{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:43:40Z","timestamp":1771472620637,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FAEPEX-unicamp"},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jep.2018.05.036","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T05:55:00Z","timestamp":1527314100000},"page":"126-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained arterial pressure reduction and protection from cardiac remodeling on rats with renovascular hypertension"],"prefix":"10.1016","volume":"224","author":[{"given":"Paulo C\u00e9sar","family":"de Paula Vasconcelos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleide Adriani Signor","family":"Tirloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhanany Alan Calloi","family":"Palozi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maicon Matos","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Tainara Soares","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysa Isernhagen","family":"Schaedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniely Oliveira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roosevelt Isaias Carvalho","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Jos\u00e9","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arquimedes Gasparotto","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2018.05.036_bib1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.HYP.0000182154.61862.52","article-title":"Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension","volume":"46","author":"Arruda","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2018.05.036_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/ajpregu.00933.2007","article-title":"AT1 receptor participates in the cardiac hypertrophy induced by resistance training in rats","volume":"295","author":"Barauna","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jep.2018.05.036_bib3","series-title":"The Useful Plants of West Tropical Africa v.1, p.61; v.2, p.338","author":"Burkill","year":"1984"},{"key":"10.1016\/j.jep.2018.05.036_bib4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1590\/S0102-33062011000300022","article-title":"Etnobot\u00e2nica de Plantas medicinais no assentamento monjolinho, munic\u00edpio de Anast\u00e1cio, Mato Grosso do Sul, Brasil","volume":"25","author":"Cunha","year":"2011","journal-title":"Acta Bot. Bras."},{"key":"10.1016\/j.jep.2018.05.036_bib5","doi-asserted-by":"crossref","DOI":"10.1097\/00004872-199208000-00005","article-title":"In vivo left ventricular anatomy in rats with two-kidney, one clip and one-kidney, one clip renovascular hypertension","volume":"10","author":"de Simone","year":"1992","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jep.2018.05.036_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jep.2013.06.015","article-title":"Involvement of bradykinin and prostaglandins in the diuretic effects of Achillea millefolium L. (Asteraceae)","volume":"149","author":"de Souza","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.05.036_bib7","first-page":"208","article-title":"Screening of Indian plants for biological activity: part VI","volume":"15","author":"Dhawan","year":"1977","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jep.2018.05.036_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1440-1797.2006.00598.x","article-title":"Diuretics: a modern day treatment option?","volume":"11","author":"Gallagher","year":"2006","journal-title":"Nephrology"},{"key":"10.1016\/j.jep.2018.05.036_bib9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jep.2012.03.018","article-title":"Mechanisms underlying the diuretic effects of Tropaeolum majus L. extracts and its main component isoquercitrin","volume":"141","author":"Gasparotto Junior","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.05.036_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1517\/14728214.11.1.49","article-title":"Calcium-channel modulators for cardiovascular disease","volume":"11","author":"Godfraind","year":"2006","journal-title":"Exp. Opin. Emerg. Drugs"},{"key":"10.1016\/j.jep.2018.05.036_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.59.3.347","article-title":"Studies on experimental hypertension-II: the production of persistent elevation of systolic blood pressure by means of renal ischaemia","volume":"59","author":"Goldblatt","year":"1934","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jep.2018.05.036_bib12","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/01.CIR.92.9.2690","article-title":"Cardiac rennin-angiotensin system in the hypertrophied heart","volume":"92","author":"Iwai","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2018.05.036_bib13","first-page":"21","article-title":"Pharmacologic nephrectomy with chronic angiotensin converting enzyme inhibitor treatment in renovascular hypertension in the rat","volume":"115","author":"Jackson","year":"1990","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.jep.2018.05.036_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.amjhyper.2004.08.035","article-title":"A unifying pathway for essential hypertension","volume":"18","author":"Johnson","year":"2005","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.jep.2018.05.036_bib15","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ki.1997.442","article-title":"Hypothesis: the role of acquired tubulointerstitial disease in the pathogenesis of salt-dependent hypertension","volume":"52","author":"Johnson","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2018.05.036_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0160-5402(84)90054-8","article-title":"A method for screening diuretic agents in the rat","volume":"11","author":"Kau","year":"1984","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.jep.2018.05.036_bib17","first-page":"H683","article-title":"NPY modulates neurotransmission of CGRP-containing vasodilator nerves in rat mesenteric arteries","volume":"261","author":"Kawasaki","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jep.2018.05.036_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/335164a0","article-title":"Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat","volume":"335","author":"Kawasaki","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.jep.2018.05.036_bib19","doi-asserted-by":"crossref","first-page":"173S","DOI":"10.1042\/bst024173s","article-title":"Effect