{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:54:54Z","timestamp":1791377694815,"version":"4.3.2"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Administration of Traditional Chinese Medicine of Zhejiang Province","award":["2018ZQ033"],"award-info":[{"award-number":["2018ZQ033"]}]},{"name":"Administration of Traditional Chinese Medicine of Zhejiang Province","award":["2018ZQ029"],"award-info":[{"award-number":["2018ZQ029"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81502937"],"award-info":[{"award-number":["81502937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jep.2018.05.002","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T16:09:26Z","timestamp":1525536566000},"page":"149-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"special_numbering":"C","title":["Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review"],"prefix":"10.1016","volume":"224","author":[{"given":"Qiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Shentu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2018.05.002_bib1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fct.2005.08.017","article-title":"Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells","volume":"44","author":"An","year":"2006","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib2","first-page":"134","article-title":"anti-oxidant and free radical scavenging potential of Yakuchinone B derivatives in reduction of lipofuscin formation using H2O2-treated neuroblastoma cells","volume":"15","author":"Bayati","year":"2011","journal-title":"Iran. Biomed. J."},{"issue":"10","key":"10.1016\/j.jep.2018.05.002_bib3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1080\/10286020.2013.816297","article-title":"Two new anti-oxidant diarylheptanoids from the fruits of Alpinia oxyphylla","volume":"15","author":"Bian","year":"2013","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2018.05.002_bib4","series-title":"Alpinia oxyphylla. International Collation of Traditional and Folk Medicine: Northeast Asia. Part II","first-page":"202","author":"But","year":"1997"},{"key":"10.1016\/j.jep.2018.05.002_bib5","article-title":"GC determination of p-cymene in volatile oil from fruits of Alpinia oxyphylla Miq","author":"Chang","year":"2009","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.jep.2018.05.002_bib6","doi-asserted-by":"crossref","first-page":"2624384","DOI":"10.1155\/2017\/2624384","article-title":"Inhibition of cardiac hypertrophy Effects in D-galactose-induced senescent hearts by Alpinate oxyphyllae Fructus treatment","author":"Chang","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12906-017-1695-2","article-title":"Alpinia oxyphylla fruit extract activates IGFR-PI3K\/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration","volume":"17","author":"Chang","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1271\/bbb.120541","article-title":"Alpinate oxyphyllae fructus (Alpinia oxyphylla Miq) extracts inhibit angiotensin-II induced cardiac apoptosis in H9c2 cardiomyoblast cells","volume":"77","author":"Chang","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"5","key":"10.1016\/j.jep.2018.05.002_bib9","doi-asserted-by":"crossref","first-page":"402","DOI":"10.5301\/ijao.5000313","article-title":"Alpinia oxyphylla Miquel fruit extract activates MAPK-mediated signaling of PAs and MMP2\/9 to induce Schwann cell migration and nerve regeneration","volume":"37","author":"Chang","year":"2014","journal-title":"Int. J. Artif. Organs"},{"key":"10.1016\/j.jep.2018.05.002_bib10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jpba.2014.04.037","article-title":"Identification of known chemicals and their metabolites from Alpinia oxyphylla fruit extract in rat plasma using liquid chromatography\/tandem mass spectrometry (LC-MS\/MS) with selected reaction monitoring","volume":"97","author":"Chen","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib11","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.3390\/molecules19044510","article-title":"Different accumulation profiles of multiple components between pericarp and seed of Alpinia oxyphylla capsular fruit as determined by UFLC-MS\/MS","volume":"19","author":"Chen","year":"2014","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.jep.2018.05.002_bib12","first-page":"664","article-title":"Buyuan Congnao decoction decreases hippocampal beta-amyloid expression in a rat model of Alzheimer's disease","volume":"7","author":"Chen","year":"2012","journal-title":"Neural Regen. Res."},{"issue":"21","key":"10.1016\/j.jep.2018.05.002_bib13","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.14233\/ajchem.2014.16546","article-title":"Chemical composition, antibacterial activity and mechanism of action of oil and phenolics from AOF (Alpinia oxyphylla Miq.)","volume":"26","author":"Chen","year":"2014","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.jep.2018.05.002_bib14","first-page":"357","article-title":"Effects of some medicinal plants on 48-hour homologus passive cutaneous anaphylaxis and chemical mediators","volume":"36","author":"Choi","year":"1992","journal-title":"Yakhak Hoeji"},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3727\/096504002108747944","article-title":"Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae)","volume":"13","author":"Chun","year":"2002","journal-title":"Oncol. Res."