{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:58Z","timestamp":1792172398705,"version":"4.4.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Science and Technology (DST), Govt. of West Bengal","award":["117(Sanc)\/ST\/P\/S&T\/9G-08\/2012"],"award-info":[{"award-number":["117(Sanc)\/ST\/P\/S&T\/9G-08\/2012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jep.2017.08.017","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T03:47:02Z","timestamp":1503114422000},"page":"209-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases"],"prefix":"10.1016","volume":"210","author":[{"given":"Rana","family":"Adhikary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahin","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswadev","family":"Bishayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.08.017_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0076-6879(86)32005-6","article-title":"Basic methods for the study of phagocytosis","volume":"1986","author":"Absolom","year":"1986","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2017.08.017_bib2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2174\/138945011798109464","article-title":"Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases","volume":"12","author":"Aggarwal","year":"2011","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.jep.2017.08.017_bib3","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/ar2974","article-title":"A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis","volume":"12","author":"Arntz","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2017.08.017_bib4","first-page":"22","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-Hydroxy-2-Nonenal","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2017.08.017_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/10715769800300291","article-title":"Absorption and excretion of conjugated flavonols, including quercetin-41-O-beta-glucoside and isorhamnetin-41-O-beta-glucoside by human volunteers after the consumption of onions","volume":"29","author":"Aziz","year":"1998","journal-title":"Free. Radic. Res."},{"key":"10.1016\/j.jep.2017.08.017_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2017.08.017_bib7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/IAI.66.3.912-922.1998","article-title":"Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice","volume":"66","author":"Bergeron","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2017.08.017_bib8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.7897\/2230-8407.0512188","article-title":"In vitro antirheumatoid arthritic activity of aqueous root extract of Clitoria ternatea","volume":"5","author":"Bharathee","year":"2014","journal-title":"Int. Res. J. Pharm."},{"key":"10.1016\/j.jep.2017.08.017_bib9","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1093\/emboj\/19.18.4976","article-title":"Deficiency of I2K leads to apoptotic liver degradation and impaired NF-\u03baB dependent gene transcription","volume":"19","author":"Bonnard","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jep.2017.08.017_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2015.08.015","article-title":"Superoxide anion induced pain and inflammation depends on TNF\u03b1\/TNFR1 signaling in mice","volume":"605","author":"Borin","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2017.08.017_bib11","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nprot.2007.173","article-title":"Collagen-induced arthritis","volume":"5","author":"Brand","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2017.08.017_bib12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Method. Enzymol."},{"key":"10.1016\/j.jep.2017.08.017_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jep.2017.08.017_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12906-015-0546-2","article-title":"Inhibitory effect of Clitoria ternatea flower petal extract on fructose-induced protein glycation and oxidation-dependent damages to albumin in vitro","volume":"15","author":"Chayaratanasin","year":"2015","journal-title":"BMC Complement. Alt. Med."},{"key":"10.1016\/j.jep.2017.08.017_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2005.08.005","article-title":"Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT 1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia","volume":"521","author":"Chen","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2017.08.017_bib16","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s10753-016-0308-4","article-title":"Knockdown of TNFR1 suppresses expression of TLR2 in the cellular response to Staphylococcal aureus infection","volume":"39","author":"Chen","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2017.08.017_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1021624520740","article-title":"Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-\u03baB pathway in lipolysaccharide-stimulated macrophage","volume":"243","author":"Cho","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jep.2017.08.017_bib18","doi-asserted-by":"crossref","first-page":"35564","DOI":"10.1074\/jbc.M704003200","article-title":"TNFR1 and TNFR2 signaling interplay in cardiac myocytes","volume":"282","author":"Defer","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2017.08.017_bib19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.berh.2006.06.002","article-title":"Problems encountered during anti-tumour necrosis factor therapy","volume":"20","author":"Desai","year":"2006","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jep.2017.08.017_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10753-009-9107-5","article-title":"Repeated systemic Escherichia coli infection enhances anti-oxidant response in hypercholesterolemic mice inducing cardiovascular inflammation","volume":"32","author":"Dutta","year":"2009","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2017.08.017_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.2008.03634.x","article-title":"Redox signalling and the inflammatory response in rheumatoid arthritis","volume":"152","author":"Filippin","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jep.2017.08.017_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/antib4010048","article-title":"Targeting sTNF\/TNFR1 signaling as a new therapeutic strategy","volume":"4","author":"Fischer","year":"2015","journal-title":"Antibodies"},{"key":"10.1016\/j.jep.2017.08.017_bib23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.intimp.2013.11.010","article-title":"Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosia","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2017.08.017_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/10715760802005169","article-title":"The differential NF-\u03baB modulation by S-adenosyl- L-methionine. N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis","volume":"42","author":"GarcI\u2032a-Roma\u2032n","year":"2008","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.jep.2017.08.017_bib25","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1182\/blood-2010-11-322206","article-title":"A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils","volume":"117","author":"Geering","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jep.2017.08.017_bib26","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0002-9440(10)63560-2","article-title":"Receptor activator of nuclear factor-\u03baB ligand (RANKL)\/ Osteoprotegerin (OPG) ratio is increased in severe osteolysis","volume":"163","author":"Grimaud","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2017.08.017_bib27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/1874312901206010220","article-title":"c-Jun N-Terminal Kinase in inflammation and rheumatic diseases","volume":"6","author":"Guma","year":"2012","journal-title":"Open J. Rheumatol."