{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:11:50Z","timestamp":1791475910022,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Secretar\u00eda General de Ciencia y T\u00e9cnica","award":["17\/12F010"],"award-info":[{"award-number":["17\/12F010"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jep.2017.09.015","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T16:46:11Z","timestamp":1506012371000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["The effects of Cissampelos pareira extract on envenomation induced by Bothropsdiporus snake venom"],"prefix":"10.1016","volume":"212","author":[{"given":"B\u00e1rbara","family":"Ricciardi Verrastro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Maria Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Teibler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Maru\u00f1ak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Barnaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Larcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Dellacassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.09.015_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3923\/jbs.2016.112.119","article-title":"Beneficial role of quercetin on Echiscoloratus snake venom induced hepatorenal toxicity in rats","volume":"16","author":"Al Asmari","year":"2016","journal-title":"J. Biol. Sci."},{"key":"10.1016\/j.jep.2017.09.015_bib2","first-page":"71","article-title":"Chemomodulatory influence of Cissampelos pareira (L.) Hirsuta on gastric cancer and antioxidant system in experimental animal","volume":"49","author":"Amresh","year":"2007","journal-title":"Acta Pharm. Sci."},{"key":"10.1016\/j.jep.2017.09.015_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jep.2006.10.009","article-title":"Evaluation of anti-inflammatory activity of Cissampelos pareira root in rats","volume":"110","author":"Amresh","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jep.2006.12.026","article-title":"Antinociceptive and antiarthritic activity of Cissampelos pareira roots","volume":"111","author":"Amresh","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib5","first-page":"38","article-title":"An inside review of Cissampelos pareira Linn: a potential medicinal plant of India","volume":"3","author":"Arora","year":"2012","journal-title":"Int. Res. J. Pharm."},{"key":"10.1016\/j.jep.2017.09.015_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1590\/S0104-79302001000100006","article-title":"Venomous snake bites in children and adolescents: a 12 year retrospective review","volume":"7","author":"Avila-Aguero","year":"2001","journal-title":"J. Venom. Anim. Toxins"},{"key":"10.1016\/j.jep.2017.09.015_bib7","first-page":"S1028","article-title":"Efecto de plantas usadas etnom\u00e9dicamente sobre la actividad hemorr\u00e1gica y proteol\u00edtica inducida por Bothrops asper","volume":"11","author":"Badilla Baltodano","year":"2006","journal-title":"Rev. Cuba. Plantas Med."},{"key":"10.1016\/j.jep.2017.09.015_bib8","first-page":"27","article-title":"Effects of an extract of Cissampelospareira on the hemorrhagic and proteolytic activities from Bothropsasper venom","volume":"4","author":"Badilla","year":"2008","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.jep.2017.09.015_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2015.10.085","article-title":"Identification and quantification of 56 targeted phenols in wines, spirits, and vinegars by online solid-phase extraction\u2013ultrahigh-performance liquid chromatography-quadrupole-orbitrap mass spectrometry","volume":"1423","author":"Barnaba","year":"2015","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jep.2017.09.015_bib10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.foodchem.2016.03.040","article-title":"Free and glycosylated simple phenol profiling in Apulian Italian wines","volume":"206","author":"Barnaba","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2017.09.015_bib11","first-page":"140","article-title":"Preliminary biological evaluation of plants extracts used in the Sierra Nevada de Santa Marta against the snake Bothrops asper venom","volume":"9","author":"Barranco P\u00e9rez","year":"2010","journal-title":"Rev. Fac. Cien. Sal."