{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:16:04Z","timestamp":1782396964068,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81370339"],"award-info":[{"award-number":["81370339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81570206"],"award-info":[{"award-number":["81570206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Innovation Promoting Project","award":["TJSHG201510025005"],"award-info":[{"award-number":["TJSHG201510025005"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jep.2017.09.014","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T10:01:55Z","timestamp":1505383315000},"page":"434-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats"],"prefix":"10.1016","volume":"210","author":[{"given":"Zhiqiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.09.014_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0049-3848(80)90170-X","article-title":"Protective effect of ticlopidine on experimentally induced peripheral arterial occlusive disease in rats","volume":"18","author":"Ashida","year":"1980","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jep.2017.09.014_bib2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ijcard.2012.03.103","article-title":"Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism","volume":"167","author":"Biscetti","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2017.09.014_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1475-2840-8-49","article-title":"Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPAR\u03b3 stimulation","volume":"8","author":"Biscetti","year":"2009","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jep.2017.09.014_bib4","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2017.09.014_bib5","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S2213-8587(14)70144-5","article-title":"Diabetes in China: a societal solution for a personal challenge","volume":"2","author":"Chan","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jep.2017.09.014_bib6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.RES.0000232352.90786.fa","article-title":"Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and \u22129 in human type 2 diabetic arterial vasculature","volume":"99","author":"Chung","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2017.09.014_bib7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/labinvest.2014.12","article-title":"Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats","volume":"94","author":"Cui","year":"2014","journal-title":"Lab. Investig."},{"key":"10.1016\/j.jep.2017.09.014_bib8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/glycob\/cwm014","article-title":"A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds","volume":"17","author":"Cumashi","year":"2007","journal-title":"Glycobiology"},{"key":"10.1016\/j.jep.2017.09.014_bib9","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1161\/01.CIR.0000130172.62481.90","article-title":"In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion","volume":"109","author":"Durand","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2017.09.014_bib10","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/01.tp.0000261109.97928.9c","article-title":"Low molecular weight fucoidan prevents neointimal hyperplasia after aortic allografting","volume":"83","author":"Fr\u00e9guin-Bouilland","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.jep.2017.09.014_bib11","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.041359198","article-title":"Predominant role of endothelial nitric oxide synthase in VEGF-induced angiogenesis and vascular perm","volume":"98","author":"Gohongi","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jep.2017.09.014_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijcard.2015.06.070","article-title":"Fucoidan protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in a murine hindlimb ischemia model","volume":"198","author":"Han","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2017.09.014_bib13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCRESAHA.107.160630","article-title":"Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1","volume":"101","author":"Hazarika","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2017.09.014_bib14","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1089\/jmf.2013.0053","article-title":"Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults","volume":"17","author":"Hern\u00e1ndezcorona","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2017.09.014_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bcp.2010.09.021","article-title":"Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression","volume":"81","author":"Hlawaty","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2017.09.014_bib16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2017.09.014_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejvs.2011.07.015","article-title":"Cilostazol stimulates revascularisation in response to ischaemia via an eNOS-dependent mechanism","volume":"43","author":"Hori","year":"2012","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.jep.2017.09.014_bib18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1474-4422(08)70094-2","article-title":"Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study","volume":"7","author":"Huang","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2017.09.014_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jmri.22819","article-title":"Automated multiscale vessel analysis for the quantification of MR angiography of peripheral arteriogenesis","volume":"35","author":"Jaspers","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.jep.2017.09.014_bib20","doi-asserted-by":"crossref","first-page":"H3740","DOI":"10.1152\/ajpheart.00009.2007","article-title":"Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise","volume":"293","author":"Ji","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jep.2017.09.014_bib21","first-page":"2035","article-title":"Diabetes and cardiovascular disease: the Framingham study","volume":"35","author":"Kannel","year":"1979","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jep.2017.09.014_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yjmcc.2016.05.011","article-title":"Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease","volume":"97","author":"Lee","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2017.09.014_bib23","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.2337\/diacare.27.12.2843","article-title":"Peripheral arterial disease, diabetes, and mortality","volume":"27","author":"Leibson","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jep.2017.09.014_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jep.2016.06.054","article-title":"Low molecular weight fucoidan ameliorates streptozotocin-induced hyper-responsiveness of aortic smooth muscles in type 1 diabetes rats","volume":"191","author":"Liang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.014_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.102.046144","article-title":"Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hindlimb ischemia","volume":"305","author":"Luyt","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jep.2017.09.014_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2009.03.073","article-title":"Effects of prasugrel, a novel P2Y12 inhibitor, in rat models of cerebral and peripheral artery occlusive diseases","volume":"612","author":"Ogawa","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2017.09.014_bib27","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1017\/S000711451200606X","article-title":"Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects","volume":"110","author":"Ren","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jep.2017.09.014_bib28","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1016\/j.biomaterials.2008.03.026","article-title":"The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine","volume":"29","author":"Rocha","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jep.2017.09.014_bib29","first-page":"38","article-title":"Therapeutic effect of fucoidan-stimulated endothelial colony-forming cells in peripheral ischemia","volume":"10","author":"Sarlon","year":"2012"},{"key":"10.1016\/j.jep.2017.09.014_bib30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2176\/nmc.52.516","article-title":"Deterioration after surgical treatment of spinal dural arteriovenous fistula associated with spinal perimedullary fistula","volume":"52","author":"Sasaki","year":"2012","journal-title":"Neurol. Med.-Chir."},{"key":"10.1016\/j.jep.2017.09.014_bib31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S1474-4422(10)70198-8","article-title":"Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial","volume":"9","author":"Shinohara","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2017.09.014_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/157016112798829760","article-title":"The role of nitric oxide on endothelial function","volume":"10","author":"Tousoulis","year":"2012","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.jep.2017.09.014_bib33","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.2337\/db15-1668","article-title":"High density lipoproteins rescue diabetes-Impaired angiogenesis via scavenger receptor class B type I","volume":"65","author":"Tan","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2017.09.014_bib34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejphar.2006.02.048","article-title":"Effect of YM-254890, a specific Galphaq\/11 inhibitor, on experimental peripheral arterial disease in rats","volume":"536","author":"Uemura","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2017.09.014_bib35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nm0312-328","article-title":"Limb-saving medicines sought to prevent amputations","volume":"18","author":"Willyard","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2017.09.014_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S0192415X16500889","article-title":"Traditional Chinese medicine, food therapy, and hypertension control: a narrative review of Chinese literature","volume":"44","author":"Zou","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2017.09.014_bib37","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.thromres.2010.02.011","article-title":"Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation","volume":"125","author":"Zhu","year":"2010","journal-title":"Thromb. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117321165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117321165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T18:01:23Z","timestamp":1535392883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874117321165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":37,"alternative-id":["S0378874117321165"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.09.014","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}