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1615\/JEnvironPatholToxicolOncol.v21.i2.60","article-title":"Effects of Yakuchinone A and Yakuchinone B on the phorbol ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin","volume":"21","author":"Chun","year":"2002","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2018.05.002_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1383-5742(99)00031-9","article-title":"Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin","volume":"428","author":"Chun","year":"1999","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40659-017-0111-1","article-title":"Alpinia oxyphylla extract changes miRNA expression profiles in db-\/db- mouse kidney","volume":"50","author":"Du","year":"2017","journal-title":"Biol. Res."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0928-0987(03)00118-0","article-title":"Development of sesquiterpenes from Alpinia oxyphylla as novel skin permeation enhancers","volume":"19","author":"Fang","year":"2003","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2018.05.002_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuroscience.2014.12.048","article-title":"Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin","volume":"289","author":"Filho","year":"2015","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib21","first-page":"85","article-title":"Inhibition of diarylheptanoids from Alpinia oxyphylla on angiogenesis","volume":"46","author":"Gao","year":"2015","journal-title":"J. China Pharm. Univ."},{"issue":"7","key":"10.1016\/j.jep.2018.05.002_bib22","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.bmc.2011.01.062","article-title":"Microbial transformation of (+)-nootkatone and the antiproliferative activity of its metabolites","volume":"19","author":"Gliszczy\u0144ska","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jep.2018.05.002_bib23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/1472-6882-14-352","article-title":"Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss","volume":"14","author":"Ha","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jep.2010.08.024","article-title":"Anti-angiogenic effects of the fruit of Alpinia oxyphylla","volume":"132","author":"He","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-8741(85)90025-X","article-title":"Antihepatotoxic actions of gingerols and diarylheptanoids","volume":"14","author":"Hikino","year":"1985","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib26","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3390\/molecules20011551","article-title":"New sesquiterpenoids and a diterpenoid from Alpinia oxyphylla","volume":"20","author":"Hou","year":"2015","journal-title":"Molecules"},{"issue":"47","key":"10.1016\/j.jep.2018.05.002_bib27","first-page":"4430","article-title":"Effects of volatile oil extracted from Alpinia oxyphylla on the apoptosis of substantial nigra neuron in PD mice model","volume":"22","author":"Huang","year":"2011","journal-title":"China Pharm."},{"issue":"17","key":"10.1016\/j.jep.2018.05.002_bib28","first-page":"3","article-title":"Study on difference between components in volatile oil of Fructus Alpinia oxyphylla before and after stir-fried with salt","volume":"5","author":"Huang","year":"2008","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2018.05.002_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.steroids.2017.01.003","article-title":"Neuroprotective effect and mechanism of daucosterol palmitate in ameliorating learning and memory impairment in a rat model of Alzheimer's disease","volume":"119","author":"Ji","year":"2017","journal-title":"Steroids"},{"issue":"13","key":"10.1016\/j.jep.2018.05.002_bib30","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1016\/j.bmcl.2013.04.072","article-title":"New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia","volume":"23","author":"Jiang","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/08923970009016420","article-title":"Suppression of immunoglobulin E-mediated anaphylactic reaction by Alpinia oxyphylla in rats","volume":"22","author":"Kim","year":"2000","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ptr.1382","article-title":"Protective effects of Alpinae oxyphyllae fructus (Alpinia oxyphylla MIQ) water-extracts on neurons from ischemic damage and neuronal cell toxicity","volume":"18","author":"Koo","year":"2004","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2018.05.002_bib33","article-title":"Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: review on the basis of in vitro and in vivo studies in rodents and humans","author":"Krzysztoforska","year":"2017","journal-title":"Nutr. Neurosci."