},{"key":"10.1016\/j.jep.2017.09.015_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1254\/jjp.20.246","article-title":"Studies on curariform activity of hayatininmethochloride, an alkaloid of Cissampelos pareira","volume":"20","author":"Basu","year":"1970","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib13","series-title":"Envenenamiento por animales ponzo\u00f1osos","author":"Bolet\u00edn Epidemiol\u00f3gico Peri\u00f3dico","year":"2009"},{"key":"10.1016\/j.jep.2017.09.015_bib14","unstructured":"Camargo, F., Torres, A., Ricciardi, G., Ricciardi, A., Dellacassa, E., 2011. SDS PAGE: A Useful Tool for Preliminary Screening of Antisnake Activity of Plant Extracts. B. Latinoam. Caribe Pl. 10, pp. 429\u2013434."},{"key":"10.1016\/j.jep.2017.09.015_bib15","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.biopha.2017.02.080","article-title":"Protective effect of Dracontium dubium against Bothrops asper venom","volume":"89","author":"Caro","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2017.09.015_bib16","series-title":"Complementary Pediatrics","first-page":"123","article-title":"Snake bites in pediatric patients, a current view","author":"Cavazos","year":"2012"},{"key":"10.1016\/j.jep.2017.09.015_bib17","first-page":"554","article-title":"Some common ethnomedicinal uses of various diseases in Purulia district, West Bengal","volume":"5","author":"Chakraborty","year":"2006","journal-title":"Ind. J. Trad. Knowl."},{"key":"10.1016\/j.jep.2017.09.015_bib18","first-page":"515","article-title":"Snake-bites: appraisal of the global situation","volume":"76","author":"Chippaux","year":"1998","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jep.2017.09.015_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jep.2014.12.020","article-title":"Plants used to treat snakebites in Santar\u00e9m, western Par\u00e1, Brazil: an assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom","volume":"161","author":"De Moura","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib20","first-page":"1","article-title":"Potential antiophidian botanicals from the canning sub-division of the District South 24 Parganas, West Bengal, India","volume":"3","author":"Dey","year":"2013","journal-title":"Insight Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/jcim-2012-0058","article-title":"Detoxification of Echisocellatus venom induced toxicity by Annona senegalensis Pers","volume":"11","author":"Emmanuel","year":"2014","journal-title":"J. Complement. Integr. Med."},{"key":"10.1016\/j.jep.2017.09.015_bib22","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.2042-7158.1962.tb11139.x","article-title":"Pharmacological screening of some West Indian medicinal plants","volume":"14","author":"Feng","year":"1962","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jep.2017.02.011","article-title":"Medicinal plants used to treat snakebite in Central America: review and assessment of scientific evidence","volume":"199","author":"Giovannini","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6101742","article-title":"Aqueous leaf extract of Jatropha mollissima (Pohl) Bail decreases local effects induced by Bothropic venom","author":"Gomes","year":"2016","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.jep.2017.09.015_bib25","unstructured":"Gonz\u00e1lez Torres, D., 2005. Cat\u00e1logo de plantas medicinales (y alimenticias y \u00fatiles) usadas en Paraguay. Editorial Servilibro, Asunci\u00f3n, pp. 258."},{"key":"10.1016\/j.jep.2017.09.015_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/macp.1956.020210103","article-title":"Chromatography of phenols on polyamides","volume":"21","author":"Grassmann","year":"1956","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.jep.2017.09.015_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0041-0101(88)90010-4","article-title":"An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica","volume":"26","author":"Guti\u00e9rrez","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2017.09.015_bib28","first-page":"377","article-title":"Comprendiendo los venenos de serpientes: 50 a\u00f1os de investigaciones en America Latina","volume":"50","author":"Gutierrez","year":"2002","journal-title":"Rev. Biol. Trop."},{"key":"10.1016\/j.jep.2017.09.015_bib29","unstructured":"Houghton, P., 1993. In vitro testing of some West African and Indian plants used to treat snakebites. M\u00e9dicament et nutrition: L\u2019approche ethnopharmacologique. Actas del 2\u00b0 Colloque Europ\u00e9en d\u2019Ethnopharmacologie, Heidelberg, pp. 263\u2013274."