{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:16:52Z","timestamp":1791047812513,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001342","name":"DST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012359","name":"DBT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jep.2018.12.008","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T02:55:09Z","timestamp":1544237709000},"page":"111634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection"],"prefix":"10.1016","volume":"243","author":[{"given":"Ved Prakash","family":"Dwivedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debapriya","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashima","family":"Bhaskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Sobia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc Van","family":"Kaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobardhan","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2018.12.008_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1286-4579(99)80003-3","article-title":"Antimicrobial properties of allicin from garlic","volume":"1","author":"Ankri","year":"1999","journal-title":"Microbes Infect."},{"issue":"7","key":"10.1016\/j.jep.2018.12.008_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.archoralbio.2004.12.002","article-title":"Inhibitory effect of garlic extract on oral bacteria","volume":"50","author":"Bakri","year":"2005","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jep.2018.12.008_bib3","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1038\/ncomms7049","article-title":"Host ICAMs play a role in cell invasion by mycobacterium tuberculosis and plasmodium falciparum","volume":"6","author":"Bhalla","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2018.12.008_bib4","doi-asserted-by":"crossref","first-page":"16508","DOI":"10.1074\/jbc.M114.558098","article-title":"Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis","volume":"289","author":"Bhattacharya","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2018.12.008_bib5","doi-asserted-by":"crossref","first-page":"33404","DOI":"10.1074\/jbc.M114.600452","article-title":"Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances bacillus calmette-guerin vaccine efficacy","volume":"289","author":"Bhattacharya","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2018.12.008_bib6","first-page":"2","article-title":"Extraction of garlic and enhancing antibiotic activity of allicin","volume":"4","author":"Biradar","year":"2014","journal-title":"Int J. Phytomed. Res."},{"issue":"11","key":"10.1016\/j.jep.2018.12.008_bib7","doi-asserted-by":"crossref","first-page":"e1002378","DOI":"10.1371\/journal.ppat.1002378","article-title":"Early secreted antigen ESAT-6 of mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner","volume":"7","author":"Chatterjee","year":"2011","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.jep.2018.12.008_bib8","doi-asserted-by":"crossref","first-page":"e1001880","DOI":"10.1371\/journal.pmed.1001880","article-title":"Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal","volume":"12","author":"Cohen","year":"2015","journal-title":"PLoS Med."},{"issue":"3","key":"10.1016\/j.jep.2018.12.008_bib9","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mi.2011.13","article-title":"Role of innate cytokines in mycobacterial infection","volume":"4","author":"Cooper","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jep.2018.12.008_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pmpp.2004.11.006","article-title":"Broad-spectrum activity of the volatile phytoanticipinallicin in extacts of garlic (Allium sativum L.) against plant pathogenic bacteria, fungi and Oomycetes","volume":"65","author":"Curtis","year":"2004","journal-title":"Physiol. Mol. Plant Pathol."},{"issue":"4","key":"10.1016\/j.jep.2018.12.008_bib11","first-page":"465","article-title":"The potential role of garlic (Allium sativum) against the multi-drug resistant tuberculosis pandemic: a review","volume":"47","author":"Dini","year":"2011","journal-title":"Ann. Ist. Super. Sanit\u00e0"},{"key":"10.1016\/j.jep.2018.12.008_bib12","doi-asserted-by":"crossref","first-page":"33656","DOI":"10.1074\/jbc.M112.375154","article-title":"Mycobacterium tuberculosis directs T helper 2 cell differentiation by inducing interleukin-1\u03b2 production in dendritic cells","volume":"287","author":"Dwivedi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2018.12.008_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fcimb.2017.00149","article-title":"The phytochemical bergenin enhances T helper 1 responses and anti-Mycobacterial immunity by activating the MAP kinase pathway in macrophages","volume":"7","author":"Dwivedi","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1645","key":"10.1016\/j.jep.2018.12.008_bib14","doi-asserted-by":"crossref","first-page":"20130426","DOI":"10.1098\/rstb.2013.0426","article-title":"After 2015: infectious diseases in a new era of health and development","volume":"369","author":"Dye","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jep.2018.12.008_bib15","first-page":"25","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect. Med. Chem."},{"key":"10.1016\/j.jep.2018.12.008_bib16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bbrc.2007.01.174","article-title":"Allicin-induced suppression of Mycobacterium tuberculosis 85B mRNA in human monocytes","volume":"355","author":"Hasan","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.jep.2018.12.008_bib17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1128\/MMBR.00032-13","article-title":"Host-directed therapeutics for tuberculosis: can we harness the host?","volume":"77","author":"Hawn","year":"2013","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jep.2018.12.008_bib18","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1086\/315771","article-title":"Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis","volume":"182","author":"Juffermans","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jep.2018.12.008_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0005-2736(99)00174-1","article-title":"The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity","volume":"1463","author":"Miron","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2018.12.008_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0003-2697(02)00010-6","article-title":"A spectro photometric assay for allicin, allin and alliinase (alliin-lyase) with a chromogenic thiol: reaction of 4-mercaptopyridine with thiosulfinates","volume":"307","author":"Miron","year":"2002","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.jep.2018.12.008_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"7","key":"10.1016\/j.jep.2018.12.008_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/0973-7847.65321","article-title":"Extracts from the history and medical properties of garlic","volume":"4","author":"Petrovska","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.jep.2018.12.008_bib23","first-page":"129","article-title":"Treatment of drug-resistant tuberculosis","volume":"4","author":"Pinto","year":"2011","journal-title":"Infect. Drug Resist."