{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:44:27Z","timestamp":1792856667662,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573580"],"award-info":[{"award-number":["81573580"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Polysaccharide Bioactivity Evaluation of TCM of Liaoning Province"},{"name":"Key Laboratory of Quality Control of TCM of Liaoning Province","award":["17\u2013137-1-00"],"award-info":[{"award-number":["17\u2013137-1-00"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jep.2018.02.015","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:40:16Z","timestamp":1518439216000},"page":"98-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Protective effects of Alpinae Oxyphyllae Fructus extracts on lipopolysaccharide-induced animal model of Alzheimer's disease"],"prefix":"10.1016","volume":"217","author":[{"given":"Yunlong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongde","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaishun","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2018.02.015_bib1","doi-asserted-by":"crossref","first-page":"7039816","DOI":"10.1155\/2017\/7039816","article-title":"Nutrition and AGE-ing: focusing on Alzheimer's disease","volume":"2017","author":"Abate","year":"2017","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.jep.2018.02.015_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1073\/pnas.81.24.7907","article-title":"Nucleotide sequence of human monocyte interleukin 1 precursor cDNA","volume":"81","author":"Auron","year":"1984","journal-title":"Proc. Nati. Acad. Sci."},{"issue":"2","key":"10.1016\/j.jep.2018.02.015_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.expneurol.2005.08.001","article-title":"Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides","volume":"196","author":"Awasthi","year":"2005","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.jep.2018.02.015_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3233\/JAD-2012-120571","article-title":"Amyloid-beta and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model","volume":"32","author":"Bitel","year":"2012","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.jep.2018.02.015_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tips.2015.03.002","article-title":"Amyloid biomarkers in Alzheimer's disease","volume":"36","author":"Blennow","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2018.02.015_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MCO.0b013e32835ada13","article-title":"Inflamm-ageing","volume":"16","author":"Cevenini","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.jep.2018.02.015_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbi.2016.10.021","article-title":"Preventive effect of genetic knockdown and pharmacological blockade of CysLT1R on lipopolysaccharide (LPS)-induced memory deficit and neurotoxicity in vivo","volume":"60","author":"Chen","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.jep.2018.02.015_bib8","first-page":"8","article-title":"Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease","volume":"155","author":"Christine Stadelmann","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2018.02.015_bib9","series-title":"Chinese Pharmacopeia","author":"Commission","year":"2015"},{"issue":"1","key":"10.1016\/j.jep.2018.02.015_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/glia.22350","article-title":"Microglia and neurodegeneration: the role of systemic inflammation","volume":"61","author":"Cunningham","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.jep.2018.02.015_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1742-2094-7-56","article-title":"LPS- induced inflammation exacerbates phosphotau pathology in rTg4510 mice","volume":"7","author":"Daniel C Lee","year":"2010","journal-title":"J. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.jep.2018.02.015_bib12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbadis.2015.11.002","article-title":"Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain","volume":"1862","author":"Dasuri","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2018.02.015_bib13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.jep.2018.02.015_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000283480","article-title":"Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease","volume":"7","author":"Eikelenboom","year":"2010","journal-title":"Neurodegener. Dis."},{"issue":"4","key":"10.1016\/j.jep.2018.02.015_bib15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0928-0987(03)00118-0","article-title":"Development of sesquiterpenes from Alpinia oxyphylla as novel skin permeation enhancers","volume":"19","author":"Fang","year":"2003","journal-title":"Eur. J. Pharm. Sci."},{"issue":"9","key":"10.1016\/j.jep.2018.02.015_bib16","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/gerona\/glw240","article-title":"Chronic inflammation: accelerator of biological aging","volume":"72","author":"Fougere","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2018.02.015_bib17","first-page":"S79","article-title":"Amyloid-beta and cognition in aging and Alzheimer's disease: molecular and neurophysiological mechanisms","volume":"33","author":"Hampel","year":"2013","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.jep.2018.02.015_bib18","first-page":"39","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Haruhiko Akiyama","year":"2000"},{"issue":"6","key":"10.1016\/j.jep.2018.02.015_bib19","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jep.2018.02.015_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1248\/cpb.54.377","article-title":"Suppression of inducible nitric oxide synthase expression by Yakuchinones and their analogues","volume":"54","author":"Hwa Jin Lee","year":"2006","journal-title":"Chem. Pharm. Bull."