{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:54:13Z","timestamp":1775141653895,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY14H270009"],"award-info":[{"award-number":["LY14H270009"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY16H270011"],"award-info":[{"award-number":["LY16H270011"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY16H060005"],"award-info":[{"award-number":["LY16H060005"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY17H270016"],"award-info":[{"award-number":["LY17H270016"]}]},{"name":"Major Science and Technology Special Project of Zhejiang Province","award":["2014C03035"],"award-info":[{"award-number":["2014C03035"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774331"],"award-info":[{"award-number":["81774331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673997"],"award-info":[{"award-number":["81673997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Major Science and Technology Project of Medical and Health of China","award":["201487674"],"award-info":[{"award-number":["201487674"]}]},{"name":"Zhejiang Provincial Science and Technology Project of Traditional Chinese Medicine of China","award":["2013ZQ007"],"award-info":[{"award-number":["2013ZQ007"]}]},{"name":"Zhejiang Provincial Science and Technology Project of Traditional Chinese Medicine of China","award":["2016ZQ010"],"award-info":[{"award-number":["2016ZQ010"]}]},{"name":"Zhejiang Provincial Science and Technology Project of Traditional Chinese Medicine of China","award":["2016ZZ011"],"award-info":[{"award-number":["2016ZZ011"]}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"publisher","award":["2014A610277"],"award-info":[{"award-number":["2014A610277"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jep.2018.12.004","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T17:26:42Z","timestamp":1544030802000},"page":"545-554","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis"],"prefix":"10.1016","volume":"231","author":[{"given":"Caiwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fucun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luwei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijian","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jida","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letian","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.rdc.2004.04.002","article-title":"Apoptosis in osteoarthritis","volume":"30","author":"Aigner","year":"2004","journal-title":"Rheum. Dis. Clin. N. Am."},{"issue":"7","key":"10.1016\/j.jep.2018.12.004_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ncprheum0534","article-title":"Mechanisms of disease: role of osteoarthritis\u2013structure, chaos and senescence","volume":"3","author":"Aigner","year":"2007","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1016\/j.jep.2018.12.004_bib3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.joca.2007.03.014","article-title":"Transcriptional profiling and pathway analysis of mono\u2013iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease","volume":"15","author":"Barve","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.jep.2018.12.004_bib4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1136\/ard.2004.025270","article-title":"Synovial tissue inflammation in early and late osteoarthritis","volume":"64","author":"Benito","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2018.12.004_bib5","doi-asserted-by":"crossref","unstructured":"Bijlsma, J.W., Berenbaum, F., Lafeber, F.P., 2011. Osteoarthritis: an update with relevance for.","DOI":"10.1016\/S0140-6736(11)60243-2"},{"key":"10.1016\/j.jep.2018.12.004_bib6","first-page":"S230","article-title":"The economic burden of osteoarthritis","volume":"15","author":"Bitton","year":"2009","journal-title":"Am. J. Manag. Care"},{"issue":"6","key":"10.1016\/j.jep.2018.12.004_bib7","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar2099","article-title":"The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis","volume":"8","author":"Bondeson","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2018.12.004_bib8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(11)60752-6","article-title":"Knee replacement","volume":"379","author":"Carr","year":"2012","journal-title":"Lancet"},{"issue":"25","key":"10.1016\/j.jep.2018.12.004_bib9","first-page":"3569","article-title":"Optimization of decoction process of Agkistrodon by orthogonal experiment","volume":"26","author":"Chai","year":"2016","journal-title":"China Pharm."},{"issue":"1","key":"10.1016\/j.jep.2018.12.004_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib11","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1159\/000481645","article-title":"Licochalcone a inhibits MMPs and ADAMTSs via the NF\u2013\u03baB and Wnt\/\u03b2\u2013catenin signaling pathways in rat chondrocytes","volume":"43","author":"Chen","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2018.12.004_bib12","series-title":"Pharmacopeia of the People's Republic of China (the First Division)","first-page":"177","author":"China Pharmacopeia Committee","year":"2010"},{"issue":"2\u20133","key":"10.1016\/j.jep.2018.12.004_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neulet.2004.08.023","article-title":"The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rat?","volume":"370","author":"Combe","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2018.12.004_bib14","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2018.12.004_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biomaterials.2018.07.011","article-title":"Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes","volume":"180","author":"Dai","year":"2018","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jep.2018.12.004_bib16","first-page":"603","article-title":"MMP\u20132\/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage","volume":"22","author":"Duerr","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jep.2018.12.004_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.joca.2015.09.013","article-title":"Synovitis and the risk of knee osteoarthritis: the most study","volume":"24","author":"Felson","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.jep.2018.12.004_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1089\/pho.2008.2297","article-title":"The effect of low\u2013level laser in knee osteoarthritis: a double\u2013blind, randomized, placebo\u2013controlled trial","volume":"27","author":"Hegedus","year":"2007","journal-title":"Photomed. Laser Surg."