},{"issue":"10","key":"10.1016\/j.jep.2018.05.002_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1248\/yakushi1947.115.10_852","article-title":"Study on Alpiniae Fructus. I. Pharmacological evidence of efficacy of Alpiniae Fructus on ancient herbal literature","volume":"115","author":"Kubo","year":"1995","journal-title":"Yakugaku Zasshi"},{"issue":"6","key":"10.1016\/j.jep.2018.05.002_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bej.2013.03.009","article-title":"Alpinia oxyphylla, Miq. bioactive extracts from supercritical fluid carbon dioxide extraction","volume":"78","author":"Lee","year":"2013","journal-title":"Biochem. Eng. J."},{"issue":"8","key":"10.1016\/j.jep.2018.05.002_bib36","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/carcin\/19.8.1377","article-title":"Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae)","volume":"19","author":"Lee","year":"1998","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib37","first-page":"94","article-title":"Chemical constituents in Alpinia oxyphylla seed","volume":"20","author":"Lei","year":"2011","journal-title":"J. Plant Resour. Environ."},{"issue":"5","key":"10.1016\/j.jep.2018.05.002_bib38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.21010\/ajtcam.v13i5.4","article-title":"Diuretic and anti-diuretic bioactivity differences of the seed and shell extracts of A. oxyphylla fruit","volume":"13","author":"Li","year":"2016","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"issue":"8","key":"10.1016\/j.jep.2018.05.002_bib39","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1021\/acs.jproteome.6b00152","article-title":"Discovery, Synthesis, and functional characterization of a novel Neuroprotective natural product from the fruit of Alpinia oxyphylla for use in Parkinson's disease Through LC\/MS-based multivariate data analysis-guided fractionation","volume":"15","author":"Li","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jep.2018.05.002_bib40","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jpba.2016.02.035","article-title":"Metabonomic study of the fruits of Alpinia oxyphylla as an effective treatment for chronic renal injury in rats","volume":"124","author":"Li","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2018.05.002_bib41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1752-153X-7-134","article-title":"Analysis of nine compounds from Alpinia oxyphylla fruit at different harvest time using UFLC-MS\/MS and an extraction method optimized by orthogonal design","volume":"7","author":"Li","year":"2013","journal-title":"Chem. Cent. J."},{"issue":"08","key":"10.1016\/j.jep.2018.05.002_bib42","first-page":"448","article-title":"GC-MS analysis of essential oil components of Alpinia oxphylla","volume":"23","author":"Lin","year":"2000","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2018.05.002_bib43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1472-6882-13-237","article-title":"anti-oxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of Yakuchinone A from Alpinia oxyphylla","volume":"13","author":"Lin","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib44","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.intimp.2014.10.028","article-title":"5-Hydroxymethylfurfural, an anti-oxidant agent from Alpinia oxyphylla improves cognitive impairment in A\u03b2 1-42 mouse model of Alzheimer's disease","volume":"23","author":"Liu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2018.05.002_bib45","first-page":"54","article-title":"Extraction of Alpinia oxyphylla Miquel essence via supercritical carbon dioxide and anti-oxidant activity of the extracts","volume":"34","author":"Liu","year":"2006","journal-title":"J. South China Univ. Technol. (Nat. Sci. Ed.)"},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/09637486.2012.694852","article-title":"Evaluation of multi-activities of 14 edible species from Zingiberaceae","volume":"64","author":"Lu","year":"2013","journal-title":"Int. J. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib47","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.phytol.2011.11.009","article-title":"Sesquiterpenoids from the fruits of Alpinia oxyphylla and inhibition of nitric oxide production in lipopolysaccaride-activated macrophages","volume":"5","author":"Luo","year":"2012","journal-title":"Phytochem. Lett."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib48","first-page":"147","article-title":"Study on optimizing the process of steam distillation for extraction volatile oil from Alpinia oxyphylla and its anti-microbial activities in vitro","volume":"26","author":"Luo","year":"2011","journal-title":"West China J. Pharm. Sci."},{"issue":"04","key":"10.1016\/j.jep.2018.05.002_bib49","first-page":"46","article-title":"Chemical constituents in volatile oil from fruits of Alpinia oxyphylla","volume":"26","author":"Luo","year":"2001","journal-title":"China J. Chin. Mater. Med."