},{"issue":"1998","key":"10.1016\/j.jep.2018.02.015_bib21","first-page":"57","article-title":"Microglia-specific localisation of a novel calcium binding protein, Iba1","volume":"57","author":"Ito","year":"1998","journal-title":"Mol. Brain Res."},{"issue":"13","key":"10.1016\/j.jep.2018.02.015_bib22","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1016\/j.bmcl.2013.04.072","article-title":"New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia","volume":"23","author":"Jiang","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.jep.2018.02.015_bib23","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.nbd.2004.12.004","article-title":"Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease","volume":"18","author":"Kang","year":"2005","journal-title":"Neurobiol. Dis."},{"issue":"9","key":"10.1016\/j.jep.2018.02.015_bib24","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00018-016-2147-8","article-title":"Inflammation and its role in age-related macular degeneration","volume":"73","author":"Kauppinen","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"39","key":"10.1016\/j.jep.2018.02.015_bib25","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.jep.2018.02.015_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ptr.1382","article-title":"Protective effects of alpinae oxyphyllae fructus (Alpinia oxyphylla MIQ) water-extracts on neurons from ischemic damage and neuronal cell toxicity","volume":"18","author":"Koo","year":"2004","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2018.02.015_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-2094-5-37","article-title":"Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation","volume":"5","author":"Lee","year":"2008","journal-title":"J. Neuroinflamm."},{"issue":"7082","key":"10.1016\/j.jep.2018.02.015_bib28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A specific amyloid-beta protein assembly in the brain impairs memory","volume":"440","author":"Lesne","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jep.2018.02.015_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.intimp.2014.10.028","article-title":"5-Hydroxymethylfurfural, an antioxidant agent from Alpinia oxyphylla Miq. improves cognitive impairment in A\u03b21\u201342 mouse model of Alzheimer's disease","volume":"23","author":"Liu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2018.02.015_bib30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12974-016-0493-y","article-title":"Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A","volume":"13","author":"Liu","year":"2016","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.jep.2018.02.015_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s13311-014-0316-8","article-title":"The evolving biology of microglia in Alzheimer's disease","volume":"12","author":"Malm","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jep.2018.02.015_bib32","first-page":"4","article-title":"Absolute Stereostructures of novel Norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla","volume":"11","author":"Osamu Muraoka","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.jep.2018.02.015_bib33","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.molmed.2015.03.003","article-title":"Tau immunotherapy for Alzheimer's disease","volume":"21","author":"Pedersen","year":"2015","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.jep.2018.02.015_bib34","first-page":"10","article-title":"Sesquiterpenoids from the fruits of Alpinia oxyphylla and their antiacetylcholinesterase activity","volume":"97","author":"Ping Chen","year":"2014","journal-title":"Helv. Chim. Acta"},{"issue":"03","key":"10.1016\/j.jep.2018.02.015_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4236\/aad.2015.43007","article-title":"Activated caspase-3 and neurodegeneration and synaptic plasticity in Alzheimer's disease","volume":"04","author":"P\u0142\u00f3ciennik","year":"2015","journal-title":"Adv. Alzheimer's Dis."},{"key":"10.1016\/j.jep.2018.02.015_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbi.2013.11.014","article-title":"Calorie restriction attenuates lipopolysaccharide (LPS)-induced microglial activation in discrete regions of the hypothalamus and the subfornical organ","volume":"38","author":"Radler","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2018.02.015_bib37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.11.035","article-title":"Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats","volume":"117","author":"Rai","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2018.02.015_bib38","first-page":"3","article-title":"Tau oligomers as a therapeutic target for Alzheimer's disease","volume":"357","author":"Rakeza","year":"2015","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2018.02.015_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000369101","article-title":"Amyloid-beta: a crucial factor in Alzheimer's disease","volume":"24","author":"Sadigh-Eteghad","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.jep.2018.02.015_bib40","doi-asserted-by":"crossref","first-page":"5470831","DOI":"10.1155\/2017\/5470831","article-title":"IL-1beta-Induced Accumulation of Amyloid: macroautophagy in Skeletal Muscle Depends on ERK","volume":"2017","author":"Schmidt","year":"2017","journal-title":"Mediat. Inflamm."