the GABA-benzodiazepine receptor","volume":"73","author":"J\u00e4ger","year":"2007","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.jep.2016.08.053_bib19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.sajb.2006.08.001","article-title":"Trichomes, essential oil composition and biological activities of Salvia albicaulis Benth. and S. dolomitica Codd, two species from the Cape region of South Africa","volume":"73","author":"Kamatou","year":"2007","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.jep.2016.08.053_bib20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jep.2009.06.003","article-title":"Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)","volume":"124","author":"Kassuya","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.08.053_bib21","unstructured":"K\u00f6rbes, V.C., 1995. Plantas medicinais, Francisco Beltr\u00e3o: Associa\u00e7\u00e3o DE Estudos, Orienta\u00e7\u00e3o e Assist\u00eancia Rural (ASSESOAR), 51 ed., p. 188."},{"key":"10.1016\/j.jep.2016.08.053_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1515\/jcim-2015-0032","article-title":"Anti-inflammatory and antioxidant effect of ginger in tuberculosis","volume":"13","author":"Kulkarni","year":"2016","journal-title":"J. Complement. Integr. Med."},{"key":"10.1016\/j.jep.2016.08.053_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/bmb\/ldw019","article-title":"Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs","volume":"118","author":"Maitra","year":"2016","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.jep.2016.08.053_bib24","first-page":"478","article-title":"Excitatory and inhibitory effects of paraguayan medicinal plants Equisetum giganteum, Acanthospermum australe, Allophylus edulis and Cordia salicifolia on contraction of rabbit aorta and guinea-pig left atrium","volume":"51","author":"Matsunaga","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2016.08.053_bib25","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3892\/ol.2015.4050","article-title":"Evaluation of the cytotoxic effects of extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines","volume":"11","author":"Memariani","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2016.08.053_bib26","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1021\/jf9707041","article-title":"Inhibition of Acetylcholinesterase Activity by Essential Oils of Mentha Species","volume":"46","author":"Miyazawa","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2016.08.053_bib27","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1128\/AAC.46.8.2720-2722.2002","article-title":"Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis","volume":"46","author":"Palomino","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2016.08.053_bib28","unstructured":"Piaggio, M., Delfino, L., 2003. Plantas nativas del Uruguay. \u3008http:\/\/micol.fcien.edu.uy\/flora\/Allphyllus-edulis.html\u3009 (accessed 26.04.2016)."},{"key":"10.1016\/j.jep.2016.08.053_bib29","first-page":"1","article-title":"Corticosteroids for managing tuberculous meningitis","volume":"4","author":"Prasad","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2016.08.053_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1108\/00070709510100163","article-title":"Antioxidants \u2013 the Case for fruit and vegetables in the diet","volume":"97","author":"Rice-Evans","year":"1995","journal-title":"Br. Food J."},{"key":"10.1016\/j.jep.2016.08.053_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2016.08.053_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF02004709","article-title":"Effects of sera and exudate from carrageenan-treated rats on two models of acute inflammation","volume":"11","author":"Sedgwick","year":"1981","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2016.08.053_bib33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.5897\/AJPP2015.4270","article-title":"Evaluation of the antioxidant activity, antimicrobial effect and acute toxicity from leaves of Allophylus edulis (A. St.-Hil., A. Juss. Cambess &.) Hieron. ex Niederl","volume":"9","author":"Tirloni","year":"2015","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2016.08.053_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bse.2014.02.004","article-title":"Temperature stress causes different profiles of volatile compounds in two chemotypes of Salvia lavandulifolia Vahl","volume":"54","author":"Usano-Alemany","year":"2014","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2016.08.053_bib35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3181\/00379727-143-37397","article-title":"Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat","volume":"143","author":"Vinegar","year":"1973","journal-title":"Exp. Biol. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116305888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116305888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T06:30:01Z","timestamp":1568356201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116305888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":35,"alternative-id":["S0378874116305888"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.08.053","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk.","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}