},{"issue":"23","key":"10.1016\/j.jep.2018.12.008_bib24","doi-asserted-by":"crossref","first-page":"14407","DOI":"10.1074\/jbc.M115.653600","article-title":"Mycobacterium tuberculosis TlyA negatively regulates Th1 and Th17 differentiation and promotes tuberculosis pathogenesis","volume":"290","author":"Rahman","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2018.12.008_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/157441b0","article-title":"Inhibition of Mycobacterium tuberculosis by garlic extract","volume":"157","author":"Rao","year":"1946","journal-title":"Nature"},{"key":"10.1016\/j.jep.2018.12.008_bib26","series-title":"Garlic: The Science and Therapeutic Applications of Allium sativum L. and Related Species","first-page":"135","article-title":"Therapeutic effects and applications of garlic and its preparations","author":"Reuter","year":"1996"},{"key":"10.1016\/j.jep.2018.12.008_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2005.04.025","article-title":"Medicinal plants and antimicrobial activity","volume":"100","author":"Rios","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"3s","key":"10.1016\/j.jep.2018.12.008_bib28","doi-asserted-by":"crossref","first-page":"951S","DOI":"10.1093\/jn\/131.3.951S","article-title":"Historical perspective on the use of garlic","volume":"131","author":"Rivlin","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.jep.2018.12.008_bib29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652407780598557","article-title":"Th2 cytokines in susceptibility to tuberculosis","volume":"7","author":"Rook","year":"2007","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jep.2018.12.008_bib30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1128\/AEM.67.1.475-480.2001","article-title":"Antimicrobial properties of garlic oil against human enteric bacteria: evaluation of methodologies and comparisons with garlic oil sulfides and garlic powder","volume":"67","author":"Ross","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"issue":"11","key":"10.1016\/j.jep.2018.12.008_bib31","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/eji.1830241108","article-title":"Macrophage\u2013T cell interaction in experimental mycobacterial infection. Selective regulation of co-stimulatory molecules on Mycobacterium infected macrophages and its implication in the suppression of cell-mediated immune response","volume":"24","author":"Saha","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2018.12.008_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1462-5822.2003.00263.x","article-title":"Macrophage signaling upon mycobacterial infection: the MAP kinases lead the way","volume":"5","author":"Schorey","year":"2003","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jep.2018.12.008_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2017.07.001","article-title":"Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches","author":"Sharifi-Rad","year":"2017","journal-title":"Biotechnol.Adv."},{"key":"10.1016\/j.jep.2018.12.008_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.med.60.053107.103955","article-title":"Extensively drug-resistant tuberculosis: a new face to an old pathogen","volume":"60","author":"Shenoi","year":"2009","journal-title":"Annu. Rev. Med."},{"issue":"9","key":"10.1016\/j.jep.2018.12.008_bib35","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/infdis\/jiw395","article-title":"Blockade of the Kv1.3 K+ channel enhances BCG vaccine efficacy by expanding central memory lymphocytes","volume":"214","author":"Singh","year":"2016","journal-title":"J. Infect. Dis."},{"issue":"12","key":"10.1016\/j.jep.2018.12.008_bib36","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.intimp.2006.07.021","article-title":"Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway","volume":"6","author":"Son","year":"2006","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.jep.2018.12.008_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00421-008-0699-5","article-title":"Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity","volume":"103","author":"Su","year":"2008","journal-title":"Eur. J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2018.12.008_bib38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jep.2018.12.008_bib39","doi-asserted-by":"crossref","first-page":"30190","DOI":"10.1074\/jbc.C114.598946","article-title":"Isoniazid induces apoptosis of activated CD4+T Cells: implications for post-therapy tuberculosis reactivation and reinfection","volume":"289","author":"Tousif","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.jep.2018.12.008_bib40","doi-asserted-by":"crossref","first-page":"e112726","DOI":"10.1371\/journal.pone.0112726","article-title":"Garlic revisited: antimicrobial activity of allicin- containing garlic extracts against Burkholderia cepacia complex","volume":"9","author":"Wallock-Richards","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2018.12.008_bib41","unstructured":"WHO, 2013. Global Tuberculosis Report. Geneva."},{"key":"10.1016\/j.jep.2018.12.008_bib42","unstructured":"WHO, 2015a. Tuberculosis Vaccine Development. Geneva."},{"key":"10.1016\/j.jep.2018.12.008_bib43","unstructured":"WHO, 2015b. Global Tuberculosis Report. Geneva."},{"key":"10.1016\/j.jep.2018.12.008_bib44","unstructured":"WHO, 2016. Global Tuberculosis Report 2016. Geneva."},{"key":"10.1016\/j.jep.2018.12.008_bib45","doi-asserted-by":"crossref","first-page":"378684","DOI":"10.1155\/2014\/378684","article-title":"Role of JNK activation and mitochondrial Bax translocation in allicin-induced apoptosis in human ovarian cancer SKOV3 cells","volume":"2014","author":"Xu","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2018.12.008_bib46","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/labinvest.3780079","article-title":"Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha\/beta double-knockout mice","volume":"80","author":"Yamada","year":"2000","journal-title":"Lab Invest"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411831763X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411831763X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T14:31:47Z","timestamp":1571927507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411831763X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":46,"alternative-id":["S037887411831763X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2018.12.008","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2018.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111634"}}