},{"issue":"4","key":"10.1016\/j.jep.2018.12.004_bib19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jor.22577","article-title":"Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes","volume":"32","author":"Hen","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jep.2018.12.004_bib20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/jcp.21317","article-title":"Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes","volume":"215","author":"Im","year":"2008","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib21","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pain.2006.12.022","article-title":"Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF\u20133 and pharmacological characterisation","volume":"128","author":"Ivanavicius","year":"2007","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib22","first-page":"937","article-title":"The evaluation of the effect of herbal extract on osteoarthritis: in vitro and in vivo study","volume":"43","author":"Kim","year":"2016","journal-title":"Cell Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib23","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1074\/jbc.271.3.1544","article-title":"Biochemical characterization of human collagenase\u20133","volume":"271","author":"Knauper","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00590-013-1205-2","article-title":"Useful animal models for the research of osteoarthritis","volume":"24","author":"Lampropoulou\u2013Adamidou","year":"2014","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.jep.2018.12.004_bib25","doi-asserted-by":"crossref","first-page":"90781","DOI":"10.18632\/oncotarget.21796","article-title":"Effects of baicalein on IL\u20131\u03b2\u2013induced inflammation and apoptosis in rat articular chondrocytes","author":"Li","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.jep.2018.12.004_bib26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00726-015-2168-x","article-title":"Alterations of amino acids metabolism in osteoarthritis: its implications for nutrition and health","volume":"48","author":"Li","year":"2016","journal-title":"Amino Acids"},{"issue":"03","key":"10.1016\/j.jep.2018.12.004_bib27","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/039463201302600331","article-title":"Expression of gelatinases (MMP\u20132,MMP\u20139) in human articular cartilage","volume":"26","author":"Lipari","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.jep.2018.12.004_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J. Bone Jt. Surg. [Am.]"},{"key":"10.1016\/j.jep.2018.12.004_bib29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-61779-561-9_18","article-title":"The monosodium iodoacetate model of osteoarthritis pain in the rat","volume":"851","author":"Marker","year":"2012","journal-title":"Methods Mol. Biol."},{"issue":"11","key":"10.1016\/j.jep.2018.12.004_bib30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1590\/s0102-865020160110000010","article-title":"Osteoarthritis model induced by intra\u2013articular monosodium iodoacetate in rats knee","volume":"31","author":"Morais","year":"2016","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.jep.2018.12.004_bib31","first-page":"180453","article-title":"A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis","author":"Moreau","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2018.12.004_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1172\/JCI10564","article-title":"Postnatal expression in hyaline cartilage of constitutively active human collagenase\u2013(MMP\u201313) induces osteoarthritis in mice","volume":"107","author":"Neuhold","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2018.12.004_bib33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-155-11-201112060-00004","article-title":"Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data","volume":"155","author":"Nguyen","year":"2011","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.jep.2018.12.004_bib34","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/j.1532-2149.2012.00223.x","article-title":"Pain\u2013like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57B\/6 mice","volume":"17","author":"Ogbonna","year":"2013","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.jep.2018.12.004_bib35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/ard.60.2.91","article-title":"Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care","volume":"60","author":"Peat","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2018.12.004_bib36","doi-asserted-by":"crossref","unstructured":"Peboul, P., Pelletier, J.P., Tardif, G., Cloutier, J.M., Martel\u2013Pelletier, J., 1996. The new collagenase, collagenase\u20133, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis, 97(9), 2011\u20132019.","DOI":"10.1172\/JCI118636"},{"key":"10.1016\/j.jep.2018.12.004_bib37","first-page":"111","article-title":"The monoiodoacetate model osteoarthritis pain in the mouse","volume":"16","author":"Pitcher","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jep.2018.12.004_bib38","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/S0140-6736(12)60607-2","article-title":"Hip arthroplasty","volume":"380","author":"Pivec","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pain.2004.11.008","article-title":"Development and pharmacological characterization of a rat model of osteoarthritis pain","volume":"114","author":"Pnmonis","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.jep.2018.12.004_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/ar148","article-title":"Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis","volume":"3","author":"Sandell","year":"2001","journal-title":"Arthritis Res."},{"key":"10.1016\/j.jep.2018.12.004_bib41","series-title":"DPS Data Processing System: Experimental Design, Statistical Analysis and Data Mining","author":"Tang","year":"2007"},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/1529-0131(200103)44:3<585::AID-ANR107>3.0.CO;2-C","article-title":"Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage","volume":"44","author":"Tetlow","year":"2001","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.jep.2018.12.004_bib43","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jep.2013.11.048","article-title":"Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe\u2013stage osteoarthritis model induced by mono\u2013iodoacetate","volume":"151","author":"Tong","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2018.12.004_bib44","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/art.10428","article-title":"Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13","volume":"46","author":"Wu","year":"2002","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.jep.2018.12.004_bib45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/230949900501300103","article-title":"Morphological studies on the ageing and osteoarthritis of the articular cartilage in C57 black mice","volume":"13","author":"Yamamoto","year":"2005","journal-title":"J. Orthop. Surg."},{"issue":"4","key":"10.1016\/j.jep.2018.12.004_bib46","doi-asserted-by":"crossref","first-page":"14811","DOI":"10.4238\/2015.November.18.46","article-title":"High MMP\u20131, MMP\u20132, and MMP\u20139 protein levels in osteoarthritis","volume":"14","author":"Zeng","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"8","key":"10.1016\/j.jep.2018.12.004_bib47","first-page":"862","article-title":"Chemical composition and pharmacological effects in Agkistrodon","volume":"36","author":"Zhang","year":"2016","journal-title":"Jilin J. Trad. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2018.12.004_bib48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.intimp.2014.05.006","article-title":"Baicalein ameliorates inflammatory\u2013related apoptotic and catabolic phenotypes in human chondrocytes","volume":"21","author":"Zhang","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2018.12.004_bib49","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cger.2010.03.001","article-title":"Epidemiology of osteoarthritis","volume":"26","author":"Zhang","year":"2010","journal-title":"Clin. Geriatr. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118321925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874118321925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T22:04:18Z","timestamp":1605564258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874118321925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":49,"alternative-id":["S0378874118321925"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.12.004","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}