{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:26:24Z","timestamp":1778019984589,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403041"],"award-info":[{"award-number":["81403041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603258"],"award-info":[{"award-number":["81603258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20140961"],"award-info":[{"award-number":["BK20140961"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB505300"],"award-info":[{"award-number":["2011CB505300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB505303"],"award-info":[{"award-number":["2011CB505303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jep.2017.11.031","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T23:32:43Z","timestamp":1512171163000},"page":"71-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Gancao-Gansui combination impacts gut microbiota diversity and related metabolic functions"],"prefix":"10.1016","volume":"214","author":[{"given":"Jingao","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erxin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhe","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Yue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2017.11.031_bib1","doi-asserted-by":"crossref","first-page":"e0148824","DOI":"10.1371\/journal.pone.0148824","article-title":"An integrated metabolomic and microbiome analysis identified specific gut microbiota associated with fecal cholesterol and coprostanol in clostridium difficile infection","volume":"11","author":"Antharam","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2017.11.031_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.freeradbiomed.2016.01.028","article-title":"Detrimental effects for colonocytes of an increased exposure to luminal hydrogen sulfide: the adaptive response","volume":"93","author":"Beaumont","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2017.11.031_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00726-009-0445-2","article-title":"Luminal sulfide and large intestine mucosa: friend or foe?","volume":"39","author":"Blachier","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.jep.2017.11.031_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.2276","article-title":"Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing","volume":"10","author":"Bokulich","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jep.2017.11.031_bib5","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2017.11.031_bib6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.cell.2010.05.009","article-title":"Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine","volume":"141","author":"Cadwell","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jep.2017.11.031_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11655-011-0609-2","article-title":"Research on frequency of application with modern Chinese herbal medicine","volume":"17","author":"Cai","year":"2011","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2017.11.031_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fphar.2016.00385","article-title":"The role of hydrogen sulfide in renal system","volume":"7","author":"Cao","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2017.11.031_bib9","doi-asserted-by":"crossref","first-page":"e0168027","DOI":"10.1371\/journal.pone.0168027","article-title":"Euphorbia Kansui Reactivates Latent HIV","volume":"11","author":"Cary","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2017.11.031_bib10","doi-asserted-by":"crossref","first-page":"e0148028","DOI":"10.1371\/journal.pone.0148028","article-title":"Comparing apples and oranges?: Next generation sequencing and its impact on microbiome analysis","volume":"11","author":"Clooney","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2017.11.031_bib11","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1096\/fj.02-0883fje","article-title":"Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells","volume":"17","author":"Deplancke","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2017.11.031_bib12","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2017.11.031_bib13","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2017.11.031_bib14","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1096\/fj.14-266015","article-title":"Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1\u03b1","volume":"29","author":"Flannigan","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2017.11.031_bib15","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.phymed.2014.07.006","article-title":"Data mining and frequency analysis for licorice as a \u201ctwo-Face\u201d herb in Chinese Formulae based on Chinese Formulae Database","volume":"21","author":"Guo","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2017.11.031_bib16","series-title":"A Materia Medica for Chinese Medicine","first-page":"84","article-title":"Herbs that purge and drain","author":"Hempen","year":"2009"},{"key":"10.1016\/j.jep.2017.11.031_bib17","series-title":"Molecular Biology and Pathogenicity of Mycoplasmas","first-page":"221","article-title":"Mycoplasmas and the minimal genome concept","author":"Hutchison","year":"2002"},{"key":"10.1016\/j.jep.2017.11.031_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yrtph.2006.06.002","article-title":"Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin","volume":"46","author":"Isbrucker","year":"2006","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2017.11.031_bib19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0196-9781(96)00333-6","article-title":"Motilin and clinical application","volume":"18","author":"Itoh","year":"1997","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2017.11.031_bib20","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1007\/s13197-012-0847-0","article-title":"Spray drying of liquorice (Glycyrrhiza glabra) extract","volume":"51","author":"Karaaslan","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.jep.2017.11.031_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature13960","article-title":"An