{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:14:14Z","timestamp":1792858454545,"version":"4.5.0"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["3292\/2013"],"award-info":[{"award-number":["3292\/2013"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["402332\/2013-0"],"award-info":[{"award-number":["402332\/2013-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jep.2018.09.038","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T22:00:37Z","timestamp":1538431237000},"page":"29-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":302,"special_numbering":"C","title":["Rosmarinus officinalis essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved"],"prefix":"10.1016","volume":"229","author":[{"given":"Raphaelle Sousa","family":"Borges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Lorena S\u00e1nchez","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlindo C\u00e9sar Matias","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hady","family":"Keita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos Tavares","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2018.09.038_bib1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jep.2016.06.023","article-title":"Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan","volume":"191","author":"Abu-Darwish","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.fct.2013.02.008","article-title":"Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei","volume":"56","author":"Afoulous","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2018.09.038_bib3","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3109\/13880209.2014.984855","article-title":"Transdermal absorption enhancing effect of the essential oil of Rosmarinus officinalis on percutaneous absorption of Na diclofenac from topical gel","volume":"53","author":"Akbari","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2018.09.038_bib4","series-title":"Leafy Medicinal Herbs","author":"Ambrose","year":"2016"},{"key":"10.1016\/j.jep.2018.09.038_bib5","doi-asserted-by":"crossref","first-page":"FSO283","DOI":"10.4155\/fsoa-2017-0124","article-title":"Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity","volume":"4","author":"Andrade","year":"2018","journal-title":"Futur. Sci. OA"},{"key":"10.1016\/j.jep.2018.09.038_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-8741(91)90161-6","article-title":"Relaxant effect of the volatile oil of Romarinus officinalis on tracheal smooth muscle","volume":"33","author":"Aqel","year":"1992","journal-title":"J. Ethmopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib7","first-page":"2016","article-title":"Role of antioxidants and natural products in inflammation","author":"Arulselvan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2018.09.038_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev-ecolsys-040212-092530","article-title":"Inflammation: mechanisms, costs, and natural variation","volume":"43","author":"Ashley","year":"2012","journal-title":"Annu. Rev. Ecol. Evol. Syst."},{"key":"10.1016\/j.jep.2018.09.038_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.sajb.2016.01.001","article-title":"Ethnobotanical survey of culinary herbs and spices used in the traditional medicinal system of Nkonkobe Municipality, Eastern Cape, South Africa","volume":"104","author":"Asowata-Ayodele","year":"2016","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.jep.2018.09.038_bib10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.lfs.2012.08.035","article-title":"Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis","volume":"91","author":"Bae","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2018.09.038_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.indcrop.2017.05.063","article-title":"Antioxidant and antibacterial activities of the essential oils obtained from seven Iranian populations of Rosmarinus officinalis","volume":"107","author":"Bajalan","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2018.09.038_bib12","unstructured":"Baker, B.P., Grant, J.A., 2018. Rosemary & Rosemary Oil Profile."},{"key":"10.1016\/j.jep.2018.09.038_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2018.09.038_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1742-7843.2010.00622.x","article-title":"Inhaled 1,8-cineole reduces inflammatory parameters in airways of ovalbumin-challenged guinea pigs","volume":"108","author":"Bastos","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2018.09.038_bib15","first-page":"61","article-title":"An in-depth review on the medicinal flora Rosmarinus officinalis (lamiaceae)","volume":"12","author":"Begum","year":"2013","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"10.1016\/j.jep.2018.09.038_bib16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.5455\/jice.20160814115725","article-title":"Medicinal plants used by traditional healers from South-west Algeria: an ethnobotanical