{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:06:49Z","timestamp":1773799609427,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Science and Technology, Government of India","award":["SR\/SO\/HS-0085\/2012"],"award-info":[{"award-number":["SR\/SO\/HS-0085\/2012"]}]},{"name":"JNU"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jep.2016.12.050","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:33:48Z","timestamp":1483648428000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Proteomic analysis of the protective effects of aqueous bark extract of Terminalia arjuna (Roxb.) on isoproterenol-induced cardiac hypertrophy in rats"],"prefix":"10.1016","volume":"198","author":[{"given":"Santosh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md.","family":"Jahangir Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayeed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subir K.","family":"Maulik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyamal K.","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2016.12.050_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2012.03.002","article-title":"Novel therapies in acute and chronic heart failure","volume":"135","author":"Aronson","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2016.12.050_bib2","first-page":"170","article-title":"Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate","volume":"54","author":"Bharani","year":"2002","journal-title":"Indian Heart J."},{"key":"10.1016\/j.jep.2016.12.050_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0167-5273(95)02320-V","article-title":"Salutary effect of Terminalia Arjuna in patients with severe refractory heart failure","volume":"49","author":"Bharani","year":"1995","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2016.12.050_bib4","doi-asserted-by":"crossref","first-page":"I57","DOI":"10.1161\/CIRCULATIONAHA.104.526137","article-title":"Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support","volume":"112","author":"Birks","year":"2005","journal-title":"Circulation"},{"issue":"202\u2013204","key":"10.1016\/j.jep.2016.12.050_bib5","first-page":"206","article-title":"Extraction of nuclear proteins from striated muscle tissue","volume":"26","author":"Blough","year":"1999","journal-title":"BioTechniques"},{"key":"10.1016\/j.jep.2016.12.050_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BJ20091193","article-title":"Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy","volume":"430","author":"Diers","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.jep.2016.12.050_bib7","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCGENETICS.113.000063","article-title":"Gene network and proteomic analyses of cardiac responses to pathological and physiological stress","volume":"6","author":"Drozdov","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.jep.2016.12.050_bib8","first-page":"52","article-title":"A prospective trial of ayurveda for coronary heart disease: a pilot study","volume":"21","author":"DuBroff","year":"2015","journal-title":"Altern. Ther. Health Med."},{"key":"10.1016\/j.jep.2016.12.050_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4103\/2225-4110.139103","article-title":"Revisiting Terminalia arjuna \u2013 an ancient cardiovascular drug","volume":"4","author":"Dwivedi","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jep.2016.12.050_bib10","first-page":"507","article-title":"Beneficial effects of Terminalia arjuna in coronary artery disease","volume":"49","author":"Dwivedi","year":"1997","journal-title":"Indian Heart J."},{"key":"10.1016\/j.jep.2016.12.050_bib11","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/CIRCRESAHA.114.303429","article-title":"Regulation of acetylation of histone deacetylase 2 by p300\/CBP-associated factor\/histone deacetylase 5 in the development of cardiac hypertrophy","volume":"114","author":"Eom","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2016.12.050_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jep.2004.08.040","article-title":"Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein","volume":"96","author":"Gauthaman","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.12.050_bib13","doi-asserted-by":"crossref","first-page":"e0116807","DOI":"10.1371\/journal.pone.0116807","article-title":"Fetal-adult cardiac transcriptome analysis in rats with contrasting left ventricular mass reveals new candidates for cardiac hypertrophy","volume":"10","author":"Grabowski","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2016.12.050_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yjmcc.2014.02.009","article-title":"\u03b2-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1\/2 and Akt","volume":"72","author":"Grisanti","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2016.12.050_bib15","first-page":"231","article-title":"Antioxidant and hypocholesterolaemic effects of Terminalia arjuna tree-bark powder: a randomised placebo-controlled trial","volume":"49","author":"Gupta","year":"2001","journal-title":"J. Assoc. Phys. India"},{"key":"10.1016\/j.jep.2016.12.050_bib16","doi-asserted-by":"crossref","unstructured":"Hilfiker-Kleiner, D., Landmesser, U., Drexler, H., 2006. Molecular mechanisms in heart failure: focus on cardiac hypertrophy, inflammation, angiogenesis, and apoptosis. J. Am. Coll. Cardiol., Critical Issues in Cardiovascular Research Proceedings From the Leducq Foundation Symposium 48, A56\u2013A66. doi: http:\/\/dx.doi.org\/10.1016\/j.jacc.2006.07.007.","DOI":"10.1016\/j.jacc.2006.07.007"},{"key":"10.1016\/j.jep.2016.12.050_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/cvr\/cvt094","article-title":"Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction","volume":"99","author":"Hill","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2016.12.050_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2016.06.052","article-title":"Botanical drugs in ayurveda and traditional chinese medicine","author":"Jaiswal","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.12.050_bib19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fphys.2014.00353","article-title":"Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations","volume":"5","author":"Kazmierczak","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2016.12.050_bib20","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1211\/jpp.61.11.0013","article-title":"Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.)","volume":"61","author":"Kumar","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2016.12.050_bib21","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1113\/expphysiol.2012.068262","article-title":"Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms","volume":"98","author":"Lehnart","year":"2013","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.jep.2016.12.050_bib22","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.cellsig.2014.08.006","article-title":"NF-\u03baB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms","volume":"26","author":"Liao","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jep.2016.12.050_bib23","doi-asserted-by":"crossref","first-page":"40782","DOI":"10.1074\/jbc.M111.263046","article-title":"Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2016.12.050_bib24","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1159\/000443096","article-title":"Endoplasmic reticulum stress is involved in DFMO attenuating Isoproterenol-induced cardiac hypertrophy in rats. cell","volume":"38","author":"Lin","year":"2016","journal-title":"Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2016.12.050_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/11598990-000000000-00000","article-title":"Therapeutic potential of Terminalia arjuna in cardiovascular disorders","volume":"12","author":"Maulik","year":"2012","journal-title":"Am. J. Cardiovasc. Drugs Drugs Devices Interv."