enteric virus can replace the beneficial function of commensal bacteria","volume":"516","author":"Kernbauer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.11.031_bib22","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2017.11.031_bib23","doi-asserted-by":"crossref","first-page":"7620817","DOI":"10.1155\/2016\/7620817","article-title":"Effect of glycyrrhiza on the diuretic function of Euphorbia kansui: an Ascites mouse model","volume":"2016","author":"Lin","year":"2016","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2017.11.031_bib24","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1021\/jf000772e","article-title":"Constituents and their sweetness of food additive enzymatically modified licorice extract","volume":"48","author":"Liu","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2017.11.031_bib25","series-title":"Essentials of Chinese Medicine","first-page":"285","article-title":"Basic principles of CM herbal formulation","author":"Liu","year":"2010"},{"key":"10.1016\/j.jep.2017.11.031_bib26","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jep.2017.11.031_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2116\/analsci.32.581","article-title":"Bioassay-guided separation of anti-tumor components from Euphorbia kansui by means of two-dimensional preparative high performance liquid chromatography and real-time cell analysis","volume":"32","author":"Ma","year":"2016","journal-title":"Anal. Sci."},{"key":"10.1016\/j.jep.2017.11.031_bib28","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2017.11.031_bib29","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"Markle","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jep.2017.11.031_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/187221313804004727","article-title":"Effects of amine oxidases in allergic and histamine-mediated conditions","volume":"7","author":"Mondovi","year":"2013","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"10.1016\/j.jep.2017.11.031_bib31","first-page":"275","article-title":"Neutral sterol excretions in rats fed skim milk and skim milk yogurt diets","volume":"46","author":"Navder","year":"1992","journal-title":"Indian J. Med. Sci."},{"key":"10.1016\/j.jep.2017.11.031_bib32","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1021\/pr300637d","article-title":"Gut microbial activity, implications for health and disease: the potential role of metabolite analysis","volume":"11","author":"Nyangale","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jep.2017.11.031_bib33","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2017.11.031_bib34","doi-asserted-by":"crossref","first-page":"3285074","DOI":"10.1155\/2016\/3285074","article-title":"Implications of hydrogen sulfide in glucose regulation: how H2S can alter glucose homeostasis through metabolic hormones","volume":"2016","author":"Pichette","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2017.11.031_bib35","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.tvjl.2004.08.011","article-title":"Mycoplasma host specificity: fact or fiction?","volume":"170","author":"Pitcher","year":"2005","journal-title":"Vet. J."},{"key":"10.1016\/j.jep.2017.11.031_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.39.1.1","article-title":"Hydrogen sulphide: a bacterial toxin in ulcerative colitis?","volume":"39","author":"Pitcher","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.jep.2017.11.031_bib37","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1099\/ijs.0.63472-0","article-title":"Mucispirillum schaedleri gen. nov., sp. nov., a spiral-shaped bacterium colonizing the mucus layer of the gastrointestinal tract of laboratory rodents","volume":"55","author":"Robertson","year":"2005","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.jep.2017.11.031_bib38","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jep.2017.11.031_bib39","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nature13398","article-title":"High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity","volume":"514","author":"Schulz","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.11.031_bib40","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.jep.2017.11.031_bib41","doi-asserted-by":"crossref","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jep.2017.11.031_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1142\/S0192415X16500154","article-title":"The Chemical and Biological Properties of Euphorbia kansui","volume":"44","author":"Shen","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2017.11.031_bib43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.chroma.2013.05.001","article-title":"Analysis of herb-herb interaction when decocting together by using ultra-high-performance liquid chromatography-tandem mass spectrometry and fuzzy chemical identification strategy with poly-proportion design","volume":"1297","author":"Shen","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2017.11.031_bib44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jep.2016.04.012","article-title":"The dosage-toxicity-efficacy relationship of kansui and licorice in malignant pleural effusion rats based on factor analysis","volume":"186","author":"Shen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.11.031_bib45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2013.02.024","article-title":"Microbial regulation of host hydrogen sulfide bioavailability and metabolism","volume":"60","author":"Shen","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2017.11.031_bib46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox Biology of Hydrogen Sulfide: implications for Physiology, Pathophysiology, and Pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2017.11.031_bib47","doi-asserted-by":"crossref","unstructured":"Su, G., Morris, J.H., Demchak, B., Bader, G.D., 2014. Biological network exploration with Cytoscape 