},{"issue":"3","key":"10.1016\/j.jep.2018.05.002_bib50","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1248\/cpb.59.402","article-title":"Four new sesquiterpenoids from the fruits of Alpinia oxyphylla","volume":"59","author":"Lv","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2018.05.002_bib51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jpba.2014.10.014","article-title":"GC-FID coupled with chemometrics for quantitative and chemical fingerprinting analysis of Alpinia oxyphylla oil","volume":"102","author":"Miao","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10575630108041261","article-title":"Insecticidal diarylheptanoid from Alpinia oxyphylla against larvae of Drosophila melanogaster","volume":"15","author":"Miyazawa","year":"2001","journal-title":"Nat. Prod. Lett."},{"issue":"8","key":"10.1016\/j.jep.2018.05.002_bib53","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1021\/jf000325z","article-title":"Insecticidal sesquiterpene from Alpinia oxyphylla against Drosophila melanogaster","volume":"48","author":"Miyazawa","year":"2000","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.jep.2018.05.002_bib54","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1021\/np020078o","article-title":"Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells","volume":"65","author":"Morikawa","year":"2002","journal-title":"J. Nat. Prod."},{"issue":"16","key":"10.1016\/j.jep.2018.05.002_bib55","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/S0960-894X(01)00413-9","article-title":"Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla","volume":"11","author":"Muraoka","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.canlet.2014.07.007","article-title":"Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3","volume":"353","author":"Oh","year":"2014","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.jep.2018.05.002_bib57","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s12272-016-0735-7","article-title":"Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal","volume":"39","author":"Park","year":"2016","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jep.2018.05.002_bib58","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12943-015-0377-2","article-title":"anti-cancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression","volume":"14","author":"Park","year":"2015","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.jep.2018.05.002_bib59","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.5012\/bkcs.2014.35.5.1565","article-title":"A New Noreudesmane-type Sesquiterpenoid from Alpinia oxyphylla","volume":"35","author":"Park","year":"2014","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.jep.2018.05.002_bib60","series-title":"Pharmacopoeia of the People\u2019s Republic of China","volume":"vol. I","author":"Pharmacopoeia Committee","year":"2015"},{"issue":"8","key":"10.1016\/j.jep.2018.05.002_bib61","first-page":"355","article-title":"Frequency of the modern application of traditional Chinese medicine in Alzheimer's disease","volume":"19","author":"Shi","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Formula."},{"key":"10.1016\/j.jep.2018.05.002_bib62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.physbeh.2014.11.016","article-title":"Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments","volume":"139","author":"Shi","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jep.2018.05.002_bib63","doi-asserted-by":"crossref","first-page":"451802","DOI":"10.1155\/2014\/451802","article-title":"The effects of sesquiterpenes-rich extract of Alpinia oxyphylla on amyloid-\u03b2-induced cognitive impairment and neuronal abnormalities in the cortex and hippocampus of mice","volume":"2014","author":"Shi","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1142\/S0192415X01000319","article-title":"Effect of Alpinia oxyphylla fruit extract on compound 48\/80-induced anaphylactic reactions","volume":"29","author":"Shin","year":"2001","journal-title":"Am. J. Chin. Med."},{"issue":"6","key":"10.1016\/j.jep.2018.05.002_bib65","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/jps.2600730639","article-title":"Structural determination of nootkatol, a new sesquiterpene isolated from Alpinia oxyphylla Miquel possessing calcium-antagonistic activity","volume":"73","author":"Shoji","year":"1984","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib66","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-2007-969667","article-title":"Isolation of a cardiotonic principle from Alpinia oxyphylla","volume":"50","author":"Shoji","year":"1984","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.jep.2018.05.002_bib67","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/dta.1462","article-title":"Characterization of nucleobases and nucleosides in the fruit of Alpinia oxyphylla collected from different cultivation regions","volume":"6","author":"Song","year":"2014","journal-title":"Drug. Test. Anal."},{"key":"10.1016\/j.jep.2018.05.002_bib68","series-title":"Chinese Materia Medica","first-page":"603","author":"State Administration of traditional Chinese medicine \u201cChinese Maeria Medica\u201d editorial board","year":"1999"},{"issue":"1\u20132","key":"10.1016\/j.jep.2018.05.002_bib69","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1383-5742(99)00057-5","article-title":"Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances","volume":"428","author":"Surh","year":"1999","journal-title":"Mutat. Res."