{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:51:14Z","timestamp":1789084274060,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773857"],"award-info":[{"award-number":["81773857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Major Project Fund of the Major new drug discovery","award":["2014ZX09301308-003"],"award-info":[{"award-number":["2014ZX09301308-003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jep.2018.09.033","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T13:54:57Z","timestamp":1538056497000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats"],"prefix":"10.1016","volume":"229","author":[{"given":"Ming-Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Ji","family":"Deng Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Yu","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Xiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge-Jia","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.jep.2018.09.033_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0300-483X(03)00157-4","article-title":"Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients","volume":"189","author":"Basu","year":"2003","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.jep.2018.09.033_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jep.2018.09.033_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1432-1033.1974.tb03720.x","article-title":"Acetate, a major end product of fatty-acid oxidation in hamster brown-adipose-tissue mitochondria","volume":"47","author":"Bernson","year":"1974","journal-title":"Eur. J. Biochem."},{"issue":"9","key":"10.1016\/j.jep.2018.09.033_bib4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/BF02236039","article-title":"Zinc and collagen content of cirrhotic liver","volume":"15","author":"Boyett","year":"1970","journal-title":"Am. J. Dig. Dis."},{"issue":"6","key":"10.1016\/j.jep.2018.09.033_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0891-5849(96)00233-X","article-title":"Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure","volume":"21","author":"Ceballos-Picot","year":"1996","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.jep.2018.09.033_bib6","doi-asserted-by":"crossref","first-page":"e77899","DOI":"10.1371\/journal.pone.0077899","article-title":"Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis","volume":"8","author":"Cha","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jep.2018.09.033_bib7","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/ac048630x","article-title":"Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets","volume":"77","author":"Cloarec","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jep.2018.09.033_bib8","series-title":"Pharmacopoeia of the People's Republic of China","author":"Commission","year":"2010"},{"issue":"2","key":"10.1016\/j.jep.2018.09.033_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nbt0208-162","article-title":"Metabolite identification via the Madison Metabolomics Consortium Database","volume":"26","author":"Cui","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2018.09.033_bib10","series-title":"Jing Zhu Ben Cao","author":"Danzengpengcuo","year":"1986"},{"issue":"10","key":"10.1016\/j.jep.2018.09.033_bib11","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1021\/ac7025964","article-title":"NMR-based characterization of metabolic alterations in hypertension using an adaptive, intelligent binning algorithm","volume":"80","author":"De Meyer","year":"2008","journal-title":"Anal. Chem."},{"issue":"13","key":"10.1016\/j.jep.2018.09.033_bib12","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac051632c","article-title":"Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics","volume":"78","author":"Dieterle","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jep.2018.09.033_bib13","first-page":"1","article-title":"Two new polyhydroxyl polyacetylenes from fruits of Herpetospermum caudigerum","author":"Feng","year":"2017","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2018.09.033_bib14","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3389\/fphar.2018.00965","article-title":"Tibetan medical formula Shi-Wei-Gan-Ning-Pill protects against carbon tetrachloride-induced liver fibrosis-an NMR-based metabolic profiling","volume":"9","author":"Feng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2018.09.033_bib15","article-title":"Hepatoprotective effect of Herpetospermum caudigerum Wall. on carbon tetrachloride-induced hepatic fibrosis in rats","volume":"7","author":"Feng","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"10.1016\/j.jep.2018.09.033_bib16","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/j.fct.2008.07.010","article-title":"Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats","volume":"46","author":"Gowri Shankar","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.jep.2018.09.033_bib17","first-page":"745","article-title":"Isolation of herpetin from Herpetospermum seed and hepatoprotective activity of liposomal herpetin against carbon tetrachloride-induced liver injury in mice","volume":"70","author":"Gu","year":"2015","journal-title":"Pharmazie"},{"issue":"7","key":"10.1016\/j.jep.2018.09.033_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/sim.4780090710","article-title":"More powerful procedures for multiple significance testing","volume":"9","author":"Hochberg","year":"1990","journal-title":"Stat. Med."