{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:11:51Z","timestamp":1791475911513,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31560455"],"award-info":[{"award-number":["31560455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Chengdu Medical College","award":["CYZ16-12"],"award-info":[{"award-number":["CYZ16-12"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jep.2017.02.037","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T04:00:18Z","timestamp":1487995218000},"page":"228-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Effects of the ethanol extract of black mulberry ( Morus nigra L.) fruit on experimental atherosclerosis in rats"],"prefix":"10.1016","volume":"200","author":[{"given":"Yan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Rong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Chun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.02.037_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/109662002753723160","article-title":"Inhibitory activity of minor polyphenolic and non-polyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation","volume":"5","author":"Andrikopoulos","year":"2002","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2017.02.037_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/157488609789006949","article-title":"Adverse effects of statins- mechanisms and consequences","volume":"4","author":"Beltowski","year":"2009","journal-title":"Curr. Drug Saf."},{"key":"10.1016\/j.jep.2017.02.037_bib3","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1021\/jf030065w","article-title":"Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits","volume":"51","author":"Chen","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.foodchem.2004.06.039","article-title":"Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits","volume":"91","author":"Chen","year":"2005","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cbi.2009.09.024","article-title":"Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells","volume":"183","author":"Chen","year":"2010","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.jep.2017.02.037_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.foodchem.2004.11.015","article-title":"Contents of polyphenols in fruit and vegetables","volume":"94","author":"Cieslik","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.nutres.2004.05.001","article-title":"The vasculoprotective effects of flavonoid-rich cocoa and chocolate","volume":"24","author":"Engler","year":"2004","journal-title":"Nutr. Res."},{"issue":"Suppl. 6","key":"10.1016\/j.jep.2017.02.037_bib8","first-page":"sl","article-title":"Differentiation between calcium-and cholesterol-dominated types of atherosclerosis lesion: antiartheriosclerotic aspects of calcium antagonist","volume":"18","author":"Fleckenstein-Grun","year":"1991","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.jep.2017.02.037_bib9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge","volume":"18","author":"Friedwald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib10","first-page":"57","article-title":"Role of the liver in lipids metabolism in human body","volume":"18","author":"Fu","year":"2004","journal-title":"Chin. J. Liaoning Med. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1365-2621.1996.tb14186.x","article-title":"Characterization of red radish anthocyanins","volume":"61","author":"Giusti","year":"1996","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2017.02.037_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nutres.2007.12.012","article-title":"Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats","volume":"28","author":"Hassimotto","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.jep.2017.02.037_bib13","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/S0024-3205(01)01363-7","article-title":"Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits","volume":"69","author":"Jeon","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2017.02.037_bib14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.foodchem.2014.11.083","article-title":"Chemical properties in fruits of mulberry species from the Xinjiang province of China","volume":"174","author":"Jiang","year":"2015","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2017.02.037_bib15","first-page":"451","article-title":"Effects of anthocyanins derived from Xinjiang black mulberry fruit on delaying aging","volume":"39","author":"Jiang","year":"2010","journal-title":"Chin. J. Hyg. Res. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib16","first-page":"98","article-title":"Research progress on active ingredients and pharmacological functions of black mulberry (Morus nigra L.)","volume":"37","author":"Jiang","year":"2011","journal-title":"Chin. J. Sci. Seric. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib17","first-page":"45","article-title":"Antioxidant activity of anthocyanins from Morus nigra L. in vitro","volume":"32","author":"Jiang","year":"2011","journal-title":"Chin. J. Food Sci. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib18","series-title":"Evaluated Principles and Methods about Functional Food","first-page":"6","author":"Jin","year":"1995"},{"key":"10.1016\/j.jep.2017.02.037_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2005.11.001","article-title":"Dietary antioxidants in preventing atherogenesis","volume":"187","author":"Kaliora","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jep.2017.02.037_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7326\/0003-4819-90-1-85","article-title":"Cholesterol in the prediction of atherosclerotic disease","volume":"90","author":"Kannel","year":"1979","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jep.2017.02.037_bib21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S1567-5769(03)00073-0","article-title":"A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits","volume":"3","author":"Kim","year":"2003","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2017.02.037_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9343(01)00995-0","article-title":"Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer","volume":"113","author":"Kris-Etherton","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jep.2017.02.037_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.atherosclerosis.2004.12.003","article-title":"Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits","volume":"179","author":"Kurosawa","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jep.2017.02.037_bib24","first-page":"292","article-title":"Folin-Ciocalteu colorimetric determination of total polyphenols in mulberry fruits","volume":"39","author":"Li","year":"2009","journal-title":"Chin. J. Food Sci. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib25","first-page":"44","article-title":"The anti-hyperlipemia and anti-oxidation effects of anthocyanins from blueberry","volume":"34","author":"Li","year":"2008","journal-title":"Chin. J. Food Ferment. Ind. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.02.037_bib27","first-page":"890","article-title":"Determination of polyphenols and anthocyanins in mulberry fruits","volume":"29","author":"Lin","year":"2013","journal-title":"Chin. J. Mod. Food Technol."},{"key":"10.1016\/j.jep.2017.02.037_bib28","first-page":"294","article-title":"Geographical distribution and morphological characteristics of Morus cultivated in Xinjiang","volume":"34","author":"Maimaiti","year":"2008","journal-title":"Chin. J. Sci. Seric. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jfca.2006.04.010","article-title":"Polyphenolic content and in vitro antioxidant characteristics of wine industry and other agri-food solid waste extracts","volume":"20","author":"Makris","year":"2007","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.jep.2017.02.037_bib30","doi-asserted-by":"crossref","first-page":"11485","DOI":"10.1021\/jf801876n","article-title":"Anthocyanins from purple sweet potato Ipomoea batatas cultivar Ayamurasaki suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and soluble vascular cell adhesion molecule-1 in apolipoprotein E-deficient mice","volume":"56","author":"Miyazaki","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF00805570","article-title":"Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein","volume":"92","author":"Napoli","year":"1997","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jep.2017.02.037_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2017.02.037_bib33","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.foodchem.2006.06.021","article-title":"Antioxidant capacity, phenol, anthocyanin and ascorbic acid contents in raspberries, blackberries, red currants, gooseberries and Cornelian cherries","volume":"102","author":"Pantelidis","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib34","first-page":"339","article-title":"The relationship between high density lipoprotein cholesterol and triglyceride and the residual risk of cardiovascular disease","volume":"35","author":"Rong","year":"2015","journal-title":"Chin. J. Gerontol. (Chin.)"},{"key":"10.1016\/j.jep.2017.02.037_bib35","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis for atherosclerosis: a perspective for the 1990's","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"issue":"7\u20138","key":"10.1016\/j.jep.2017.02.037_bib36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.nut.2016.01.007","article-title":"Dietary sweet cherry anthocyanins attenuates diet-induced hepatic steatosis by improving hepatic lipid metabolism in mice","volume":"32","author":"Song","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.jep.2017.02.037_bib37","doi-asserted-by":"crossref","first-page":"9133","DOI":"10.1021\/jf9022228","article-title":"Phytochemical profiles of different mulberry (Morus sp.) species from China","volume":"57","author":"Song","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib38","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2017.02.037_bib39","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1021\/jf301888y","article-title":"Metabolite profiling of Jaboticaba (Myrciaria cauliflora) and other dark-colored fruit juices","volume":"60","author":"Wu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2017.02.037_bib40","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/jn\/136.8.2220","article-title":"An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein E-deficient mice","volume":"136","author":"Xia","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.jep.2017.02.037_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0021-9150(98)00230-5","article-title":"Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits","volume":"142","author":"Yamakoshi","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jep.2017.02.037_bib42","first-page":"1653","article-title":"Establishment and evaluation of an atherosclerosis rat model","volume":"43","author":"Yang","year":"2016","journal-title":"Chin. J. Mod. Prev. Med. (Chin.)"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116323145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116323145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T03:05:30Z","timestamp":1601694330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116323145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":42,"alternative-id":["S0378874116323145"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.02.037","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the ethanol extract of black mulberry (Morus nigra L.) fruit on experimental atherosclerosis in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.02.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}