study","volume":"5","author":"Benarba","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nrrheum.2014.193","article-title":"Exercise as an anti-inflammatory therapy for rheumatic diseases - Myokine regulation","volume":"11","author":"Benatti","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2018.09.038_bib18","article-title":"Anti-inflammatory activity of nanoemulsions of essential oil from Rosmarinus officinalis L.: in vitro and in zebrafish studies","author":"Borges","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2018.09.038_bib19","article-title":"Anti-inflammatory and antialgic actions of a nanoemulsion of Rosmarinus officinalis L. essential oil and a molecular docking study of its major chemical constituents","author":"Borges","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2018.09.038_bib20","doi-asserted-by":"crossref","first-page":"20585","DOI":"10.3390\/ijms151120585","article-title":"Rosmarinus officinalis leaves as a natural source of bioactive compounds","volume":"15","author":"Borr\u00e1s-Linares","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2018.09.038_bib21","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.1021\/jf0715323","article-title":"Antimicrobial and antioxidant properties of Rosemary and Sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils","volume":"55","author":"Bozin","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2018.09.038_bib22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pupt.2010.11.001","article-title":"Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction","volume":"24","author":"Brightling","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2018.09.038_bib23","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s10753-015-0135-z","article-title":"The specific roles of JAK\/STAT signaling pathway in sepsis","volume":"38","author":"Cai","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2018.09.038_bib24","first-page":"285","article-title":"Plantas medicinales de los Andes ecuatorianos","author":"Cer\u00f3n Mart\u00ednez","year":"2006","journal-title":"Bot\u00e1nica Econ\u00f3mica los Andes Cent."},{"key":"10.1016\/j.jep.2018.09.038_bib25","first-page":"227","article-title":"Essential oils: a natural alternative to combat antibiotics resistance. A natural alternative to combat antibiotics resistance","author":"Ch\u00e1vez-Gonz\u00e1lez","year":"2016","journal-title":"Antibiot. Resist. Mech. New Antimicrob. Approaches"},{"key":"10.1016\/j.jep.2018.09.038_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2017.04.017","article-title":"Essential oil of Artemisia argyi suppresses inflammatory responses by inhibiting JAK\/STATs activation","volume":"204","author":"Chen","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib27","series-title":"Encyclopedia of Herbal Medicine","author":"Chevallier","year":"2016"},{"key":"10.1016\/j.jep.2018.09.038_bib28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1055\/s-2005-873173","article-title":"Relaxant effects of the essential oil of Eucalyptus tereticornis and its main constituent 1,8-Cineole on guinea-pig tracheal smooth muscle","volume":"71","author":"Coelho-de-Souza","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2018.09.038_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0160-5402(91)90056-B","article-title":"A new method for measuring auricular inflammation in the mouse","volume":"77","author":"Colorado","year":"1991","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.jep.2018.09.038_bib30","first-page":"54","article-title":"Rosmarinus officinalis L. Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas","author":"Correa","year":"1984","journal-title":"Minist. da Agric., Servi\u00e7o Inf. Agr\u00edc. Bras\u00edlia Dist. Fed. Bras."},{"key":"10.1016\/j.jep.2018.09.038_bib31","first-page":"1","article-title":"Rosmarinus officinalis L. essential oils from Spain: composition, antioxidant capacity, lipoxygenase and acetylcholinesterase inhibitory capacities, and antimicrobial activities","volume":"3504","author":"Cutillas","year":"2018","journal-title":"Plant Biosyst."},{"key":"10.1016\/j.jep.2018.09.038_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/DER.0000000000000174","article-title":"Essential oils, Part II","volume":"27","author":"de Groot","year":"2016","journal-title":"Dermatitis"},{"key":"10.1016\/j.jep.2018.09.038_bib33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1089\/jmf.2010.0159","article-title":"Rosmarinus officinalis L. Essential Oil Inhibits In Vivo and In Vitro Leukocyte Migration","volume":"14","author":"de Melo","year":"2011","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2018.09.038_bib34","article-title":"The mevalonate and methylerythritol phosphate pathways: terpenoids and steroids","author":"Dewick","year":"2009","journal-title":"Med. Nat. Prod."