},{"issue":"3","key":"10.1016\/j.jep.2018.05.002_bib70","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1089\/jmf.2014.3340","article-title":"Alpinate oxyphyllae fructus inhibits IGFII-related signaling pathway to attenuate Ang II-Induced pathological hypertrophy in H9c2 cardiomyoblasts","volume":"19","author":"Tsai","year":"2016","journal-title":"J. Med. Food"},{"issue":"11","key":"10.1016\/j.jep.2018.05.002_bib71","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3109\/13880209.2013.794844","article-title":"In vitro anti-oxidant and cytotoxic properties of ethanol extract of Alpinia oxyphylla fruits","volume":"51","author":"Wang","year":"2013","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2018.05.002_bib72","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopha.2017.10.088","article-title":"Ameliorating effect of Alpinia oxyphylla-Schisandra chinensis herb pair on cognitive impairment in a mouse model of Alzheimer's disease","volume":"97","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2018.05.002_bib73","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jep.2015.03.066","article-title":"Antidiarrheal effect of Alpinia oxyphylla (Zingiberaceae) in experimental mice and its possible mechanism of action","volume":"168","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.05.002_bib74","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jep.2018.02.015","article-title":"Protective effects of Alpinae Oxyphyllae Fructus extracts on lipopolysaccharide-induced animal model of Alzheimer's disease","volume":"217","author":"Wang","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib75","article-title":"Ethanol extract of Alpinia oxyphylla fructus, shows inhibition of tau protein phosphorylation in cell culture(J)","volume":"25","author":"Wong","year":"2004","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.jep.2018.05.002_bib76","first-page":"1569","article-title":"The compounds from n-butanol fraction of Alpinia oxyphylla","volume":"49","author":"Xie","year":"2014","journal-title":"Yao Xue Xue Bao"},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib77","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.foodchem.2009.04.011","article-title":"Isolation and purification of nootkatone from the essential oil of fruits of Alpinia oxyphylla Miquel by high-speed counter-current chromatography","volume":"117","author":"Xie","year":"2009","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib78","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3892\/etm.2017.4152","article-title":"Anti-diabetic effect of Alpinia oxyphylla extract on 57BL\/KsJ db-\/db- mice","volume":"13","author":"Xie","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"8","key":"10.1016\/j.jep.2018.05.002_bib79","first-page":"990","article-title":"Studies on chemical constituents in fruit of Alpinia oxyphylla","volume":"34","author":"Xu","year":"2009","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2018.05.002_bib80","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/hlca.200900040","article-title":"Three unusual new sesquiterpenes from Alpinia oxyphylla","volume":"92","author":"Xu","year":"2009","journal-title":"Helv. Chim. Acta"},{"issue":"8","key":"10.1016\/j.jep.2018.05.002_bib81","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.cclet.2009.03.029","article-title":"Oxyphyllones A and B, novel sesquiterpenes with an Unusual 4, 5-Secoeudesmane skeleton from Alpinia oxyphylla","volume":"40","author":"Xu","year":"2009","journal-title":"Chin. Chem. Lett."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib82","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.bmcl.2011.12.114","article-title":"Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide","volume":"22","author":"Xu","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib83","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3724\/SP.J.1009.2010.00006","article-title":"Two new Norsesquiterpenes from the fruits of Alpinia oxyphylla","volume":"8","author":"Xu","year":"2010","journal-title":"Chin. J. Nat. Med."},{"issue":"11","key":"10.1016\/j.jep.2018.05.002_bib84","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1248\/cpb.38.3053","article-title":"Anti-ulcer effect in rats of bitter cardamon constituents","volume":"38","author":"Yamahara","year":"1990","journal-title":"Chem. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.jep.2018.05.002_bib85","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0014-2999(00)00620-8","article-title":"Diarylheptanoids suppress expression of leukocyte adhesion molecules on human vascular endothelial cells","volume":"404","author":"Yamazaki","year":"2000","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2018.05.002_bib86","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/ptr.5651","article-title":"Brain-derived neurotrophic factor signaling mediates the antidepressant-like effect of the total flavonoids of Alpiniae Oxyphyllae fructus in chronic unpredictable mild stress mice","volume":"30","author":"Yan","year":"2016","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.jep.2018.05.002_bib87","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-4274(03)00219-4","article-title":"Neuroprotective effect of Alpinia oxyphylla fruits against glutamate-induced apoptosis in cortical neurons","volume":"144","author":"Yu","year":"2003","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib88","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4314\/ajtcam.v11i4.18","article-title":"Izalpinin from fruits of Alpinia oxyphylla with antagonistic activity against the rat bladder contractility","volume":"11","author":"Yuan","year":"2014","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"10.1016\/j.jep.2018.05.002_bib89","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fitote.2013.04.001","article-title":"Anti-diarrheal constituents of Alpinia oxyphylla","volume":"89","author":"Zhang","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2018.05.002_bib90","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2015.03.073","article-title":"Anti-proliferative and pro-apoptotic activities of Alpinia oxyphylla on HepG2 cells through ROS-mediated signaling pathway","volume":"169","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.05.002_bib91","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopha.2017.04.131","article-title":"Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl4-induced oxidative damage in vitro and in vivo with the involvement of Nrf2","volume":"91","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"03","key":"10.1016\/j.jep.2018.05.002_bib92","first-page":"131","article-title":"Studies on the chemical constituents of Yizhiren (Alpinia oxyphylla)","volume":"28","author":"Zhang","year":"1997","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"12","key":"10.1016\/j.jep.2018.05.002_bib93","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s12272-012-1211-7","article-title":"Two new natural products from the fruits of Alpinia oxyphylla with inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophage cells","volume":"35","author":"Zhang","year":"2012","journal-title":"Arch. Pharm. Res."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib94","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/cbf.1757","article-title":"Anti-ageing effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice","volume":"29","author":"Zhang","year":"2011","journal-title":"Cell Biochem. Funct."},{"issue":"1","key":"10.1016\/j.jep.2018.05.002_bib95","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10571-011-9731-0","article-title":"Ethanolic extract of fructus Alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish","volume":"32","author":"Zhang","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jep.2018.05.002_bib96","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.freeradbiomed.2015.02.030","article-title":"Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease","volume":"84","author":"Zhang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib97","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s12031-015-0511-z","article-title":"Neuroprotective mechanisms of 9-Hydroxy epinootkatol against glutamate-induced neuronal apoptosis in primary neuron culture","volume":"56","author":"Zhao","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jep.2018.05.002_bib98","first-page":"24","article-title":"Traditional processing for Alpinia oxyphylla capsular fruit","volume":"16","author":"Zhao","year":"1994","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2018.05.002_bib99","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.chemosphere.2016.08.122","article-title":"Multi-elements determination in medical and edible Alpinia oxyphylla and Morinda officinalis and their decoctions by ICP-MS","volume":"164","author":"Zhao","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.jep.2018.05.002_bib100","doi-asserted-by":"crossref","first-page":"7571802","DOI":"10.1155\/2016\/7571802","article-title":"Determination of heavy metals in Alpinia oxyphylla collected from different cultivation regions","volume":"2016","author":"Zhou","year":"2016","journal-title":"J. Anal. Methods Chem."},{"issue":"4","key":"10.1016\/j.jep.2018.05.002_bib101","doi-asserted-by":"crossref","first-page":"1200457","DOI":"10.3732\/apps.1200457","article-title":"Development and characterization of microsatellite markers for Alpinia oxyphylla (Zingiberaceae)","volume":"1","author":"Zou","year":"2013","journal-title":"Appl. Plant. Sci."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117342381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874117342381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T07:01:15Z","timestamp":1751612475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874117342381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":101,"alternative-id":["S0378874117342381"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.05.002","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}