{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:26:13Z","timestamp":1784823973863,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Traditional Chinese Medicine Development Special Funds","award":["PDYNZJ2015-02"],"award-info":[{"award-number":["PDYNZJ2015-02"]}]},{"name":"Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai","award":["PWR12015-05"],"award-info":[{"award-number":["PWR12015-05"]}]},{"name":"State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources","award":["ME2016012)"],"award-info":[{"award-number":["ME2016012)"]}]},{"name":"Talents Training Program of Seventh People's Hospital of Shanghai University of TCM","award":["XX2017-01"],"award-info":[{"award-number":["XX2017-01"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jep.2017.06.034","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T21:00:30Z","timestamp":1498251630000},"page":"57-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Anti-inflammatory effect of Man-Pen-Fang, a Chinese herbal compound, on chronic pelvic inflammation in rats"],"prefix":"10.1016","volume":"208","author":[{"given":"Li-Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Nan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.06.034_bib1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0090-4295(98)00390-2","article-title":"Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis\/chronic pelvic pain syndrome","volume":"52","author":"Alexander","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.jep.2017.06.034_bib2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1258\/095646205774763270","article-title":"A review on pelvic inflammatory disease","volume":"16","author":"Barrett","year":"2005","journal-title":"Int. J. STD AIDS"},{"key":"10.1016\/j.jep.2017.06.034_bib3","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.clinbiochem.2008.08.080","article-title":"Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome","volume":"41","author":"Basic Kes","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jep.2017.06.034_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/547251","article-title":"Effects of \"Danzhi decoction\" on chronic pelvic pain, hemodynamics, and proinflammatory factors in the murine model of sequelae of pelvic inflammatory disease","volume":"2015","author":"Bu","year":"2015","journal-title":"Evid.-Based Compliment. Altern. Med."},{"key":"10.1016\/j.jep.2017.06.034_bib5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/clinids\/8.1.86","article-title":"Pelvic inflammatory disease: a review with emphasis on antimicrobial therapy","volume":"8","author":"Burnakis","year":"1986","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.jep.2017.06.034_bib6","first-page":"20","article-title":"Pelvic inflammatory disease: a review","volume":"3","author":"Cassell","year":"1997","journal-title":"J. Int. Assoc. Physicians AIDS Care"},{"key":"10.1016\/j.jep.2017.06.034_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s11655-012-1291-5","article-title":"Blood stasis syndrome and its treatment with activating blood circulation to remove blood stasis therapy","volume":"18","author":"Chen","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2017.06.034_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jep.2011.03.033","article-title":"Anti-hyperuricemic and nephroprotective effects of Smilax china L","volume":"135","author":"Chen","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2017.06.034_bib9","article-title":"Drug particles of Fuyanning to Cheonic pelvic inflammatory disease model of the impact of rats IL-2, IL-6","volume":"26","author":"Chen","year":"2008","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2017.06.034_bib10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3109\/13693786.2013.772689","article-title":"The importance of pro-inflammatory and anti-inflammatory cytokines in Pneumocystis jirovecii pneumonia","volume":"51","author":"Chou","year":"2013","journal-title":"Med. Mycol."},{"key":"10.1016\/j.jep.2017.06.034_bib11","first-page":"6951","article-title":"Inflammatory response of the body to surgery illustrated by pro-inflammatory and anti-inflammatory cytokines","volume":"160","author":"Christensen","year":"1998","journal-title":"Ugeskr. Laege."},{"key":"10.1016\/j.jep.2017.06.034_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood-2016-05-711796","article-title":"IL-2, the next best thing in chronic GVHD therapy?","volume":"128","author":"Curtis","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jep.2017.06.034_bib13","first-page":"91","article-title":"Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings","volume":"11","author":"Dinarello","year":"1997","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.jep.2017.06.034_bib14","first-page":"13","article-title":"The role of Fas\/FasL system in induction of hepatocyte apoptosis in chronic viral hepatitides","volume":"65","author":"Dmitrieva","year":"2003","journal-title":"Arkh Patol"},{"key":"10.1016\/j.jep.2017.06.034_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijantimicag.2015.05.004","article-title":"A review of antibiotic therapy for pelvic inflammatory disease","volume":"46","author":"Duarte","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jep.2017.06.034_bib16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jep.2017.06.034_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/aos.13096","article-title":"Inhibition of HIF-1alpha decreases expression of pro-inflammatory IL-6 and TNF-alpha in diabetic retinopathy","author":"Gao","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.jep.2017.06.034_bib18","first-page":"791","article-title":"Pelvic inflammatory disease","volume":"85","author":"Gradison","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.jep.2017.06.034_bib19","first-page":"401","article-title":"TGF-beta1 polymorphism in glioma","volume":"60","author":"Guo","year":"2016","journal-title":"J. Neurosurg. Sci."},{"key":"10.1016\/j.jep.2017.06.034_bib20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/01.olq.0000162361.69041.a5","article-title":"Predictors of chronic pelvic pain in an urban population of women with symptoms and signs of pelvic inflammatory disease","volume":"32","author":"Haggerty","year":"2005","journal-title":"Sex. Transm. Dis."