{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:00:33Z","timestamp":1770447633454,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jep.2017.01.017","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T19:31:26Z","timestamp":1484249486000},"page":"444-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica)"],"prefix":"10.1016","volume":"198","author":[{"given":"Bruno C\u00e9sar","family":"de Albuquerque Ugoline","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Cristina","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilma Schimith","family":"Ferraz-Filha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazielle Brand\u00e3o","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00eania Antunes","family":"Sa\u00fade-Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.01.017_bib1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jep.2008.02.031","article-title":"Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout","volume":"117","author":"Ahmad","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0031-9422(96)00343-3","article-title":"Triterpene alcohols from flowers of compositae and their anti-inflammatory effects","volume":"43","author":"Akihisa","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2017.01.017_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jep.2008.04.001","article-title":"In vivo anti-inflammatory and antinociceptive actions of some Lamium species","volume":"19","author":"Akkol","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib4","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0031-9422(81)83051-8","article-title":"A guaianolide and other constituents from Lychnophora species","volume":"20","author":"Bohlmann","year":"1981","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2017.01.017_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0305-1978(98)00004-0","article-title":"Sesquiterpene lactones, triterpenes and flavones from Lychnophora ericoides and Lychnoplora pseudovillosissima","volume":"26","author":"Borella","year":"1998","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2017.01.017_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of micro- gram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2017.01.017_bib7","unstructured":"Brasil, 2012. Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. Resolu\u00e7\u00e3o RDC N\u00b0. 27, de 17 de maio de 2012. Guia para valida\u00e7\u00e3o de m\u00e9todos anal\u00edticos e bioanal\u00edticos. \u3008http:\/\/e-legis.bvs.br\/\u3009 (acessed 01.04.16)."},{"key":"10.1016\/j.jep.2017.01.017_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0100-879X2000000200004","article-title":"Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines","volume":"33","author":"Calixto","year":"2000","journal-title":"Braz. J. Biol. Res."},{"key":"10.1016\/j.jep.2017.01.017_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jep.2011.03.034","article-title":"Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian Arnica)","volume":"135","author":"Capelari-Oliveira","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib10","first-page":"551","article-title":"A\u00e7\u00e3o analg\u00e9sica do extrato bruto aquoso liofilizado do caule e folhas da Lychnophora ericoides Mart.(arnica)","volume":"39","author":"Cerqueira","year":"1987","journal-title":"Ci\u00eanc. Cult."},{"key":"10.1016\/j.jep.2017.01.017_bib11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bjp.2015.06.003","article-title":"Useful brazilian plants under the view of the writer-naturalist Jo\u00e3o Guimar\u00e3es Rosa","volume":"25","author":"Chaves","year":"2015","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2017.01.017_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bse.2003.08.003","article-title":"Flavonoids from Lychnophora passerina (Asteraceae): potential antioxidants and UV-protectants","volume":"32","author":"Chicaro","year":"2004","journal-title":"Biochem. Syst. Ecol."},{"issue":"Suppl 1","key":"10.1016\/j.jep.2017.01.017_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar1908","article-title":"The inflammatory process of gout and its treatment","volume":"8","author":"Cronstein","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2017.01.017_bib14","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1136\/ard.2010.136218","article-title":"Hyperuricaemia and gout: state of the art and future perspectives","volume":"69","author":"Dalbeth","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2017.01.017_bib15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jep.2012.06.012","article-title":"Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents","volume":"142","author":"De Souza","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib16","first-page":"1","article-title":"Tabebuia roseoalba: in vivo hypouricemic and anti-inflammatory effects of its ethanolic extract and constituents","volume":"82","author":"Ferraz-Filha","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2017.01.017_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1590\/S0100-40422007000200026","article-title":"Plantas medicinais: fatores de influ\u00eancia no conte\u00fado de metab\u00f3litos secund\u00e1rios","volume":"30","author":"Gobbo-Neto","year":"2007","journal-title":"Qu\u00edm. Nova"},{"key":"10.1016\/j.jep.2017.01.017_bib18","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1590\/S0100-40422012001100007","article-title":"Seasonal variation of the major secondary metabolities present in the extract of Eremanthus mattogrossensis less (Asteraceae: Vernoniceae) leaves","volume":"35","author":"Gouvea","year":"2012","journal-title":"Qu\u00edm. Nova"},{"key":"10.1016\/j.jep.2017.01.017_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jep.2007.11.006","article-title":"Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species","volume":"116","author":"Guzzo","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib20","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3923\/pjbs.2008.1779.1784","article-title":"Effects of onion on serum uric acid levels and hepatic xanthine dehidrogenase\/xanthine oxidase activities in hyperuricemic rats","volume":"11","author":"Haidari","year":"2008","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.jep.2017.01.017_bib21","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/0024-3205(90)90507-N","article-title":"Substituted cyclic imides as potencial anti-gout agents","volume":"46","author":"Hall","year":"1990","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2017.01.017_bib22","series-title":"Introduction to Ecological Biochemistry","author":"Harborne","year":"1993"},{"key":"10.1016\/j.jep.2017.01.017_bib23","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1021\/jo00135a028","article-title":"Structure of goyazensolide and its congeners","volume":"47","author":"Herz","year":"1982","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2017.01.017_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.surneu.2006.03.038","article-title":"Spinal gout in a renal transplant patient: a case report and literature review","volume":"67","author":"Hou","year":"2007","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.jep.2017.01.017_bib25","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1211\/jpp.58.6.0016","article-title":"Sesquiterpene lactones from Lychnophora pohlii: neutrophil chemiluminescence inhibition and free radical scavenger activity","volume":"58","author":"Kanashiro","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib26","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1590\/S0100-40422010001000038","article-title":"Lychnophorinae (asteraceae): a survey of its chemical constituents and biological activities","volume":"33","author":"Keles","year":"2010","journal-title":"Qu\u00edm. Nova"},{"key":"10.1016\/j.jep.2017.01.017_bib27","first-page":"791","article-title":"Abordagem actual da gota","volume":"24","author":"Miguel","year":"2011","journal-title":"Acta Med. Port."},{"key":"10.1016\/j.jep.2017.01.017_bib28","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Institutes of Health, Public Health Service","year":"1985"},{"key":"10.1016\/j.jep.2017.01.017_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/mrc.819","article-title":"Reassignment of RMN spectra and conformational study of the sesquiterpene lactone goyazensolide","volume":"39","author":"Perry","year":"2001","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jep.2017.01.017_bib30","first-page":"1201","article-title":"Spinal cord compression by tophaceous gout with fluorodeoxyglucose-positronemission tomographic\/MRI fusion imaging","volume":"6","author":"Popovich","year":"2006","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.jep.2017.01.017_bib31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1055\/s-2000-8657","article-title":"Inhibition of serine proteases by anti-inflammatory triterpenoids","volume":"66","author":"Rajic","year":"2000","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2017.01.017_bib32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.phcgj.2012.08.001","article-title":"Antiedematogenic and antinociceptive effects of leaves extracts from Protium spruceanum Benth","volume":"5","author":"Rodrigues","year":"2013","journal-title":"(Engler). Pharmacogn. J."},{"key":"10.1016\/j.jep.2017.01.017_bib33","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/S0968-0896(99)00195-9","article-title":"Inhibition of transcription factor NF-kB by sesquiterpene lactones: a proposed molecular mechanism of action","volume":"7","author":"R\u00fcngeler","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jep.2017.01.017_bib34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1021\/np020314v","article-title":"Sesquiterpenes lactones from Lychnophora ericoides","volume":"66","author":"Sakamoto","year":"2003","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2017.01.017_bib35","first-page":"7","article-title":"Constituents from the aerial parts of Lychnophora trichocarpha","volume":"69","author":"Sa\u00fade","year":"1998","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2017.01.017_bib36","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jep.2009.05.018","article-title":"In vitro xanthine oxidase inhibitory activity of the fractions of Erythrina stricta Roxb","volume":"124","author":"Umamaheswari","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.01.017_bib37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0031-9422(00)89082-2","article-title":"Goyazensolide, a schistosomicidal heliangolide from Eremanthus goyazensis","volume":"15","author":"Vichnewsky","year":"1976","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2017.01.017_bib38","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carragenan-induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116317251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116317251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:25:31Z","timestamp":1566469531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116317251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":38,"alternative-id":["S0378874116317251"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.01.017","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}