},{"key":"10.1016\/j.jep.2017.08.017_bib28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1182\/blood-2008-03-139923","article-title":"Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor-2","volume":"113","author":"He","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jep.2017.08.017_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1189\/jlb.0310126","article-title":"Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis","volume":"88","author":"Huang","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jep.2017.08.017_bib30","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1158\/1078-0432.CCR-06-0360","article-title":"Antisense oligonucleotide inhibition of tumor necrosis factor receptor 1 protects the liver from radiation-induced apoptosis","volume":"12","author":"Huang","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jep.2017.08.017_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0031-9422(02)00486-7","article-title":"Malonylated flavonol glycosides from the petals of Clitoria ternatea","volume":"62","author":"Kazuma","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2017.08.017_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor Necrosis Factor-\u03b1 stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL\u2013RANK Interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jep.2017.08.017_bib33","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.4049\/jimmunol.148.10.3152","article-title":"Inhibition of tumor necrosis factor (TNF)-mediated NF-kappa B activation by selective blockade of the human 55-kDa TNF receptor","volume":"148","author":"Kruppa","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2017.08.017_bib34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri915","article-title":"Anti-inflammatory lipid mediators and insights into the resolution of inflammation","volume":"2","author":"Lawrence","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2017.08.017_bib35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000070037","article-title":"4- hydroxycinnamate lowers plasma and hepatic lipids without changing anti-oxidant enzyme activities","volume":"47","author":"Lee","year":"2003","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.jep.2017.08.017_bib36","first-page":"49","article-title":"Role of molecular oxygen in the generation of hydroxyl and superoxide anion radicals during enzymatic Cr (VI) reduction and its implication to Cr (VI)-induced carcinogenesis","volume":"19","author":"Leonard","year":"2000","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.jep.2017.08.017_bib37","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/ijms17060921","article-title":"Flavonoids as cytokine modulators: a possible therapy for inflammation-related diseases","volume":"17","author":"Leyva-L\u00f3pez","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2017.08.017_bib38","doi-asserted-by":"crossref","first-page":"R81","DOI":"10.1186\/ar3006","article-title":"Altered micro RNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis","volume":"12","author":"Li","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2017.08.017_bib39","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s10753-013-9808-7","article-title":"The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by Mycobacterium tuberculosis ESAT-6","volume":"37","author":"Liu","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2017.08.017_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2017.08.017_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12035-013-8425-7","article-title":"Role of the Toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway","volume":"48","author":"Lucas","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2017.08.017_bib42","doi-asserted-by":"crossref","first-page":"666","DOI":"10.4103\/0250-474X.100242","article-title":"Estimation of total phenols and flavonoids in extracts of Actaeas picata roots and antioxidant activity studies","volume":"73","author":"Madaan","year":"2011","journal-title":"Ind. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2017.08.017_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12263-014-0400-z","article-title":"Flavonoids in modulation of cell survival signalling pathways","volume":"9","author":"Mansuri","year":"2014","journal-title":"Genes Nutr."},{"key":"10.1016\/j.jep.2017.08.017_bib44","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/jn\/135.6.1359","article-title":"Quercetin attenuates nuclear factor-\u03baB activation and nitric oxide production in interleukin-1-b-activated rat hepatocytes","volume":"135","author":"MartI\u2032nez-Flo\u2032 rez","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.jep.2017.08.017_bib45","first-page":"2014","article-title":"TLR2 elicits IL-17-mediated RANKL expression, IL-17, and OPG production in neutrophils from arthritic mice","author":"Milanova","year":"2014","journal-title":"Medtr. Inflamm."},{"key":"10.1016\/j.jep.2017.08.017_bib46","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1084\/jem.20090687","article-title":"Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo","volume":"206","author":"Momi","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jep.2017.08.017_bib47","first-page":"31","article-title":"A single chain TNF receptor antagonist is an effective inhibitor of TNF mediated cytotoxicity","volume":"2","author":"Moosmayer","year":"1995","journal-title":"Ther. Immunol."},{"key":"10.1016\/j.jep.2017.08.017_bib48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jep.2008.09.009","article-title":"The Ayurvedic medicine Clitoria ternatea from traditional use to scientific assessment","volume":"120","author":"Mukherjee","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.08.017_bib49","first-page":"1229","article-title":"Chemical composition and anti-proliferative properties of flowers of Clitoria ternatea","volume":"20","author":"Neda","year":"2013","journal-title":"Int. Food Res. J."