},{"key":"10.1016\/j.jep.2017.06.034_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jep.2008.10.009","article-title":"Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies","volume":"121","author":"Khan","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.06.034_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.5851\/kosfa.2015.35.5.604","article-title":"The Synergic Anti-inflammatory Impact of Gleditsia sinensis Lam. and Lactobacillus brevis KY21 on Intestinal Epithelial Cells in a DSS-induced Colitis Model","volume":"35","author":"Kim","year":"2015","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"10.1016\/j.jep.2017.06.034_bib23","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/ajrccm.163.3.2003065","article-title":"Fas\/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice","volume":"163","author":"Kitamura","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jep.2017.06.034_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/emm.2001.43","article-title":"Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root","volume":"33","author":"Lee","year":"2001","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2017.06.034_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jep.2016.07.020","article-title":"In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action","volume":"192","author":"Li","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.06.034_bib26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/10286020600883419","article-title":"A new anti-HIV lupane acid from Gleditsia sinensis Lam","volume":"9","author":"Li","year":"2007","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2017.06.034_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11033-016-4037-4","article-title":"Associations of TNF-alpha and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: taichung Community Health Study for Elders (TCHS-E)","volume":"43","author":"Lin","year":"2016","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2017.06.034_bib28","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1995-7645(14)60173-5","article-title":"Effect of Danzhi decoction on expression of angiogenesis factors in patients with sequelae of pelvic inflammatory disease","volume":"7","author":"Liu","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"13\u201319","key":"10.1016\/j.jep.2017.06.034_bib29","first-page":"23","article-title":"Pelvic inflammatory disease: a review of therapy","volume":"8","author":"Loucks","year":"1983","journal-title":"Nurse Pract."},{"key":"10.1016\/j.jep.2017.06.034_bib30","first-page":"236","article-title":"Effect of Smilax china bioactive fraction on tumor necrosis factor-alpha and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease","volume":"34","author":"Luo","year":"2014","journal-title":"J. South. Med. Univ."},{"key":"10.1016\/j.jep.2017.06.034_bib31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-5347(01)69139-0","article-title":"Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome","volume":"167","author":"Miller","year":"2002","journal-title":"J. Urol."},{"key":"10.1016\/j.jep.2017.06.034_bib32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0090-4295(01)01597-7","article-title":"Nerve growth factor and chronic prostatitis\/chronic pelvic pain syndrome","volume":"59","author":"Miller","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.jep.2017.06.034_bib33","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.idc.2013.08.004","article-title":"Pelvic inflammatory disease: current concepts in pathogenesis, diagnosis and treatment","volume":"27","author":"Mitchell","year":"2013","journal-title":"Infect. Dis. Clin. North. Am."},{"key":"10.1016\/j.jep.2017.06.034_bib34","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-5347(05)67497-6","article-title":"IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis","volume":"164","author":"Nadler","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.jep.2017.06.034_bib35","first-page":"815","article-title":"The pathogenesis of chronic inflammation and malignant transformation in the human upper airways: the role of beta-defensins, eNOS, cell proliferation and apoptosis","volume":"24","author":"Pacova","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jep.2017.06.034_bib36","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jep.2005.06.041","article-title":"Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice","volume":"102","author":"Park","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.06.034_bib37","first-page":"19","article-title":"Pharmacognostic study of Smilax china L. rhizome","volume":"21C","author":"Shah","year":"1962","journal-title":"J. Sci. Ind. Res. (C.)"},{"key":"10.1016\/j.jep.2017.06.034_bib38","first-page":"129","article-title":"Apoptosis and MMP-2, TIMP-2 expression in cleft lip and palate","volume":"15","author":"Smane","year":"2013","journal-title":"Stomatologija"},{"key":"10.1016\/j.jep.2017.06.034_bib39","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/00003081-195902030-00022","article-title":"Chronic pelvic inflammation and infertility","volume":"2","author":"Snaith","year":"1959","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.jep.2017.06.034_bib40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1530\/jrf.0.0950031","article-title":"Genetic susceptibility to chlamydial salpingitis and subsequent infertility in mice","volume":"95","author":"Tuffrey","year":"1992","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.jep.2017.06.034_bib41","doi-asserted-by":"crossref","first-page":"44448","DOI":"10.18632\/oncotarget.9844","article-title":"Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR\/ABL in hematopoietic cells","volume":"7","author":"Umezawa","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2017.06.034_bib42","first-page":"1043","article-title":"Analgesic and anti-inflammatory effects of hydroalcoholic extract isolated from semen vaccariae","volume":"28","author":"Wang","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2017.06.034_bib43","first-page":"92","article-title":"Experimental study on anti-inflammatory and analgesic effect of ManPenFang","volume":"50","author":"Ye","year":"2016","journal-title":"Shanghai J. TCM"},{"key":"10.1016\/j.jep.2017.06.034_bib44","first-page":"12539","article-title":"Notch1\/3 and p53\/p21 are a potential therapeutic target for APS-induced apoptosis in non-small cell lung carcinoma cell lines","volume":"8","author":"Zhang","year":"2015","journal-title":"Int J. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2017.06.034_bib45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/14786410701192637","article-title":"Antibacterial phenolic compounds from the spines of Gleditsia sinensis Lam","volume":"21","author":"Zhou","year":"2007","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2017.06.034_bib46","doi-asserted-by":"crossref","first-page":"39171","DOI":"10.18632\/oncotarget.10047","article-title":"IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116325351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874116325351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T08:51:38Z","timestamp":1535705498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874116325351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":46,"alternative-id":["S0378874116325351"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.06.034","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory effect of Man-Pen-Fang, a Chinese herbal compound, on chronic pelvic inflammation in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}