},{"key":"10.1016\/j.jep.2016.12.050_bib26","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1006\/jmcc.1996.0353","article-title":"Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart","volume":"29","author":"Morano","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2016.12.050_bib27","first-page":"259","article-title":"The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes. Phytomedicine Int","volume":"18","author":"Oberoi","year":"2011","journal-title":"J. Phytother. Phytopharm."},{"key":"10.1016\/j.jep.2016.12.050_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3727\/105221611X12973615737505","article-title":"Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression","volume":"15","author":"Pandya","year":"2010","journal-title":"Gene Expr."},{"key":"10.1016\/j.jep.2016.12.050_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/1074248411416816","article-title":"Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenol-induced chronic heart failure rats","volume":"17","author":"Parveen","year":"2012","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2016.12.050_bib30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12012-010-9099-2","article-title":"Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats","volume":"11","author":"Parveen","year":"2011","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.jep.2016.12.050_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/jmcc.1994.1028","article-title":"Modification of cardiac membrane adenylate cyclase activity and Gs alpha by NAD and endogenous ADP-ribosyltransferase","volume":"26","author":"Quist","year":"1994","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2016.12.050_bib32","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.molmed.2016.07.007","article-title":"An \u201comics\u201d perspective on cardiomyopathies and heart failure","volume":"22","author":"Raghow","year":"2016","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.jep.2016.12.050_bib33","first-page":"1082","article-title":"Traditional herbs: a remedy for cardiovascular disorders","volume":"23","author":"Rastogi","year":"2016","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.jep.2016.12.050_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4103\/0250-474X.107067","article-title":"Characterisation of polyphenols in Terminalia arjuna bark extract","volume":"74","author":"Saha","year":"2012","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.jep.2016.12.050_bib35","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0140-6736(11)60894-5","article-title":"In search of new therapeutic targets and strategies for heart failure: recent advances in basic science","volume":"378","author":"Shah","year":"2011","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.jep.2016.12.050_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jep.2012.01.011","article-title":"Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats","volume":"141","author":"Shaik","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.12.050_bib37","first-page":"810","article-title":"Terminalia arjuna (Roxb.) Wight & Arn. augments cardioprotection via antioxidant and antiapoptotic cascade in isoproterenol induced cardiotoxicity in rats","volume":"53","author":"Shukla","year":"2015","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jep.2016.12.050_bib38","first-page":"59","article-title":"A solubility optimization protocol for two-dimensional gel electrophoresis of cardiac tissue","volume":"357","author":"Stanley","year":"2007","journal-title":"Methods Mol. Biol. Clifton NJ"},{"key":"10.1016\/j.jep.2016.12.050_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","article-title":"Return to the fetal gene program: a suggested metabolic link to gene expression in the heart","volume":"1188","author":"Taegtmeyer","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jep.2016.12.050_bib40","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1006\/jmcc.1999.1033","article-title":"Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling","volume":"31","author":"Takemoto","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2016.12.050_bib41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.redox.2015.05.005","article-title":"Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation","volume":"5","author":"Thakur","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2016.12.050_bib42","series-title":"Ayurvedic Herbs: A Clinical Guide to the Healing Plants of Traditional Indian Medicine","first-page":"119","article-title":"Ayurvedic herbs: a clinical guide to the healing plants of traditional indian medicine","author":"Tyler","year":"2012"},{"issue":"Pt B","key":"10.1016\/j.jep.2016.12.050_bib43","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jep.2014.07.013","article-title":"Traditional herbal medicines worldwide, from reappraisal to assessment in Europe","volume":"158","author":"van Galen","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2016.12.050_bib44","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jep.2016.12.050_bib45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/CIRCRESAHA.112.265959","article-title":"Cardiac P2X(4) receptors: targets in ischemia and heart failure?","volume":"111","author":"Yang","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2016.12.050_bib46","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/CIRCHEARTFAILURE.113.001023","article-title":"Novel protective role of endogenous cardiac myocyte P2\u00d74 receptors in heart failure","volume":"7","author":"Yang","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.jep.2016.12.050_bib47","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.bbrc.2013.05.079","article-title":"MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2","volume":"436","author":"Yang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2016.12.050_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2014.10.002","article-title":"Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-\u03baB both in vitro and in vivo","volume":"79","author":"Zeng","year":"2015","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116325958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116325958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T20:06:43Z","timestamp":1658347603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116325958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":48,"alternative-id":["S0378874116325958"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2016.12.050","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic analysis of the protective effects of aqueous bark extract of Terminalia arjuna (Roxb.) on isoproterenol-induced cardiac hypertrophy in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2016.12.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}