},{"key":"10.1016\/j.jep.2017.09.015_bib30","series-title":"El laboratorio en la pr\u00e1ctica cl\u00ednica","first-page":"168","author":"Iovine","year":"1985"},{"key":"10.1016\/j.jep.2017.09.015_bib31","first-page":"763","article-title":"Indigenous uses of economically important flora of Margallah Hills National Park, Islamabad, Pakistan","volume":"8","author":"Jabeen","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.jep.2017.09.015_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1248\/cpb.38.297","article-title":"Structure of rutinpentamethanol","volume":"38","author":"Jin","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2017.09.015_bib33","doi-asserted-by":"crossref","unstructured":"Jolis, J., 1789. Saggio sulla storia natural e della provincia del Gran Chaco e sulle pratiche, e su' costumi dei popoli che l\u2032abitano. Tomo 1. Ed. Lodovico Genestri, Faenza.","DOI":"10.5962\/bhl.title.104745"},{"key":"10.1016\/j.jep.2017.09.015_bib34","first-page":"296","article-title":"Folklore claims on snakebite among some tribal communities of Central India","volume":"7","author":"Kadel","year":"2008","journal-title":"Ind. J. Trad. Knowl."},{"key":"10.1016\/j.jep.2017.09.015_bib35","first-page":"494","article-title":"Additions to the traditional folk herbal medicines from Shekhawati region of Rajasthan","volume":"5","author":"Katewa","year":"2006","journal-title":"Ind. J. Trad. Knowl."},{"key":"10.1016\/j.jep.2017.09.015_bib36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.09.015_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0041-0101(94)90020-5","article-title":"The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron microscopic study","volume":"32","author":"Lomonte","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2017.09.015_bib38","unstructured":"Manfred, L., 2014. 7000 recetas bot\u00e1nicas a base de 1300 plantas medicinales americanas. Ed. Kier, Buenos Aires."},{"key":"10.1016\/j.jep.2017.09.015_bib39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.30972\/vet.2111849","article-title":"Acci\u00f3n del veneno de Bothrops diporus (yarar\u00e1 chica) del nordeste argentino sobre la hemostasia en diferentes mam\u00edferos","volume":"21","author":"Maru\u00f1ak","year":"2010","journal-title":"Rev. Vet."},{"key":"10.1016\/j.jep.2017.09.015_bib40","series-title":"Materia m\u00e9dica misionera","author":"Montenegro","year":"2007"},{"key":"10.1016\/j.jep.2017.09.015_bib41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0031-9422(00)00229-6","article-title":"Plant natural products active against snake bite- the molecular approach","volume":"55","author":"Mors","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2017.09.015_bib42","first-page":"256","article-title":"Modeling studies on phospholipase A2 \u2013 inhibitor complexes","volume":"45","author":"Nirmal","year":"2008","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.jep.2017.09.015_bib43","first-page":"55","article-title":"Antisnake venom activity of flavonoids from the root bark extract of Parina ricuratellifolia in mice","volume":"4","author":"Omale","year":"2012","journal-title":"Int. J. Pharm. Res."},{"key":"10.1016\/j.jep.2017.09.015_bib44","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0041-0101(95)00009-B","article-title":"Ability of six Latin American antivenoms to neutralize the venom of mapan\u00e1equis Bothrop satrox. from Antioquia and Choc\u00f3 Colombia","volume":"33","author":"Otero","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2017.09.015_bib45","first-page":"57","article-title":"Electrophoretic analysis tricine-SDS-PAGE of bovine caseins","volume":"21","author":"Pardo","year":"2002","journal-title":"Acta Farm. Bonaer."},{"key":"10.1016\/j.jep.2017.09.015_bib46","series-title":"Caracterizaci\u00f3n funcional y estructural de prote\u00ednas","volume":"159","author":"Pilosof","year":"2000"},{"key":"10.1016\/j.jep.2017.09.015_bib47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jep.2003.10.014","article-title":"Anti-venom potential of butanolic extract of Eclipta prostrata against Malayanpitvipervenom","volume":"90","author":"Pithayanukul","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib48","first-page":"91","article-title":"Etnobot\u00e1nica y ecolog\u00eda de plantas utilizadas por tres curanderos contra la mordedura de serpiente en la regi\u00f3n de Acayucan, Veracruz, M\u00e9xico","volume":"81","author":"Ramos-Hernandez","year":"2007","journal-title":"Bol. Soc. Bot. Mex."