},{"key":"10.1016\/j.jep.2018.09.038_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jbiotec.2016.07.005","article-title":"Essential oil nanoemulsions as antimicrobial agents in food","volume":"233","author":"Dons\u00ec","year":"2016","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jep.2018.09.038_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.18773\/austprescr.2017.037","article-title":"Peptic ulcer disease and non-steroidal anti-inflammatory drugs","volume":"40","author":"Drini","year":"2017","journal-title":"Aust. Prescr."},{"key":"10.1016\/j.jep.2018.09.038_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jtcme.2016.06.006","article-title":"Chemical composition, acute toxicity, antioxidant and anti-inflammatory activities of Moroccan Tetraclinis articulata L.","volume":"7","author":"El Jemli","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jep.2018.09.038_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/096374899100987","article-title":"Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis","volume":"50","author":"Fahim","year":"1999","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2018.09.038_bib39","first-page":"515","article-title":"The effect of Artemisia fragrans willd. essential oil on inducible nitric oxide synthase gene expression and nitric oxide production in lipopolysaccharide-stimulated murine macrophage cell line","volume":"15","author":"Farghadan","year":"2016","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.jep.2018.09.038_bib40","first-page":"1","article-title":"Anti-inflammatory and antinociceptive activities of the essential oil from Rosmarinus officinalis L . ( Lamiaceae )","volume":"7","author":"Faria","year":"2011","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.jep.2018.09.038_bib41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.foodchem.2013.10.139","article-title":"Solvent-free microwave extraction of essential oil from aromatic herbs: from laboratory to pilot and industrial scale","volume":"150","author":"Filly","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2018.09.038_bib42","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.3390\/molecules20047329","article-title":"Antibacterial activity of essential oils and their isolated constituents against cariogenic bacteria: a systematic review","volume":"20","author":"Freires","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2018.09.038_bib43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1081\/CUS-120013039","article-title":"The mouse ear as a model for cutaneous irritation","volume":"21","author":"G\u00e1bor","year":"2002","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.jep.2018.09.038_bib44","unstructured":"Gafner, S., 2018. Journals Skeptical of Antioxidant Assays [WWW Document]. URL \u3008http:\/\/cms.herbalgram.org\/heg\/volume15\/01January\/JournalsSkepticalofAssays.html?Ts=1537416511&signature=424d00222d43e3a6ba75aee248532f0b&ts=1537416596&signature=f61439c336d5f56da654f56d86eb3bfe\u3009 (Accessed 20 September 2018)."},{"key":"10.1016\/j.jep.2018.09.038_bib45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1746-4269-6-29","article-title":"Ethnopharmacological survey among migrants living in the Southeast Atlantic Forest of Diadema, S\u00e3o Paulo, Brazil","volume":"6","author":"Garcia","year":"2010","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2018.09.038_bib46","first-page":"0","article-title":"Ethnobotany in the center of Portugal (Santarem)","volume":"47","author":"Gaspar","year":"2002","journal-title":"Nat. Prod. New Millenn. Prospect. Ind. Appl."},{"key":"10.1016\/j.jep.2018.09.038_bib47","article-title":"NF-kB target genes [www document]","author":"Gilmore","year":"2018","journal-title":"Bost. Univ."},{"key":"10.1016\/j.jep.2018.09.038_bib48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-8741(91)90035-C","article-title":"Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala","volume":"34","author":"Gir\u00f3n","year":"1991","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib49","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.foodcont.2009.09.005","article-title":"Spinning cone column isolation of rosemary essential oil","volume":"21","author":"Graber","year":"2010","journal-title":"Food Control"},{"key":"10.1016\/j.jep.2018.09.038_bib50","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.bbamcr.2013.07.001","article-title":"1,8-Cineol inhibits nuclear translocation of NF-\u03baB p65 and NF-\u03baB-dependent transcriptional activity","volume":"1833","author":"Greiner","year":"2013","journal-title":"Biochim. Biophys. Acta - Mol. Cell Res."},{"key":"10.1016\/j.jep.2018.09.038_bib51","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1039\/C5SM02958A","article-title":"Nanoemulsions: formation, properties and applications","volume":"12","author":"Gupta","year":"2016","journal-title":"Soft Matter"},{"key":"10.1016\/j.jep.2018.09.038_bib52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/187152809787582534","article-title":"Molecular basis of the anti-inflammatory effects of terpenoids","volume":"8","author":"Heras","year":"2009","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"10.1016\/j.jep.2018.09.038_bib53","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2018.09.038_bib54","unstructured":"IHA, 2018. Herb of the YearTM, The International Herb Association [WWW Document]. URL \u3008https:\/\/iherb.org\/herb-of-the-year\/\u3009 (Accessed 14 July 2018)."