},{"issue":"11\/12","key":"10.1016\/j.jep.2018.09.033_bib19","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1055\/s-0042-108210","article-title":"Herpecaudin from Herpetospermum caudigerum, a xanthine oxidase inhibitor with a novel isoprenoid scaffold","volume":"82","author":"Jiang","year":"2016","journal-title":"Planta Med."},{"issue":"7298","key":"10.1016\/j.jep.2018.09.033_bib20","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/465562a","article-title":"Q&A: cancer: clues from cell metabolism","volume":"465","author":"Kaelin Jr","year":"2010","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.jep.2018.09.033_bib21","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1016\/S0040-4039(01)81544-6","article-title":"Herpetetradione, nouveau lignoide tetramere isole d\u2032Herpetospermum caudigerum wall","volume":"25","author":"Kaouadji","year":"1984","journal-title":"Tetrahedron Lett."},{"issue":"3","key":"10.1016\/j.jep.2018.09.033_bib22","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/hep.24412","article-title":"Branched-chain amino acids as pharmacological nutrients in chronic liver disease","volume":"54","author":"Kawaguchi","year":"2011","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2018.09.033_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"7","key":"10.1016\/j.jep.2018.09.033_bib24","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.nutres.2012.06.007","article-title":"Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease","volume":"32","author":"Kuwahata","year":"2012","journal-title":"Nutr. Res."},{"issue":"1","key":"10.1016\/j.jep.2018.09.033_bib25","first-page":"1","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC\u00a0Bioinforma"},{"issue":"11","key":"10.1016\/j.jep.2018.09.033_bib26","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.fct.2007.05.010","article-title":"Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice","volume":"45","author":"Lee","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.jep.2018.09.033_bib27","first-page":"981","article-title":"Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats","volume":"35","author":"Li","year":"2014","journal-title":"Saudi Med. J."},{"issue":"4","key":"10.1016\/j.jep.2018.09.033_bib28","doi-asserted-by":"crossref","DOI":"10.1039\/C6TX00011H","article-title":"Multi-tissue metabolic responses of goldfish (Carassius auratis) exposed to glyphosate-based herbicide","volume":"5","author":"Li","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jep.2018.09.033_bib29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fphar.2017.00447","article-title":"Nuclear magnetic resonance-based metabolomics approach to evaluate the prevention effect of Camellia nitidissima Chi on colitis-associated carcinogenesis","volume":"8","author":"Li","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2018.09.033_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aquatox.2017.05.004","article-title":"Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure","volume":"188","author":"Li","year":"2017","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.jep.2018.09.033_bib31","first-page":"567","article-title":"Protective effect and mechanism of total lignans from Tibetan medicinal Herpetospermum seeds on carbon tetrachloride-induced liver fibrosis in rats","volume":"42","author":"Liu","year":"2017","journal-title":"China\u00a0J. Chin. Mater. Med."},{"issue":"5","key":"10.1016\/j.jep.2018.09.033_bib32","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/hep.510230523","article-title":"Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis","volume":"23","author":"Marchesini","year":"1996","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.jep.2018.09.033_bib33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1542-3565(05)00017-0","article-title":"Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis","volume":"3","author":"Muto","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.jep.2018.09.033_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1478-3231.2007.01463.x","article-title":"Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents","volume":"27","author":"Naik","year":"2007","journal-title":"Liver Int."},{"issue":"2","key":"10.1016\/j.jep.2018.09.033_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nut.2006.10.008","article-title":"BCAA-enriched snack improves nutritional state of cirrhosis","volume":"23","author":"Nakaya","year":"2007","journal-title":"Nutrition"},{"issue":"1","key":"10.1016\/j.jep.2018.09.033_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: Kyoto Encyclopedia of genes and genomes","volume":"27","author":"Ogata","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"27","key":"10.1016\/j.jep.2018.09.033_bib37","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1021\/bi00027a027","article-title":"Oxidative and Nonoxidative Mechanisms of Site-Specific DNA Cleavage Induced by Copper-Containing Metallothioneins","volume":"34","author":"Oikawa","year":"1995","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.jep.2018.09.033_bib38","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jtemb.2014.07.019","article-title":"Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging","volume":"28","author":"Prasad","year":"2014","journal-title":"J. Trace Elem. Med Biol."