},{"issue":"3","key":"10.1016\/j.jep.2018.02.015_bib41","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neulet.2006.02.057","article-title":"Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo","volume":"403","author":"Shi","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2018.02.015_bib42","doi-asserted-by":"crossref","first-page":"451802","DOI":"10.1155\/2014\/451802","article-title":"The effects of sesquiterpenes-rich extract of Alpinia oxyphylla Miq. on amyloid-beta-induced cognitive impairment and neuronal abnormalities in the cortex and hippocampus of mice","volume":"2014","author":"Shi","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jep.2018.02.015_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.physbeh.2014.11.016","article-title":"Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments","volume":"139","author":"Shi","year":"2015","journal-title":"Physiol. Behav."},{"issue":"8","key":"10.1016\/j.jep.2018.02.015_bib44","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.4049\/jimmunol.1500906","article-title":"IL-1beta and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development","volume":"196","author":"Stouch","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2018.02.015_bib45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.foodres.2014.11.022","article-title":"Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity","volume":"67","author":"Tang","year":"2015","journal-title":"Food Res. Int."},{"issue":"9","key":"10.1016\/j.jep.2018.02.015_bib46","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/glia.23024","article-title":"Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease","volume":"64","author":"Tischer","year":"2016","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.jep.2018.02.015_bib47","first-page":"7","article-title":"Absolute Stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells","volume":"65","author":"Toshio Morikawa","year":"2002","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.jep.2018.02.015_bib48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/j.semnuclmed.2016.09.006","article-title":"A\u03b2-amyloid and tau imaging in dementia","volume":"47","author":"Villemagne","year":"2017","journal-title":"Semin. Nucl. Med."},{"issue":"1\u20132","key":"10.1016\/j.jep.2018.02.015_bib49","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jns.2014.05.052","article-title":"Tau protein, beta-amyloid(1)(-)(4)(2) and clusterin CSF levels in the differential diagnosis of Parkinsonian syndrome with dementia","volume":"343","author":"Vranova","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jep.2018.02.015_bib50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.intimp.2016.11.001","article-title":"Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia","volume":"42","author":"Wang-Sheng","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2018.02.015_bib51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuropharm.2015.02.020","article-title":"Donepezil attenuates Abeta-associated mitochondrial dysfunction and reduces mitochondrial Abeta accumulation in vivo and in vitro","volume":"95","author":"Ye","year":"2015","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.jep.2018.02.015_bib52","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1007\/s12035-014-9088-8","article-title":"Methylene bue improves brain mitochondrial ABAD functions and decreases abeta in a neuroinflammatory Alzheimer's disease mouse model","volume":"53","author":"Zakaria","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.jep.2018.02.015_bib53","first-page":"14","article-title":"Actin-binding proteins Coronin-1a and IBA-1 Are effective microglial markers for immunohistochemistry","volume":"55","author":"Zeshan Ahmed","year":"2007","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jep.2018.02.015_bib54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2015.03.073","article-title":"Anti-proliferative and pro-apoptotic activities of Alpinia oxyphylla on HepG2 cells through ROS-mediated signaling pathway","volume":"169","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.02.015_bib55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroscience.2016.11.037","article-title":"NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide","volume":"343","author":"Zhu","year":"2017","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jep.2018.02.015_bib56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/JAD-2010-101434","article-title":"Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model","volume":"23","author":"Zilkova","year":"2011","journal-title":"J. Alzheimers Dis."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117331173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117331173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T17:06:08Z","timestamp":1570727168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874117331173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":56,"alternative-id":["S0378874117331173"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.02.015","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of Alpinae Oxyphyllae Fructus extracts on lipopolysaccharide-induced animal model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}