},{"key":"10.1016\/j.jep.2017.08.017_bib50","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jep.2007.10.025","article-title":"Antidiabetic activity of Vatairea macrocarpa extract in rats","volume":"115","author":"Oliveira","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.08.017_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00048","article-title":"Classical and paradoxical effects of TNF\u03b1 on bone homeostasis","volume":"5","author":"Osta","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2017.08.017_bib52","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/ar2137","article-title":"Differential expression of RANK, RANKL, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophils","volume":"9","author":"Poubelle","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2017.08.017_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0072156","article-title":"Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): receptor binding and in vitro bioactivity","volume":"8","author":"Richter","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.jep.2017.08.017_bib54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.autrev.2011.04.010","article-title":"Anti-TNF therapy: safety aspects of taking the risk","volume":"10","author":"Rosenblum","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jep.2017.08.017_bib55","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jn\/137.5.1208","article-title":"Quercetin inhibits TNF-induced NF-\u03baB transcription factor recruitment to pro-inflammatory gene promoters in murine intestinal epithelial cells","volume":"137","author":"Ruiz","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.jep.2017.08.017_bib56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12291-009-0007-0","article-title":"Multiple matrix metalloproteinases in type II collagen induced arthritis","volume":"24","author":"Sandya","year":"2009","journal-title":"Ind. J. Clin. Biochem."},{"key":"10.1016\/j.jep.2017.08.017_bib57","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Ann. Biochem"},{"key":"10.1016\/j.jep.2017.08.017_bib58","first-page":"15","article-title":"Total flavonoids of Bidens bipinnata L. ameliorate experimental adjuvant-induced arthritis through induction of synovial apoptosis","author":"Shen","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.jep.2017.08.017_bib59","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00005-011-0116-3","article-title":"Pathogenesis of joint destruction in rheumatoid arthritis","volume":"59","author":"Shiozawa","year":"2011","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.jep.2017.08.017_bib60","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/0031-9422(95)00383-I","article-title":"Syringetin 3-O-(6\u2032\u2019-acetyl)-\u03b2-glucopyranoside and other flavonols from needles of Norway spruce,\u00a0Picea abies","volume":"40","author":"Slimestad","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2017.08.017_bib61","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/art.23386","article-title":"Altered expression of Micro RNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis","volume":"58","author":"Stanczyk","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2017.08.017_bib62","first-page":"3","article-title":"Medicinal plants in treatment of arthritis","volume":"2","author":"Subramoniam","year":"2013","journal-title":"Ann. Phytomed."},{"key":"10.1016\/j.jep.2017.08.017_bib63","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/s30800276","article-title":"Measurement of nitric oxide production in biological systems by using Griess reaction assay","volume":"3","author":"Sun","year":"2003","journal-title":"Sensors"},{"key":"10.1016\/j.jep.2017.08.017_bib64","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-2999(02)02848-0","article-title":"Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential","volume":"459","author":"Tan","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2017.08.017_bib65","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0092-8674(93)90464-2","article-title":"A novel domain within the 55 KD TNF receptor signals cell death","volume":"74","author":"Tartaglia","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jep.2017.08.017_bib66","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/BSR20110089","article-title":"Tumour necrosis factor receptor trafficking dysfunction opens the TRAPS door to pro-inflammatory cytokine secretion","volume":"32","author":"Turner","year":"2012","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2017.08.017_bib67","first-page":"1560","article-title":"Evaluation of in-vitro anti-arthritic potential of aerial parts of Ipomoeapes caprae (L.) R. brand establishment of its mechanism of action","volume":"4","author":"Venkataraman","year":"2013","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"10.1016\/j.jep.2017.08.017_bib68","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S1473-3099(08)70227-5","article-title":"Tumour necrosis factor antagonists: structure, function, and tuberculosis risks","volume":"8","author":"Wallis","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jep.2017.08.017_bib69","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1146\/annurev.immunol.23.021704.115719","article-title":"Network communications: lymphotoxins, LIGHT, and TNF","volume":"23","author":"Ware","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2017.08.017_bib70","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.jep.2017.08.017_bib71","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.4049\/jimmunol.165.12.7240","article-title":"Evaluation of TNF\u03b1and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF\u03b1\/anti-CD-4 therapy","volume":"163","author":"Williams","year":"2000","journal-title":"J. Immunol."},{"issue":"352\u2013371","key":"10.1016\/j.jep.2017.08.017_bib72","article-title":"Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses","volume":"92","author":"Yang","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2017.08.017_bib73","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/cr.2013.75","article-title":"ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages","volume":"23","author":"Zhang","year":"2013","journal-title":"Cell. Res."},{"key":"10.1016\/j.jep.2017.08.017_bib74","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1074\/jbc.M008198200","article-title":"Tumor necrosis factor-\u03b1 (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 Receptor and RANK signaling pathways","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2017.08.017_bib75","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/0973-1296.186346","article-title":"Anti-arthritic effects of total flavonoids from Juniperus sabina on complete Freund's adjuvant induced arthritis in rats","volume":"12","author":"Zhao","year":"2016","journal-title":"Pharmacogn. Mag."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117302465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117302465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T04:33:06Z","timestamp":1692937986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874117302465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":75,"alternative-id":["S0378874117302465"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.08.017","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}