},{"key":"10.1016\/j.jep.2018.09.038_bib55","first-page":"315","article-title":"Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice","volume":"16","author":"Inoue","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2018.09.038_bib56","unstructured":"ISO, 2018. International Organization for Standardization: Essential oil of rosemary (Rosmarinus officinalis L.) [WWW Document]. URL \u3008https:\/\/www.iso.org\/standard\/56521.html\u3009 (Accessed 14 April 2018)."},{"key":"10.1016\/j.jep.2018.09.038_bib57","unstructured":"ITIS, 2018. Integrated Taxonomic Information System: Rosmarinus officinalis [WWW Document]. URL \u3008www.itis.gov\/servlet\/SingleRpt\/SingleRpt?Search_topic=TSN&search_value=32677\u3009."},{"key":"10.1016\/j.jep.2018.09.038_bib58","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jep.2014.03.016","article-title":"Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments","volume":"154","author":"Jamila","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib59","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1055\/s-0034-1372609","article-title":"Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases","volume":"64","author":"Juergens","year":"2014","journal-title":"Drug Res."},{"key":"10.1016\/j.jep.2018.09.038_bib60","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/rmed.2003.1432","article-title":"Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial","volume":"97","author":"Juergens","year":"2003","journal-title":"Respir. Med."},{"key":"10.1016\/j.jep.2018.09.038_bib61","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pupt.2004.06.002","article-title":"Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes","volume":"17","author":"Juergens","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2018.09.038_bib62","first-page":"508","article-title":"Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1,8-cineole) in human blood monocytes in vitro","volume":"17","author":"Juergens","year":"1998","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.jep.2018.09.038_bib63","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2754\/avb200978010121","article-title":"Anti-inflammatory effects of Rosmarinus officinalis essential oil in mice","volume":"78","author":"Juh\u00e1s","year":"2009","journal-title":"Acta Vet. Brno"},{"key":"10.1016\/j.jep.2018.09.038_bib64","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/s13197-011-0610-y","article-title":"Microwave-Assisted hydrodistillation of essential oil from rosemary","volume":"51","author":"Karakaya","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.jep.2018.09.038_bib65","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.carbpol.2015.06.014","article-title":"Promising applications of cyclodextrins in food: improvement of essential oils retention, controlled release and antiradical activity","volume":"131","author":"Kfoury","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2018.09.038_bib66","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s11064-013-1231-9","article-title":"1,8-Cineole (Eucalyptol) mitigates inflammation in amyloid beta toxicated PC12 cells: relevance to Alzheimer\u2019s Disease","volume":"39","author":"Khan","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2018.09.038_bib67","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1176\/appi.ajp.2015.15020152","article-title":"Inflammation: depression fans the flames and feasts on the heat","volume":"172","author":"Kiecolt-Glaser","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jep.2018.09.038_bib68","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1142\/S0192415X15500457","article-title":"Alpha-pinene exhibits anti-inflammatory activity through the suppression of MAPKs and the NF-\u03baB pathway in mouse peritoneal macrophages","volume":"43","author":"Kim","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2018.09.038_bib69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/13880209.2016.1226356","article-title":"Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves","volume":"55","author":"Kohoude","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2018.09.038_bib70","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1016\/B0-12-227055-X\/00593-9","article-title":"Herbs of the Labiatae","author":"Kokkini","year":"2003","journal-title":"Encycl. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2018.09.038_bib71","series-title":"Estudio de variabilidad quimica, propiedades antioxidantes y biocidas de poblaciones espontaneas de Rosmarinus officinalis","author":"Lax","year":"2014"},{"key":"10.1016\/j.jep.2018.09.038_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-4269-2-4","article-title":"Ethno-diversity within current ethno-pharmacology as part of Israeli traditional medicine - a review","volume":"2","author":"Lev","year":"2006","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2018.09.038_bib73","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jfda.2015.12.006","article-title":"Essential oils from Taiwan: chemical composition and antibacterial activity against Escherichia coli","volume":"24","author":"Lin","year":"2016","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jep.2018.09.038_bib74","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jep.2004.07.027","article-title":"In vitro biological activity and essential oil composition of four indigenous South African Helichrysum species","volume":"95","author":"Lourens","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib75","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.foodchem.2012.09.028","article-title":"Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L","volume":"136","author":"Machado","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2018.09.038_bib76","article-title":"Rosmarinus officinalis","author":"Marchiori","year":"2004","journal-title":"Funda\u00e7\u00e3o Herb."},{"key":"10.1016\/j.jep.2018.09.038_bib77","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1055\/s-2006-959755","article-title":"Anti-inflammatory activity of the essential oil of Bupleurum fruticescens","author":"Martin","year":"1993","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2018.09.038_bib78","first-page":"2016","article-title":"In vitro antimicrobial activity of essential oil of thymus schimperi, Matricaria chamomilla, Eucalyptus globulus, and Rosmarinus officinalis","author":"Mekonnen","year":"2016","journal-title":"Int. J. Microbiol."},{"key":"10.1016\/j.jep.2018.09.038_bib79","first-page":"8","article-title":"Notes about the uses of plants by one of the last healers in the Basilicata region (South Italy)","author":"Montesano","year":"2012","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2018.09.038_bib80","first-page":"1","article-title":"Botanical latin: the poetry of herb names","author":"Morgan","year":"2005","journal-title":"MediHerb"},{"key":"10.1016\/j.jep.2018.09.038_bib81","first-page":"115","article-title":"Carrageenan-induced paw edema in the rat and mouse","volume":"225","author":"Morris","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2018.09.038_bib82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jcou.2017.06.003","article-title":"Supercritical CO2 extraction from endemic Corsican plants; Comparison of oil composition and extraction yield with hydrodistillation method","volume":"20","author":"Mouahid","year":"2017","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.jep.2018.09.038_bib83","series-title":"Plantas\u00a0medicinales espa\u00f1olas:Medicinales Espa\u00f1olas:\u00a0Rosmarinus officinalis L. (Lamiaceae) (romero)","author":"Mu\u00f1oz-Centeno","year":"2002"},{"key":"10.1016\/j.jep.2018.09.038_bib84","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.intimp.2014.09.010","article-title":"The therapeutic efficacy of \u03b1-pinene in an experimental mouse model of allergic rhinitis","volume":"23","author":"Nam","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib85","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.bse.2010.04.001","article-title":"Screening of the essential oil composition of wild Sicilian rosemary","volume":"38","author":"Napoli","year":"2010","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2018.09.038_bib86","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/cbdv.201400274","article-title":"Wild sicilian Rosemary: phytochemical and morphological screening and antioxidant activity evaluation of extracts and essential oils","volume":"12","author":"Napoli","year":"2015","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2018.09.038_bib87","series-title":"Element Encyclopedia of Secret Signs and Symbols","author":"Nozedar","year":"2008"},{"key":"10.1016\/j.jep.2018.09.038_bib88","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jep.2005.10.023","article-title":"Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L","volume":"105","author":"Orhan","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib89","first-page":"27","article-title":"A etnobot\u00e2nica e as plantas usadas como rem\u00e9dio na comunidade bom Jardim, Mt, Brasil","volume":"3","author":"Pasa","year":"2011","journal-title":"Flovet"},{"key":"10.1016\/j.jep.2018.09.038_bib90","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/19440049.2015.1040081","article-title":"Plant essential oils and allied volatile fractions as multifunctional additives in meat and fish-based food products: a review","volume":"32","author":"Patel","year":"2015","journal-title":"Food Addit. Contam. - Part A Chem. Anal. Control. Expo. Risk Assess."