},{"issue":"3","key":"10.1016\/j.jep.2018.09.033_bib39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jep.2009.10.019","article-title":"Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats","volume":"127","author":"Ranawat","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"8401","key":"10.1016\/j.jep.2018.09.033_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0140-6736(84)92567-4","article-title":"Oral zinc supplementation improves hepatic encephalopathy.\u00a0Results of a randomised controlled trial","volume":"2","author":"Reding","year":"1984","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jep.2018.09.033_bib41","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jep.2008.05.021","article-title":"A study on antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts","volume":"118","author":"Roome","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"28","key":"10.1016\/j.jep.2018.09.033_bib42","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"Sanchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"4","key":"10.1016\/j.jep.2018.09.033_bib43","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.hepres.2005.01.009","article-title":"Clinical comparison of branched-chain amino acid (L-Leucine, L-Isoleucine, L-Valine) granules and oral nutrition for hepatic insufficiency in patients with decompensated liver cirrhosis (LIV-EN study)","volume":"31","author":"Sato","year":"2005","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jep.2018.09.033_bib44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jep.2015.01.044","article-title":"Hepatoprotective effects of lignans extract from Herpetospermum caudigerum against CCl\u2084-induced acute liver injury in mice","volume":"164","author":"Shen","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.033_bib45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2016.04.024","article-title":"Glutamine inhibits CCl4 induced liver fibrosis in mice and TGF-beta1 mediated epithelial-mesenchymal transition in mouse hepatocytes","volume":"93","author":"Shrestha","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2018.09.033_bib46","first-page":"39","article-title":"Effect of adenosine and inosine on carbon tetrachloride-induced liver damage in rats","volume":"36","author":"Singh","year":"1992","journal-title":"Indian J. Physiol. Pharmacol."},{"issue":"30","key":"10.1016\/j.jep.2018.09.033_bib47","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1074\/jbc.M117.783985","article-title":"Loss of the clock protein PER2 shortens the erythrocyte life span in mice","volume":"292","author":"Sun","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jep.2018.09.033_bib48","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ejcn.2016.161","article-title":"Contribution of branched-chain amino acids to purine nucleotide cycle: a pilot study","volume":"71","author":"Tang","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.jep.2018.09.033_bib49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"Van","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.jep.2018.09.033_bib50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/hep.23639","article-title":"Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide","volume":"52","author":"Varela-Rey","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jep.2018.09.033_bib51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2018.09.033_bib52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00011.2016","article-title":"Ammonia transporters and their role in acid-base balance","volume":"97","author":"Weiner","year":"2017","journal-title":"Physiol. Rev."},{"issue":"D1","key":"10.1016\/j.jep.2018.09.033_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.jep.2018.09.033_bib54","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1080\/10286020.2014.996137","article-title":"Two new coumarin glycosides from Herpetospermum caudigerum","volume":"17","author":"Xu","year":"2015","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"11","key":"10.1016\/j.jep.2018.09.033_bib55","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1248\/cpb.54.1592","article-title":"Hepatitis B virus inhibiting constituents from Herpetospermum caudigerum","volume":"54","author":"Yuan","year":"2006","journal-title":"Chem. Pharm. Bull."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118323171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118323171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T03:16:23Z","timestamp":1541992583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118323171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":55,"alternative-id":["S0378874118323171"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.09.033","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}