},{"key":"10.1016\/j.jep.2017.09.015_bib49","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1078\/0944-7113-00020","article-title":"Evaluation of biological activity of crude extracts from plants used in Yucatecan traditional medicine Part I: antioxidant, antimicrobial and beta-glucosidase inhibition activities","volume":"8","author":"Sanchez-Medina","year":"2001","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2017.09.015_bib50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/08923970802279019","article-title":"Inhibitors of snake venoms and development of new therapeutics","volume":"30","author":"S\u00e1nchez","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2017.09.015_bib51","first-page":"1089","article-title":"Ethnobotanical study of medicinal plants used by traditional users in Villupuram district of Tamil Nadu, India","volume":"4","author":"Sankaranarayanan","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.jep.2017.09.015_bib52","first-page":"2409","article-title":"Evaluaci\u00f3n de la capacidad neutralizante de extractos de plantas de uso popular en Guatemala como ant\u00eddotos para el envenenamiento por la mordedura de Bothrops asper","volume":"2","author":"Saravia-Otten","year":"2015","journal-title":"Cienc. Tecnol. Salud"},{"key":"10.1016\/j.jep.2017.09.015_bib53","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jep.2014.06.054","article-title":"From arrow poison to herbal medicine- The ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae)","volume":"155","author":"Semwal","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.09.015_bib54","first-page":"114","article-title":"An inside preview of ethnopharmacology of Cissampelos pareira Linn","volume":"1","author":"Singh","year":"2010","journal-title":"Int. J. Biol. Technol."},{"key":"10.1016\/j.jep.2017.09.015_bib55","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.2174\/092986705774370655","article-title":"Medicinal plants with inhibitory properties against snake venoms","volume":"12","author":"Soares","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2017.09.015_bib56","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/2225-4110.114902","article-title":"Effect of Cissampelos pareira leaves on anxiety-like behavior in experimental animals","volume":"3","author":"Thakur","year":"2013","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jep.2017.09.015_bib57","series-title":"Chemotaxonomic Characterization of Species Belonging to the Genus Nectandra in the Argentine Northeast. Evaluation of Its Antivenom Potential in Accidents Caused by Bothrops Neuwiedii Diporus (Ph.D. thesis)","author":"Torres","year":"2012"},{"key":"10.1016\/j.jep.2017.09.015_bib58","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/10412905.2014.882277","article-title":"Nectandra megapotamica (Spreng.) Mez.: phytochemical characterization and neutralizing effect on Bothrops diporus venom","volume":"26","author":"Torres","year":"2014","journal-title":"J. Essent. Oil Res."},{"key":"10.1016\/j.jep.2017.09.015_bib59","first-page":"60","article-title":"Implications of phytochemicals in snakebite management: present status and future prospective","volume":"33","author":"Urs","year":"2014","journal-title":"Toxin Rev."},{"key":"10.1016\/j.jep.2017.09.015_bib60","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.2174\/156802611797633438","article-title":"Protective effect of Schizolobium parahyba flavonoids against snake venoms and isolated toxins","volume":"11","author":"Vale","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jep.2017.09.015_bib61","series-title":"Progress in the Characterization of Venoms and Standardization of Antivenoms","author":"World Health Organization","year":"1981"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117317956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117317956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T22:55:37Z","timestamp":1602975337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874117317956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":61,"alternative-id":["S0378874117317956"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.09.015","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of Cissampelos pareira extract on envenomation induced by Bothropsdiporus snake venom","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}