},{"key":"10.1016\/j.jep.2018.09.038_bib91","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1211\/0022357991772808","article-title":"Medicinal plants and Alzheimer\u2019s Disease: from ethnobotany to phytotherapy**","volume":"51","author":"Perry","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib92","series-title":"Rang and Dale\u2019s pharmacology","author":"Rang","year":"2011"},{"key":"10.1016\/j.jep.2018.09.038_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-225","article-title":"Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential","volume":"14","author":"Ra\u0161kovi\u0107","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.jep.2018.09.038_bib94","article-title":"Rosemary production, agriculture, forestry & fisheries","author":"Republic of South Africa","year":"2009","journal-title":"Pretoria"},{"key":"10.1016\/j.jep.2018.09.038_bib95","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids--new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2018.09.038_bib96","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tifs.2015.07.015","article-title":"A novel insight on an ancient aromatic plant: the rosemary (Rosmarinus officinalis L.)","volume":"45","author":"Ribeiro-Santos","year":"2015","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.jep.2018.09.038_bib97","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1021\/np400828x","article-title":"Anti-inflammatory and chondroprotective activity of (+)-\u03b1-pinene: structural and enantiomeric selectivity","volume":"77","author":"Rufino","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2018.09.038_bib98","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejphar.2015.01.018","article-title":"Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis","volume":"750","author":"Rufino","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib99","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/bcpt.12221","article-title":"Structure-activity relationship of terpenes with anti-inflammatory profile - a systematic review","volume":"115","author":"Santana Souza","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2018.09.038_bib100","article-title":"The historical evolution of the medicinal use of rosemary (Rosmarinus officinalis L.), a Spanish panacea","author":"Santayana","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2018.09.038_bib101","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X","article-title":"Antiinflammatory and antinociceptive effects of 1, 8-cineole a terpenoid oxide present in many plant essential oils","volume":"14","author":"Santos","year":"2000","journal-title":"Phyther. Res."},{"key":"10.1016\/j.jep.2018.09.038_bib102","series-title":"The Aromatherapy Encyclopedia","author":"Schiller","year":"2008"},{"key":"10.1016\/j.jep.2018.09.038_bib103","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.bioeng.8.061505.095708","article-title":"Analysis of inflammation","volume":"8","author":"Schmid-Sch\u00f6nbein","year":"2006","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.jep.2018.09.038_bib104","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/07315724.2015.1080105","article-title":"Anti-inflammatory diets","volume":"34","author":"Sears","year":"2015","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.jep.2018.09.038_bib105","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pathophys.2017.08.002","article-title":"Rosemary (Rosmarinus officinalis) essential oil components exhibit anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects in experimental diabetes","volume":"24","author":"Selmi","year":"2017","journal-title":"Pathophysiology"},{"key":"10.1016\/j.jep.2018.09.038_bib106","first-page":"2807","article-title":"Caracteriza\u00e7\u00e3o Etnobot\u00e2nica E Histoqu\u00edmica De Plantas Medicinais Utilizadas Pelos Moradores Do Bairro Carrilho, Goian\u00e9sia (Go)","volume":"10","author":"Silva","year":"2014","journal-title":"Enciclop\u00e9dia Biosf."},{"key":"10.1016\/j.jep.2018.09.038_bib107","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.4314\/tjpr.v13i12.13","article-title":"Effect of camphor on the behavior of leukocytes in vitro and in vivo in acute inflammatory response","volume":"13","author":"Silva-Filho","year":"2014","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.jep.2018.09.038_bib108","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3390\/molecules18011227","article-title":"A review on anti-inflammatory activity of monoterpenes","volume":"18","author":"Silveira e S\u00e1","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2018.09.038_bib109","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vph.2015.03.005","article-title":"The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)","volume":"71","author":"Siti","year":"2015","journal-title":"Vasc. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2018.09.038_bib110","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1507\/endocrj.EJ12-0271","article-title":"Adipose tissue inflammation and ectopic lipid accumulation","volume":"59","author":"Suganami","year":"2012","journal-title":"Endocr. J."},{"key":"10.1016\/j.jep.2018.09.038_bib111","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/jmf.2007.0524","article-title":"Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models","volume":"11","author":"Takaki","year":"2008","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2018.09.038_bib112","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.apjtb.2015.09.027","article-title":"Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat","volume":"6","author":"Takayama","year":"2016","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jep.2018.09.038_bib113","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.indcrop.2016.03.026","article-title":"Does fertilizer type and method of application cause significant differences in essential oil yield and composition in rosemary (Rosmarinus officinalis L.)?","volume":"88","author":"Tawfeeq","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2018.09.038_bib114","first-page":"349","article-title":"Rosmarinus officinalis L. (rosemary): in vitro culture, regeneration of plants, and the level of essential oil and monoterpenoid constituents","volume":"41","author":"Tawfik","year":"1998","journal-title":"Biotechnol. Agric. For."},{"key":"10.1016\/j.jep.2018.09.038_bib115","unstructured":"The Plant List, 2018. Rosmarinus officinalis [WWW Document]. URL \u3008http:\/\/www.theplantlist.org\/tpl1.1\/record\/kew-179873\u3009 (Accessed 19 September 2018)."},{"key":"10.1016\/j.jep.2018.09.038_bib116","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/09168451.2016.1146066","article-title":"Enantioselective GC\u2013MS analysis of volatile components from rosemary (Rosmarinus officinalis L.) essential oils and hydrosols","volume":"80","author":"Tomi","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2018.09.038_bib117","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ffj.2730010402","article-title":"The essential oils of some rosemary cultivars","volume":"1","author":"Tucker","year":"1986","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.jep.2018.09.038_bib118","series-title":"Etnobot\u00e2nica de plantas medicinais comercializadas em mercados p\u00fablicos do nordeste brasileiro","author":"Vieira","year":"2012"},{"key":"10.1016\/j.jep.2018.09.038_bib119","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.fpsl.2016.04.002","article-title":"Antimicrobial effect of essential oils of Laurus nobilis L. and Rosmarinus officinallis L. on shelf-life of minced \u201cMaronesa\u201d beef stored under different packaging conditions","volume":"8","author":"Vilela","year":"2016","journal-title":"Food Packag. Shelf Life"},{"key":"10.1016\/j.jep.2018.09.038_bib120","first-page":"1","article-title":"Advanced analytical techniques for the extraction and characterization of plant-derived essential oils by gas chromatography with mass spectrometry","author":"Waseen","year":"2014","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jep.2018.09.038_bib121","series-title":"Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases","first-page":"189","article-title":"Terpenes","author":"Wiart","year":"2014"},{"key":"10.1016\/j.jep.2018.09.038_bib122","first-page":"782","article-title":"Anti-inflammatory activity and chemical composition of the essential oils from Senecio flammeus","volume":"13","author":"Xiao","year":"2014","journal-title":"EXCLI J."},{"key":"10.1016\/j.jep.2018.09.038_bib123","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.indcrop.2012.07.044","article-title":"Changes in essential oil composition and phenolic fraction in Rosmarinus officinalis L. var. typicus Batt. organs during growth and incidence on the antioxidant activity","volume":"43","author":"Yosr","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2018.09.038_bib124","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 years of NF-\u03baB: a blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jep.2018.09.038_bib125","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s10753-013-9770-4","article-title":"1,8-cineol attenuates LPS-induced acute pulmonary inflammation in mice","volume":"37","author":"Zhao","year":"2014","journal-title":"Inflammation"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118314107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118314107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:18:52Z","timestamp":1759940332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118314107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":125,"alternative-id":["S0378874118314107"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.09.038","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosmarinus officinalis essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.09.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}