of flavonoids on arachidonic acid metabolism and prostacyclin (PGI2) formation in human vascular endothelial cells","volume":"24","author":"Khaza'ai","year":"1996","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jep.2018.05.036_bib20","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0008-6363(99)00169-8","article-title":"Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure","volume":"43","author":"Kojda","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2018.05.036_bib21","first-page":"679","article-title":"Arteriolar sclerosis in hypertensive and non-hypertensive individuals","volume":"13","author":"Moritz","year":"1937","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2018.05.036_bib22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/35002501","article-title":"Biodiversity hotspots for conservation priorities","volume":"403","author":"Myers","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jep.2018.05.036_bib23","first-page":"191","article-title":"Medicinal plants of muzaffarnagar district used in treatment of urinary tract and kidney stone","volume":"8","author":"Prachi","year":"2009","journal-title":"Indian J. Tradit. Knowl."},{"key":"10.1016\/j.jep.2018.05.036_bib24","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.phymed.2015.10.020","article-title":"Involvement of bradykinin B2 and muscarinic receptors in the prolonged diuretic and antihypertensive properties of Echinodorus grandiflorus (Cham. & Schltdl.) Micheli","volume":"23","author":"Prando","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2018.05.036_bib25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/01.HYP.7.2.244","article-title":"An improved fluorometric assay of rat serum and plasma converting enzyme","volume":"7","author":"Santos","year":"1985","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2018.05.036_bib26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jash.2009.02.003","article-title":"Experimental animal models of hypertension","volume":"3","author":"Sarikonda","year":"2009","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.jep.2018.05.036_bib27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0006-291X(89)91067-X","article-title":"Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol","volume":"165","author":"Schmidt","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2018.05.036_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/ajcn\/73.1.36","article-title":"Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells","volume":"73","author":"Schramm","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2018.05.036_bib29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0955-2863(98)00051-5","article-title":"Potential effects of flavonoids on the etiology of vascular disease","volume":"9","author":"Schramm","year":"1998","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jep.2018.05.036_bib30","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1139\/cjpp-2015-0615","article-title":"Antihypertensive effects of fargesin in vitro and in vivo via attenuating oxidative stress and promoting nitric oxide release","volume":"94","author":"Sha","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2018.05.036_bib31","first-page":"581","article-title":"Study of primary metabolites and antimicrobial activity of Gomphrena celosioides mart","volume":"2","author":"Sharma","year":"2011","journal-title":"Int. J. Pharma Biol. Sci."},{"key":"10.1016\/j.jep.2018.05.036_bib32","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.phymed.2011.02.005","article-title":"Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats","volume":"18","author":"Souza","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2018.05.036_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4314\/agrosh.v13i2.7","article-title":"Growth and development of Gomphrena celosioides mart under screen house conditions in Ilorin, southern guinea savanna zone of Nigeria","volume":"13","author":"Takim","year":"2013","journal-title":"Agrosearch"},{"key":"10.1016\/j.jep.2018.05.036_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jep.2017.03.007","article-title":"Mechanisms underlying the diuretic effect of Gomphrena celosioides Mart. (Amaranthaceae)","volume":"202","author":"Vasconcelos","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.05.036_bib35","series-title":"Biotechnology in Agriculture and Forestry","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-3-662-30369-6_17","author":"Vieira","year":"1994"},{"key":"10.1016\/j.jep.2018.05.036_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/01.HYP.20.2.233","article-title":"Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension","volume":"20","author":"Wenzel","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2018.05.036_bib37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/bmj.328.7440.634","article-title":"British hypertension society guidelines for hypertension management 2004 (BHS-IV): summary","volume":"328","author":"Williams","year":"2004","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jep.2018.05.036_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2007.07.023","article-title":"Herbal medicines as diuretics: a review of the scientific evidence","volume":"114","author":"Wright","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.05.036_bib39","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/HYPERTENSIONAHA.108.117531","article-title":"Cross-talk between mineralocorticoid and angiotensin II signaling for cardiac remodeling","volume":"52","author":"Zhang","year":"2008","journal-title":"Hypertension"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118300175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118300175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T06:10:33Z","timestamp":1569391833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118300175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":39,"alternative-id":["S0378874118300175"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.05.036","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained arterial pressure reduction and protection from cardiac remodeling on rats with renovascular hypertension","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.05.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}