3. In: Current Protocols in Bioinformatics. John Wiley & Sons, Inc., Hoboken, NJ, USA, pp. 8.13.1\u20138.13.24. \u3008http:\/\/doi.org\/10.1002\/0471250953.bi0813s47\u3009.","DOI":"10.1002\/0471250953.bi0813s47"},{"key":"10.1016\/j.jep.2017.11.031_bib48","doi-asserted-by":"crossref","unstructured":"Toledo, A., Benach, J.L., 2015. Hijacking and use of host lipids by intracellular pathogens. In: Virulence Mechanisms of Bacterial Pathogens. Fifth Edition. American Society of Microbiology, pp. 637\u2013666. \u3008http:\/\/doi.org\/10.1128\/microbiolspec.VMBF-0001-2014\u3009.","DOI":"10.1128\/microbiolspec.VMBF-0001-2014"},{"key":"10.1016\/j.jep.2017.11.031_bib49","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3390\/molecules21111558","article-title":"Gut bacteria and hydrogen sulfide: the new old players in circulatory system homeostasis","volume":"21","author":"Tomasova","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2017.11.031_bib50","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.11.031_bib51","doi-asserted-by":"crossref","first-page":"e89312","DOI":"10.1371\/journal.pone.0089312","article-title":"Metabolomic analysis of three Mollicute species","volume":"9","author":"Vanyushkina","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2017.11.031_bib52","doi-asserted-by":"crossref","first-page":"18132","DOI":"10.1073\/pnas.1011737107","article-title":"Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes","volume":"107","author":"Veiga","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jep.2017.11.031_bib53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/ars.2011.4351","article-title":"Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury","volume":"17","author":"Wallace","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"569\u201378","key":"10.1016\/j.jep.2017.11.031_bib54","first-page":"578.e1","article-title":"Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats","volume":"137","author":"Wallace","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2017.11.031_bib55","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jep.2017.11.031_bib56","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jep.2013.09.055","article-title":"Liquorice, a unique \u201cguide drug\u201d of traditional Chinese medicine: a review of its role in drug interactions","volume":"150","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2017.11.031_bib57","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of Type 1 diabetes","volume":"455","author":"Wen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.11.031_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000171432","article-title":"Diamine oxidase: an overview of historical, biochemical and functional aspects","volume":"12","author":"Wolvekamp","year":"1994","journal-title":"Dig. Dis."},{"key":"10.1016\/j.jep.2017.11.031_bib59","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1007\/s00253-015-7257-y","article-title":"Comparison of the fecal microbiota of dholes high-throughput Illumina sequencing of the V3-V4 region of the 16S rRNA gene","volume":"100","author":"Wu","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jep.2017.11.031_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/med.21431","article-title":"Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota","author":"Xu","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2017.11.031_bib61","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/482035d","article-title":"Asian medicine: call for more safety data","volume":"482","author":"Xu","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.11.031_bib62","doi-asserted-by":"crossref","first-page":"26924","DOI":"10.1038\/srep26924","article-title":"Effect of the interaction of Veratrum nigrum with Panax ginseng on estrogenic activity in vivo and in vitro","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2017.11.031_bib63","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3390\/molecules21060813","article-title":"An ingenol derived from Euphorbia kansui induces hepatocyte cytotoxicity by triggering G0\/G1 cell cycle arrest and regulating the mitochondrial apoptosis pathway in vitro","volume":"21","author":"Yan","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2017.11.031_bib64","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jep.2017.11.031_bib65","doi-asserted-by":"crossref","first-page":"892797","DOI":"10.1155\/2014\/892797","article-title":"The correlation between chemical composition, as determined by UPLC-TOF-MS, and acute toxicity of Veratrum nigrum L. and Radix paeoniae alba","volume":"2014","author":"Zhang","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2017.11.031_bib66","doi-asserted-by":"crossref","first-page":"594","DOI":"10.7150\/ijbs.14151","article-title":"Revealing the effects of the herbal pair of Euphorbia kansui and Glycyrrhiza on hepatocellular carcinoma ascites with integrating network target analysis and experimental validation","volume":"12","author":"Zhang","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2017.11.031_bib67","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ismej.2013.185","article-title":"Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota","volume":"8","author":"Zhang","year":"2014","journal-title":"ISME J."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117312874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117312874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T16:42:37Z","timestamp":1589820157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874117312874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":67,"alternative-id":["S0378874117312874"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2017.11.031","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gancao-Gansui combination impacts gut microbiota diversity and related metabolic functions","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2017.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}