{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:46:45Z","timestamp":1773694005893,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670359"],"award-info":[{"award-number":["31670359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81374066"],"award-info":[{"award-number":["81374066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Liaoning"],"award-info":[{"award-number":["Liaoning"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["High"],"award-info":[{"award-number":["High"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Education"],"award-info":[{"award-number":["Education"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Science"],"award-info":[{"award-number":["Science"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Projects"],"award-info":[{"award-number":["Projects"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201610163L16"],"award-info":[{"award-number":["201610163L16"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011636","name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines","doi-asserted-by":"crossref","award":["GTZK201703"],"award-info":[{"award-number":["GTZK201703"]}],"id":[{"id":"10.13039\/501100011636","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Liaoning Excellent Talents","award":["LR2017041"],"award-info":[{"award-number":["LR2017041"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jep.2018.08.011","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T13:10:52Z","timestamp":1534165852000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Therapeutic effects of Caesalpinia minax Hance on complete Freund's adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components"],"prefix":"10.1016","volume":"226","author":[{"given":"Ziwei","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhou","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuzhi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2018.08.011_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrrheum.2009.80","article-title":"Type 17T helper cells-origins, features and possible roles in rheumatic disease","volume":"5","author":"Annunziato","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2018.08.011_bib2","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1172\/JCI36389","article-title":"Evidence that cytokines play a role in rheumatoid arthritis","volume":"118","author":"Brennan","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2018.08.011_bib3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10067-008-1075-x","article-title":"Therapeutics effect of antiascular endothelial growth fact or receptor I antibody in the established collagen-induced arthritis mouse model","volume":"28","author":"Choi","year":"2009","journal-title":"J. Clin. Rheumatol."},{"key":"10.1016\/j.jep.2018.08.011_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/0091270005277938","article-title":"Rheumatoid arthritis: an overview of new and emerging therapies","volume":"45","author":"Doan","year":"2005","journal-title":"J. Clin. Pharm."},{"key":"10.1016\/j.jep.2018.08.011_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.phytochem.2015.06.025","article-title":"Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance","volume":"117","author":"Dong","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2018.08.011_bib6","first-page":"117","article-title":"Study on chemical constituents of Caesalpinia minax","volume":"19","author":"Guo","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Form."},{"key":"10.1016\/j.jep.2018.08.011_bib7","first-page":"101","volume":"19","author":"Han","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Form."},{"key":"10.1016\/j.jep.2018.08.011_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jep.2016.09.008","article-title":"Inhibitory effects of Saussurea involucrata, (Kar. et Kir.) Sch. -Bip. on adjuvant arthritis in rats","volume":"194","author":"Han","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.08.011_bib9","first-page":"37","article-title":"Ultrasonic assisted extraction process and contents of total flavonoids in Caesalpinia minax Hance","volume":"12","author":"Huang","year":"2012","journal-title":"J. Liaoning Univ. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2018.08.011_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0083-6729(06)74016-X","article-title":"The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation","volume":"74","author":"Jacques","year":"2006","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.jep.2018.08.011_bib11","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1039\/b107473n","article-title":"Isolation and characterization of spirocaesalmin, a novel rearranged vouacapane diterpenoid from Caesalpinia minax Hance","volume":"1","author":"Jiang","year":"2001","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"10.1016\/j.jep.2018.08.011_bib12","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1046\/j.1365-2567.1998.00646.x","article-title":"Specific NF\u2010\u03bab blockade selectively inhibits tumour necrosis factor\u2010\u03b1\u2010induced COX\u20102 but not constitutive COX\u20101 gene expression in HT\u201029 cells","volume":"95","author":"Jobin","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.jep.2018.08.011_bib13","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.2174\/092986709788682155","article-title":"Recent advances on the roles of NO in cancer and chronic inflammatory disorders","volume":"16","author":"Kanwar","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2018.08.011_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/BOR.0000000000000016","article-title":"Adaptive immunity in rheumatoid arthritis: anticitrulline and other antibodies in the pathogenesis of rheumatoid arthritis","volume":"26","author":"Klareskog","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2018.08.011_bib15","unstructured":"Li, S.J., Zhang, D.X., Chen, Z.Y., 2006. Revision of the genus Caesalpinia L. (Leguminosae: Caesalpinioideae) from China. Guihaia. 26, 8-12."},{"key":"10.1016\/j.jep.2018.08.011_bib16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/hlca.200890104","article-title":"Cassane\u2010type Diterpenoids from the seeds of Caesalpinia magnifoliolata","volume":"91","author":"Li","year":"2008","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.jep.2018.08.011_bib17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fitote.2011.12.007","article-title":"A review on cassane and norcassane diterpenes and their pharmacological studies","volume":"83","author":"Maurya","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2018.08.011_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-8741(98)00150-0","article-title":"Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil","volume":"65","author":"Shinde","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.08.011_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fitote.2013.11.002","article-title":"Seven new cassane furanoditerpenes from the seeds of Caesalpinia minax","volume":"92","author":"Wu","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2018.08.011_bib20","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/cbdv.201000176","article-title":"Chemical constituents of plants from the genus Caesalpinia","volume":"8","author":"Wu","year":"2011","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2018.08.011_bib21","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1002\/jssc.201500868","article-title":"Simultaneous identification and analysis of cassane diterpenoids in Caesalpinia minax Hance by high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry","volume":"38","author":"Wu","year":"2015","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jep.2018.08.011_bib22","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0006-2944(85)90006-7","article-title":"The increase of lipid peroxidation in rat adjuvant arthritis and its inhibition by superoxide dismutase","volume":"33","author":"Yoshikawa","year":"1985","journal-title":"Biochem. Med."},{"key":"10.1016\/j.jep.2018.08.011_bib23","first-page":"65","article-title":"Determination of chemical constituents of volatile constituents from the ordinary powder and micronized powder of the shell of Caesalpinia minax Hance","volume":"20","author":"Yuan","year":"2009","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2018.08.011_bib24","first-page":"502","article-title":"Relation between animal models of RA and clinic","volume":"18","author":"Zhang","year":"2002","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.jep.2018.08.011_bib25","first-page":"3016","article-title":"The anti-inflammatory and analgesia experiment research of the extract of Caesalpinia minax Hance","volume":"12","author":"Zou","year":"2009","journal-title":"Lishizhen Med. Mater. Med. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118305373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118305373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T14:23:44Z","timestamp":1535552624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118305373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":25,"alternative-id":["S0378874118305373"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.08.011","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic effects of Caesalpinia minax Hance on complete Freund's adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}